CS215008B2 - Method of gaining natural polar fractions with antipsoriatic activity - Google Patents

Method of gaining natural polar fractions with antipsoriatic activity Download PDF

Info

Publication number: CS215008B2
Authority: CS; Czechoslovakia
Prior art keywords: polypodium; extraction; solution; rhizomes; fraction
Prior art date: 1978-07-07

Application number

CS794777A

Other languages

Czech (cs)

English (en)

Inventor

Francisco R A Salgado

Original Assignee

Conrad Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-07-07

Filing date

1979-07-06

Publication date

1982-06-25

1979-07-06 Application filed by Conrad Ltd filed Critical Conrad Ltd

1982-06-25 Publication of CS215008B2 publication Critical patent/CS215008B2/cs

Links

238000000034 method Methods 0.000 title claims description 10
230000002682 anti-psoriatic effect Effects 0.000 title claims description 5
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract description 29
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
241001362840 Serpocaulon triseriale Species 0.000 claims abstract description 3
229940075984 polypodium leucotomos Drugs 0.000 claims abstract description 3
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract 3
239000000920 calcium hydroxide Substances 0.000 claims abstract 3
229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract 3
241001518143 Polypodium <fern> Species 0.000 claims abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
239000007787 solid Substances 0.000 claims description 9
238000000605 extraction Methods 0.000 claims description 7
239000008346 aqueous phase Substances 0.000 claims description 6
239000002904 solvent Substances 0.000 claims description 6
241000196324 Embryophyta Species 0.000 claims description 5
239000002245 particle Substances 0.000 claims description 5
239000000463 material Substances 0.000 claims description 4
239000002775 capsule Substances 0.000 claims description 3
239000007903 gelatin capsule Substances 0.000 claims description 3
229920005989 resin Polymers 0.000 claims description 3
239000011347 resin Substances 0.000 claims description 3
108010010803 Gelatin Proteins 0.000 claims description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
241000487005 Phlebodium decumanum Species 0.000 claims description 2
239000008273 gelatin Substances 0.000 claims description 2
229920000159 gelatin Polymers 0.000 claims description 2
235000019322 gelatine Nutrition 0.000 claims description 2
235000011852 gelatine desserts Nutrition 0.000 claims description 2
239000011521 glass Substances 0.000 claims description 2
239000008187 granular material Substances 0.000 claims description 2
239000004615 ingredient Substances 0.000 claims description 2
239000008101 lactose Substances 0.000 claims description 2
239000012452 mother liquor Substances 0.000 claims description 2
239000002244 precipitate Substances 0.000 claims description 2
239000000047 product Substances 0.000 claims description 2
239000000454 talc Substances 0.000 claims description 2
229910052623 talc Inorganic materials 0.000 claims description 2
239000005995 Aluminium silicate Substances 0.000 claims 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
229920002472 Starch Polymers 0.000 claims 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
230000002378 acidificating effect Effects 0.000 claims 2
235000012211 aluminium silicate Nutrition 0.000 claims 2
150000001450 anions Chemical class 0.000 claims 2
229920001577 copolymer Polymers 0.000 claims 2
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 2
239000008107 starch Substances 0.000 claims 2
235000019698 starch Nutrition 0.000 claims 2
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims 1
241000905957 Channa melasoma Species 0.000 claims 1
239000004793 Polystyrene Substances 0.000 claims 1
239000011575 calcium Substances 0.000 claims 1
125000002091 cationic group Chemical group 0.000 claims 1
150000001768 cations Chemical class 0.000 claims 1
230000002262 irrigation Effects 0.000 claims 1
238000003973 irrigation Methods 0.000 claims 1
239000000049 pigment Substances 0.000 claims 1
229920002223 polystyrene Polymers 0.000 claims 1
229920005990 polystyrene resin Polymers 0.000 claims 1
229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
201000004681 Psoriasis Diseases 0.000 abstract description 10
238000000746 purification Methods 0.000 abstract description 3
241000723185 Cyathea Species 0.000 abstract description 2
241000393483 Dryopteris crassirhizoma Species 0.000 abstract description 2
241000985694 Polypodiopsida Species 0.000 abstract description 2
241000244324 Polypodium aureum Species 0.000 abstract description 2
241000592274 Polypodium vulgare Species 0.000 abstract description 2
239000002798 polar solvent Substances 0.000 abstract 2
JYVHOGDBFNJNMR-UHFFFAOYSA-N hexane;hydrate Chemical compound O.CCCCCC JYVHOGDBFNJNMR-UHFFFAOYSA-N 0.000 abstract 1
230000003472 neutralizing effect Effects 0.000 abstract 1
239000012454 non-polar solvent Substances 0.000 abstract 1
238000000638 solvent extraction Methods 0.000 abstract 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
239000003814 drug Substances 0.000 description 8
230000000694 effects Effects 0.000 description 8
201000010099 disease Diseases 0.000 description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
229940079593 drug Drugs 0.000 description 7
239000000243 solution Substances 0.000 description 7
239000000203 mixture Substances 0.000 description 6
238000005342 ion exchange Methods 0.000 description 5
239000007788 liquid Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
