CR9366A - "derivados de 1,2,4- triazinas, su preparacion y su aplicacion en terapeutica humana - Google Patents
"derivados de 1,2,4- triazinas, su preparacion y su aplicacion en terapeutica humanaInfo
- Publication number
- CR9366A CR9366A CR9366A CR9366A CR9366A CR 9366 A CR9366 A CR 9366A CR 9366 A CR9366 A CR 9366A CR 9366 A CR9366 A CR 9366A CR 9366 A CR9366 A CR 9366A
- Authority
- CR
- Costa Rica
- Prior art keywords
- derivatives
- triazins
- preparation
- application
- alkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical class O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 150000007942 carboxylates Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- -1 hydroxycarbonylvinyl Chemical group 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Liquid Crystal Substances (AREA)
Abstract
La invencion se refiere a derivados de 3,5-dioxo-(2H, 4H)-1,2,4-triazina de la formula general I en los cuales -R1 y R2 pueden ser identicos o diferentes y representan un radical alquilo o alquenilo, lineal o ramificado C1-C7, un radical alquilo C1-C6 substituido con grupos tales como trifluormetilo, cicloalquilo C5-C6, nitrilo, alcoxicarbonilvinilo C1-C4, hidroxicarbonilvinilo, alcoxicarbonilo C1-C4, carboxilato, benciloxi o fenilo (para el cual el nucleo fenilo esta posiblemente sustituido con uno o mas grupos tales como alquilo C1-C4, alcoxi C1-C4, nitro, halogeno o trifluormetilo).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0502152A FR2882750B1 (fr) | 2005-03-03 | 2005-03-03 | Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9366A true CR9366A (es) | 2008-02-12 |
Family
ID=35116027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9366A CR9366A (es) | 2005-03-03 | 2007-09-04 | "derivados de 1,2,4- triazinas, su preparacion y su aplicacion en terapeutica humana |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7713971B2 (es) |
| EP (1) | EP1856065B1 (es) |
| JP (1) | JP5269420B2 (es) |
| KR (1) | KR20070112230A (es) |
| CN (1) | CN101155790A (es) |
| AR (1) | AR053155A1 (es) |
| AT (1) | ATE448211T1 (es) |
| AU (1) | AU2006219802A1 (es) |
| BR (1) | BRPI0607567A2 (es) |
| CA (1) | CA2599848A1 (es) |
| CR (1) | CR9366A (es) |
| DE (1) | DE602006010337D1 (es) |
| ES (1) | ES2336823T3 (es) |
| FR (1) | FR2882750B1 (es) |
| IL (1) | IL185586A0 (es) |
| MA (1) | MA29343B1 (es) |
| MX (1) | MX2007010787A (es) |
| MY (1) | MY140662A (es) |
| NI (1) | NI200700224A (es) |
| NO (1) | NO20074881L (es) |
| PL (1) | PL1856065T3 (es) |
| PT (1) | PT1856065E (es) |
| RU (1) | RU2007136027A (es) |
| TN (1) | TNSN07335A1 (es) |
| TW (1) | TW200643016A (es) |
| WO (1) | WO2006092507A1 (es) |
| ZA (1) | ZA200707730B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2736229C (en) * | 2008-09-05 | 2015-06-09 | Acucela Inc. | Sulfur-linked compounds for treating opthalmic diseases and disorders |
| EP2612669A4 (en) | 2010-08-31 | 2014-05-14 | Snu R&Db Foundation | USING THE FÖTAL REPROGRAMMING OF A PPAR AGONIST |
| CN107074823B (zh) * | 2014-09-05 | 2021-05-04 | 基因泰克公司 | 治疗性化合物及其用途 |
| TWI884745B (zh) * | 2018-10-12 | 2025-05-21 | 美商拓臻股份有限公司 | 甲狀腺素受體β促效劑化合物 |
| CN111320609A (zh) | 2018-12-13 | 2020-06-23 | 拓臻股份有限公司 | 一种THRβ受体激动剂化合物及其制备方法和用途 |
| AU2020336272A1 (en) | 2019-08-23 | 2022-04-14 | Terns Pharmaceuticals, Inc. | Thyroid hormone receptor beta agonist compounds |
| WO2021050945A1 (en) | 2019-09-12 | 2021-03-18 | Terns, Inc. | Thyroid hormone receptor beta agonist compounds |
| EP4568664B1 (en) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2707294B1 (fr) * | 1993-07-06 | 1995-09-29 | Pf Medicament | Nouveaux dérivés de la 3,5-dioxo-(2H,4H)-1,2,4-triazine, leur préparation et leur application en thérapeutique humaine. |
