MA56474A - Contorsbody - liant de cible à chaîne unique - Google Patents

Contorsbody - liant de cible à chaîne unique

Info

Publication number
MA56474A
MA56474A MA056474A MA56474A MA56474A MA 56474 A MA56474 A MA 56474A MA 056474 A MA056474 A MA 056474A MA 56474 A MA56474 A MA 56474A MA 56474 A MA56474 A MA 56474A
Authority
MA
Morocco
Prior art keywords
contorsbody
single chain
chain target
target binder
binder
Prior art date
Application number
MA056474A
Other languages
English (en)
Inventor
Stefan Dengl
Guy Georges
Friederike Hesse
Sabine Imhof-Jung
Josef Platzer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA56474A publication Critical patent/MA56474A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA056474A 2016-05-02 2017-05-02 Contorsbody - liant de cible à chaîne unique MA56474A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16167920 2016-05-02

Publications (1)

Publication Number Publication Date
MA56474A true MA56474A (fr) 2022-05-11

Family

ID=56008478

Family Applications (1)

Application Number Title Priority Date Filing Date
MA056474A MA56474A (fr) 2016-05-02 2017-05-02 Contorsbody - liant de cible à chaîne unique

Country Status (18)

Country Link
US (3) US20190389971A1 (fr)
EP (2) EP3889175A1 (fr)
JP (2) JP6675017B2 (fr)
KR (1) KR102523682B1 (fr)
CN (1) CN109071635B (fr)
AU (1) AU2017259869A1 (fr)
BR (1) BR112018069890A2 (fr)
CA (1) CA3019524A1 (fr)
CL (1) CL2018003007A1 (fr)
CR (1) CR20180509A (fr)
IL (1) IL262523A (fr)
MA (1) MA56474A (fr)
MX (1) MX2018013342A (fr)
PE (1) PE20181890A1 (fr)
RU (1) RU2018141360A (fr)
SG (1) SG11201809620UA (fr)
UA (1) UA123323C2 (fr)
WO (1) WO2017191101A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2963274C (fr) * 2014-12-05 2024-01-30 Avidbiotics Corp. Fragments variables inserables d'anticorps et domaines a1-a2 modifies de ligands nkg2d
CN111246885B (zh) 2017-10-20 2024-06-11 豪夫迈·罗氏有限公司 从单特异性抗体生成多特异性抗体的方法
JP7438942B2 (ja) 2017-10-30 2024-02-27 エフ． ホフマン－ラ ロシュ アーゲー 単一特異性抗体から多重特異性抗体をインビボ生成させるための方法
WO2019086394A1 (fr) 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag "compbody" - lieur cible multivalent
MX2020004196A (es) * 2017-11-01 2020-11-09 Hoffmann La Roche Trifab-contorsbody.
MY205342A (en) * 2017-11-01 2024-10-16 Hoffmann La Roche Bispecific 2+1 contorsbodies
EP3735254A4 (fr) 2018-01-05 2021-11-03 City of Hope Liants de ligands multi-spécifiques
MX2021000827A (es) 2018-08-03 2021-03-25 Chugai Pharmaceutical Co Ltd Molecula de union a antigeno que contiene dos dominios de union a antigeno que estan enlazados entre si.
US12509524B2 (en) 2018-09-28 2025-12-30 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region
CN115175930A (zh) 2020-02-05 2022-10-11 中外制药株式会社 用于产生和/或富集重组抗原结合分子的方法
CR20220541A (es) 2020-03-31 2022-11-28 Chugai Pharmaceutical Co Ltd Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos
US20230265152A1 (en) * 2020-07-02 2023-08-24 Sanofi Glp-1r agonist / fgf21 fusion proteins
KR20220104423A (ko) 2021-01-18 2022-07-26 성기봉 페달엔진자전거(실용모델)
KR102604934B1 (ko) * 2021-10-27 2023-11-23 주식회사 베르티스 피분석물을 검출 또는 측정하기 위한 조성물
KR20240062555A (ko) 2022-11-02 2024-05-09 성기봉 회전 기어 방식의 적용 도르레

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US20240166771A1 (en) 2024-05-23
CN109071635A (zh) 2018-12-21
UA123323C2 (uk) 2021-03-17
CR20180509A (es) 2019-02-15
CN109071635B (zh) 2023-09-01
RU2018141360A3 (fr) 2020-10-16
BR112018069890A2 (pt) 2019-02-05
IL262523A (en) 2018-12-31
EP3889175A1 (fr) 2021-10-06
MX2018013342A (es) 2019-05-09
SG11201809620UA (en) 2018-11-29
AU2017259869A1 (en) 2018-09-27
JP2019521084A (ja) 2019-07-25
EP3452502A1 (fr) 2019-03-13
KR20190003678A (ko) 2019-01-09
KR102523682B1 (ko) 2023-04-19
CL2018003007A1 (es) 2019-02-08
RU2018141360A (ru) 2020-06-03
US20190389971A1 (en) 2019-12-26
US20210347916A1 (en) 2021-11-11
PE20181890A1 (es) 2018-12-11
CA3019524A1 (fr) 2017-11-09
EP3452502B1 (fr) 2021-03-03
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