239000004480 active ingredient Substances 0.000 description 4
238000001704 evaporation Methods 0.000 description 4
230000008020 evaporation Effects 0.000 description 4
239000008194 pharmaceutical composition Substances 0.000 description 4
239000012071 phase Substances 0.000 description 4
241000699670 Mus sp. Species 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000000969 carrier Substances 0.000 description 3
210000000170 cell membrane Anatomy 0.000 description 3
239000013078 crystal Substances 0.000 description 3
239000003937 drug carrier Substances 0.000 description 3
239000006193 liquid solution Substances 0.000 description 3
239000006194 liquid suspension Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
241000282472 Canis lupus familiaris Species 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
208000001840 Dandruff Diseases 0.000 description 2
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
241000700159 Rattus Species 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
230000037396 body weight Effects 0.000 description 2
201000011510 cancer Diseases 0.000 description 2
238000001035 drying Methods 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
239000004744 fabric Substances 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
239000002184 metal Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
206010033898 parapsoriasis Diseases 0.000 description 2
230000008807 pathological lesion Effects 0.000 description 2
239000000825 pharmaceutical preparation Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
230000008569 process Effects 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
235000000346 sugar Nutrition 0.000 description 2
150000008163 sugars Chemical class 0.000 description 2
239000006228 supernatant Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
229910002012 Aerosil® Inorganic materials 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
208000036487 Arthropathies Diseases 0.000 description 1
208000017667 Chronic Disease Diseases 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 1
240000001879 Digitalis lutea Species 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
208000018522 Gastrointestinal disease Diseases 0.000 description 1
208000012659 Joint disease Diseases 0.000 description 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
240000007472 Leucaena leucocephala Species 0.000 description 1
235000010643 Leucaena leucocephala Nutrition 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
230000009471 action Effects 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000010419 agar Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
239000003708 ampul Substances 0.000 description 1
150000008064 anhydrides Chemical class 0.000 description 1
229940030999 antipsoriatics Drugs 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000003610 charcoal Substances 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000005530 etching Methods 0.000 description 1
230000004090 etiopathogenesis Effects 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000035558 fertility Effects 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
230000030414 genetic transfer Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
238000003306 harvesting Methods 0.000 description 1
210000003494 hepatocyte Anatomy 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
230000003907 kidney function Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
230000003908 liver function Effects 0.000 description 1
210000005228 liver tissue Anatomy 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
230000035800 maturation Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
230000002107 myocardial effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
238000010827 pathological analysis Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
230000035699 permeability Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000001185 psoriatic effect Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
210000005084 renal tissue Anatomy 0.000 description 1
238000011160 research Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
210000003625 skull Anatomy 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000010972 statistical evaluation Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000000829 suppository Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
230000003390 teratogenic effect Effects 0.000 description 1
238000012360 testing method Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000759 toxicological effect Toxicity 0.000 description 1
238000005353 urine analysis Methods 0.000 description 1
239000004474 valine Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Natural Medicines & Medicinal Plants (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Alternative & Traditional Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Botany (AREA)
Medical Informatics (AREA)
Dermatology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CS794777A 1978-07-07 1979-07-06 Method of gaining natural polar fractions with antipsoriatic activity CS215008B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES471572A ES471572A1 (es)	1978-07-07	1978-07-07	Procedimiento de obtencion de fraccion polar natural con ac-tividad antipsoriatica

Publications (1)

Publication Number	Publication Date
CS215008B2 true CS215008B2 (en)	1982-06-25

Family

ID=8476458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS794777A CS215008B2 (en)	1978-07-07	1979-07-06	Method of gaining natural polar fractions with antipsoriatic activity

Country Status (35)