| UA82048C2 (uk) * | 2000-11-10 | 2008-03-11 | Эли Лилли Энд Компани | Агоністи альфа-рецепторів, активованих проліфератором пероксисом |
| GB0113233D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
| FR2866339B1 (fr) * | 2004-02-18 | 2006-05-05 | Pf Medicament | Derives de 1,2,4-triazines, leur preparation et leur application en therapeutique humaine |
-
2005
- 2005-03-03 FR FR0502152A patent/FR2882750B1/fr not_active Expired - Fee Related
-
2006
- 2006-03-02 EP EP06726008A patent/EP1856065B1/fr not_active Expired - Lifetime
- 2006-03-02 PL PL06726008T patent/PL1856065T3/pl unknown
- 2006-03-02 CA CA002599848A patent/CA2599848A1/fr not_active Abandoned
- 2006-03-02 DE DE602006010337T patent/DE602006010337D1/de not_active Expired - Lifetime
- 2006-03-02 AR ARP060100797A patent/AR053155A1/es unknown
- 2006-03-02 MX MX2007010787A patent/MX2007010787A/es active IP Right Grant
- 2006-03-02 US US11/885,630 patent/US7713971B2/en not_active Expired - Fee Related
- 2006-03-02 AT AT06726008T patent/ATE448211T1/de not_active IP Right Cessation
- 2006-03-02 CN CNA2006800114913A patent/CN101155790A/zh active Pending
- 2006-03-02 TW TW095107034A patent/TW200643016A/zh unknown
- 2006-03-02 JP JP2007557542A patent/JP5269420B2/ja not_active Expired - Fee Related
- 2006-03-02 KR KR1020077022414A patent/KR20070112230A/ko not_active Abandoned
- 2006-03-02 AU AU2006219802A patent/AU2006219802A1/en not_active Abandoned
- 2006-03-02 ES ES06726008T patent/ES2336823T3/es not_active Expired - Lifetime
- 2006-03-02 RU RU2007136027/04A patent/RU2007136027A/ru not_active Application Discontinuation
- 2006-03-02 WO PCT/FR2006/000469 patent/WO2006092507A1/fr not_active Ceased
- 2006-03-02 PT PT06726008T patent/PT1856065E/pt unknown
- 2006-03-02 BR BRPI0607567-3A patent/BRPI0607567A2/pt not_active IP Right Cessation
- 2006-03-03 MY MYPI20060914A patent/MY140662A/en unknown
-
2007
- 2007-08-29 IL IL185586A patent/IL185586A0/en unknown
- 2007-08-30 NI NI200700224A patent/NI200700224A/es unknown
- 2007-08-31 TN TNP2007000335A patent/TNSN07335A1/fr unknown
- 2007-09-04 CR CR9366A patent/CR9366A/es not_active Application Discontinuation
- 2007-09-10 ZA ZA200707730A patent/ZA200707730B/en unknown
- 2007-09-25 MA MA30243A patent/MA29343B1/fr unknown
- 2007-09-25 NO NO20074881A patent/NO20074881L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE448211T1 (de) | 2009-11-15 |
| ZA200707730B (en) | 2008-05-28 |
| CA2599848A1 (fr) | 2006-09-08 |
| JP2008531662A (ja) | 2008-08-14 |
| PL1856065T3 (pl) | 2010-04-30 |
| NI200700224A (es) | 2008-03-27 |
| US7713971B2 (en) | 2010-05-11 |
| EP1856065B1 (fr) | 2009-11-11 |
| IL185586A0 (en) | 2008-01-06 |
| AR053155A1 (es) | 2007-04-25 |
| KR20070112230A (ko) | 2007-11-22 |
| WO2006092507A1 (fr) | 2006-09-08 |
| TNSN07335A1 (fr) | 2008-12-31 |
| ES2336823T3 (es) | 2010-04-16 |
| PT1856065E (pt) | 2010-02-10 |
| BRPI0607567A2 (pt) | 2011-10-18 |
| TW200643016A (en) | 2006-12-16 |
| FR2882750B1 (fr) | 2007-05-11 |
| CN101155790A (zh) | 2008-04-02 |
| MY140662A (en) | 2010-01-15 |
| NO20074881L (no) | 2007-11-27 |
| WO2006092507A8 (fr) | 2007-11-01 |
| US20080167313A1 (en) | 2008-07-10 |
| MA29343B1 (fr) | 2008-03-03 |
| MX2007010787A (es) | 2007-09-25 |
| AU2006219802A1 (en) | 2006-09-08 |
| FR2882750A1 (fr) | 2006-09-08 |
| RU2007136027A (ru) | 2009-04-10 |
| JP5269420B2 (ja) | 2013-08-21 |
| DE602006010337D1 (de) | 2009-12-24 |
| EP1856065A1 (fr) | 2007-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |