CR7490A - 5-(2-hidroxi-3-1-(3-trifluorometilfenil)-ciclopropil-propionilamino)-ftalida y compuestos relacionados con actividad moduladora del receptor de progesterona para ser empleados en la contracepcion y en una terapia de reemplazo hormonal - Google Patents
5-(2-hidroxi-3-1-(3-trifluorometilfenil)-ciclopropil-propionilamino)-ftalida y compuestos relacionados con actividad moduladora del receptor de progesterona para ser empleados en la contracepcion y en una terapia de reemplazo hormonalInfo
- Publication number
- CR7490A CR7490A CR7490A CR7490A CR7490A CR 7490 A CR7490 A CR 7490A CR 7490 A CR7490 A CR 7490A CR 7490 A CR7490 A CR 7490A CR 7490 A CR7490 A CR 7490A
- Authority
- CR
- Costa Rica
- Prior art keywords
- progesterone receptor
- contraception
- replacement therapy
- trifluorometilfenil
- propionilamino
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 3
- 102000003998 progesterone receptors Human genes 0.000 title abstract 3
- 108090000468 progesterone receptors Proteins 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title 1
- 238000009256 replacement therapy Methods 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 abstract 3
- 230000001404 mediated effect Effects 0.000 abstract 2
- 210000000481 breast Anatomy 0.000 abstract 1
- 229940011871 estrogen Drugs 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940127234 oral contraceptive Drugs 0.000 abstract 1
- 239000003539 oral contraceptive agent Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 210000004291 uterus Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Progestinas no esteroides de la formula general (I) donde R y R, son independientemente entre si, -H o -F, R ES -CH o -CF, Y Ar es o un derivado o analogo del mismo aceptable para uso farmaceutico. Estas progestinas son adecuadas para modular selectivamente los efectos mediados por el receptor de progesterona en diferente tejidos de interes, en particular en tejidos de utero versus tejido de mama. Por ello, las progestinas de la presente invencion, optativamente en combinacion con estrogenos, se pueden utilizar en la contracepcion (en particular en los anticonceptivos orales libres de estrogenos), en una terapia de reemplazo hormonal y en el tratamiento de trastornos ginecologicos. La presente invencion se relaciona ademas con metodos para modular efectivamente los efectos mediados por el receptor de progesterona en diferente tejidos u organos de interes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36304402P | 2002-03-11 | 2002-03-11 | |
| EP02005530A EP1344776A1 (en) | 2002-03-11 | 2002-03-11 | 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR7490A true CR7490A (es) | 2006-02-07 |
Family
ID=27806515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR7490A CR7490A (es) | 2002-03-11 | 2004-09-21 | 5-(2-hidroxi-3-1-(3-trifluorometilfenil)-ciclopropil-propionilamino)-ftalida y compuestos relacionados con actividad moduladora del receptor de progesterona para ser empleados en la contracepcion y en una terapia de reemplazo hormonal |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7388006B2 (es) |
| EP (1) | EP1482925B1 (es) |
| JP (1) | JP2005526064A (es) |
| CN (1) | CN1652768A (es) |
| AR (1) | AR035904A1 (es) |
| AU (1) | AU2003209720A1 (es) |
| BR (1) | BR0308394A (es) |
| CA (1) | CA2478948A1 (es) |
| CR (1) | CR7490A (es) |
| DE (1) | DE60311236T2 (es) |
| DK (1) | DK1482925T3 (es) |
| ES (1) | ES2280766T3 (es) |
| HR (1) | HRP20040923A2 (es) |
| IL (1) | IL164032A0 (es) |
| MX (1) | MXPA04008881A (es) |
| NO (1) | NO20044279L (es) |
| NZ (1) | NZ535427A (es) |
| PE (1) | PE20040157A1 (es) |
| PL (1) | PL372490A1 (es) |
| PT (1) | PT1482925E (es) |
| RS (1) | RS89504A (es) |
| RU (1) | RU2314299C2 (es) |
| TW (1) | TW200307674A (es) |
| UA (1) | UA78027C2 (es) |
| UY (1) | UY27715A1 (es) |
| WO (1) | WO2003075915A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004062182B4 (de) * | 2004-12-20 | 2007-06-06 | Bayer Schering Pharma Ag | Transdermales Pflaster mit Progesteron A-Spezifische Liganden (PRASL) als Wirkstoff |
| US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
| DE102005030294A1 (de) * | 2005-06-24 | 2007-01-04 | Schering Ag | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| US7408060B2 (en) | 2005-06-24 | 2008-08-05 | Schering Ag | Nonsteroidal progesterone receptor modulators |
| US7261742B2 (en) | 2005-10-13 | 2007-08-28 | S.C. Johnson & Son, Inc. | Method of deodorizing a textile |
| CN101326169B (zh) * | 2005-12-09 | 2011-11-16 | 霍夫曼-拉罗奇有限公司 | 作为抗炎剂的糖皮质激素受体调节剂 |
| CA2632531A1 (en) * | 2005-12-09 | 2007-06-14 | F. Hoffmann-La Roche Ag | Propionamide compounds as antiinflammatory agents |
| UY30805A1 (es) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | Moduladores no esteroides de receptores de progesterona |
