CR9815A - Compuestos de imidazol para el tratamiento de transtornos neurologicos - Google Patents

Compuestos de imidazol para el tratamiento de transtornos neurologicos

Info

Publication number
CR9815A
CR9815A CR9815A CR9815A CR9815A CR 9815 A CR9815 A CR 9815A CR 9815 A CR9815 A CR 9815A CR 9815 A CR9815 A CR 9815A CR 9815 A CR9815 A CR 9815A
Authority
CR
Costa Rica
Prior art keywords
compounds
neurological disorders
treatment
formula
imidazol compounds
Prior art date
Application number
CR9815A
Other languages
English (en)
Inventor
Aaren Brodney Michael
Liang Chen Yuhpyng
Jean Coffman Karen
Fox Kleinman Edward
Thomas O'neill Brian
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CR9815A publication Critical patent/CR9815A/es

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
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  • Cardiology (AREA)
  • Dermatology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invencion se refiere a los compuestos de formula I, en la que R1, R2, R3, R4, R6, R7, y A son como se ha definido. Los compuestos de la formula I tienen actividad en la inhibicion de la produccion de AB-peptidos. La invencion tambien se refiere a las composiciones farmaceuticas y procedimientos para tratar enfermedades y trastornos, por ejemplo, trastornos neurodegenerativos y / o neurologicos, por ejemplo enfermedad de Alzheimer, en un mamifero que comprende los compuestos de la formula I.
CR9815A 2005-09-22 2008-03-13 Compuestos de imidazol para el tratamiento de transtornos neurologicos CR9815A (es)

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US71952105P 2005-09-22 2005-09-22

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CR9815A true CR9815A (es) 2008-04-16

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CR9815A CR9815A (es) 2005-09-22 2008-03-13 Compuestos de imidazol para el tratamiento de transtornos neurologicos

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US (2) US7781435B2 (es)
EP (1) EP1940802A2 (es)
JP (1) JP2009508934A (es)
KR (1) KR20080040010A (es)
CN (1) CN101282941A (es)
AR (1) AR055205A1 (es)
AU (1) AU2006293619A1 (es)
BR (1) BRPI0616141A2 (es)
CA (1) CA2619068A1 (es)
CR (1) CR9815A (es)
EA (1) EA200800659A1 (es)
EC (1) ECSP088280A (es)
GT (1) GT200600425A (es)
IL (1) IL189524A0 (es)
MA (1) MA29793B1 (es)
NL (1) NL1032552C2 (es)
NO (1) NO20081845L (es)
PE (1) PE20070617A1 (es)
RS (1) RS20080139A (es)
TN (1) TNSN08138A1 (es)
TW (1) TW200804300A (es)
UY (1) UY29806A1 (es)
WO (1) WO2007034326A2 (es)

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ATE399155T1 (de) * 2004-03-23 2008-07-15 Pfizer Prod Inc Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen
BRPI0616141A2 (pt) * 2005-09-22 2011-06-07 Pfizer Prod Inc compostos imidazol para o tratamento de distúrbios neurológicos
FR2913886B1 (fr) 2007-03-22 2012-03-02 Guerbet Sa Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer
KR20180030545A (ko) * 2015-06-22 2018-03-23 다이닛본 스미토모 세이야꾸 가부시끼가이샤 바이사이클릭 헤테로사이클릭 아미드 유도체
JP6896701B2 (ja) 2016-02-26 2021-06-30 大日本住友製薬株式会社 イミダゾリルアミド誘導体
TWI905452B (zh) 2021-09-01 2025-11-21 美商斯普林渥克斯治療有限公司 尼羅司他（ｎｉｒｏｇａｃｅｓｔａｔ）之合成

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US20070066613A1 (en) 2007-03-22
KR20080040010A (ko) 2008-05-07
NO20081845L (no) 2008-06-19
EA200800659A1 (ru) 2008-08-29
AR055205A1 (es) 2007-08-08
WO2007034326A2 (en) 2007-03-29
CN101282941A (zh) 2008-10-08
CA2619068A1 (en) 2007-03-29
TW200804300A (en) 2008-01-16
NL1032552C2 (nl) 2007-09-25
MA29793B1 (fr) 2008-09-01
EP1940802A2 (en) 2008-07-09
ECSP088280A (es) 2008-04-28
US20100184737A1 (en) 2010-07-22
AU2006293619A1 (en) 2007-03-29
WO2007034326A3 (en) 2007-08-30
BRPI0616141A2 (pt) 2011-06-07
TNSN08138A1 (fr) 2009-07-14
PE20070617A1 (es) 2007-07-18
JP2009508934A (ja) 2009-03-05
IL189524A0 (en) 2008-08-07
NL1032552A1 (nl) 2007-03-23
UY29806A1 (es) 2007-04-30
RS20080139A (sr) 2009-05-06

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