CR20170592A - Anticuerpos anti-cd40 y sus usos - Google Patents

Anticuerpos anti-cd40 y sus usos

Info

Publication number
CR20170592A
CR20170592A CR20170592A CR20170592A CR20170592A CR 20170592 A CR20170592 A CR 20170592A CR 20170592 A CR20170592 A CR 20170592A CR 20170592 A CR20170592 A CR 20170592A CR 20170592 A CR20170592 A CR 20170592A
Authority
CR
Costa Rica
Prior art keywords
antibodies
activity
portions
human
hcd40
Prior art date
Application number
CR20170592A
Other languages
English (en)
Inventor
Chung-Ming Hsieh
Maria A Argiriadi
Bradford L Mcrae
Lorenzo Benatuil
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CR20170592A publication Critical patent/CR20170592A/es

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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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Abstract

La presente invención engloba anticuerpos anti-CD40 antagonistas y porciones de unión al antígeno de estos. En concreto, la invención se refiere a anticuerpos anti-CD40 humanizados. En ciertas realizaciones, los anticuerpos de la invención neutralizan la actividad de CD40 humano (hCD40). Los anticuerpos, o porciones de anticuerpos, de la invención son útiles para detectar CD40 y para inhibir la actividad de CD40, p. ej., en un sujeto humano que padece un trastorno en el que la actividad de CD40 resulta perjudicial.
CR20170592A 2015-05-29 2016-05-27 Anticuerpos anti-cd40 y sus usos CR20170592A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168425P 2015-05-29 2015-05-29
PCT/US2016/034716 WO2016196314A1 (en) 2015-05-29 2016-05-27 Anti-cd40 antibodies and uses thereof

Publications (1)

Publication Number Publication Date
CR20170592A true CR20170592A (es) 2018-02-13

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ID=56118046

Family Applications (1)

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CR20170592A CR20170592A (es) 2015-05-29 2016-05-27 Anticuerpos anti-cd40 y sus usos

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US (3) US10174121B2 (es)
EP (3) EP3303395B1 (es)
JP (3) JP6518917B2 (es)
KR (2) KR102661078B1 (es)
CN (2) CN113603782A (es)
AR (1) AR104809A1 (es)
AU (2) AU2016270640B2 (es)
CA (1) CA2987051A1 (es)
CL (1) CL2017003007A1 (es)
CO (1) CO2017012286A2 (es)
CR (1) CR20170592A (es)
CY (1) CY1122593T1 (es)
DK (1) DK3303395T3 (es)
DO (1) DOP2017000273A (es)
EC (1) ECSP17085333A (es)
ES (1) ES2774016T3 (es)
HR (1) HRP20200262T1 (es)
HU (1) HUE048284T2 (es)
IL (1) IL255961B (es)
LT (1) LT3303395T (es)
MX (1) MX392748B (es)
PE (1) PE20180193A1 (es)
PH (1) PH12017502161A1 (es)
PL (1) PL3303395T3 (es)
PT (1) PT3303395T (es)
RS (1) RS59935B1 (es)
RU (1) RU2715597C2 (es)
SI (1) SI3303395T1 (es)
TW (2) TWI740384B (es)
UA (1) UA125208C2 (es)
UY (1) UY36692A (es)
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