Country	Link
JP (1)	JPS6026376B2 (fr)
AR (1)	AR230188A1 (fr)
AT (1)	AT371715B (fr)
AU (1)	AU4876479A (fr)
BE (1)	BE874483A (fr)
CA (1)	CA1106285A (fr)
CH (1)	CH642085A5 (fr)
CS (1)	CS215008B2 (fr)
DD (1)	DD144719A5 (fr)
DE (1)	DE2900887A1 (fr)
DK (1)	DK180379A (fr)
EG (1)	EG14496A (fr)
ES (1)	ES471572A1 (fr)
FI (1)	FI792128A7 (fr)
FR (1)	FR2434819A1 (fr)
GB (1)	GB2024622B (fr)
GR (1)	GR65334B (fr)
HU (1)	HU179689B (fr)
IE (1)	IE48526B1 (fr)
IL (1)	IL57721A (fr)
IS (1)	IS2495A7 (fr)
IT (1)	IT7919807A0 (fr)
LU (1)	LU81464A1 (fr)
MA (1)	MA18512A1 (fr)
MX (1)	MX5596E (fr)
NL (1)	NL7905251A (fr)
NO (1)	NO792260L (fr)
NZ (1)	NZ190933A (fr)
OA (1)	OA06288A (fr)
PH (1)	PH14338A (fr)
PL (1)	PL124244B1 (fr)
PT (1)	PT69067A (fr)
RO (1)	RO76833A (fr)
SE (1)	SE7903762L (fr)
ZA (1)	ZA793398B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES470204A1 (es) *	1978-05-24	1979-01-01	Conrad Ltd	Procedimiento de obtencion de terpenos naturales con activi-dad antipsoriatica
ES490293A0 (es) *	1980-04-02	1981-04-16	Conrad Ltd	Un procedimiento de obtencion de un extracto de las fraccio-nes polares de los helechos de la familia polypodiaceae.
NO150880C (no) *	1981-06-01	1985-01-16	Borregaard Ind	Nye aza-krone-etere og anvendelse derav
MC2056A1 (fr) *	1987-12-23	1990-09-04	Psoricur Ltd	Composition therapeutique contre le psoriasis,procede pour sa preparation et utilisation de plantes medicinales qu'elle contient
EP0503208A1 (fr) *	1991-03-08	1992-09-16	Maracuyama International, S.A.	Procédé d'obtention d'un extrait naturel soluble dans l'eau de feuilles et/ou de rhizomes de différentes fougères possédant une activité immunologique
JPH0633820U (ja) *	1992-10-13	1994-05-06	マルヤス機械株式会社	ローラコンベア
EP0680762B1 (fr) *	1994-05-06	2002-08-14	Especialidades Farmaceuticas Centrum, S.A.	Composition pharmaceutique comprenant des extraits de fougère(s) pour le traitement des maladies neurodégénératives.
ES2068163B1 (es) *	1994-05-06	1995-09-01	Esp Farmaceuticas Centrum Sa	Procedimiento de obtencion de un extracto vegetal con actividad en el tratamiento de disfunciones cognitivas y/o neuroinmunes.
WO1999006058A1 (fr) *	1997-07-30	1999-02-11	Helsint, S.A.L.	Fractions hydrosolubles de phlebodium decumanum et leur utilisation en tant que complement nutritionnel chez des patients souffrant du sida et de cancer
ES2137900B1 (es) *	1998-06-02	2000-08-16	Helsint S A L	Empleo de formulaciones a base de una fraccion hidrosoluble de phlebodium decumanum como complemento nutricional en el tratamiento del sindrome caquectico en pacientes oncologicos.
ES2124675B1 (es) *	1997-07-30	1999-10-01	Helsint S A L	"formulaciones a base de una fraccion hidrosoluble de phlebodium decumanum, y su uso en el tratamiento del sindrome caquectico en enfermos de sida".
FR2863163B1 (fr) *	2003-12-04	2006-02-24	Oreal	Composition, notamment cosmetique, comprenant des extraits de fougere et de nacre
FR2876032B1 (fr) *	2004-10-05	2008-10-31	Greentech Sa Sa	Utilisation d'extraits de fougeres dans des preparations cosmetiques ou dermatologiques
US20060246115A1 (en) *	2005-03-04	2006-11-02	Ricardo Rueda	Nutritional products for ameliorating symptoms of rheumatoid arthritis
USD554789S1 (en) *	2006-09-14	2007-11-06	Huo-Tu Huang	Table lamp
AT515350A1 (de) *	2014-02-10	2015-08-15	Christoph Dipl Ing Brandstätter	Verfahren zur Herstellung eines Konzentrats eines Holzschutzmittels, damit hergestelltes Konzentrat und Verfahren zur Behandlung von Holz

