MA38183A1 - Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase - Google Patents

Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase

Info

Publication number
MA38183A1
MA38183A1 MA38183A MA38183A MA38183A1 MA 38183 A1 MA38183 A1 MA 38183A1 MA 38183 A MA38183 A MA 38183A MA 38183 A MA38183 A MA 38183A MA 38183 A1 MA38183 A1 MA 38183A1
Authority
MA
Morocco
Prior art keywords
relates
btk
compounds
inhibitors
kinase inhibitors
Prior art date
Application number
MA38183A
Other languages
English (en)
Inventor
Wei Chen
David J Loury
Longcheng Wang
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50728514&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA38183(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of MA38183A1 publication Critical patent/MA38183A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés qui forment des liaisons covalentes avec la tyrosine kinase de bruton (btk). L'invention concerne également des inhibiteurs irréversibles de btk. De plus, l'invention concerne également des inhibiteurs réversibles de btk. L'invention concerne également des compositions pharmaceutiques qui comprennent les composés. L'invention concerne des procédés d'utilisation des inhibiteurs de btk, seuls en combinaison avec d'autres agents thérapeutiques, pour le traitement de maladies auto-immunes ou d'états auto-immuns, de maladies hétéro-immunes ou d'états hétéro-immuns, le cancer, comprenant un lymphome, et des maladies ou états inflammatoires.
MA38183A 2012-11-15 2013-11-14 Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase MA38183A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261727031P 2012-11-15 2012-11-15
PCT/US2013/070164 WO2014078578A1 (fr) 2012-11-15 2013-11-14 Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase

Publications (1)

Publication Number Publication Date
MA38183A1 true MA38183A1 (fr) 2017-03-31

Family

ID=50728514

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38183A MA38183A1 (fr) 2012-11-15 2013-11-14 Composés pyrrolopyrimidines en tant qu'inhibiteurs de kinase

Country Status (24)

Country Link
US (3) US9096604B2 (fr)
EP (1) EP2920180A4 (fr)
JP (1) JP2015537033A (fr)
KR (1) KR20150084923A (fr)
CN (1) CN104854107A (fr)
AR (1) AR093518A1 (fr)
AU (1) AU2013344656A1 (fr)
BR (1) BR112015011171A2 (fr)
CA (1) CA2890934A1 (fr)
CL (1) CL2015001268A1 (fr)
CR (1) CR20150263A (fr)
DO (1) DOP2015000108A (fr)
EA (1) EA201590855A1 (fr)
HK (1) HK1215253A1 (fr)
IL (1) IL238728A0 (fr)
MA (1) MA38183A1 (fr)
MX (1) MX2015006168A (fr)
NI (1) NI201500067A (fr)
PE (1) PE20151495A1 (fr)
PH (1) PH12015501067A1 (fr)
SG (1) SG11201503842PA (fr)
TN (1) TN2015000174A1 (fr)
TW (1) TWI522359B (fr)
WO (1) WO2014078578A1 (fr)

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HK1215253A1 (zh) 2016-08-19
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EP2920180A4 (fr) 2016-04-13
MX2015006168A (es) 2015-08-10
US9096604B2 (en) 2015-08-04
US20140142126A1 (en) 2014-05-22
TW201425315A (zh) 2014-07-01
JP2015537033A (ja) 2015-12-24
KR20150084923A (ko) 2015-07-22
IL238728A0 (en) 2015-06-30
PE20151495A1 (es) 2015-10-23
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PH12015501067A1 (en) 2015-08-10
CN104854107A (zh) 2015-08-19
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EA201590855A1 (ru) 2015-11-30
AR093518A1 (es) 2015-06-10
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SG11201503842PA (en) 2015-06-29
US20150239897A1 (en) 2015-08-27
TWI522359B (zh) 2016-02-21
CA2890934A1 (fr) 2014-05-22
CL2015001268A1 (es) 2015-07-10
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