CS9100619A2 - Contrast means and method of its production - Google Patents

Contrast means and method of its production

Info

Publication number: CS9100619A2
Authority: CS; Czechoslovakia
Prior art keywords: concn; esp; dissolved; sodium; pref
Prior art date: 1990-03-09

Application number

CS91619A

Other languages

English (en)

Inventor

Torsten Almen

Lars Baath

Audun Nesheim Oksendal

Per Jynge

Original Assignee

Nycomed As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-09

Filing date

1991-03-08

Publication date

1991-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10682193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CS9100619(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-03-09 Priority claimed from EP90200580A external-priority patent/EP0390242B1/en

1991-03-08 Application filed by Nycomed As filed Critical Nycomed As

1991-09-15 Publication of CS9100619A2 publication Critical patent/CS9100619A2/cs

1999-05-12 Publication of CZ285071B6 publication Critical patent/CZ285071B6/cs

Links

BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 3
239000002872 contrast media Substances 0.000 abstract 3
239000011575 calcium Substances 0.000 abstract 2
239000011734 sodium Substances 0.000 abstract 2
229910001415 sodium ion Inorganic materials 0.000 abstract 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
XUHXFSYUBXNTHU-UHFFFAOYSA-N Iotrolan Chemical compound IC=1C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C=1N(C)C(=O)CC(=O)N(C)C1=C(I)C(C(=O)NC(CO)C(O)CO)=C(I)C(C(=O)NC(CO)C(O)CO)=C1I XUHXFSYUBXNTHU-UHFFFAOYSA-N 0.000 abstract 1
AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
229910001424 calcium ion Inorganic materials 0.000 abstract 1
159000000007 calcium salts Chemical class 0.000 abstract 1
229960004359 iodixanol Drugs 0.000 abstract 1
NBQNWMBBSKPBAY-UHFFFAOYSA-N iodixanol Chemical compound IC=1C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C(I)C=1N(C(=O)C)CC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NBQNWMBBSKPBAY-UHFFFAOYSA-N 0.000 abstract 1
229960001025 iohexol Drugs 0.000 abstract 1
NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 abstract 1
229960004647 iopamidol Drugs 0.000 abstract 1
XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 abstract 1
229960003182 iotrolan Drugs 0.000 abstract 1
229960004537 ioversol Drugs 0.000 abstract 1
229940029407 ioxaglate Drugs 0.000 abstract 1
TYYBFXNZMFNZJT-UHFFFAOYSA-N ioxaglic acid Chemical compound CNC(=O)C1=C(I)C(N(C)C(C)=O)=C(I)C(C(=O)NCC(=O)NC=2C(=C(C(=O)NCCO)C(I)=C(C(O)=O)C=2I)I)=C1I TYYBFXNZMFNZJT-UHFFFAOYSA-N 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
159000000003 magnesium salts Chemical class 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection

Landscapes

Health & Medical Sciences (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Liquid Crystal (AREA)
Medicinal Preparation (AREA)
Devices For Indicating Variable Information By Combining Individual Elements (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Lubricants (AREA)
Silicates, Zeolites, And Molecular Sieves (AREA)
Paints Or Removers (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Compositions Of Macromolecular Compounds (AREA)
Diaphragms For Electromechanical Transducers (AREA)

CS91619A 1990-03-09 1991-03-08 Kontrastní prostředek a způsob jeho výroby CZ285071B6 (cs)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP90200580A EP0390242B1 (en)	1989-03-17	1990-03-09	Contrast media
GB909020091A GB9020091D0 (en)	1990-09-14	1990-09-14	Contrast media

Publications (2)

Publication Number	Publication Date
CS9100619A2 true CS9100619A2 (en)	1991-09-15
CZ285071B6 CZ285071B6 (cs)	1999-05-12

Family

ID=10682193

Country Status (32)

