CS249311B1 - Proteolytic wound dressing - Google Patents

Proteolytic wound dressing Download PDF

Info

Publication number: CS249311B1
Authority: CS; Czechoslovakia
Prior art keywords: cellulose; proteolytic; buffer; wound; trypsin
Prior art date: 1983-09-29

Application number

CS713883A

Other languages

Czech (cs)

English (en)

Inventor

Jaroslava Turkova

Jiri Stamberg

Vladimir Pitrak

Zuzana Hostonska

Lenka Jelinkova

Karel Sebesta

Mojmir Sebestik

Original Assignee

Jaroslava Turkova

Jiri Stamberg

Vladimir Pitrak

Zuzana Hostonska

Lenka Jelinkova

Karel Sebesta

Mojmir Sebestik

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-29

Filing date

1983-09-29

Publication date

1987-03-12

1983-09-29 Application filed by Jaroslava Turkova, Jiri Stamberg, Vladimir Pitrak, Zuzana Hostonska, Lenka Jelinkova, Karel Sebesta, Mojmir Sebestik filed Critical Jaroslava Turkova

1983-09-29 Priority to CS713883A priority Critical patent/CS249311B1/cs

1984-09-21 Priority to GB08423913A priority patent/GB2147206B/en

1984-09-24 Priority to SE8404769A priority patent/SE8404769L/xx

1984-09-25 Priority to DD26764384A priority patent/DD258121A3/de

1984-09-28 Priority to JP59202175A priority patent/JPS6094916A/ja

1984-09-28 Priority to HU369184A priority patent/HUT35956A/hu

1984-09-28 Priority to DE19843435718 priority patent/DE3435718A1/de

1984-09-28 Priority to FR8414969A priority patent/FR2552667B1/fr

1984-09-28 Priority to CA000464332A priority patent/CA1217134A/en

1987-03-04 Priority to CS143087A priority patent/CS264607B3/cs

1987-03-12 Publication of CS249311B1 publication Critical patent/CS249311B1/cs

Links

230000002797 proteolythic effect Effects 0.000 title claims description 17
229920002678 cellulose Polymers 0.000 claims abstract description 35
239000001913 cellulose Substances 0.000 claims abstract description 34
239000012588 trypsin Substances 0.000 claims abstract description 10
108090000631 Trypsin Proteins 0.000 claims abstract description 9
102000004142 Trypsin Human genes 0.000 claims abstract description 9
239000004365 Protease Substances 0.000 claims abstract description 8
108091005804 Peptidases Proteins 0.000 claims abstract description 7
239000002245 particle Substances 0.000 claims abstract description 6
239000000872 buffer Substances 0.000 claims description 16
102000004190 Enzymes Human genes 0.000 claims description 15
108090000790 Enzymes Proteins 0.000 claims description 15
229940088598 enzyme Drugs 0.000 claims description 15
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
238000000034 method Methods 0.000 claims description 8
108090000317 Chymotrypsin Proteins 0.000 claims description 5
102000035195 Peptidases Human genes 0.000 claims description 5
229960002376 chymotrypsin Drugs 0.000 claims description 5
238000005406 washing Methods 0.000 claims description 5
238000004108 freeze drying Methods 0.000 claims description 4
239000012535 impurity Substances 0.000 claims description 4
231100000331 toxic Toxicity 0.000 claims description 4
230000002588 toxic effect Effects 0.000 claims description 4
108010093096 Immobilized Enzymes Proteins 0.000 claims description 3
108090000787 Subtilisin Proteins 0.000 claims description 2
239000012798 spherical particle Substances 0.000 claims description 2
238000002955 isolation Methods 0.000 claims 1
239000007788 liquid Substances 0.000 claims 1
239000004627 regenerated cellulose Substances 0.000 claims 1
238000001256 steam distillation Methods 0.000 claims 1
206010052428 Wound Diseases 0.000 abstract description 28
208000027418 Wounds and injury Diseases 0.000 abstract description 28
230000001338 necrotic effect Effects 0.000 abstract description 8
239000000843 powder Substances 0.000 abstract description 7
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract description 2
-1 chymotrypsine Proteins 0.000 abstract 1
235000010980 cellulose Nutrition 0.000 description 33
230000007547 defect Effects 0.000 description 27
238000002360 preparation method Methods 0.000 description 15
230000028327 secretion Effects 0.000 description 14
238000005469 granulation Methods 0.000 description 12
230000003179 granulation Effects 0.000 description 12
230000000694 effects Effects 0.000 description 9
239000000243 solution Substances 0.000 description 9
230000009467 reduction Effects 0.000 description 8
206010012665 Diabetic gangrene Diseases 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
238000002266 amputation Methods 0.000 description 6
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 5
238000010521 absorption reaction Methods 0.000 description 5
230000003647 oxidation Effects 0.000 description 5
238000007254 oxidation reaction Methods 0.000 description 5
125000003172 aldehyde group Chemical group 0.000 description 4
MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
229910000033 sodium borohydride Inorganic materials 0.000 description 4
239000012279 sodium borohydride Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
210000003371 toe Anatomy 0.000 description 4
206010007882 Cellulitis Diseases 0.000 description 3
206010017711 Gangrene Diseases 0.000 description 3
206010028851 Necrosis Diseases 0.000 description 3
229920002201 Oxidized cellulose Polymers 0.000 description 3
239000000427 antigen Substances 0.000 description 3
108091007433 antigens Proteins 0.000 description 3
102000036639 antigens Human genes 0.000 description 3
239000011324 bead Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
230000035876 healing Effects 0.000 description 3
230000017074 necrotic cell death Effects 0.000 description 3
229940107304 oxidized cellulose Drugs 0.000 description 3
230000008569 process Effects 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
206010003210 Arteriosclerosis Diseases 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
208000033809 Suppuration Diseases 0.000 description 2
208000025865 Ulcer Diseases 0.000 description 2
