CR8094A - Derivados de imidazol antagonistas del receptor de glutamato - Google Patents
Derivados de imidazol antagonistas del receptor de glutamatoInfo
- Publication number
- CR8094A CR8094A CR8094A CR8094A CR8094A CR 8094 A CR8094 A CR 8094A CR 8094 A CR8094 A CR 8094A CR 8094 A CR8094 A CR 8094A CR 8094 A CR8094 A CR 8094A
- Authority
- CR
- Costa Rica
- Prior art keywords
- antagonists
- imidazol derivatives
- glutamate
- receiver
- derivatives antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a derivados del imidazol que son antagonistas del receptor mGluR5, los cuales estan representados por la formula general I, en donde R1, R2, R3 y R4 son como se han definido en la especificacion, a un procedimiento para la obtencion de los mismos, asi como tambien a las sales farmaceuticamente aceptables de los mismos para la elaboracion de un medicamento para el tratamiento o la prevencion de trastornos inducidos por el receptor mGLUR5, tales como trastornos neurologicos agudos y/o cronicos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03012200 | 2003-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR8094A true CR8094A (es) | 2006-05-30 |
Family
ID=33483899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR8094A CR8094A (es) | 2003-06-05 | 2005-11-14 | Derivados de imidazol antagonistas del receptor de glutamato |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US7332510B2 (es) |
| EP (1) | EP1636206B1 (es) |
| JP (1) | JP4401384B2 (es) |
| KR (1) | KR100778948B1 (es) |
| CN (1) | CN100408572C (es) |
| AR (1) | AR044478A1 (es) |
| AT (1) | ATE377008T1 (es) |
| AU (1) | AU2004245208B2 (es) |
| BR (1) | BRPI0411095B8 (es) |
| CA (1) | CA2527315C (es) |
| CL (1) | CL2004001347A1 (es) |
| CR (1) | CR8094A (es) |
| CY (1) | CY1107856T1 (es) |
| DE (1) | DE602004009796T2 (es) |
| DK (1) | DK1636206T3 (es) |
| EA (1) | EA010577B1 (es) |
| EC (1) | ECSP056202A (es) |
| ES (1) | ES2294504T3 (es) |
| GT (1) | GT200400117A (es) |
| HN (1) | HN2004000208A (es) |
| HR (1) | HRP20070529T3 (es) |
| IL (1) | IL171930A (es) |
| MA (1) | MA27881A1 (es) |
| MX (1) | MXPA05013149A (es) |
| MY (2) | MY137272A (es) |
| NO (1) | NO332143B1 (es) |
| NZ (1) | NZ543637A (es) |
| PA (1) | PA8604101A1 (es) |
| PE (1) | PE20050162A1 (es) |
| PL (1) | PL1636206T3 (es) |
| PT (1) | PT1636206E (es) |
| RS (1) | RS53183B (es) |
| SI (1) | SI1636206T1 (es) |
| TN (2) | TNSN05309A1 (es) |
| TW (1) | TWI338007B (es) |
| UA (1) | UA80888C2 (es) |
| WO (1) | WO2004108701A1 (es) |
| ZA (2) | ZA200509807B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7531529B2 (en) | 2003-06-05 | 2009-05-12 | Roche Palo Alto Llc | Imidazole derivatives |
| US7452909B2 (en) | 2003-09-04 | 2008-11-18 | Hoffman-La Roche Inc. | Imidazole derivatives |
| KR101057032B1 (ko) * | 2004-06-01 | 2011-08-16 | 에프. 호프만-라 로슈 아게 | Ｍｇｌｕ5 수용체 길항제로서 피리딘-4-일-에틴일-이미다졸및 피라졸 |