Country	Link
US (2)	US5328680A (cs)
EP (1)	EP0521880B2 (cs)
JP (1)	JP3215703B2 (cs)
KR (1)	KR100189271B1 (cs)
CN (1)	CN1055864C (cs)
AT (1)	ATE141519T1 (cs)
CA (1)	CA2076861A1 (cs)
CZ (1)	CZ285071B6 (cs)
DE (1)	DE69121562T3 (cs)
DK (1)	DK0521880T4 (cs)
DZ (1)	DZ1506A1 (cs)
EG (1)	EG19889A (cs)
ES (1)	ES2090315T5 (cs)
FI (1)	FI100698B (cs)
GB (1)	GB9020091D0 (cs)
GE (1)	GEP19971155B (cs)
GR (2)	GR3020842T3 (cs)
HK (1)	HK1003563A1 (cs)
HR (1)	HRP930773B1 (cs)
HU (1)	HU217075B (cs)
IE (1)	IE76916B1 (cs)
IL (1)	IL97455A (cs)
LV (1)	LV10058B (cs)
MY (1)	MY105493A (cs)
NO (1)	NO304352B1 (cs)
OA (1)	OA09667A (cs)
PT (1)	PT96978B (cs)
RO (1)	RO111543B1 (cs)
SK (1)	SK278621B6 (cs)
TR (1)	TR25738A (cs)
WO (1)	WO1991013636A1 (cs)
YU (1)	YU48683B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1256248B (it) *	1992-12-24	1995-11-29	Bracco Spa	Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
GB9419206D0 (en) *	1994-09-23	1994-11-09	Nycomed Innovation Ab	Contrast media
GB9419203D0 (en) *	1994-09-23	1994-11-09	Nycomed Innovation Ab	Contrast media
SK101398A3 (en) *	1996-01-25	1998-12-02	Schering Ag	Improved concentrated injection and infusion solutions for intravenous administration
DE19648650C2 (de) *	1996-01-29	1998-07-02	Schering Ag	Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
DE10126405A1 (de) *	2001-05-22	2003-02-27	Trommsdorff Gmbh & Co	Physiologisch verträgliche Kalium- und Magnesiumsalze enthaltendes pharmazeutisches Präparat sowie dessen Verwendung zur Prophylaxe und/oder Therapie von QT-Zeitverlängerungen
US7498018B2 (en) *	2003-10-03	2009-03-03	Bracco Diagnostics Inc.	Contrast media for use in medical and diagnostic procedures and methods of using the same
DE102005028882A1 (de) *	2005-06-22	2007-01-04	Siemens Ag	Lösung und Verfahren zum Unterstützen der Bildgebung an einem Patienten
EP1989179B1 (en)	2006-02-15	2011-01-26	Ge Healthcare As	Contrast agents
US20100233096A1 (en) *	2006-03-29	2010-09-16	Lerche Mathilde H	Method to produce hyperpolarised carboxylates and sulphonates
FR2899581B1 (fr) *	2006-04-07	2008-06-27	Guerbet Sa	Procede d'atomisation du ioxilan
US7662859B2 (en)	2007-02-16	2010-02-16	Ge Healthcare As	Contrast agents
BRPI0814811A2 (pt)	2007-07-12	2015-02-03	Ge Healthcare As	Composto, agente, método, e composição de diagnóstico, uso de um composto, e, método de formação de imagem
CN101820924A (zh)	2007-10-12	2010-09-01	通用电气医疗集团股份有限公司	造影剂
CN101821231A (zh)	2007-10-12	2010-09-01	通用电气医疗集团股份有限公司	对比剂
CN101820923A (zh)	2007-10-12	2010-09-01	通用电气医疗集团股份有限公司	对比剂
JP2011500532A (ja)	2007-10-12	2011-01-06	ジーイー・ヘルスケア・アクスイェ・セルスカプ	造影剤
CN102271715A (zh)	2009-01-09	2011-12-07	通用电气医疗集团股份有限公司	对比剂组合物
EP2243767A1 (en)	2009-04-21	2010-10-27	Bracco Imaging S.p.A	Process for the iodination of aromatic compounds
IN2012DN02126A (cs)	2009-10-29	2015-08-21	Ge Healthcare As
CN102114249B (zh) *	2009-12-30	2013-01-30	四川大学华西医院	一种携氧冠脉造影剂及其制备方法
US20140065076A1 (en) *	2012-08-30	2014-03-06	Otsuka Pharmaceutical Co. Ltd.	Container with concentrated substance and method of using the same
WO2014158965A1 (en)	2013-03-27	2014-10-02	Ge Healthcare As	Method and reagent for preparing a diagnostic composition
HUE039982T2 (hu) *	2013-12-04	2019-02-28	Hovione Scientia Ltd	Kontrasztanyag, amely ízelfedõ kiszereléseket tartalmaz

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1858142A (en) *	1928-01-21	1932-05-10	Nat Aniline & Chem Co Inc	Colloidal mono-sodium tetraiodophenolphthalein
NL127881C (cs) *	1963-03-25
US3175952A (en) *	1963-05-29	1965-03-30	Sterling Drug Inc	Aqueous radiopaque solutions containing sodium and calcium ions
GB1069437A (en) *	1963-10-23	1967-05-17	Nyegaard & Co As	Injectable x-ray contrast media
DE2909439A1 (de) *	1979-03-08	1980-09-18	Schering Ag	Neue nichtionische roentgenkontrastmittel
DE2928417A1 (de) *	1979-07-12	1981-01-29	Schering Ag	Trijodierte basen
DE3038853A1 (de) *	1980-10-10	1982-05-27	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
US4957939A (en) *	1981-07-24	1990-09-18	Schering Aktiengesellschaft	Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
ATE82500T1 (de) *	1984-06-22	1992-12-15	Richard L Veech	Elektrolytloesungen und deren (in vivo) verwendung.
CA1249970A (en) *	1984-06-22	1989-02-14	Richard L. Veech	Electrolyte solutions containing polyanionic materials
US4863714A (en) *	1987-02-05	1989-09-05	Cook Imaging Corporation	Sterilization of compositions of limited stability
JPH0625094B2 (ja) *	1988-03-01	1994-04-06	マリンクロット，インコーポレイテッド	非イオン性ｘ線コントラスト剤、組成物及び方法
US5011925A (en) *	1989-03-09	1991-04-30	Mallinckrodt, Inc.	Morpholinoamido EDTA derivatives
GB8906130D0 (en) *	1989-03-17	1989-05-04	Nycomed As	Compositions

1990
- 1990-09-14 GB GB909020091A patent/GB9020091D0/en active Pending
1991
- 1991-03-06 DZ DZ910035A patent/DZ1506A1/fr active
- 1991-03-06 IL IL9745591A patent/IL97455A/en not_active IP Right Cessation
- 1991-03-07 AT AT91905048T patent/ATE141519T1/de not_active IP Right Cessation
- 1991-03-07 ES ES91905048T patent/ES2090315T5/es not_active Expired - Lifetime
- 1991-03-07 RO RO92-01165A patent/RO111543B1/ro unknown
- 1991-03-07 US US07/923,926 patent/US5328680A/en not_active Ceased
- 1991-03-07 JP JP50518691A patent/JP3215703B2/ja not_active Expired - Lifetime
- 1991-03-07 HU HU9202870A patent/HU217075B/hu unknown
- 1991-03-07 CA CA002076861A patent/CA2076861A1/en not_active Abandoned
- 1991-03-07 DK DK91905048T patent/DK0521880T4/da active
- 1991-03-07 EP EP91905048A patent/EP0521880B2/en not_active Expired - Lifetime
- 1991-03-07 HK HK98102624A patent/HK1003563A1/en not_active IP Right Cessation
- 1991-03-07 YU YU40891A patent/YU48683B/sh unknown
- 1991-03-07 DE DE69121562T patent/DE69121562T3/de not_active Expired - Lifetime
- 1991-03-07 WO PCT/EP1991/000425 patent/WO1991013636A1/en not_active Ceased
- 1991-03-08 CZ CS91619A patent/CZ285071B6/cs not_active IP Right Cessation
- 1991-03-08 SK SK619-91A patent/SK278621B6/sk not_active IP Right Cessation
- 1991-03-08 PT PT96978A patent/PT96978B/pt not_active IP Right Cessation
- 1991-03-08 IE IE77591A patent/IE76916B1/en not_active IP Right Cessation
- 1991-03-09 CN CN91101421A patent/CN1055864C/zh not_active Expired - Lifetime
- 1991-03-09 EG EG13791A patent/EG19889A/xx active
- 1991-03-09 MY MYPI91000386A patent/MY105493A/en unknown
- 1991-03-11 TR TR91/0237A patent/TR25738A/xx unknown
1992
- 1992-08-24 OA OA60263A patent/OA09667A/en unknown
- 1992-09-04 FI FI923962A patent/FI100698B/fi active
- 1992-09-08 NO NO923485A patent/NO304352B1/no not_active IP Right Cessation
- 1992-09-09 KR KR1019920702186A patent/KR100189271B1/ko not_active Ceased
- 1992-12-30 LV LVP-92-595A patent/LV10058B/lv unknown
1993
- 1993-04-02 HR HR930773A patent/HRP930773B1/xx not_active IP Right Cessation
- 1993-07-26 GE GEAP19931164A patent/GEP19971155B/en unknown
1996
- 1996-03-15 US US08/616,245 patent/USRE36418E/en not_active Expired - Lifetime
- 1996-08-22 GR GR960402066T patent/GR3020842T3/el unknown
2000
- 2000-07-05 GR GR20000401583T patent/GR3033898T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU7345191A (en)	1991-10-10
AU645544B2 (en)	1994-01-20
US5328680A (en)	1994-07-12
FI100698B (fi)	1998-02-13
RO111543B1 (ro)	1996-11-29
DE69121562T3 (de)	2000-11-23
HRP930773A2 (en)	1997-10-31
HRP930773B1 (en)	2000-10-31
DE69121562D1 (de)	1996-09-26
EP0521880B2 (en)	2000-05-31
MY105493A (en)	1994-10-31
GB9020091D0 (en)	1990-10-24
DZ1506A1 (fr)	2004-09-13
PT96978A (pt)	1991-10-31
LV10058A (lv)	1994-05-10
GEP19971155B (en)	1997-08-11
NO304352B1 (no)	1998-12-07
KR100189271B1 (ko)	1999-06-01
SK278621B6 (en)	1997-11-05
DE69121562T2 (de)	1997-01-16
JP3215703B2 (ja)	2001-10-09
IL97455A0 (en)	1992-06-21
LV10058B (en)	1994-10-20
OA09667A (en)	1993-05-15
HUT62490A (en)	1993-05-28
EP0521880B1 (en)	1996-08-21
ES2090315T3 (es)	1996-10-16
USRE36418E (en)	1999-11-30
IE76916B1 (en)	1997-11-05
GR3020842T3 (en)	1996-11-30
JPH05504953A (ja)	1993-07-29
IE910775A1 (en)	1991-09-11
FI923962L (fi)	1992-09-04
WO1991013636A1 (en)	1991-09-19
GR3033898T3 (en)	2000-11-30
HU9202870D0 (en)	1992-11-30
DK0521880T4 (da)	2000-09-04
EG19889A (en)	1996-03-31
YU48683B (sh)	1999-06-15
DK0521880T3 (da)	1996-09-09
IL97455A (en)	1995-11-27
CN1056058A (zh)	1991-11-13
CN1055864C (zh)	2000-08-30
PT96978B (pt)	2001-07-31
TR25738A (tr)	1993-09-01
ES2090315T5 (es)	2000-08-01
HU217075B (hu)	1999-11-29
HK1003563A1 (en)	1998-10-30
ATE141519T1 (de)	1996-09-15
FI923962A0 (fi)	1992-09-04
NO923485L (no)	1992-11-05
CA2076861A1 (en)	1991-09-10
YU40891A (sh)	1994-04-05
NO923485D0 (no)	1992-09-08
EP0521880A1 (en)	1993-01-13
CZ285071B6 (cs)	1999-05-12

Legal Events

Date	Code	Title	Description
2000-06-30	IF00	In force as of 2000-06-30 in czech republic
2011-03-16	MK4A	Patent expired	Effective date: 20110308

Publication	Publication Date	Title
CS9100619A2 (en)	1991-09-15	Contrast means and method of its production
KR930021248A (ko)	1993-11-22	정수용재, 이의 제조 방법 및 정수방법
DE69527660D1 (de)	2002-09-05	Osmotisches Mittel für die Peritonealdialyse
AR077487A2 (es)	2011-08-31	Composiciones atenuadas para dialisis
MX173881B (es)	1994-04-07	Reduccion metalotermimca de oxidos de de tierra rara
AU1102095A (en)	1995-05-29	Oxygen absorber
GR3019922T3 (en)	1996-08-31	Disinfecting and cleaning composition for contact lenses
RU95107885A (ru)	1997-01-27	Способы получения металлического магния
BG95330A (bg)	1993-12-24	Контрастни средства
HUT56274A (en)	1991-08-28	Process for producing low viscosity, high concentration surface active suspensions
HUT73589A (en)	1996-08-28	Compositions based on aluminium polychloride and on iron salts and method of preparation thereof and application thereof in water treatment
NZ234066A (en)	1992-01-29	A method of purifying water containing aluminium by adding alkali and a source of silicon
RU97115263A (ru)	1999-06-20	Способ лечения гнойных гайморитов
AT136142B (de)	1934-01-10	Röntgenologisches Verfahren.
Leonov et al.	1994	Significance of ion exchange in the water treatment by natural zeolites
UA42070C2 (uk)	2001-10-15	Спосіб лікування шлунково-кишкових розладів у новонароджених телят
WO1997007062B1 (en)	1997-05-15	Improved method of treating water
DE69417864D1 (de)	1999-05-20	Verfahren zur herstellung eines stark mit metall ausgewechselten zeoliths y
DD284417A5 (de)	1990-11-14	Regenerierverfahren fuer ionenaustauscher bei ihrem einsatz zur restentfernung von erdalkaliionen aus stark alkalisalzhaltigen waessern