CU20090117A7 - Compuesto de [1,2,3]-benzotriazinona-3-. sustituido para mejorar las respuestas sinápticas glutamatergicas - Google Patents
Compuesto de [1,2,3]-benzotriazinona-3-. sustituido para mejorar las respuestas sinápticas glutamatergicasInfo
- Publication number
- CU20090117A7 CU20090117A7 CU20090117A CU20090117A CU20090117A7 CU 20090117 A7 CU20090117 A7 CU 20090117A7 CU 20090117 A CU20090117 A CU 20090117A CU 20090117 A CU20090117 A CU 20090117A CU 20090117 A7 CU20090117 A7 CU 20090117A7
- Authority
- CU
- Cuba
- Prior art keywords
- treatment
- glutamatergical
- benzotriazinona
- composite
- replaced
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title 1
- 230000000946 synaptic effect Effects 0.000 title 1
- 210000004556 brain Anatomy 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000003930 cognitive ability Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Esta invención se refiere a la prevención y tratamiento de insuficiencia cerebral, incluyendo incremento del funcionamiento de receptores en la sinapsis en las redes cerebrales responsables de comportamientos de orden superior. Estas redes cerebrales están implicadas en las capacidades cognitivas relacionadas con la alteración de la memoria, tal como se observa en una variedad de demencias y en desequilibrios de la actividad neuronal entre diferentes regiones cerebrales, como se sugiere en trastornos tales como la enfermedad de Parkinson, esquizofrenia y trastornos afectivos. En un aspecto particular, la presente invención se refiere a un compuesto útil para el tratamiento de dichas condiciones y a métodos para utilizar este compuesto para dicho tratamiento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87850307P | 2007-01-03 | 2007-01-03 | |
| US92143307P | 2007-04-02 | 2007-04-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20090117A7 true CU20090117A7 (es) | 2011-10-05 |
| CU23804B7 CU23804B7 (es) | 2012-03-15 |
Family
ID=39608956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20090117A CU23804B7 (es) | 2007-01-03 | 2009-07-03 | Compuesto [1,2,3]-benzotriazinona sustituido en 3 para incrementar las respuestas sinápticas glutamatergicas |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US8173644B2 (es) |
| EP (1) | EP2144506B1 (es) |
| JP (1) | JP5139446B2 (es) |
| CN (1) | CN101616592B (es) |
| AP (1) | AP2502A (es) |
| AR (1) | AR064740A1 (es) |
| AT (1) | ATE527269T1 (es) |
| AU (1) | AU2007342365B2 (es) |
| BR (1) | BRPI0720749A2 (es) |
| CA (1) | CA2674460C (es) |
| CR (1) | CR10906A (es) |
| CU (1) | CU23804B7 (es) |
| CY (1) | CY1112493T1 (es) |
| DK (1) | DK2144506T3 (es) |
| EA (1) | EA017437B1 (es) |
| EC (1) | ECSP099499A (es) |
| ES (1) | ES2374995T3 (es) |
| GE (1) | GEP20125438B (es) |
| GT (1) | GT200900189A (es) |
| HN (1) | HN2009001268A (es) |
| HR (1) | HRP20110970T1 (es) |
| IL (1) | IL199651A (es) |
| MA (1) | MA31160B1 (es) |
| ME (1) | ME00819B (es) |
| MX (1) | MX2009007242A (es) |
| MY (1) | MY154877A (es) |
| NI (1) | NI200900131A (es) |
| NZ (1) | NZ578293A (es) |
| PL (1) | PL2144506T3 (es) |
| PT (1) | PT2144506E (es) |
| RS (1) | RS52108B (es) |
| SG (1) | SG163545A1 (es) |
| SI (1) | SI2144506T1 (es) |
| SV (1) | SV2009003322A (es) |
| TN (1) | TN2009000277A1 (es) |
| WO (1) | WO2008085506A1 (es) |
| ZA (1) | ZA200904826B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ578290A (en) * | 2007-01-03 | 2012-03-30 | Cortex Pharma Inc | 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses |
| WO2008143963A1 (en) * | 2007-05-17 | 2008-11-27 | Cortex Pharmaceuticals, Inc. | Di-substituted amides for enhancing glutamatergic synaptic responses |
| US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| BRPI0823262A2 (pt) | 2007-08-10 | 2013-09-24 | