CS777988A3 - Process of amikacin - Google Patents

Process of amikacin

Info

Publication number: CS777988A3
Authority: CS; Czechoslovakia
Prior art keywords: amikacin; synthesis; derivative; economicity; kanamycin
Prior art date: 1987-11-27

Application number

CS887779A

Other languages

English (en)

Other versions

CS277017B6 (en

Inventor

Alberto Mangia

Original Assignee

Pierrel Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-27

Filing date

1988-11-25

Publication date

1992-06-17

1988-11-25 Application filed by Pierrel Spa filed Critical Pierrel Spa

1992-06-17 Publication of CS777988A3 publication Critical patent/CS777988A3/cs

1992-11-18 Publication of CS277017B6 publication Critical patent/CS277017B6/cs

Links

229960004821 amikacin Drugs 0.000 title abstract 2
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 2
238000003786 synthesis reaction Methods 0.000 abstract 2
IVUOMFWNDGNLBJ-VKHMYHEASA-N (2s)-4-amino-2-hydroxybutanoic acid Chemical class NCC[C@H](O)C(O)=O IVUOMFWNDGNLBJ-VKHMYHEASA-N 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
239000007810 chemical reaction solvent Substances 0.000 abstract 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Insulating Materials (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymerisation Methods In General (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
Peptides Or Proteins (AREA)
Steroid Compounds (AREA)

CS887779A 1987-11-27 1988-11-25 Process of amikacin CS277017B6 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8722783A IT1225484B (it)	1987-11-27	1987-11-27	Procedimento di sintesi dell'amikacina

Publications (2)

Publication Number	Publication Date
CS777988A3 true CS777988A3 (en)	1992-06-17
CS277017B6 CS277017B6 (en)	1992-11-18

Family

ID=11200418

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS887779A CS277017B6 (en)	1987-11-27	1988-11-25	Process of amikacin

Country Status (23)

Country	Link
US (1)	US5763587A (cs)
EP (1)	EP0317970B1 (cs)
JP (1)	JPH0637512B2 (cs)
AT (1)	ATE125544T1 (cs)
AU (1)	AU608665B2 (cs)
BG (1)	BG49048A3 (cs)
CA (1)	CA1324375C (cs)
CS (1)	CS277017B6 (cs)
DD (1)	DD283564A5 (cs)
DE (1)	DE3854225T2 (cs)
DK (1)	DK170050B1 (cs)
ES (1)	ES2074431T3 (cs)
FI (1)	FI90243C (cs)
HU (1)	HU201771B (cs)
IT (1)	IT1225484B (cs)
NO (1)	NO171505C (cs)
NZ (1)	NZ227113A (cs)
PH (1)	PH25818A (cs)
PL (1)	PL161416B1 (cs)
RO (1)	RO102339B1 (cs)
RU (1)	RU1776262C (cs)
YU (1)	YU47063B (cs)
ZA (1)	ZA888855B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW465235B (en)	1998-09-17	2001-11-21	United Video Properties Inc	Electronic program guide with digital storage
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
WO2007041156A2 (en) *	2005-09-29	2007-04-12	Nektar Therapeutics	Antibiotic formulations, unit doses, kits, and methods
AU2006320374B2 (en)	2005-12-02	2012-08-30	Isis Pharmaceuticals, Inc.	Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
US7862812B2 (en)	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions
JP2010527913A (ja) *	2007-04-10	2010-08-19	アカオジェンインコーポレイテッド	抗菌性１，４，５置換アミノグリコシド類似体
WO2010030704A2 (en)	2008-09-10	2010-03-18	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010030690A1 (en)	2008-09-10	2010-03-18	Isis Pharmaceuticals, Inc.	Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
CN102256989B (zh)	2008-10-03	2016-01-06	聚糖生物科学有限责任公司	糖基化细菌代谢物的阴离子轭合物
WO2010042850A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
WO2010042851A1 (en)	2008-10-09	2010-04-15	Achaogen, Inc.	Antibacterial aminoglycoside analogs
CA2777107A1 (en)	2009-10-09	2011-04-14	Achaogen, Inc.	Antibacterial aminoglycoside analogs
CN103282370A (zh)	2010-11-17	2013-09-04	尔察祯有限公司	抗菌氨基糖苷类类似物
CN103113429B (zh) *	2013-03-05	2015-02-18	齐鲁天和惠世制药有限公司	一种由阿米卡星制备硫酸阿米卡星的方法
CN105440090B (zh) *	2014-08-27	2018-03-09	北大医药重庆大新药业股份有限公司	一种阿米卡星的合成方法
CN111233952A (zh) *	2020-04-02	2020-06-05	管炫棣	一种阿卡米星的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI60217C (fi) *	1973-11-14	1981-12-10	Bristol Myers Co	Foerfarande foer framstaellning av 1-(l-(-)-ny-amino-alfa-hydroxibutyryl)kanamycin a
JPS51127045A (en) *	1975-04-24	1976-11-05	Microbial Chem Res Found	A process for preparing 3'- deoxykanamycin a derivatives.
GB1530201A (en) *	1976-04-14	1978-10-25	Pfizer Ltd	Process for the preparation of aminoglycoside antibiotics and intermediates therefor
US4136254A (en) *	1976-06-17	1979-01-23	Schering Corporation	Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE54288B1 (en) *	1982-03-05	1989-08-16	Fujisawa Pharmaceutical Co	New 1,4-diaminocyclitol derivatives, processes for their preparation and pharmaceutical compositions containing them
JPS6041692A (ja) *	1983-08-15	1985-03-05	Microbial Chem Res Found	２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) *	1985-10-10	1989-01-27	Pierrel Spa	Procedimento di sentisi dell'amikacina

