CR20200255A - Análogos de incretina y sus usos - Google Patents

Análogos de incretina y sus usos

Info

Publication number
CR20200255A
CR20200255A CR20200255A CR20200255A CR20200255A CR 20200255 A CR20200255 A CR 20200255A CR 20200255 A CR20200255 A CR 20200255A CR 20200255 A CR20200255 A CR 20200255A CR 20200255 A CR20200255 A CR 20200255A
Authority
CR
Costa Rica
Prior art keywords
incretine
analogues
activity
receptors
incretin analogs
Prior art date
Application number
CR20200255A
Other languages
English (en)
Inventor
Jorge Alsina-Fernandez
Lili Guo
Hongchang Qu
Tamer Coskun
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR20200255A publication Critical patent/CR20200255A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Details Of Garments (AREA)

Abstract

Se proporcionan análogos de incretina que tienen actividad en cada uno de los receptores de GIP, GLP-1 y glucagón. Los análogos de incretina tienen características estructurales que dan como resultado una actividad equilibrada y una duración de acción extendida en cada uno de estos receptores. También se proporcionan métodos para tratar enfermedades tales como diabetes mellitus, dislipidemia, hepatopatía grasa, síndrome metabólico, esteatohepatitis no alcohólica y obesidad.
CR20200255A 2017-12-21 2018-12-14 Análogos de incretina y sus usos CR20200255A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762608613P 2017-12-21 2017-12-21
PCT/US2018/065663 WO2019125938A1 (en) 2017-12-21 2018-12-14 Incretin analogs and uses thereof

Publications (1)

Publication Number Publication Date
CR20200255A true CR20200255A (es) 2020-07-12

Family

ID=65003519

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20200255A CR20200255A (es) 2017-12-21 2018-12-14 Análogos de incretina y sus usos

Country Status (34)

Country Link
US (4) US11542313B2 (es)
EP (2) EP4691555A3 (es)
JP (3) JP6961838B2 (es)
KR (2) KR102622642B1 (es)
CN (1) CN111491658B (es)
AR (1) AR113486A1 (es)
AU (1) AU2018388962B2 (es)
BR (1) BR112020010244A2 (es)
CA (1) CA3084005C (es)
CL (1) CL2020001635A1 (es)
CO (1) CO2020006255A2 (es)
CR (1) CR20200255A (es)
DK (1) DK3727426T3 (es)
DO (1) DOP2020000123A (es)
EA (1) EA202091290A1 (es)
EC (1) ECSP20032650A (es)
ES (1) ES3061179T3 (es)
FI (1) FI3727426T3 (es)
HR (1) HRP20260186T1 (es)
IL (2) IL325353A (es)
JO (1) JOP20200137B1 (es)
LT (1) LT3727426T (es)
MA (1) MA51288B1 (es)
MX (2) MX2020006548A (es)
MY (1) MY199143A (es)
PE (2) PE20210162A1 (es)
PH (1) PH12020551025A1 (es)
PL (1) PL3727426T3 (es)
PT (1) PT3727426T (es)
RS (1) RS67748B1 (es)
SG (1) SG11202005606VA (es)
TW (3) TWI912614B (es)
UA (1) UA129012C2 (es)
WO (1) WO2019125938A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI912614B (zh) * 2017-12-21 2026-01-21 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
CN111171134B (zh) * 2018-11-12 2023-08-15 天津药物研究院有限公司 胰高血糖素衍生肽及其用途
MX2022002115A (es) * 2019-08-19 2022-03-17 Lilly Co Eli Metodos para preparar analogos de incretina.
CA3157387A1 (en) * 2019-12-03 2021-06-10 Mette Marie Rosenkilde Optimized gip peptide analogues
TWI795698B (zh) * 2019-12-18 2023-03-11 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
AR121650A1 (es) * 2020-03-25 2022-06-22 Takeda Pharmaceuticals Co Dosificación qd de compuestos peptídicos agonistas del receptor de gip y sus usos
EP4236991A1 (en) 2020-10-30 2023-09-06 Novo Nordisk A/S Glp-1, gip and glucagon receptor triple agonists
CN114685642B (zh) * 2020-12-29 2024-03-29 浙江和泽医药科技股份有限公司 一种肠促胰岛素类似物药学上可接受盐及制备方法和用途
WO2022159395A1 (en) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
TW202423476A (zh) * 2021-03-23 2024-06-16 美商美國禮來大藥廠 含腸促胰島素(incretin)類似物之組合物及其用途
US20250129135A1 (en) * 2021-05-26 2025-04-24 The United Bio-Technology (Hengqin) Co., Ltd Multi-Agonist and Use Thereof
WO2022268029A1 (zh) * 2021-06-21 2022-12-29 广东东阳光药业有限公司 Glp-1、gcg和gip受体的三重激动剂
CN117915939A (zh) * 2021-06-23 2024-04-19 伊莱利利公司 肠降血糖素类似物用于血糖控制和体重管理
MX2024003236A (es) 2021-09-15 2024-06-19 Viking Therapeutics Inc Composiciones y metodos para el tratamiento de trastornos metabolicos y hepaticos.
TWI828434B (zh) * 2021-11-19 2024-01-01 大陸商南京明德新藥研發有限公司 釘合肽及其應用
AU2022392980B2 (en) * 2021-11-19 2025-12-18 Jiangsu Deyuan Pharmaceutical Co., Ltd. Stapled peptide and use thereof
CN116162147B (zh) * 2021-11-24 2023-10-03 成都奥达生物科技有限公司 一种长效胰岛素类似物
CN114957387B (zh) * 2022-05-18 2023-06-20 华南理工大学 一种具有降血糖作用的巴旦木多肽及其制备方法与应用
CA3266547A1 (en) 2022-08-29 2024-03-07 Eli Lilly And Company COMPOSITIONS FOR ORAL ADMINISTRATION
CN120795089A (zh) * 2022-09-28 2025-10-17 广东东阳光药业股份有限公司 Glp-1/gcg/gip三受体激动剂及其用途
JP2025533109A (ja) * 2022-10-05 2025-10-03 イーライ リリー アンド カンパニー インクレチン合成のためのペプチド
KR20250110330A (ko) * 2022-11-21 2025-07-18 일라이 릴리 앤드 캄파니 Gip/glp1 이중 효능제의 제조 방법
JP2026502943A (ja) 2022-12-30 2026-01-27 アルギファルマ エーエス 経口投与されるポリペプチド治療剤の全身バイオアベイラビリティを高める組成物および方法
PE20252287A1 (es) 2023-01-31 2025-09-18 Lilly Co Eli Agonistas del trirreceptor gip/glp1/gcg y usos de estos
CN118684758A (zh) * 2023-03-23 2024-09-24 上海民为生物技术有限公司 肠促胰岛素类似物及其应用
WO2024213022A1 (zh) * 2023-04-11 2024-10-17 上海多米瑞生物技术有限公司 肠促胰素类似物及其制备方法和应用
EP4724471A1 (en) * 2023-06-09 2026-04-15 Sun Pharmaceutical Industries Limited Glp-1/gip dual, glp-1/gcg dual and glp-1/gip/gcg triple receptor agonists
EP4727524A1 (en) 2023-06-15 2026-04-22 Novo Nordisk A/S Pharmaceutical formulations of an amylin receptor agonist and a glp-1 receptor agonist comprising a cyclodextrin
