CS215142B2 - Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers - Google Patents

Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers Download PDF

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Publication number
CS215142B2
CS215142B2 CS806756A CS675680A CS215142B2 CS 215142 B2 CS215142 B2 CS 215142B2 CS 806756 A CS806756 A CS 806756A CS 675680 A CS675680 A CS 675680A CS 215142 B2 CS215142 B2 CS 215142B2
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CS
Czechoslovakia
Prior art keywords
compound
acid
mol
mixture
solvate
Prior art date
Application number
CS806756A
Other languages
Czech (cs)
English (en)
Inventor
Billy G Jackson
Donna Gardner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS215142B2 publication Critical patent/CS215142B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CS806756A 1979-10-09 1980-10-07 Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers CS215142B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number Publication Date
CS215142B2 true CS215142B2 (en) 1982-07-30

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
CS806756A CS215142B2 (en) 1979-10-09 1980-10-07 Method of making the solid solvates of the syn-+l2-+l-amino-4-thiazolyl+p-2-methoxyimino+p acetymido-3-acetoxymethyl-3-cefem-4-carboxyl acid with cycling ethers

Country Status (27)

Country Link
US (1) US4252951A (da)
EP (1) EP0027050B1 (da)
JP (1) JPS5661388A (da)
KR (1) KR840000866B1 (da)
AT (1) AT369008B (da)
AU (1) AU6306180A (da)
BE (1) BE885569A (da)
CA (1) CA1146539A (da)
CH (1) CH647523A5 (da)
CS (1) CS215142B2 (da)
DD (1) DD153375A5 (da)
DE (1) DE3065181D1 (da)
DK (1) DK424680A (da)
ES (1) ES495753A0 (da)
FI (1) FI803200A7 (da)
FR (1) FR2467211A1 (da)
GB (1) GB2059966B (da)
GR (1) GR70219B (da)
HU (1) HU183230B (da)
IE (1) IE50390B1 (da)
IL (1) IL61227A (da)
IT (1) IT1132926B (da)
PH (1) PH15023A (da)
PT (1) PT71886B (da)
RO (1) RO80664B (da)
YU (1) YU256480A (da)
ZA (1) ZA806192B (da)

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US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
JP2006521355A (ja) 2003-03-17 2006-09-21 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア・センター・フオー・テクノロジー・トランスフアー 表面的に両親媒性のポリマー及びオリゴマーならびにそれらの使用
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
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AU2005208771B2 (en) 2004-01-23 2011-11-24 The Trustees Of The University Of Pennsylvania Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof
US7825278B2 (en) * 2004-05-06 2010-11-02 The Regents Of The University Of California Substituted enaminones, their derivatives and uses thereof
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
JP2008531585A (ja) * 2005-02-25 2008-08-14 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用
EP2418191A1 (en) * 2005-02-28 2012-02-15 Meiji Co., Ltd. Long-chain trimethoxyphenylalkanol derivatives, and pharmaceuticals comprising the same
CN101410367A (zh) * 2005-08-10 2009-04-15 约翰·霍普金斯大学 多胺用在抗寄生虫与抗癌治疗学以及作为赖氨酸-特异性脱甲基酶抑制剂
ES2530991T3 (es) * 2005-08-15 2015-03-09 Boehringer Ingelheim Int Procedimiento para la obtención de betamiméticos
PL1940844T3 (pl) * 2005-10-28 2010-03-31 Irm Llc Związki i kompozycje jako inhibitory kinazy białkowej
EP1954259A2 (en) * 2005-11-29 2008-08-13 Hammersmith Imanet, Ltd Amidine derivatives for in vivo imaging
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US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
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Also Published As

Publication number Publication date
DK424680A (da) 1981-04-10
HU183230B (en) 1984-04-28
PT71886B (en) 1981-08-13
ATA498080A (de) 1982-04-15
ZA806192B (en) 1982-05-26
DE3065181D1 (en) 1983-11-10
FR2467211A1 (fr) 1981-04-17
PT71886A (en) 1980-11-01
ES8201166A1 (es) 1981-12-01
CH647523A5 (fr) 1985-01-31
IE50390B1 (en) 1986-04-16
RO80664B (ro) 1983-02-28
DD153375A5 (de) 1982-01-06
KR830004314A (ko) 1983-07-09
GB2059966A (en) 1981-04-29
FI803200L (fi) 1981-04-10
IE802086L (en) 1981-04-09
GB2059966B (en) 1983-09-01
IT8025200A0 (it) 1980-10-08
PH15023A (en) 1982-05-13
EP0027050A1 (en) 1981-04-15
ES495753A0 (es) 1981-12-01
BE885569A (fr) 1981-04-08
JPS5661388A (en) 1981-05-26
KR840000866B1 (ko) 1984-06-20
YU256480A (en) 1983-02-28
EP0027050B1 (en) 1983-10-05
AT369008B (de) 1982-11-25
IL61227A0 (en) 1980-12-31
FR2467211B1 (da) 1983-06-10
IL61227A (en) 1983-07-31
CA1146539A (en) 1983-05-17
US4252951A (en) 1981-02-24
AU6306180A (en) 1981-04-16
GR70219B (da) 1982-08-31
FI803200A7 (fi) 1981-04-10
IT1132926B (it) 1986-07-09
RO80664A (ro) 1983-02-15

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