1987
- 1987-11-27 IT IT8722783A patent/IT1225484B/it active
1988
- 1988-11-23 AT AT88119460T patent/ATE125544T1/de not_active IP Right Cessation
- 1988-11-23 DE DE3854225T patent/DE3854225T2/de not_active Expired - Fee Related
- 1988-11-23 ES ES88119460T patent/ES2074431T3/es not_active Expired - Lifetime
- 1988-11-23 EP EP88119460A patent/EP0317970B1/en not_active Expired - Lifetime
- 1988-11-25 FI FI885489A patent/FI90243C/fi not_active IP Right Cessation
- 1988-11-25 RU SU884356995A patent/RU1776262C/ru active
- 1988-11-25 DK DK661588A patent/DK170050B1/da not_active IP Right Cessation
- 1988-11-25 HU HU886072A patent/HU201771B/hu not_active IP Right Cessation
- 1988-11-25 CS CS887779A patent/CS277017B6/cs unknown
- 1988-11-25 BG BG086218A patent/BG49048A3/xx unknown
- 1988-11-25 ZA ZA888855A patent/ZA888855B/xx unknown
- 1988-11-25 CA CA000584227A patent/CA1324375C/en not_active Expired - Fee Related
- 1988-11-25 PH PH37859A patent/PH25818A/en unknown
- 1988-11-25 NO NO885270A patent/NO171505C/no unknown
- 1988-11-25 DD DD88322213A patent/DD283564A5/de not_active IP Right Cessation
- 1988-11-26 JP JP63299382A patent/JPH0637512B2/ja not_active Expired - Lifetime
- 1988-11-28 NZ NZ227113A patent/NZ227113A/en unknown
- 1988-11-28 YU YU218888A patent/YU47063B/sh unknown
- 1988-11-28 PL PL1988276047A patent/PL161416B1/pl unknown
- 1988-11-28 RO RO88136098A patent/RO102339B1/ro unknown
- 1988-11-28 AU AU25963/88A patent/AU608665B2/en not_active Ceased
1992
- 1992-02-14 US US07/834,991 patent/US5763587A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RO102339B1 (ro)	1992-08-01
AU2596388A (en)	1989-06-01
RU1776262C (ru)	1992-11-15
DE3854225D1 (de)	1995-08-31
NO171505C (no)	1993-03-24
NO171505B (no)	1992-12-14
IT1225484B (it)	1990-11-14
AU608665B2 (en)	1991-04-11
FI90243C (fi)	1994-01-10
BG49048A3 (en)	1991-07-15
YU47063B (sh)	1994-12-28
ZA888855B (en)	1990-02-28
HU201771B (en)	1990-12-28
ES2074431T3 (es)	1995-09-16
IT8722783A0 (it)	1987-11-27
EP0317970A3 (en)	1991-08-28
PL161416B1 (pl)	1993-06-30
CA1324375C (en)	1993-11-16
CS277017B6 (en)	1992-11-18
EP0317970A2 (en)	1989-05-31
FI885489A0 (fi)	1988-11-25
NO885270D0 (no)	1988-11-25
DD283564A5 (de)	1990-10-17
ATE125544T1 (de)	1995-08-15
FI90243B (fi)	1993-09-30
JPH01186900A (ja)	1989-07-26
PH25818A (en)	1991-11-05
DK661588D0 (da)	1988-11-25
DE3854225T2 (de)	1996-01-04
EP0317970B1 (en)	1995-07-26
YU218888A (en)	1989-12-31
DK170050B1 (da)	1995-05-08
DK661588A (da)	1989-05-28
FI885489L (fi)	1989-05-28
PL276047A1 (en)	1989-07-10
US5763587A (en)	1998-06-09
JPH0637512B2 (ja)	1994-05-18
NO885270L (no)	1989-05-29
NZ227113A (en)	1991-01-29
HUT49144A (en)	1989-08-28