| GB0514296D0 (en) * | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| DE102006011574A1 (de) * | 2006-03-10 | 2007-10-31 | Grünenthal GmbH | Substituierte Imidazo[2,1-b]thiazol-Verbindungen und ihre Verwendung zur Herstellung von Arzneimitteln |
| JP5405311B2 (ja) * | 2006-12-21 | 2014-02-05 | エフ．ホフマン−ラ ロシュ アーゲー | ｍＧｌｕＲ５受容体アンタゴニストの多形 |
| US8334287B2 (en) * | 2009-07-17 | 2012-12-18 | Hoffmann-La Roche Inc. | Imidazoles |
| US20120039999A1 (en) | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| US20120040008A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
| MX2013010698A (es) | 2011-03-18 | 2014-02-17 | Novartis Ag | Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson. |
| CN104603110B (zh) * | 2012-10-18 | 2016-08-31 | 霍夫曼-拉罗奇有限公司 | 作为mGluR5受体活性的调节剂的乙炔基衍生物 |
| SG11201501392TA (en) * | 2012-10-18 | 2015-05-28 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
| BR112018069868A2 (pt) * | 2016-03-30 | 2019-01-29 | Sinntaxis AB | modulador alostérico negativo do receptor metabotrópico de glutamato 5, usos de um nam, e método de tratamento ou atenuação de dano cerebral maduro |
| EP4069685A1 (en) * | 2019-12-02 | 2022-10-12 | F. Hoffmann-La Roche AG | Alkynyl-(heteroaryl)-carboxamide hcn1 inhibitors |
| IL322310A (en) | 2020-06-05 | 2025-09-01 | Noema Pharma Ag | Methods for treating multiple sclerosis complex |
| MX2023001288A (es) * | 2020-07-30 | 2023-04-28 | Noema Pharma Ag | Metodos de tratamiento de la neuralgia del trigemino. |
| IL322318A (en) | 2023-02-02 | 2025-09-01 | Noema Pharma Ag | Methods for treating Dravet syndrome |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4508560A (en) * | 1981-11-11 | 1985-04-02 | Ciba Geigy Corporation | Certain pyridylacetylene compounds, compositions containing same and herbicidal methods of use |
| TW544448B (en) * | 1997-07-11 | 2003-08-01 | Novartis Ag | Pyridine derivatives |
| JP4815083B2 (ja) * | 1999-08-31 | 2011-11-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 複素環化合物およびそれの使用方法 |
| JP5154728B2 (ja) * | 2000-07-24 | 2013-02-27 | クレニツキー・ファーマシューティカルズ，インコーポレイテッド | 神経栄養活性を有する置換５−アルキニルピリミジン |
| ATE288898T1 (de) * | 2000-12-04 | 2005-02-15 | Hoffmann La Roche | Phenylethenyl- oder phenylethinylderivate als glutamatrezeptorantagonisten |
| EP1458385A4 (en) * | 2001-12-19 | 2005-12-21 | Merck & Co Inc | METABOTROPIC GLUTAMATE RECEPTOR 5-HETEROARYL-SUBSTITUTED IMIDAZOLE MODULATORS |
| EP1556142A4 (en) * | 2002-10-24 | 2006-11-08 | Merck & Co Inc | ALKYN DERIVATIVES AS TRACERS FOR THE METABOTROPE GLUTAMATE RECEPTOR BINDING |
| TWI292318B (en) * | 2003-03-10 | 2008-01-11 | Hoffmann La Roche | Imidazol-4-yl-ethynyl-pyridine derivatives |
| UA80888C2 (en) * | 2003-06-05 | 2007-11-12 | Hoffmann La Roche | Imidazole derivatives as glutmate receptor antagonists |
| US7091222B2 (en) * | 2003-07-03 | 2006-08-15 | Hoffmann-La Roche Inc. | Imidazole derivatives |
-
2004
- 2004-01-06 UA UAA200512695A patent/UA80888C2/uk unknown
