CS267100B1 - Spósob pripravy 3,7-dimetyl-3,7-dihydro-1H-purín-2,6-dionu - Google Patents

Spósob pripravy 3,7-dimetyl-3,7-dihydro-1H-purín-2,6-dionu Download PDF

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Publication number
CS267100B1
CS267100B1 CS886560A CS656088A CS267100B1 CS 267100 B1 CS267100 B1 CS 267100B1 CS 886560 A CS886560 A CS 886560A CS 656088 A CS656088 A CS 656088A CS 267100 B1 CS267100 B1 CS 267100B1
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CS
Czechoslovakia
Prior art keywords
dione
formula
purine
dihydro
methyl
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CS886560A
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Czech (cs)
English (en)
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CS656088A1 (en
Inventor
Alfonz Ing Csc Rybar
Milan Clen Korespondent Repas
Martin Ing Tegza
Fridrich Rndr Csc Szemes
Richard Doc Ing Csc Frimm
Dusan Ing Csc Hesek
Michal Judr Ing Guttmann
Original Assignee
Rybar Alfonz
Milan Clen Korespondent Repas
Martin Ing Tegza
Szemes Fridrich
Frimm Richard
Hesek Dusan
Guttmann Nichal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Rybar Alfonz, Milan Clen Korespondent Repas, Martin Ing Tegza, Szemes Fridrich, Frimm Richard, Hesek Dusan, Guttmann Nichal filed Critical Rybar Alfonz
Priority to CS886560A priority Critical patent/CS267100B1/sk
Publication of CS656088A1 publication Critical patent/CS656088A1/cs
Publication of CS267100B1 publication Critical patent/CS267100B1/sk

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Abstract

Riešenie sa týká spósobu pripravy zlúčeniny vzorca I, ktorá sa používá vo farmaceutickom priemysle ako surovina pre výrobu liečiv na choroby srdcocievneho systému. Postup spočívá v tom, že sa nechá reagovat 3- -metyl-3,7-dihydro-lH-pur£n-2,6-dion vzorca II s metylchloridom za přítomnosti alkalického hydroxidu a/alebo alkalického uhličitanu v prostředí alifatických alkoholov s počtom uhlikov 1 až 3 a/alebo vody, připadne za přítomnosti katalytického množstva bromidu alebo jodidu alkalického kovu. Reakcia sa uskutočňuje pri teplote 35 až 110 °C, s výhodou pri 60 až 80 °c.
CS886560A 1988-10-03 1988-10-03 Spósob pripravy 3,7-dimetyl-3,7-dihydro-1H-purín-2,6-dionu CS267100B1 (sk)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS886560A CS267100B1 (sk) 1988-10-03 1988-10-03 Spósob pripravy 3,7-dimetyl-3,7-dihydro-1H-purín-2,6-dionu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS886560A CS267100B1 (sk) 1988-10-03 1988-10-03 Spósob pripravy 3,7-dimetyl-3,7-dihydro-1H-purín-2,6-dionu

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CS656088A1 CS656088A1 (en) 1989-04-14
CS267100B1 true CS267100B1 (sk) 1990-02-12

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CS886560A CS267100B1 (sk) 1988-10-03 1988-10-03 Spósob pripravy 3,7-dimetyl-3,7-dihydro-1H-purín-2,6-dionu

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CS656088A1 (en) 1989-04-14

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