CR20180509A - Contorsbody - un ligante de diana monocatenario - Google Patents

Contorsbody - un ligante de diana monocatenario

Info

Publication number
CR20180509A
CR20180509A CR20180509A CR20180509A CR20180509A CR 20180509 A CR20180509 A CR 20180509A CR 20180509 A CR20180509 A CR 20180509A CR 20180509 A CR20180509 A CR 20180509A CR 20180509 A CR20180509 A CR 20180509A
Authority
CR
Costa Rica
Prior art keywords
domain
binding domain
polypeptide
contorsbody
monocatenary
Prior art date
Application number
CR20180509A
Other languages
English (en)
Inventor
Guy Georges
Friederike; Hesse
Josef; Platzer
Sabine; Imhof-Jung
Stefan Dengl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20180509A publication Critical patent/CR20180509A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En la presente memoria se informa de un polipéptido de fusión circular que comprende una primera parte de un dominio de unión, una segunda parte de un dominio de unión y un dominio espaciador, en el que el dominio espaciador es un polipéptido y comprende por lo menos 25 residuos aminoácidos, la primera parte del dominio de unión es un polipéptido y se fusiona mediante un primer conector con el extremo N-terminal del dominio espaciador, la segunda parte del dominio de unión es un polipéptido y se fusiona mediante un segundo conector con el extremo C-terminal del dominio espaciador, la primera parte del dominio de unión y la segunda parte del dominio de unión se asocian entre sí y forman un sitio de unión que se une específicamente a una diana.
CR20180509A 2016-05-02 2017-05-02 Contorsbody - un ligante de diana monocatenario CR20180509A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16167920 2016-05-02
PCT/EP2017/060354 WO2017191101A1 (en) 2016-05-02 2017-05-02 The contorsbody - a single chain target binder

Publications (1)

Publication Number Publication Date
CR20180509A true CR20180509A (es) 2019-02-15

Family

ID=56008478

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180509A CR20180509A (es) 2016-05-02 2017-05-02 Contorsbody - un ligante de diana monocatenario

Country Status (18)

Country Link
US (3) US20190389971A1 (es)
EP (2) EP3452502B1 (es)
JP (2) JP6675017B2 (es)
KR (1) KR102523682B1 (es)
CN (1) CN109071635B (es)
AU (1) AU2017259869A1 (es)
BR (1) BR112018069890A2 (es)
CA (1) CA3019524A1 (es)
CL (1) CL2018003007A1 (es)
CR (1) CR20180509A (es)
IL (1) IL262523A (es)
MA (1) MA56474A (es)
MX (1) MX2018013342A (es)
PE (1) PE20181890A1 (es)
RU (1) RU2018141360A (es)
SG (1) SG11201809620UA (es)
UA (1) UA123323C2 (es)
WO (1) WO2017191101A1 (es)

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LT3227311T (lt) * 2014-12-05 2022-02-25 Xyphos Biosciences Inc. Įterpiami variabilūs antikūnų fragmentai ir nkg2d ligandų modifikuoti a1-a2 domenai
WO2019077092A1 (en) 2017-10-20 2019-04-25 F. Hoffmann-La Roche Ag METHOD FOR GENERATING MULTISPECIFIC ANTIBODIES FROM MONOSPECIFIC ANTIBODIES
IL274071B2 (en) 2017-10-30 2025-10-01 Hoffmann La Roche Method for generating in vivo multispecific antibodies from monospecific antibodies
CN111295392A (zh) 2017-11-01 2020-06-16 豪夫迈·罗氏有限公司 Compbody–多价靶结合物
PE20210844A1 (es) * 2017-11-01 2021-05-10 Hoffmann La Roche Contorsbodies 2 + biespecificos
BR112020008031A2 (pt) * 2017-11-01 2020-10-27 F. Hoffmann-La Roche Ag anticorpo multiespecíficos, método para a preparação do anticorpo multiespecífico, conjunto de ácidos nucleicos, vetor de expressão, célula hospedeira e composição farmacêutica
WO2019136405A1 (en) 2018-01-05 2019-07-11 City Of Hope Multi-specific ligand binders
US12435137B2 (en) 2018-08-03 2025-10-07 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing two antigen-binding domains that are linked to each other
JP2022501325A (ja) 2018-09-28 2022-01-06 中外製薬株式会社 改変された抗体可変領域を含む抗原結合分子
JP7803856B2 (ja) 2020-02-05 2026-01-21 中外製薬株式会社 組換え抗原結合分子を製造するおよび／または濃縮するための方法
CA3173587A1 (en) 2020-03-31 2021-10-07 Chugai Seiyaku Kabushiki-Kaisha Dll3-targeting multispecific antigen-binding molecules and uses thereof
US20230265152A1 (en) * 2020-07-02 2023-08-24 Sanofi Glp-1r agonist / fgf21 fusion proteins
KR20220104423A (ko) 2021-01-18 2022-07-26 성기봉 페달엔진자전거(실용모델)
KR102604934B1 (ko) * 2021-10-27 2023-11-23 주식회사 베르티스 피분석물을 검출 또는 측정하기 위한 조성물
KR20240062555A (ko) 2022-11-02 2024-05-09 성기봉 회전 기어 방식의 적용 도르레

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