CS243486B2 - Method of new pyrimidine derivatives production - Google Patents
Method of new pyrimidine derivatives production Download PDFInfo
- Publication number
- CS243486B2 CS243486B2 CS843255A CS325584A CS243486B2 CS 243486 B2 CS243486 B2 CS 243486B2 CS 843255 A CS843255 A CS 843255A CS 325584 A CS325584 A CS 325584A CS 243486 B2 CS243486 B2 CS 243486B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- formula
- oder
- und
- methylene
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH244283 | 1983-05-05 | ||
| CH139284 | 1984-03-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS325584A2 CS325584A2 (en) | 1985-08-15 |
| CS243486B2 true CS243486B2 (en) | 1986-06-12 |
Family
ID=25687524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS843255A CS243486B2 (en) | 1983-05-05 | 1984-05-02 | Method of new pyrimidine derivatives production |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4581172A (fr) |
| EP (1) | EP0124893A3 (fr) |
| AU (1) | AU2751084A (fr) |
| CA (1) | CA1237429A (fr) |
| CS (1) | CS243486B2 (fr) |
| DK (1) | DK198784A (fr) |
| ES (1) | ES532172A0 (fr) |
| FI (1) | FI841619L (fr) |
| HU (1) | HUT34025A (fr) |
| IL (1) | IL71711A (fr) |
| MC (1) | MC1600A1 (fr) |
| NO (1) | NO841780L (fr) |
| NZ (1) | NZ207981A (fr) |
| PH (1) | PH19219A (fr) |
| PT (1) | PT78549B (fr) |
| ZW (1) | ZW6284A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3472678D1 (de) * | 1983-07-18 | 1988-08-18 | Beecham Group Plc | Benzazepine and benzoxazepine derivatives |
| GB9707251D0 (en) * | 1997-04-10 | 1997-05-28 | Smithkline Beecham Plc | Novel method and compounds |
| CN100415743C (zh) * | 1999-03-31 | 2008-09-03 | 韦尔纳利斯有限公司 | 嘧啶并[6,1-a] 异喹啉-4-酮衍生物 |
| US7169907B2 (en) * | 2002-03-01 | 2007-01-30 | Roche Diagnostics Operations, Inc. | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs |
| WO2005007092A2 (fr) * | 2003-07-08 | 2005-01-27 | Smithkline Beecham Corporation | Nouveaux composes chimiques |
| GB201502260D0 (en) | 2015-02-11 | 2015-04-01 | Verona Pharma Plc | Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound |
| WO2017016960A1 (fr) * | 2015-07-24 | 2017-02-02 | F. Hoffmann-La Roche Ag | Procédé de préparation d'analogues de l'acide (6s)-6-alkyl-10-alcoxy-9-(alcoxy substitué)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylique |
| GB201613054D0 (en) | 2016-07-28 | 2016-09-14 | Verona Pharma Plc | New compound and process |
| KR20250111408A (ko) * | 2018-07-13 | 2025-07-22 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Pde3/pde4 이중 억제제로서 융합된 트리-사이클릭 화합물 |
| FI4092022T3 (fi) * | 2020-01-15 | 2025-12-03 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Pde3/pde4-kaksoisestäjän kide ja sen käyttö |
| EP4092025B9 (fr) * | 2020-01-15 | 2024-11-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Composition pharmaceutique de composé inhibiteur double de pde3/pde4 tricyclique |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ185900A (en) * | 1976-12-10 | 1981-04-24 | Hoechst Ag | Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines |
| DE2720085A1 (de) * | 1977-05-05 | 1978-11-16 | Hoechst Ag | Pyrimido(6,1-a)isochinolin-2-on- derivate |
| FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
| DE2847693A1 (de) * | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
| DE3135831A1 (de) * | 1981-09-10 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
-
1984
- 1984-04-13 CA CA000451949A patent/CA1237429A/fr not_active Expired
- 1984-04-13 ZW ZW62/84A patent/ZW6284A1/xx unknown
- 1984-04-17 DK DK198784A patent/DK198784A/da not_active Application Discontinuation
- 1984-04-25 FI FI841619A patent/FI841619L/fi not_active Application Discontinuation
- 1984-04-25 US US06/603,793 patent/US4581172A/en not_active Expired - Fee Related
- 1984-04-27 NZ NZ207981A patent/NZ207981A/en unknown