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB256768A (en) *	1925-07-17	1926-08-19	Francesco Fumarola	Process for extraction of the active biological principles from the ether extract of male fern
US3395223A (en) *	1965-05-13	1968-07-30	Carter Wallace	Fern extract for treating gastric ulcers
FR2395266A1 (fr) *	1977-06-23	1979-01-19	Suffren Ste Parti Brevets	-lactone monomeres et leurs polymeres, sels et derives, utilisables notamment comme colorants, adjuvants de tannage et medicaments
JPS5464870A (en) *	1977-10-21	1979-05-25	Gte Laboratories Inc	Solid state microwave power supply for electrodeless light source

1978
- 1978-07-07 ES ES471572A patent/ES471572A1/es not_active Expired
- 1978-12-27 AR AR274971A patent/AR230188A1/es active
- 1978-12-28 GR GR57991A patent/GR65334B/el unknown
1979
- 1979-01-11 DE DE19792900887 patent/DE2900887A1/de not_active Withdrawn
- 1979-01-12 PT PT69067A patent/PT69067A/pt unknown
- 1979-01-29 FR FR7902226A patent/FR2434819A1/fr active Granted
- 1979-02-01 IT IT7919807A patent/IT7919807A0/it unknown
- 1979-02-27 BE BE193723A patent/BE874483A/fr not_active IP Right Cessation
- 1979-03-28 CA CA324,314A patent/CA1106285A/fr not_active Expired
- 1979-04-27 SE SE7903762A patent/SE7903762L/xx unknown
- 1979-05-02 DK DK180379A patent/DK180379A/da not_active Application Discontinuation
- 1979-05-22 CH CH477779A patent/CH642085A5/de not_active IP Right Cessation
- 1979-05-24 JP JP54064871A patent/JPS6026376B2/ja not_active Expired
- 1979-05-24 GB GB7918174A patent/GB2024622B/en not_active Expired
- 1979-05-29 MX MX798029U patent/MX5596E/es unknown
- 1979-07-04 IL IL57721A patent/IL57721A/xx unknown
- 1979-07-05 FI FI792128A patent/FI792128A7/fi not_active Application Discontinuation
- 1979-07-05 NL NL7905251A patent/NL7905251A/nl not_active Application Discontinuation
- 1979-07-05 LU LU81464A patent/LU81464A1/fr unknown
- 1979-07-05 IS IS2495A patent/IS2495A7/is unknown
- 1979-07-06 OA OA56841A patent/OA06288A/fr unknown
- 1979-07-06 NZ NZ190933A patent/NZ190933A/xx unknown
- 1979-07-06 MA MA18709A patent/MA18512A1/fr unknown
- 1979-07-06 PL PL1979216905A patent/PL124244B1/pl unknown
- 1979-07-06 ZA ZA793398A patent/ZA793398B/xx unknown
- 1979-07-06 CS CS794777A patent/CS215008B2/cs unknown
- 1979-07-06 NO NO792260A patent/NO792260L/no unknown
- 1979-07-06 HU HU79CO371A patent/HU179689B/hu unknown
- 1979-07-06 AT AT0471479A patent/AT371715B/de not_active IP Right Cessation
- 1979-07-07 RO RO7998089A patent/RO76833A/fr unknown
- 1979-07-07 EG EG415/79A patent/EG14496A/xx active
- 1979-07-09 DD DD79214207A patent/DD144719A5/de unknown
- 1979-07-09 AU AU48764/79A patent/AU4876479A/en not_active Abandoned
- 1979-07-09 PH PH22755A patent/PH14338A/en unknown
- 1979-08-08 IE IE1274/79A patent/IE48526B1/en unknown

