CR20150263A - Compuestos de pirrolopirimidina como inhibidores de quinasas - Google Patents

Compuestos de pirrolopirimidina como inhibidores de quinasas

Info

Publication number
CR20150263A
CR20150263A CR20150263A CR20150263A CR20150263A CR 20150263 A CR20150263 A CR 20150263A CR 20150263 A CR20150263 A CR 20150263A CR 20150263 A CR20150263 A CR 20150263A CR 20150263 A CR20150263 A CR 20150263A
Authority
CR
Costa Rica
Prior art keywords
compounds
pirrolopirimidine
inhibitors
quinase
quinase inhibitors
Prior art date
Application number
CR20150263A
Other languages
English (en)
Inventor
Wei Chen
David J Loury
Longcheng Wang
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50728514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20150263(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of CR20150263A publication Critical patent/CR20150263A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos que forman enlaces covalentes con la tirosina quinasa de Bruton (Btk). También se describen inhibidores irreversibles de Btk, inhibidores reversibles de Btk y composiciones farmacéuticas que incluyen los compuestos.
CR20150263A 2012-11-15 2015-05-19 Compuestos de pirrolopirimidina como inhibidores de quinasas CR20150263A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261727031P 2012-11-15 2012-11-15
PCT/US2013/070164 WO2014078578A1 (en) 2012-11-15 2013-11-14 Pyrrolopyrimidine compounds as kinase inhibitors

Publications (1)

Publication Number Publication Date
CR20150263A true CR20150263A (es) 2015-08-24

Family

ID=50728514

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150263A CR20150263A (es) 2012-11-15 2015-05-19 Compuestos de pirrolopirimidina como inhibidores de quinasas

Country Status (24)

Country Link
US (3) US9096604B2 (es)
EP (1) EP2920180A4 (es)
JP (1) JP2015537033A (es)
KR (1) KR20150084923A (es)
CN (1) CN104854107A (es)
AR (1) AR093518A1 (es)
AU (1) AU2013344656A1 (es)
BR (1) BR112015011171A2 (es)
CA (1) CA2890934A1 (es)
CL (1) CL2015001268A1 (es)
CR (1) CR20150263A (es)
DO (1) DOP2015000108A (es)
EA (1) EA201590855A1 (es)
HK (1) HK1215253A1 (es)
IL (1) IL238728A0 (es)
MA (1) MA38183A1 (es)
MX (1) MX2015006168A (es)
NI (1) NI201500067A (es)
PE (1) PE20151495A1 (es)
PH (1) PH12015501067A1 (es)
SG (1) SG11201503842PA (es)
TN (1) TN2015000174A1 (es)
TW (1) TWI522359B (es)
WO (1) WO2014078578A1 (es)

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