239000008351 acetate buffer Substances 0.000 description 2
230000004913 activation Effects 0.000 description 2
238000001994 activation Methods 0.000 description 2
150000001413 amino acids Chemical class 0.000 description 2
210000003447 amputation stump Anatomy 0.000 description 2
208000011775 arteriosclerosis disease Diseases 0.000 description 2
230000001580 bacterial effect Effects 0.000 description 2
239000002775 capsule Substances 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
238000004821 distillation Methods 0.000 description 2
238000001035 drying Methods 0.000 description 2
230000002255 enzymatic effect Effects 0.000 description 2
210000000416 exudates and transudate Anatomy 0.000 description 2
210000002683 foot Anatomy 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
239000006174 pH buffer Substances 0.000 description 2
235000019419 proteases Nutrition 0.000 description 2
238000005063 solubilization Methods 0.000 description 2
230000007928 solubilization Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
230000001629 suppression Effects 0.000 description 2
231100000397 ulcer Toxicity 0.000 description 2
108091005508 Acid proteases Proteins 0.000 description 1
208000035404 Autolysis Diseases 0.000 description 1
208000035143 Bacterial infection Diseases 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
206010057248 Cell death Diseases 0.000 description 1
QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical compound ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
101710112752 Cytotoxin Proteins 0.000 description 1
SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
206010054044 Diabetic microangiopathy Diseases 0.000 description 1
102000009123 Fibrin Human genes 0.000 description 1
108010073385 Fibrin Proteins 0.000 description 1
BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
206010062717 Increased upper airway secretion Diseases 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
208000002565 Open Fractures Diseases 0.000 description 1
108090000526 Papain Proteins 0.000 description 1
241000208465 Proteaceae Species 0.000 description 1
239000002262 Schiff base Substances 0.000 description 1
150000004753 Schiff bases Chemical class 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
206010041243 Social avoidant behaviour Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
208000002847 Surgical Wound Diseases 0.000 description 1
206010000269 abscess Diseases 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000009471 action Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
208000030961 allergic reaction Diseases 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
210000001367 artery Anatomy 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
239000003899 bactericide agent Substances 0.000 description 1
230000003385 bacteriostatic effect Effects 0.000 description 1
239000002585 base Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
210000001772 blood platelet Anatomy 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
229920003174 cellulose-based polymer Polymers 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000000470 constituent Substances 0.000 description 1
231100000599 cytotoxic agent Toxicity 0.000 description 1
239000002619 cytotoxin Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
201000009101 diabetic angiopathy Diseases 0.000 description 1
239000002612 dispersion medium Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000000428 dust Substances 0.000 description 1
238000010410 dusting Methods 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
229950003499 fibrin Drugs 0.000 description 1
239000012530 fluid Substances 0.000 description 1
210000004744 fore-foot Anatomy 0.000 description 1
239000008187 granular material Substances 0.000 description 1
229960000789 guanidine hydrochloride Drugs 0.000 description 1
PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
230000009931 harmful effect Effects 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
229920001477 hydrophilic polymer Polymers 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
230000003053 immunization Effects 0.000 description 1
238000002649 immunization Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
208000028867 ischemia Diseases 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
239000002609 medium Substances 0.000 description 1
210000003789 metatarsus Anatomy 0.000 description 1
206010062198 microangiopathy Diseases 0.000 description 1
239000000203 mixture Substances 0.000 description 1
229940101267 panthenol Drugs 0.000 description 1
235000020957 pantothenol Nutrition 0.000 description 1
239000011619 pantothenol Substances 0.000 description 1
229940055729 papain Drugs 0.000 description 1
235000019834 papain Nutrition 0.000 description 1
230000035515 penetration Effects 0.000 description 1
KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
239000012071 phase Substances 0.000 description 1
208000026435 phlegm Diseases 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000004952 protein activity Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000028043 self proteolysis Effects 0.000 description 1
BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 description 1
229910001488 sodium perchlorate Inorganic materials 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
210000005070 sphincter Anatomy 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000003892 spreading Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
230000001228 trophic effect Effects 0.000 description 1
238000009941 weaving Methods 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
230000029663 wound healing Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- C12N11/12—Cellulose or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Materials Engineering (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Materials For Medical Uses (AREA)