Also Published As

Publication number	Publication date
IE48526B1 (en)	1985-02-20
GR65334B (en)	1980-08-14
NO792260L (no)	1980-01-08
IT7919807A0 (it)	1979-02-01
JPS6026376B2 (ja)	1985-06-24
SE7903762L (sv)	1980-01-08
DK180379A (da)	1980-01-08
PT69067A (en)	1979-02-01
AU4876479A (en)	1980-01-10
IL57721A (en)	1983-07-31
ES471572A1 (es)	1979-01-16
LU81464A1 (fr)	1980-04-21
DD144719A5 (de)	1980-11-05
PL124244B1 (en)	1983-01-31
FI792128A7 (fi)	1981-01-01
OA06288A (fr)	1981-06-30
FR2434819A1 (fr)	1980-03-28
IE791274L (en)	1980-01-07
AR230188A1 (es)	1984-03-01
IL57721A0 (en)	1979-11-30
CH642085A5 (de)	1984-03-30
IS2495A7 (is)	1981-02-06
CA1106285A (fr)	1981-08-04
FR2434819B1 (fr)	1982-07-09
NZ190933A (en)	1982-11-23
JPS5511570A (en)	1980-01-26
MX5596E (es)	1983-11-04
PL216905A1 (fr)	1980-04-21
AT371715B (de)	1983-07-25
MA18512A1 (fr)	1980-04-01
NL7905251A (nl)	1980-01-09
ATA471479A (de)	1982-12-15
EG14496A (en)	1984-03-31
GB2024622A (en)	1980-01-16
RO76833A (fr)	1981-05-30
ZA793398B (en)	1981-07-29
DE2900887A1 (de)	1980-01-24
PH14338A (en)	1981-05-29
HU179689B (en)	1982-11-29
BE874483A (fr)	1979-06-18
GB2024622B (en)	1983-03-30

Publication	Publication Date	Title
ES2206511T3 (es)	2004-05-16	Extracto de pantas chinas.
US4985252A (en)	1991-01-15	Medication, dietetic product and hygienic product in the form of a powered composition obtained by adsorption of active ingredients on a rapidly dissolving sugar and process for obtaining said composition
CA1106285A (fr)	1981-08-04	Procede d'obtention d'une fraction polaire naturelle a proprietes anti-psoriatiques
WO1987003480A2 (fr)	1987-06-18	Medicament a effet anti-tumoral contenant de l'hexadecylphosphocholine
CN111056935A (zh)	2020-04-24	去芳化异戊烯基酰基间苯三酚类衍生物及其药物组合物和应用
EP0503208A1 (fr)	1992-09-16	Procédé d'obtention d'un extrait naturel soluble dans l'eau de feuilles et/ou de rhizomes de différentes fougères possédant une activité immunologique
RU2137490C1 (ru)	1999-09-20	Иммуностимулирующее средство эстифан и способ его получения
CA1122589A (fr)	1982-04-27	Procede pour l'obtention de terpenes naturels, antipsoriasiques
US6586021B2 (en)	2003-07-01	Method for extraction and purification of biologically useful molecules from a mangrove plant Salvadora persica L
DE69626548T2 (de)	2003-12-24	Macrocyclische verbindungen die aus kohlensuboxi-gruppen besteht
Krieger et al.	1976	Metabolism of 2, 2-dimethyl-2, 3-dihydrobenzofuranyl-7 N-dimethoxyphosphinothioyl-N-methylcarbamate in the house fly, rat, and mouse
GB2075834A (en)	1981-11-25	Arthritis treatment with fern extracts
CN111170967A (zh)	2020-05-19	酰基间苯三酚类衍生物及其药物组合物和应用
DE4201942A1 (de)	1992-09-24	Phenonverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69717961T2 (de)	2003-11-13	Verwendung eines flavonoid enthaltenden extraktes der planze euphorbia prostrata zur herstellung eines medikamentes zur behandlung von anoraktalen oder kolonbeschwerden
US5558866A (en)	1996-09-24	Antineoplastic chemotherapeutic of plant origin, having high selectivity and greatly reduced toxicity, and process for the preparation thereof
JPH05506674A (ja)	1993-09-30	植物抽出物に由来する抗腫瘍医薬およびその製造方法
JP2003113088A (ja)	2003-04-18	発ガンプロモーター抑制剤及びそれを含有する組成物
KR19980045814A (ko)	1998-09-15	사이트로스테디엔올을 보체 활성 조절제로 사용하는 용도 및 그의 제조방법
JP3182044B2 (ja)	2001-07-03	黒砂糖より抽出された成分を含む化粧料組成物
JP3226325B2 (ja)	2001-11-05	血行促進剤
JPH0971528A (ja)	1997-03-18	抗腫瘍剤
AU2001256653B2 (en)	2006-06-15	Biologically active aqueous fraction of an extract obtained from a mangrove plant Salvadora persica L.
Coulston et al.	1956	The relationship of psyllium seed and various fractions of the seed to kidney pigmentation
AU2005202105B2 (en)	2007-12-13	Biologically active aqueous fraction of an extract obtained from a mangrove plant Salvadora Persica L.