CR20210375A - Formas cristalinas y formas de sal de un inhibidor de cinasa - Google Patents
Formas cristalinas y formas de sal de un inhibidor de cinasaInfo
- Publication number
- CR20210375A CR20210375A CR20210375A CR20210375A CR20210375A CR 20210375 A CR20210375 A CR 20210375A CR 20210375 A CR20210375 A CR 20210375A CR 20210375 A CR20210375 A CR 20210375A CR 20210375 A CR20210375 A CR 20210375A
- Authority
- CR
- Costa Rica
- Prior art keywords
- forms
- relates
- kinase inhibitor
- crystalline forms
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a formas cristalinas de la base libre del inhibidor de c-Met, Compuesto 1. La invención también se refiere a formas cristalinas de sales del Compuesto 1. La invención también se refiere a composiciones farmacéuticas que comprenden los polimorfos sólidos de la base libre y sales del Compuesto 1. La invención se refiere además a métodos para tratar una enfermedad, trastorno o síndrome mediado al menos en parte por la modulación de la actividad in vivo de una proteína cinasa.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779430P | 2018-12-13 | 2018-12-13 | |
| US201962856469P | 2019-06-03 | 2019-06-03 | |
| PCT/US2019/065972 WO2020123800A1 (en) | 2018-12-13 | 2019-12-12 | Crystalline forms and salt forms of a kinase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210375A true CR20210375A (es) | 2021-08-18 |
Family
ID=69160358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210375A CR20210375A (es) | 2018-12-13 | 2019-12-12 | Formas cristalinas y formas de sal de un inhibidor de cinasa |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US12017995B2 (es) |
| EP (2) | EP4631505A3 (es) |
| JP (3) | JP7509779B2 (es) |
| KR (2) | KR20250103803A (es) |
| CN (1) | CN113329790A (es) |
| AU (2) | AU2019395419B2 (es) |
| BR (1) | BR112021011333A2 (es) |
| CA (1) | CA3122840A1 (es) |
| CL (1) | CL2021001537A1 (es) |
| CO (1) | CO2021007613A2 (es) |
| CR (1) | CR20210375A (es) |
| DK (1) | DK3894012T3 (es) |
| ES (1) | ES3052838T3 (es) |
| FI (1) | FI3894012T3 (es) |
| GE (1) | GEP20247596B (es) |
| HR (1) | HRP20251122T1 (es) |
| HU (1) | HUE072868T2 (es) |
| IL (2) | IL320433A (es) |
| LT (1) | LT3894012T (es) |
| MA (1) | MA54458B1 (es) |
| MD (1) | MD3894012T2 (es) |
| MX (1) | MX2021006951A (es) |
| PE (1) | PE20211757A1 (es) |
| PH (1) | PH12021551356A1 (es) |
| PL (1) | PL3894012T3 (es) |
| PT (1) | PT3894012T (es) |
| RS (1) | RS67216B1 (es) |
| SG (1) | SG11202105949RA (es) |
| SI (1) | SI3894012T1 (es) |
| SM (1) | SMT202500346T1 (es) |
| TW (2) | TWI913821B (es) |
| WO (1) | WO2020123800A1 (es) |
| ZA (1) | ZA202103844B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEAP202415420A (en) * | 2018-01-26 | 2024-12-25 | Exelixis Inc | Compounds for the treatment of kinase-dependent disorders |
| SG11202111978VA (en) * | 2019-06-03 | 2021-11-29 | Exelixis Inc | Crystalline salt forms of a kinase inhibitor |
| PE20230110A1 (es) | 2020-04-30 | 2023-01-25 | Exelixis Inc | Procesos para la preparacion de un inhibidor de cinasa |
| BR112023001792A2 (pt) | 2020-07-31 | 2023-04-11 | Exelixis Inc | Combinações para o tratamento de câncer |
| MX2023005273A (es) * | 2020-11-05 | 2023-05-23 | Exelixis Inc | Composiciones farmaceuticas de un inhibidor de cinasa. |
| CN112650176B (zh) * | 2020-12-22 | 2022-08-30 | 天能化工有限公司 | 一种盐酸解析开停车工序的dcs控制方法 |
| AR127561A1 (es) * | 2021-11-03 | 2024-02-07 | Exelixis Inc | Compuestos para el tratamiento de trastornos dependientes de cinasas |
| JP2025500436A (ja) | 2021-12-22 | 2025-01-09 | エグゼリクシス， インコーポレイテッド | キナーゼ阻害剤の結晶性形態及び塩形態 |
| CN116751161A (zh) * | 2023-06-28 | 2023-09-15 | 中国人民解放军军事科学院军事医学研究院 | 喹啉类化合物及其制备方法、药物组合物及医药用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744997A1 (en) * | 2003-09-26 | 2005-04-07 | Exelixis, Inc. | C-met modulators and method of use |
| US7314622B2 (en) | 2005-04-15 | 2008-01-01 | Neogenix Oncology, Inc. | Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers |
| CA2740746A1 (en) | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds comprising a spiro-ring and and methods of use |
| EA038195B1 (ru) | 2009-01-16 | 2021-07-22 | Экселиксис, Инк. | Малатная соль n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида и ее применение для лечения рака почек и печени |
| CN102408411B (zh) | 2011-09-19 | 2014-10-22 | 北京康辰药业股份有限公司 | 一种含喹啉基的羟肟酸类化合物及其制备方法、以及含有该化合物的药物组合物及其应用 |
| BR112015007672A2 (pt) | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
| JP6742903B2 (ja) | 2013-05-02 | 2020-08-19 | アナプティスバイオ インコーポレイティッド | プログラム死−１（ｐｄ−１）に対する抗体 |
| AU2015218236B2 (en) | 2014-02-14 | 2019-06-13 | Exelixis, Inc. | Crystalline solid forms of N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use |
| CN104817497B (zh) | 2015-03-20 | 2017-03-08 | 南京众睿缘生物科技有限公司 | 一种炔代喹啉衍生物及其制备方法和用途 |
| IL270780B2 (en) | 2017-05-26 | 2025-04-01 | Exelixis Inc | Crystalline solid forms of salts of N–{4–[(7,6–dimethoxyquinolin–4–yl)oxy]phenyl}–N'–(4–fluorophenyl)cyclopropane–1,1–dicarboxamide, processes for preparation and methods of use |
| GEAP202415420A (en) * | 2018-01-26 | 2024-12-25 | Exelixis Inc | Compounds for the treatment of kinase-dependent disorders |
| SG11202111978VA (en) * | 2019-06-03 | 2021-11-29 | Exelixis Inc | Crystalline salt forms of a kinase inhibitor |
-
2019
- 2019-12-12 EP EP25183289.5A patent/EP4631505A3/en active Pending
- 2019-12-12 CN CN201980090041.5A patent/CN113329790A/zh active Pending
- 2019-12-12 IL IL320433A patent/IL320433A/en unknown
- 2019-12-12 LT LTEPPCT/US2019/065972T patent/LT3894012T/lt unknown
- 2019-12-12 RS RS20250909A patent/RS67216B1/sr unknown
- 2019-12-12 MX MX2021006951A patent/MX2021006951A/es unknown
- 2019-12-12 MD MDE20211022T patent/MD3894012T2/ro unknown
- 2019-12-12 AU AU2019395419A patent/AU2019395419B2/en active Active
- 2019-12-12 DK DK19836338.4T patent/DK3894012T3/da active
- 2019-12-12 SI SI201930963T patent/SI3894012T1/sl unknown
- 2019-12-12 CR CR20210375A patent/CR20210375A/es unknown
- 2019-12-12 SM SM20250346T patent/SMT202500346T1/it unknown
- 2019-12-12 MA MA54458A patent/MA54458B1/fr unknown
- 2019-12-12 PL PL19836338.4T patent/PL3894012T3/pl unknown
- 2019-12-12 JP JP2021533537A patent/JP7509779B2/ja active Active
- 2019-12-12 PT PT198363384T patent/PT3894012T/pt unknown
- 2019-12-12 CA CA3122840A patent/CA3122840A1/en active Pending
- 2019-12-12 HR HRP20251122TT patent/HRP20251122T1/hr unknown
- 2019-12-12 EP EP19836338.4A patent/EP3894012B1/en active Active
- 2019-12-12 HU HUE19836338A patent/HUE072868T2/hu unknown
- 2019-12-12 SG SG11202105949RA patent/SG11202105949RA/en unknown
- 2019-12-12 KR KR1020257021669A patent/KR20250103803A/ko active Pending
- 2019-12-12 FI FIEP19836338.4T patent/FI3894012T3/fi active
- 2019-12-12 GE GEAP201915695A patent/GEP20247596B/en unknown
- 2019-12-12 IL IL283860A patent/IL283860B2/en unknown
- 2019-12-12 WO PCT/US2019/065972 patent/WO2020123800A1/en not_active Ceased
- 2019-12-12 PE PE2021000862A patent/PE20211757A1/es unknown
- 2019-12-12 BR BR112021011333-9A patent/BR112021011333A2/pt unknown
- 2019-12-12 KR KR1020217021734A patent/KR102828472B1/ko active Active
- 2019-12-12 US US17/312,658 patent/US12017995B2/en active Active
- 2019-12-12 ES ES19836338T patent/ES3052838T3/es active Active
- 2019-12-13 TW TW113127734A patent/TWI913821B/zh active
- 2019-12-13 TW TW108145868A patent/TWI852963B/zh active
-
2021
- 2021-06-04 ZA ZA2021/03844A patent/ZA202103844B/en unknown
- 2021-06-09 PH PH12021551356A patent/PH12021551356A1/en unknown
- 2021-06-10 CO CONC2021/0007613A patent/CO2021007613A2/es unknown
- 2021-06-11 CL CL2021001537A patent/CL2021001537A1/es unknown
-
2023
- 2023-12-27 JP JP2023221085A patent/JP7783870B2/ja active Active
-
2024
- 2024-05-07 US US18/657,052 patent/US20240300897A1/en active Pending
-
2025
- 2025-09-22 AU AU2025234277A patent/AU2025234277A1/en active Pending
- 2025-11-28 JP JP2025208367A patent/JP2026031599A/ja active Pending
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