CS713883A 1983-09-29 1983-09-29 Proteolytic wound dressing CS249311B1 (en)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
CS713883A CS249311B1 (en)	1983-09-29	1983-09-29	Proteolytic wound dressing
GB08423913A GB2147206B (en)	1983-09-29	1984-09-21	Proteolytic enzyme treatment of wounds
SE8404769A SE8404769L (sv)	1983-09-29	1984-09-24	Proteolytiskt sarskyddsmedel
DD26764384A DD258121A3 (de)	1983-09-29	1984-09-25	Proteolytischer wundueberzug
JP59202175A JPS6094916A (ja)	1983-09-29	1984-09-28	蛋白質分解性被覆物及びその製造方法
HU369184A HUT35956A (en)	1983-09-29	1984-09-28	Proteolytic coat for overlaying and treating wounds
DE19843435718 DE3435718A1 (de)	1983-09-29	1984-09-28	Proteolytischer wundverband
FR8414969A FR2552667B1 (fr)	1983-09-29	1984-09-28	Revetement proteolytique pour plaies et procede pour sa preparation
CA000464332A CA1217134A (en)	1983-09-29	1984-09-28	Proteolytic cover of wounds
CS143087A CS264607B3 (cs)	1983-09-29	1987-03-04	Způsob výroby proteolytického krytu na rány

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CS713883A CS249311B1 (en)	1983-09-29	1983-09-29	Proteolytic wound dressing

Publications (1)

Publication Number	Publication Date
CS249311B1 true CS249311B1 (en)	1987-03-12

Family

ID=5419947

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS713883A CS249311B1 (en)	1983-09-29	1983-09-29	Proteolytic wound dressing

Country Status (9)