CN117024528B (zh) * 2023-07-07 2024-03-22 杭州信海医药科技有限公司 一种Retatrutide的制备方法
WO2025016303A1 (zh) 2023-07-14 2025-01-23 北京拓界生物医药科技有限公司 Glp-1、gip和gcg受体三激动剂及其应用
WO2025087353A1 (zh) * 2023-10-26 2025-05-01 齐鲁制药有限公司 具有多重激动活性的多肽及其应用
CN120349393A (zh) * 2023-11-06 2025-07-22 成都奥达生物科技有限公司 一种三激动剂化合物
WO2025162423A1 (zh) * 2024-02-02 2025-08-07 杭州先为达生物科技股份有限公司 针对glp-1r、gipr和gcgr的三激动剂
WO2025264776A1 (en) * 2024-06-21 2025-12-26 Neurocrine Biosciences, Inc. Chemically modified peptides and use thereof
WO2025264809A1 (en) * 2024-06-21 2025-12-26 Neurocrine Biosciences, Inc. Chemically modified peptides and use thereof
WO2025264785A1 (en) * 2024-06-21 2025-12-26 Neurocrine Biosciences, Inc. Chemically modified peptides and use thereof
CN119978101B (zh) * 2024-07-30 2025-10-10 四川普康药业有限公司 多肽化合物及其应用
WO2026059846A1 (en) 2024-09-13 2026-03-19 Eli Lilly And Company Dissolving microneedle patch for transdermal delivery of a peptide
WO2026073030A1 (en) 2024-09-27 2026-04-02 Carmot Therapeutics Inc. Combination therapy of peptide tyrosine-tyrosine (pyy) analogues and glp-1r agonists
CN119823233A (zh) * 2025-03-18 2025-04-15 杭州思诺达医药科技有限责任公司 瑞他鲁肽的合成方法及瑞他鲁肽
CN120189527B (zh) * 2025-05-27 2026-04-03 广州富肽生物有限公司 一种多肽与抗体Fc片段的偶联物、药物组合物及其用途
CN120623312B (zh) * 2025-06-26 2026-01-23 乐普健糖药业(重庆)有限公司 Glp-1、gip、gcg三重受体激动剂及其制备方法和应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2300035T3 (en) * 2008-06-17 2015-11-16 Univ Indiana Res & Tech Corp Mixed GIP-based agonists for the treatment of metabolic diseases and obesity
EP2411054A2 (en) 2009-03-27 2012-02-01 Glaxo Group Limited Drug fusions and conjugates
BR112012018104A2 (pt) * 2010-01-20 2017-10-17 Zeland Pharma As tratamento de doenças cardíacas
AR080592A1 (es) * 2010-03-26 2012-04-18 Lilly Co Eli Peptido con actividad para el gip-r y glp-1-r, formulacion famaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de diabetes mellitus y para inducir la perdida de peso
WO2012153196A2 (en) * 2011-05-10 2012-11-15 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
AR092873A1 (es) 2012-09-26 2015-05-06 Cadila Healthcare Ltd Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
AU2014345570B2 (en) * 2013-11-06 2019-01-24 Zealand Pharma A/S Glucagon-GLP-1-GIP triple agonist compounds
MX2016005556A (es) * 2013-11-06 2016-07-15 Zealand Pharma As Compuestos agonistas duales de gip-glp-1 y procedimientos.
JO3575B1 (ar) * 2015-01-09 2020-07-05 Lilly Co Eli مركبات مساعد مشترك من gip وglp-1
WO2016198624A1 (en) 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
TWI783244B (zh) * 2015-06-22 2022-11-11 美商美國禮來大藥廠 升糖素及glp-1共激動劑化合物
TWI622596B (zh) * 2015-10-26 2018-05-01 美國禮來大藥廠 升糖素受體促效劑
WO2017116204A1 (ko) * 2015-12-31 2017-07-06 한미약품 주식회사 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체
EP3217027A1 (de) 2016-03-08 2017-09-13 HILTI Aktiengesellschaft Breites einlageelement zum einfassen einer ankerstange
TWI912614B (zh) * 2017-12-21 2026-01-21 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
TWI767095B (zh) * 2017-12-21 2022-06-11 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
EP3826662B9 (en) * 2018-07-23 2025-02-19 Eli Lilly and Company Method of using a gip/glp1 co-agonist for diabetes
CN112469731B (zh) * 2018-07-23 2024-11-29 伊莱利利公司 Gip/glp1共激动剂化合物
TWI764209B (zh) * 2019-08-01 2022-05-11 美商美國禮來大藥廠 Gipr促效劑化合物
TWI795698B (zh) * 2019-12-18 2023-03-11 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
WO2021150673A1 (en) * 2020-01-23 2021-07-29 Eli Lilly And Company Gip/glp1 co-agonist compounds
PE20252287A1 (es) * 2023-01-31 2025-09-18 Lilly Co Eli Agonistas del trirreceptor gip/glp1/gcg y usos de estos