- 1984-04-30 AU AU27510/84A patent/AU2751084A/en not_active Abandoned
- 1984-05-01 IL IL71711A patent/IL71711A/xx not_active IP Right Cessation
- 1984-05-02 HU HU841693A patent/HUT34025A/hu unknown
- 1984-05-02 MC MC841703A patent/MC1600A1/fr unknown
- 1984-05-02 CS CS843255A patent/CS243486B2/cs unknown
- 1984-05-04 EP EP84105052A patent/EP0124893A3/fr not_active Withdrawn
- 1984-05-04 PH PH30644A patent/PH19219A/en unknown
- 1984-05-04 ES ES532172A patent/ES532172A0/es active Granted
- 1984-05-04 PT PT78549A patent/PT78549B/pt unknown
- 1984-05-04 NO NO841780A patent/NO841780L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK198784A (da) | 1984-11-06 |
| HUT34025A (en) | 1985-01-28 |
| ES8505369A1 (es) | 1985-06-01 |
| CS325584A2 (en) | 1985-08-15 |
| CA1237429A (fr) | 1988-05-31 |
| PT78549B (en) | 1986-09-15 |
| EP0124893A3 (fr) | 1987-11-11 |
| PH19219A (en) | 1986-02-12 |
| NZ207981A (en) | 1987-05-29 |
| FI841619A0 (fi) | 1984-04-25 |
| US4581172A (en) | 1986-04-08 |
| ES532172A0 (es) | 1985-06-01 |
| IL71711A (en) | 1987-08-31 |
| MC1600A1 (fr) | 1985-05-09 |
| DK198784D0 (da) | 1984-04-17 |
| ZW6284A1 (en) | 1985-10-30 |
| FI841619A7 (fi) | 1984-11-06 |
| NO841780L (no) | 1984-11-06 |
| FI841619L (fi) | 1984-11-06 |
| IL71711A0 (en) | 1984-09-30 |
| EP0124893A2 (fr) | 1984-11-14 |
| PT78549A (en) | 1984-06-01 |
| AU2751084A (en) | 1984-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES3030010T3 (en) | Heterocyclic compounds as immunomodulators | |
| TWI397530B (zh) | 經取代的三唑并吡啶及其類似物 | |
| FI95377C (fi) | Menetelmä terapeuttisesti aktiivisten pyrimidiinijohdannaisten valmistamiseksi | |
| CN101516850B (zh) | 适用作e1活化酶抑制剂的杂芳基化合物 | |
| DE69304243T2 (de) | Chinolin-Verbindungen als Angiotensin-II-Antagoniste | |
| WO2018119236A1 (fr) | Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs | |
| KR20220161396A (ko) | 치환된 피리디논-피리디닐 화합물의 제조, 조성물, 및 결정형 | |
| ES2632914T3 (es) | Derivados de 1,3-dihidro-2H-bencimidazol-2-ona sustituidos con heterociclos como agentes antivirales para el virus respiratorio sincicial | |
| WO2009029473A1 (fr) | Composés tricycliques ayant une activité cytostatique et/ou cytotoxique et leurs procédés d'utilisation | |
| MX2014004859A (es) | Nuevos compuestos. | |
| JPH02500518A (ja) | 強心作用を有する化合物類 | |
| DK168046B1 (da) | 2-substituerede cycloalkenooeeaaoe1,2,4aatriazolooe1,5-caapyrimidiner, deres tautomerer og farmaceutisk acceptable salte samt fremgangsmaade til fremstilling deraf | |
| CS243486B2 (en) | Method of new pyrimidine derivatives production | |
| WO2017086832A1 (fr) | N2-(4-amino-2-méthoxyphényl)-n4-[2-(diméthyl-phosphinoyl)phényl]-5-chlor-pirimidin-2,4-diamines substituées en tant que modulateurs d'alk et d'egfr destinés au traitement du cancer | |
| EP0115469B1 (fr) | Pyrazolo(3,4-d)pyridin-3-ones condensées à un hétérocycle | |
| WO1993016076A1 (fr) | 3-(1H^_-TETRAZOL-5-YL)-4H^_-PYRIDO[1,2-a^_]PYRIMIDINE-4-ONES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET LEUR PREPARATION | |
| HU211149A9 (en) | Pyridazinedione compounds | |
| JP2023542419A (ja) | 縮合環化合物及びその製造と使用 | |
| ES2655177T3 (es) | Diaminopirimidinas útiles como inhibidores del virus respiratorio sincitial (VRS) humano | |
| CS220343B2 (en) | Method of producing new imidazoquinazoline derivatives | |
| PT85696B (pt) | Processo para a preparacao de piridinas carbociclicas hetero {_f_} fundidas uteis como agentes dopaminergicos | |
| KR102352637B1 (ko) | 피리도[3,4-d]피리미딘 유도체 또는 그 용매화물의 결정 | |
| PT1648899E (pt) | Imidazo-pirimidinas e triazolo-pirimidinas: ligandos do receptor de benzodiazepina | |
| JP2021505580A (ja) | ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子 | |
| EP3098222B1 (fr) | Dérivé d'acridine fondue et composition pharmaceutique, méthode de préparation et utilisation de celui-ci |