Country	Link
JP (1)	JPS6094916A (de)
CA (1)	CA1217134A (de)
CS (1)	CS249311B1 (de)
DD (1)	DD258121A3 (de)
DE (1)	DE3435718A1 (de)
FR (1)	FR2552667B1 (de)
GB (1)	GB2147206B (de)
HU (1)	HUT35956A (de)
SE (1)	SE8404769L (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3606265A1 (de) *	1986-02-27	1987-09-03	Roehm Pharma Gmbh	Wundauflage auf polysaccharidbasis als traeger therapeutisch wirksamer, nicht-immobilisierter enzyme und mit hoher saugfaehigkeit
FR2600897A1 (fr) *	1986-07-04	1988-01-08	Pf Medicament	Pansement proteolytique et absorbant et procede pour sa preparation
CZ277766B6 (en) *	1990-01-04	1993-04-14	Vnii Textilno	Biologically active material and process for preparing thereof
EP0498532A1 (de) *	1991-01-10	1992-08-12	E.R. SQUIBB & SONS, INC.	Proteolytische Enzyme enthaltende Puderzusammensetzung zur Entfernung von nekrotischem Gewebe
IL104734A0 (en) *	1993-02-15	1993-06-10	Univ Bar Ilan	Bioactive conjugates of cellulose with amino compounds
DE19813663A1 (de) *	1998-03-27	1999-10-07	Beiersdorf Ag	Wundauflagen zur Entfernung von Störfaktoren aus Wundflüssigkeit
US7041787B2 (en)	2000-12-29	2006-05-09	Kimberly-Clark Worldwide, Inc.	Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases
US6600057B2 (en)	2000-12-29	2003-07-29	Kimberly-Clark Worldwide, Inc.	Matrix metalloproteinase inhibitors
RU2213557C2 (ru)	2001-12-26	2003-10-10	Закрытое акционерное общество "Аксис"	Фармацевтическая композиция, обладающая тромболитическими, противовоспалительными и цитопротективными свойствами
AU2003212195A1 (en) *	2002-02-06	2003-09-02	N-Zyme Biotec Gmbh	Protease screening and novel use of proteases
US20030198631A1 (en) *	2002-04-18	2003-10-23	Healthpoint, Ltd.	Thermolysin enzymatic wound debrider
US7928282B2 (en) *	2004-04-30	2011-04-19	Kimberly-Clark Worldwide, Inc.	Absorbent products with a linked enzyme treatment
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RO57973A (de) *	1969-06-13	1975-03-15
DE1938189A1 (de) *	1969-07-28	1971-02-25	Blendax Werke Schneider Co	Enzymhaltige Zahn- und Mundpflegemittel
FR2488797A1 (fr) *	1980-08-19	1982-02-26	Lhd Lab Hygiene Dietetique	Composition dermatologique, son procede de preparation et son application dans le domaine des pansements

1983
- 1983-09-29 CS CS713883A patent/CS249311B1/cs unknown
1984
- 1984-09-21 GB GB08423913A patent/GB2147206B/en not_active Expired
- 1984-09-24 SE SE8404769A patent/SE8404769L/xx not_active Application Discontinuation
- 1984-09-25 DD DD26764384A patent/DD258121A3/de not_active IP Right Cessation
- 1984-09-28 HU HU369184A patent/HUT35956A/hu unknown
- 1984-09-28 DE DE19843435718 patent/DE3435718A1/de not_active Withdrawn
- 1984-09-28 JP JP59202175A patent/JPS6094916A/ja active Pending
- 1984-09-28 CA CA000464332A patent/CA1217134A/en not_active Expired
- 1984-09-28 FR FR8414969A patent/FR2552667B1/fr not_active Expired

Also Published As

Publication number	Publication date
SE8404769D0 (sv)	1984-09-24
DE3435718A1 (de)	1985-04-11
GB8423913D0 (en)	1984-10-31
DD258121A3 (de)	1988-07-13
GB2147206A (en)	1985-05-09
GB2147206B (en)	1988-01-27
SE8404769L (sv)	1985-03-30
FR2552667A1 (fr)	1985-04-05
HUT35956A (en)	1985-08-28
FR2552667B1 (fr)	1987-11-27
CA1217134A (en)	1987-01-27
JPS6094916A (ja)	1985-05-28

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