Also Published As

Publication number Publication date
JP2021506955A (ja) 2021-02-22
PE20251598A1 (es) 2025-06-16
FI3727426T3 (fi) 2026-02-04
CA3084005A1 (en) 2019-06-27
ECSP20032650A (es) 2020-07-31
TWI744579B (zh) 2021-11-01
TW202202518A (zh) 2022-01-16
US12365716B2 (en) 2025-07-22
KR102444783B1 (ko) 2022-09-19
PT3727426T (pt) 2026-02-03
UA129012C2 (uk) 2024-12-25
US20230203121A1 (en) 2023-06-29
CL2020001635A1 (es) 2020-10-16
PL3727426T3 (pl) 2026-03-16
DK3727426T3 (da) 2026-02-02
MA51288A (fr) 2021-03-31
CN111491658B (zh) 2024-04-26
AU2018388962A1 (en) 2020-06-04
AR113486A1 (es) 2020-05-06
JP6961838B2 (ja) 2021-11-05
JOP20200137A1 (ar) 2022-10-30
US20250313605A1 (en) 2025-10-09
NZ765277A (en) 2024-08-30
CA3084005C (en) 2024-01-02
KR20220133304A (ko) 2022-10-04
EP3727426A1 (en) 2020-10-28
JP2025093970A (ja) 2025-06-24
CN111491658A (zh) 2020-08-04
IL275468A (en) 2020-08-31
EP3727426B1 (en) 2025-11-26
JP2022033724A (ja) 2022-03-02
PE20210162A1 (es) 2021-01-26
US20200331980A1 (en) 2020-10-22
RS67748B1 (sr) 2026-03-31
KR102622642B1 (ko) 2024-01-10
WO2019125938A1 (en) 2019-06-27
SG11202005606VA (en) 2020-07-29
EP4691555A3 (en) 2026-04-22
TW201938188A (zh) 2019-10-01
EA202091290A1 (ru) 2020-09-10
LT3727426T (lt) 2026-02-10
US11542313B2 (en) 2023-01-03
JOP20200137B1 (ar) 2024-04-18
BR112020010244A2 (pt) 2020-10-13
JP7658877B2 (ja) 2025-04-08
TW202415675A (zh) 2024-04-16
TWI912614B (zh) 2026-01-21
PH12020551025A1 (en) 2021-09-06
EP4691555A2 (en) 2026-02-11
ES3061179T3 (en) 2026-03-31
CO2020006255A2 (es) 2020-05-29
HRP20260186T1 (hr) 2026-03-27
MY199143A (en) 2023-10-17
US20250059251A1 (en) 2025-02-20
KR20200088419A (ko) 2020-07-22
AU2018388962B2 (en) 2020-11-19
IL275468B1 (en) 2026-01-01
TWI809515B (zh) 2023-07-21
IL325353A (en) 2026-02-01
DOP2020000123A (es) 2020-08-31
US12371465B2 (en) 2025-07-29
MX2024010201A (es) 2024-08-26
MX2020006548A (es) 2020-09-14
MA51288B1 (fr) 2026-02-27

Similar Documents

Publication Publication Date Title
ECSP20032650A (es) Análogos de incretina y sus usos
ECSP20032306A (es) Análogos de incretina y sus usos
DOP2022000122A (es) Analogos de incretina y sus usos
IL268702B (en) Use of a long-acting dual glp-1/glucagon receptor agonist for the treatment of non-alcoholic fatty liver disease
CO2017001573A2 (es) Receptor quimérico de antígeno anti-cd123
CO2017000506A2 (es) Receptor quimérico de antígeno cll-1
MX2017001008A (es) Tratamiento de cancer utilizando un receptor quimerico de antigeno cd33.
LT3297653T (lt) Postbariatrinės hipoglikemijos gydymas glp-1 antagonistais
MX394179B (es) Liraglutida en afecciones cardiovasculares.
AR101592A1 (es) Tratamiento de cáncer usando un receptor quimérico de antígeno cd123