Publication	Publication Date	Title
ZA888855B (en)	1990-02-28	A process for the synthesis of amikacin
AU4535685A (en)	1986-02-06	Novel N-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
JPS6466189A (en)	1989-03-13	Production of penicillanic acid derivative
AU6363386A (en)	1987-04-16	Novel process for the synthesis of amikacin
GR3015293T3 (en)	1995-06-30	Process for the production of 02,2'-anhydro-1-(beta-D-arabinofuranosyl)thymine.
DE3563858D1 (en)	1988-08-25	Process for the preparation of l-alpha-aminoacids
CA2305580A1 (en)	1999-04-08	Process for production of substituted alkylamine or its salt
ES8604521A1 (es)	1986-02-01	Procedimiento para la obtencion de acidos quinolona- o bien naftiridona-carboxilicos
EP0251327A3 (en)	1988-03-23	Process for production of anthracycline compound r2ox2
GR3004216T3 (cs)	1993-03-31
CA1273347C (cs)	1990-08-28
FI911633A0 (fi)	1991-04-05	Foerfarande foer framstaellning av alkansulfonanilidderivat.
SG43092A1 (en)	1997-10-17	Process for preparing 5-arylhydantoin
HUT38102A (en)	1986-04-28	Process for production of derivatives of 9-or-11 substituated apovincamin acid
GR3025916T3 (en)	1998-04-30	PROCESS FOR PRODUCING -g(a)-HYDROXYIMINOPHENYLACETONITRILE.
JPS6419052A (en)	1989-01-23	Production of l-methylosin
JPS6419087A (en)	1989-01-23	Production of 1,3,4-tri-o-acyl-2-deoxy-beta-d-erythro-pentapyranose
RU92010801A (ru)	1995-06-19	Способ получения n-карбэтоксиметилпирролидона-2
JPS5663973A (en)	1981-05-30	Novel thiadiazol-5-ylthiol ester and its preparation
DE3760058D1 (en)	1989-04-13	3,4-dihydro-2,5,7,8-tetramethyl-2h-1-benzopyran derivatives and processes for their preparation
JPS6438041A (en)	1989-02-08	Production of 2-phenacyl-1,3-indanediones
ES2007387A6 (es)	1989-06-16	Procedimiento para la obtencion de un derivado del acido cromoglicico
JPS57149270A (en)	1982-09-14	Preparation of 3,4,5,6,7,8-hexahydrocarbostyril-5-one
SU1557956A1 (ru)	1997-06-10	Способ получения циннамилхлорида
JPS54157593A (en)	1979-12-12	Preparation of high-purity 6-acylaminoacylamido penicillanic acid