| DE102006061913A1 (de) * | 2006-12-21 | 2008-06-26 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| CN101289408B (zh) * | 2007-04-18 | 2013-02-27 | 中国科学院上海药物研究所 | 非甾体类孕激素受体调节剂及其制备方法、药物组合物和用途 |
| DE102007032800A1 (de) | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| DE102007058747A1 (de) * | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nichtsteroidale Progesteronrezeptor-Modulatoren |
| EA201070715A1 (ru) * | 2007-12-20 | 2011-02-28 | Тева Вимен'С Хелс, Инк. | Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции |
| ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| EP3079668A1 (en) | 2013-12-09 | 2016-10-19 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
| MX2016014281A (es) | 2014-05-22 | 2017-02-22 | Therapeuticsmd Inc | Formulaciones y terapias de reemplazo de combinación de hormonas naturales. |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| AU2017239645A1 (en) | 2016-04-01 | 2018-10-18 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| AU2018267059B2 (en) * | 2017-05-10 | 2021-08-12 | Ventana Medical Systems, Inc. | Stabilized two-part hematoxylin solution utilizing pH adjustment |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8617653D0 (en) * | 1986-07-18 | 1986-08-28 | Ici Plc | Amide derivatives |
| DE19723722A1 (de) * | 1997-05-30 | 1998-12-10 | Schering Ag | Nichtsteroidale Gestagene |
| US6245804B1 (en) * | 1997-05-30 | 2001-06-12 | Schering Aktiengesellschaft | Nonsteroidal gestagens |
| NO312255B1 (no) * | 2000-06-28 | 2002-04-15 | Pgs Reservoir Consultants As | Verktöy for gjennomhulling av et langsgående veggparti av et fôringsrör |
| DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| JP2004516841A (ja) * | 2000-12-28 | 2004-06-10 | シエーリング アクチエンゲゼルシャフト | プロゲステロンレセプターアイソフォーム特異的リガンドおよび組織選択的プロゲステロンレセプターリガンドについてスクリーニングする方法 |
-
2003
- 2003-03-10 WO PCT/EP2003/002441 patent/WO2003075915A1/en not_active Ceased
- 2003-03-10 NZ NZ535427A patent/NZ535427A/en unknown
- 2003-03-10 CA CA002478948A patent/CA2478948A1/en not_active Abandoned
- 2003-03-10 CN CNA038106590A patent/CN1652768A/zh active Pending
- 2003-03-10 ES ES03743862T patent/ES2280766T3/es not_active Expired - Lifetime
- 2003-03-10 RU RU2004130430/04A patent/RU2314299C2/ru not_active IP Right Cessation
- 2003-03-10 RS YU89504A patent/RS89504A/sr unknown
- 2003-03-10 AU AU2003209720A patent/AU2003209720A1/en not_active Abandoned
- 2003-03-10 DE DE60311236T patent/DE60311236T2/de not_active Expired - Fee Related
- 2003-03-10 DK DK03743862T patent/DK1482925T3/da active
- 2003-03-10 EP EP03743862A patent/EP1482925B1/en not_active Expired - Lifetime
- 2003-03-10 PL PL03372490A patent/PL372490A1/xx not_active Application Discontinuation
- 2003-03-10 PT PT03743862T patent/PT1482925E/pt unknown
- 2003-03-10 BR BR0308394-2A patent/BR0308394A/pt not_active IP Right Cessation
- 2003-03-10 MX MXPA04008881A patent/MXPA04008881A/es not_active Application Discontinuation
- 2003-03-10 IL IL16403203A patent/IL164032A0/xx unknown
- 2003-03-10 HR HRP20040923 patent/HRP20040923A2/hr not_active Application Discontinuation
- 2003-03-10 JP JP2003574190A patent/JP2005526064A/ja active Pending
- 2003-03-11 UY UY27715A patent/UY27715A1/es not_active Application Discontinuation
- 2003-03-11 US US10/384,775 patent/US7388006B2/en not_active Expired - Fee Related
- 2003-03-11 AR ARP030100820A patent/AR035904A1/es active IP Right Grant
- 2003-03-11 PE PE2003000244A patent/PE20040157A1/es not_active Application Discontinuation
- 2003-03-11 TW TW092105213A patent/TW200307674A/zh unknown
- 2003-10-03 UA UA20041008153A patent/UA78027C2/uk unknown
-
2004
- 2004-09-21 CR CR7490A patent/CR7490A/es not_active Application Discontinuation
- 2004-10-08 NO NO20044279A patent/NO20044279L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7388006B2 (en) | 2008-06-17 |
| DE60311236D1 (de) | 2007-03-08 |
| AR035904A1 (es) | 2004-07-28 |
| RS89504A (sr) | 2006-10-27 |
| PE20040157A1 (es) | 2004-06-03 |
| WO2003075915A1 (en) | 2003-09-18 |
| JP2005526064A (ja) | 2005-09-02 |
| PL372490A1 (en) | 2005-07-25 |
| CN1652768A (zh) | 2005-08-10 |
| PT1482925E (pt) | 2007-04-30 |
| TW200307674A (en) | 2003-12-16 |
| MXPA04008881A (es) | 2004-12-07 |
| DE60311236T2 (de) | 2008-02-14 |
| BR0308394A (pt) | 2005-01-25 |
| ES2280766T3 (es) | 2007-09-16 |
| RU2004130430A (ru) | 2005-08-10 |
| US20030232824A1 (en) | 2003-12-18 |
| RU2314299C2 (ru) | 2008-01-10 |
| AU2003209720A1 (en) | 2003-09-22 |
| CA2478948A1 (en) | 2003-09-18 |
| NZ535427A (en) | 2006-08-31 |
| HRP20040923A2 (en) | 2004-12-31 |
| EP1482925A1 (en) | 2004-12-08 |
| EP1482925B1 (en) | 2007-01-17 |
| UY27715A1 (es) | 2003-08-29 |
| NO20044279L (no) | 2004-12-08 |
| DK1482925T3 (da) | 2007-05-14 |
| IL164032A0 (en) | 2005-12-18 |
| UA78027C2 (en) | 2007-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |