CR6575A - Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada - Google Patents

Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada

Info

Publication number
CR6575A
CR6575A CR6575A CR6575A CR6575A CR 6575 A CR6575 A CR 6575A CR 6575 A CR6575 A CR 6575A CR 6575 A CR6575 A CR 6575A CR 6575 A CR6575 A CR 6575A
Authority
CR
Costa Rica
Prior art keywords
hydroxibutiliden
trihydrated
amino
procedure
bisphosphonic
Prior art date
Application number
CR6575A
Other languages
English (en)
Inventor
Bosch I Llado Jordi
Pagans Lista Eugenia
Del Carmen Onrubia Miguel Ma
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Publication of CR6575A publication Critical patent/CR6575A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

UN PROCEDIMIENTO PARA LA OBTENCION DEL ACIDO 4-AMINO-1-HIDROXIBUTILIDEN-1,1-BIFOSFONICO Y DE SU MONOSODICO Y DE SU SAL MONOSODICA TRIHIDRATADA CONSISTENTE EN HACER REACIONAR EL ACIDO 4-AMINOBUTIRICO CON UNA MEZCLA DE FOSFONACION E HIDROLIZAR EL PRODUCTO RESULTANTE DE LA REACCION PARA AISLAR POSTERIORMENTE, MEDIANTE EL AJUSTE DE PH ADECUADO, EL ACIDO LIBRE O LA SAL MONOSODICA, CARACTERIZADO PORQUE LA MEZCLA DE FOSFONACION ESTA FORMADA POR ACIDO FOSFOROSO Y ANHIDRIDO METANSULFONICO.
CR6575A 1999-08-06 2002-01-31 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada CR6575A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901806A ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.

Publications (1)

Publication Number Publication Date
CR6575A true CR6575A (es) 2002-08-16

Family

ID=8309563

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6575A CR6575A (es) 1999-08-06 2002-01-31 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada

Country Status (18)

Country Link
US (1) US6573401B1 (es)
EP (1) EP1205484B1 (es)
KR (1) KR100688287B1 (es)
AT (1) ATE238317T1 (es)
AU (1) AU5987300A (es)
BR (1) BR0013031A (es)
CA (1) CA2380841C (es)
CR (1) CR6575A (es)
DE (1) DE60002347T2 (es)
DK (1) DK1205484T3 (es)
ES (2) ES2153794B1 (es)
HU (1) HUP0202196A3 (es)
IL (1) IL148000A (es)
MX (1) MXPA02001293A (es)
PL (1) PL191733B1 (es)
PT (1) PT1205484E (es)
SI (1) SI1205484T1 (es)
WO (1) WO2001010874A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ552514A (en) * 2001-12-24 2008-08-29 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
IL165227A0 (en) * 2002-05-17 2005-12-18 Tva Pharmaceutical Ind Ltd Cus of certain diluents for making bisphosphonic acids
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
AR057291A1 (es) * 2005-05-06 2007-11-28 Medichem Sa Proceso para la preparacion de acidos bisfosfonicos geminales y las sales y/o hidratos farmaceuticamente aceptables de los mismos, una composicion farmaceutica que los contiene y el uso de esta en el tratamiento de la osteoporosis
EP1891081B1 (en) 2005-06-13 2014-08-20 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
BRPI0710421A2 (pt) * 2006-05-11 2011-08-09 Ind Swift Ltd processo para a preparação de ácido risedrÈnico puro ou sais
CN102639545B (zh) 2009-10-02 2016-08-03 施里特马克控股公司 制备氨基羟基二膦酸的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
GB2248061A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Amino-hydroxy-alkylidene bis phosphonic acids
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (es) 1993-08-25 1995-09-21 Merck & Co Inc
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
WO2000049026A1 (en) * 1999-02-17 2000-08-24 Teva Pharmaceutical Industries, Ltd. Novel process for preparing alendronic acid

Also Published As

Publication number Publication date
PT1205484E (pt) 2003-08-29
US6573401B1 (en) 2003-06-03
KR20020024320A (ko) 2002-03-29
CA2380841C (en) 2009-09-15
ES2194753T3 (es) 2003-12-01
AU5987300A (en) 2001-03-05
ES2153794B1 (es) 2001-10-16
HUP0202196A3 (en) 2002-12-28
WO2001010874A1 (es) 2001-02-15
ES2153794A1 (es) 2001-03-01
BR0013031A (pt) 2002-04-16
IL148000A (en) 2005-12-18
DE60002347D1 (de) 2003-05-28
SI1205484T1 (en) 2003-12-31
KR100688287B1 (ko) 2007-02-28
DK1205484T3 (da) 2003-08-11
CA2380841A1 (en) 2001-02-15
IL148000A0 (en) 2002-09-12
EP1205484A1 (en) 2002-05-15
EP1205484B1 (en) 2003-04-23
DE60002347T2 (de) 2004-02-12
HUP0202196A2 (en) 2002-10-28
MXPA02001293A (es) 2002-07-22
ATE238317T1 (de) 2003-05-15
PL191733B1 (pl) 2006-06-30
PL354033A1 (en) 2003-12-15

Similar Documents

Publication Publication Date Title
CR6575A (es) Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada
MX9606656A (es) Procedimiento para la produccion de una suspension de celulosa.
TR200002059T2 (tr) Devamlı salınan bileşim, üretim yöntemi ve kullanımı.
ECSP034437A (es) Sales estables de acido o-acetilsalicilico con aminoacidos basicos
ES2054258T3 (es) Formulaciones para minerales de fosfato calcico preparados in situ.
ES2043626T3 (es) Procedimiento para obtener un preparado farmaceutico.
ATE243667T1 (de) Betonzusatzmittel
NZ521516A (en) Nutritional mineral fortification of milk by adding an orthophosphate and either a soluble calcium or other nutritional mineral
CO4910140A1 (es) Intermediarios y proceso para preparar olanzapina
AU2003285444A8 (en) Multiple-beam antenna with photonic bandgap material
DE60025905D1 (de) In vitro methode zur synchronisation von oozytenreifung
BR0115036A (pt) Processo para a preparação de um composto
ES2186903T3 (es) Procedimiento de fabricacion de una suspension de celulosa.
BR0212542A (pt) Método para a preparação de gluconato de cálcio, e, mistura de sal de glucomato/sal de ácido orgânico
CY1109455T1 (el) Μεθοδος και εγκατασταση για την παρασκευη ασβεστονερου απο απιονισμενο υδωρ
TW200605197A (en) Structure formation
YU62000A (sh) Postupak za proizvodnju nezasićenih 4,5-alenketona, 3,5-dienketona i odgovarajućih zasićenih ketona
SE8802478L (sv) Foerfarande foer fluorescent maerkning av sockerarter
ES2133819T3 (es) Procedimiento para preparar n-fosfonometilglicina.
EA200100129A1 (ru) Способ получения гидроксиметилтиобутановой кислоты
ES2126798T3 (es) Procedimiento de preparacion de anhidrido tetrafluoroftalico.
TR200100272T2 (tr) Zofenopril kalsiyum tuzunun hazırlanmasına mahsus bir yöntem
ES554671A0 (es) Procedimiento para la fabricacion de acidos 6-alcoxi (inferior)-5-halo-1-naftoicos y sus esteres correspondientes
NO20033706D0 (no) Fremgangsmåte for fremstilling av D-pantotensyre og/eller salter som tilsetning til dyrefôr
NO20033707D0 (no) Fremgangsmåte for fremstilling av D-pantotensyre og/eller salter som tilsetning til dyrefôr