CR20210458A - Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar - Google Patents

Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar

Info

Publication number
CR20210458A
CR20210458A CR20210458A CR20210458A CR20210458A CR 20210458 A CR20210458 A CR 20210458A CR 20210458 A CR20210458 A CR 20210458A CR 20210458 A CR20210458 A CR 20210458A CR 20210458 A CR20210458 A CR 20210458A
Authority
CR
Costa Rica
Prior art keywords
bile acid
compounds
acid modulators
diseases
benzothiadiazepine
Prior art date
Application number
CR20210458A
Other languages
English (en)
Inventor
Santosh S Kulkarni
Jan Mattsson
Ingemar Starke
Per-Göran Gillberg
Original Assignee
Albireo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo Ab filed Critical Albireo Ab
Publication of CR20210458A publication Critical patent/CR20210458A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a los derivados 1,2,5 de benzotiadiazepina de la fórmula (I). Estos compuestos son moduladores del ácido biliar que tienen el transportador apical del ácido biliar dependiente del sodio (ASBT) y/o actividad inhibidora del transporte del ácido biliar del hígado (LBAT). La invención también se refiere a las composiciones farmacéuticas que comprenden estos compuestos y con el uso de estos compuestos en el tratamiento de enfermedades cardiovasculares, metabolismo del ácido graso y trastornos debido al uso de la glucosa, enfermedades gastrointestinales y enfermedades hepáticas.
CR20210458A 2019-02-06 2020-02-06 Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar CR20210458A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201911004690 2019-02-06
SE1950464 2019-04-12
IN201911049981 2019-12-04
PCT/EP2020/052942 WO2020161217A1 (en) 2019-02-06 2020-02-06 Benzothiadiazepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
CR20210458A true CR20210458A (es) 2021-11-04

Family

ID=69591608

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20210458A CR20210458A (es) 2019-02-06 2020-02-06 Compuestos de benzotiadiazepina y su uso como moduladores del ácido biliar

Country Status (34)

Country Link
US (2) US12187690B2 (es)
EP (1) EP3921028B1 (es)
JP (1) JP7504109B2 (es)
KR (1) KR102902263B1 (es)
CN (2) CN113677398B (es)
AU (1) AU2020218908B2 (es)
BR (1) BR112021015060A2 (es)
CA (1) CA3127568A1 (es)
CL (1) CL2021001934A1 (es)
CO (1) CO2021010400A2 (es)
CR (1) CR20210458A (es)
DK (1) DK3921028T3 (es)
EC (1) ECSP21056710A (es)
ES (1) ES2937153T3 (es)
FI (1) FI3921028T3 (es)
HR (1) HRP20230039T1 (es)
HU (1) HUE060905T2 (es)
IL (1) IL284983B2 (es)
LT (1) LT3921028T (es)
MX (1) MX2021008981A (es)
MY (1) MY206767A (es)
PE (1) PE20212251A1 (es)
PH (1) PH12021551848A1 (es)
PL (1) PL3921028T3 (es)
PT (1) PT3921028T (es)
RS (1) RS63899B1 (es)
SA (1) SA521422625B1 (es)
SG (1) SG11202108566VA (es)
SI (1) SI3921028T1 (es)
SM (1) SMT202300020T1 (es)
TW (1) TWI865487B (es)
UA (1) UA127911C2 (es)
WO (1) WO2020161217A1 (es)
ZA (1) ZA202106472B (es)

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