CR9436A - Derivados de aril 1,4-pirazina sustituidos - Google Patents
Derivados de aril 1,4-pirazina sustituidosInfo
- Publication number
- CR9436A CR9436A CR9436A CR9436A CR9436A CR 9436 A CR9436 A CR 9436A CR 9436 A CR9436 A CR 9436A CR 9436 A CR9436 A CR 9436A CR 9436 A CR9436 A CR 9436A
- Authority
- CR
- Costa Rica
- Prior art keywords
- pirazina
- aril
- derivatives
- substituted
- crf1
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 108091005471 CRHR1 Proteins 0.000 abstract 1
- 102100038018 Corticotropin-releasing factor receptor 1 Human genes 0.000 abstract 1
- 101000878678 Homo sapiens Corticotropin-releasing factor receptor 1 Proteins 0.000 abstract 1
- 101000948733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Probable phospholipid translocase non-catalytic subunit CRF1 Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
Abstract
La invencion se dirige a compuestos de Formula I, descrita en el presente texto, asi como a sus sales aceptables farmaceuticamente, que actuan como antagonistas de CRF1 y son utiles en el tratamiento de trastornos y enfermedades asociados con receptores CRF1, incluyendo trastornos y enfermedades relacionadas con el SNC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66291705P | 2005-03-17 | 2005-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9436A true CR9436A (es) | 2007-11-23 |
Family
ID=36617394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9436A CR9436A (es) | 2005-03-17 | 2007-10-12 | Derivados de aril 1,4-pirazina sustituidos |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20060211710A1 (es) |
| EP (1) | EP1871763A1 (es) |
| JP (1) | JP2008533124A (es) |
| KR (1) | KR20070113294A (es) |
| CN (1) | CN101160304A (es) |
| AP (1) | AP2007004174A0 (es) |
| AR (1) | AR056279A1 (es) |
| AU (1) | AU2006238976A1 (es) |
| BR (1) | BRPI0606284A2 (es) |
| CA (1) | CA2601600C (es) |
| CR (1) | CR9436A (es) |
| DO (1) | DOP2006000056A (es) |
| EA (1) | EA012874B1 (es) |
| GT (1) | GT200600116A (es) |
| IL (1) | IL185997A0 (es) |
| MA (1) | MA29336B1 (es) |
| MX (1) | MX2007011423A (es) |
| NL (1) | NL1031384C2 (es) |
| NO (1) | NO20075209L (es) |
| PE (1) | PE20061108A1 (es) |
| TN (1) | TNSN07355A1 (es) |
| TW (1) | TWI315670B (es) |
| UA (1) | UA86873C2 (es) |
| UY (1) | UY29418A1 (es) |
| WO (1) | WO2006114666A1 (es) |
| ZA (1) | ZA200707933B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| AU2010313392B2 (en) * | 2009-10-30 | 2015-07-09 | Janssen Pharmaceutica Nv | Pyrazines as delta opioid receptor modulators |
| CN102762572A (zh) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | 作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物 |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| JP2022062287A (ja) * | 2019-02-27 | 2022-04-20 | 住友化学株式会社 | ピリジルピラジン化合物の製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5872136A (en) * | 1996-04-03 | 1999-02-16 | Merck & Co., Inc. | Arylheteroaryl inhibitors of farnesyl-protein transferase |
| US5880140A (en) * | 1996-04-03 | 1999-03-09 | Merck & Co., Inc. | Biheteroaryl inhibitors of farnesyl-protein transferase |
| US5883105A (en) * | 1996-04-03 | 1999-03-16 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| PA8467401A1 (es) * | 1998-02-17 | 2000-09-29 | Pfizer Prod Inc | Procedimiento para tratar la insuficiencia cardiaca |
| MXPA02003436A (es) * | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
| ATE307121T1 (de) * | 2000-02-16 | 2005-11-15 | Neurogen Corp | Substituierte arylpyrazine |
| US6992087B2 (en) * | 2001-11-21 | 2006-01-31 | Pfizer Inc | Substituted aryl 1,4-pyrazine derivatives |
| DE60234269D1 (de) * | 2001-11-21 | 2009-12-17 | Pharmacia & Upjohn Co Llc | Substituierte aryl 1,4-pyrazin derivate |
| BR0309551A (pt) * | 2002-04-26 | 2005-02-09 | Upjohn Co | Derivados substituìdos de pirazina |
| EP1539736A1 (en) * | 2002-09-12 | 2005-06-15 | Pharmacia & Upjohn Company LLC | Substituted 1,4-pyrazine derivatives |
-
2006
- 2006-02-27 US US11/363,009 patent/US20060211710A1/en not_active Abandoned
- 2006-03-02 DO DO2006000056A patent/DOP2006000056A/es unknown
- 2006-03-06 AP AP2007004174A patent/AP2007004174A0/xx unknown
- 2006-03-06 WO PCT/IB2006/000564 patent/WO2006114666A1/en not_active Ceased
- 2006-03-06 MX MX2007011423A patent/MX2007011423A/es not_active Application Discontinuation
- 2006-03-06 EP EP06765409A patent/EP1871763A1/en not_active Withdrawn
- 2006-03-06 UA UAA200710557A patent/UA86873C2/ru unknown
- 2006-03-06 KR KR1020077023701A patent/KR20070113294A/ko not_active Ceased
- 2006-03-06 BR BRPI0606284-9A patent/BRPI0606284A2/pt not_active IP Right Cessation
- 2006-03-06 JP JP2008501437A patent/JP2008533124A/ja not_active Ceased
- 2006-03-06 AU AU2006238976A patent/AU2006238976A1/en not_active Abandoned
- 2006-03-06 CN CNA2006800128070A patent/CN101160304A/zh active Pending
- 2006-03-06 EA EA200701758A patent/EA012874B1/ru not_active IP Right Cessation
- 2006-03-06 CA CA2601600A patent/CA2601600C/en not_active Expired - Fee Related
- 2006-03-13 UY UY29418A patent/UY29418A1/es not_active Application Discontinuation
- 2006-03-15 AR ARP060100986A patent/AR056279A1/es unknown
- 2006-03-15 PE PE2006000289A patent/PE20061108A1/es not_active Application Discontinuation
- 2006-03-16 TW TW095108969A patent/TWI315670B/zh not_active IP Right Cessation
- 2006-03-16 NL NL1031384A patent/NL1031384C2/nl not_active IP Right Cessation
- 2006-03-16 GT GT200600116A patent/GT200600116A/es unknown
-
2007
- 2007-09-17 TN TNP2007000355A patent/TNSN07355A1/fr unknown
- 2007-09-17 MA MA30226A patent/MA29336B1/fr unknown
- 2007-09-17 ZA ZA200707933A patent/ZA200707933B/xx unknown
- 2007-09-17 IL IL185997A patent/IL185997A0/en unknown
- 2007-10-11 NO NO20075209A patent/NO20075209L/no not_active Application Discontinuation
- 2007-10-12 CR CR9436A patent/CR9436A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007011423A (es) | 2007-10-12 |
| ZA200707933B (en) | 2009-08-26 |
| TW200700067A (en) | 2007-01-01 |
| WO2006114666A8 (en) | 2008-04-03 |
| AU2006238976A1 (en) | 2006-11-02 |
| CA2601600C (en) | 2010-09-14 |
| GT200600116A (es) | 2006-11-09 |
| EA200701758A1 (ru) | 2008-02-28 |
| UY29418A1 (es) | 2006-10-31 |
| CA2601600A1 (en) | 2006-11-02 |
| IL185997A0 (en) | 2008-01-20 |
| NL1031384C2 (nl) | 2007-01-23 |
| AR056279A1 (es) | 2007-10-03 |
| US20060211710A1 (en) | 2006-09-21 |
| CN101160304A (zh) | 2008-04-09 |
| PE20061108A1 (es) | 2006-10-13 |
| UA86873C2 (en) | 2009-05-25 |
| NL1031384A1 (nl) | 2006-09-20 |
| MA29336B1 (fr) | 2008-03-03 |
| JP2008533124A (ja) | 2008-08-21 |
| TWI315670B (en) | 2009-10-11 |
| AP2007004174A0 (en) | 2007-10-31 |
| KR20070113294A (ko) | 2007-11-28 |
| BRPI0606284A2 (pt) | 2009-06-09 |
| EP1871763A1 (en) | 2008-01-02 |
| WO2006114666A1 (en) | 2006-11-02 |
| DOP2006000056A (es) | 2006-08-30 |
| EA012874B1 (ru) | 2009-12-30 |
| TNSN07355A1 (fr) | 2008-12-31 |
| NO20075209L (no) | 2007-10-11 |
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