- 2004-06-01 EA EA200501887A patent/EA010577B1/ru not_active IP Right Cessation
- 2004-06-01 AT AT04739484T patent/ATE377008T1/de active
- 2004-06-01 PL PL04739484T patent/PL1636206T3/pl unknown
- 2004-06-01 HR HR20070529T patent/HRP20070529T3/xx unknown
- 2004-06-01 SI SI200430525T patent/SI1636206T1/sl unknown
- 2004-06-01 BR BRPI0411095A patent/BRPI0411095B8/pt not_active IP Right Cessation
- 2004-06-01 ES ES04739484T patent/ES2294504T3/es not_active Expired - Lifetime
- 2004-06-01 MX MXPA05013149A patent/MXPA05013149A/es active IP Right Grant
- 2004-06-01 NZ NZ543637A patent/NZ543637A/en not_active IP Right Cessation
- 2004-06-01 DK DK04739484T patent/DK1636206T3/da active
- 2004-06-01 EP EP04739484A patent/EP1636206B1/en not_active Expired - Lifetime
- 2004-06-01 AU AU2004245208A patent/AU2004245208B2/en not_active Expired
- 2004-06-01 KR KR1020057023137A patent/KR100778948B1/ko not_active Expired - Lifetime
- 2004-06-01 JP JP2006508238A patent/JP4401384B2/ja not_active Expired - Lifetime
- 2004-06-01 CN CNB2004800156669A patent/CN100408572C/zh not_active Expired - Lifetime
- 2004-06-01 CA CA2527315A patent/CA2527315C/en not_active Expired - Lifetime
- 2004-06-01 RS YU20050892A patent/RS53183B/sr unknown
- 2004-06-01 DE DE602004009796T patent/DE602004009796T2/de not_active Expired - Lifetime
- 2004-06-01 PT PT04739484T patent/PT1636206E/pt unknown
- 2004-06-01 WO PCT/EP2004/005881 patent/WO2004108701A1/en not_active Ceased
- 2004-06-02 US US10/858,969 patent/US7332510B2/en not_active Expired - Lifetime
- 2004-06-02 CL CL200401347A patent/CL2004001347A1/es unknown
- 2004-06-02 PA PA20048604101A patent/PA8604101A1/es unknown
- 2004-06-02 TW TW093115811A patent/TWI338007B/zh not_active IP Right Cessation
- 2004-06-02 PE PE2004000558A patent/PE20050162A1/es active IP Right Grant
- 2004-06-03 GT GT200400117A patent/GT200400117A/es unknown
- 2004-06-03 HN HN2004000208A patent/HN2004000208A/es unknown
- 2004-06-03 MY MYPI20042150A patent/MY137272A/en unknown
- 2004-06-03 AR ARP040101908A patent/AR044478A1/es active IP Right Grant
-
2005
- 2005-05-27 MY MYPI20052424A patent/MY143353A/en unknown
- 2005-11-13 IL IL171930A patent/IL171930A/en active IP Right Grant
- 2005-11-14 CR CR8094A patent/CR8094A/es unknown
- 2005-11-18 NO NO20055465A patent/NO332143B1/no unknown
- 2005-12-01 TN TNP2005000309A patent/TNSN05309A1/fr unknown
- 2005-12-02 EC EC2005006202A patent/ECSP056202A/es unknown
- 2005-12-02 ZA ZA200509807A patent/ZA200509807B/en unknown
- 2005-12-09 MA MA28648A patent/MA27881A1/fr unknown
-
2006
- 2006-11-21 ZA ZA200609681A patent/ZA200609681B/xx unknown
- 2006-11-27 TN TNP2006000391A patent/TNSN06391A1/fr unknown
-
2007
- 2007-10-31 US US11/930,258 patent/US8481548B2/en active Active
- 2007-12-13 US US11/955,421 patent/US7973165B2/en not_active Expired - Lifetime
-
2008
- 2008-01-11 CY CY20081100047T patent/CY1107856T1/el unknown
Also Published As
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