CR20150268A - Compuestos novedosos - Google Patents

Compuestos novedosos

Info

Publication number
CR20150268A
CR20150268A CR20150268A CR20150268A CR20150268A CR 20150268 A CR20150268 A CR 20150268A CR 20150268 A CR20150268 A CR 20150268A CR 20150268 A CR20150268 A CR 20150268A CR 20150268 A CR20150268 A CR 20150268A
Authority
CR
Costa Rica
Prior art keywords
carbon atoms
new compounds
integer
alkyl
value
Prior art date
Application number
CR20150268A
Other languages
English (en)
Inventor
Diane Mary Coe
Stephen Allan Smith
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of CR20150268A publication Critical patent/CR20150268A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Los compuestos de la fórmula (I), y las sales de los mismos:en donde R1 es n-alquilo de 4 a 6 átomos de carbono o alcoxilo de 1 a 2 átomos de carbono-alquilo de 1 a 2 átomos de carbono-; R2 es hidrógeno o metilo; cada R3 es hidroxilo, halógeno o n-alquilo de 1 a 3 átomos de carbono; m es un entero que tiene un valor de 2 a 4; n es un entero que tiene un valor de 0 a 3; y p es un entero que tiene un valor de 0 a 2, son inductores del interferón humano.
CR20150268A 2012-11-20 2015-05-20 Compuestos novedosos CR20150268A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728390P 2012-11-20 2012-11-20
US201361774087P 2013-03-07 2013-03-07
PCT/US2013/070472 WO2014081645A1 (en) 2012-11-20 2013-11-18 Novel compounds

Publications (1)

Publication Number Publication Date
CR20150268A true CR20150268A (es) 2015-07-01

Family

ID=50776485

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150268A CR20150268A (es) 2012-11-20 2015-05-20 Compuestos novedosos

Country Status (32)

Country Link
US (3) US9540383B2 (es)
EP (1) EP2922549B1 (es)
JP (1) JP6228223B2 (es)
KR (1) KR20150085055A (es)
CN (1) CN104780922B (es)
AU (1) AU2013348218B2 (es)
BR (1) BR112015011400A8 (es)
CA (1) CA2892218A1 (es)
CL (1) CL2015001342A1 (es)
CR (1) CR20150268A (es)
CY (1) CY1119557T1 (es)
DK (1) DK2922549T3 (es)
DO (1) DOP2015000121A (es)
EA (1) EA028480B1 (es)
ES (1) ES2639789T3 (es)
HR (1) HRP20171150T1 (es)
HU (1) HUE13857477T2 (es)
IL (1) IL238800B (es)
LT (1) LT2922549T (es)
ME (1) ME02867B (es)
MX (1) MX358025B (es)
NZ (1) NZ707319A (es)
PE (1) PE20151086A1 (es)
PH (1) PH12015501100B1 (es)
PL (1) PL2922549T3 (es)
PT (1) PT2922549T (es)
RS (1) RS56233B1 (es)
SG (1) SG11201503282RA (es)
SI (1) SI2922549T1 (es)
SM (1) SMT201700378T1 (es)
UA (1) UA114645C2 (es)
WO (1) WO2014081645A1 (es)

Families Citing this family (14)

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UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
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MX359671B (es) 2012-08-24 2018-10-05 Glaxosmithkline Llc Star Compuestos de pirazolopiridina.
PL2922549T3 (pl) 2012-11-20 2017-11-30 Glaxosmithkline Llc Nowe związki
CA2890201A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
WO2014081643A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
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CN105732635A (zh) * 2014-12-29 2016-07-06 南京明德新药研发股份有限公司 一类Toll样受体7激动剂
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CN108349982B (zh) 2015-11-05 2020-05-05 正大天晴药业集团股份有限公司 作为tlr7激动剂的7-(噻唑-5-基)吡咯并嘧啶化合物
CN107043379A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043378A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

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Also Published As

Publication number Publication date
PH12015501100A1 (en) 2015-07-27
NZ707319A (en) 2019-09-27
US20180140695A1 (en) 2018-05-24
CA2892218A1 (en) 2014-05-30
BR112015011400A8 (pt) 2019-10-01
BR112015011400A2 (pt) 2017-07-11
SMT201700378T1 (it) 2017-09-07
JP2016500068A (ja) 2016-01-07
CN104780922B (zh) 2016-09-07
HUE13857477T2 (hu) 2018-05-28
MX2015006375A (es) 2015-10-05
SI2922549T1 (sl) 2017-10-30
US20150284396A1 (en) 2015-10-08
US9540383B2 (en) 2017-01-10
EP2922549A4 (en) 2016-04-06
LT2922549T (lt) 2017-09-11
AU2013348218B2 (en) 2016-10-13
ME02867B (me) 2018-04-20
US20170080085A1 (en) 2017-03-23
KR20150085055A (ko) 2015-07-22
EP2922549B1 (en) 2017-06-21
CL2015001342A1 (es) 2015-10-02
CN104780922A (zh) 2015-07-15
HRP20171150T1 (hr) 2017-10-06
EP2922549A1 (en) 2015-09-30
DOP2015000121A (es) 2015-11-30
HK1208826A1 (en) 2016-03-18
SG11201503282RA (en) 2015-06-29
ES2639789T3 (es) 2017-10-30
IL238800B (en) 2018-10-31
IL238800A0 (en) 2015-06-30
WO2014081645A1 (en) 2014-05-30
EA201590684A1 (ru) 2016-03-31
MX358025B (es) 2018-08-02
JP6228223B2 (ja) 2017-11-08
AU2013348218A1 (en) 2015-06-04
EA028480B1 (ru) 2017-11-30
PL2922549T3 (pl) 2017-11-30
DK2922549T3 (en) 2017-09-11
CY1119557T1 (el) 2018-03-07
US9907847B2 (en) 2018-03-06
RS56233B1 (sr) 2017-11-30
UA114645C2 (uk) 2017-07-10
PT2922549T (pt) 2017-09-01
PE20151086A1 (es) 2015-08-20
PH12015501100B1 (en) 2017-10-06

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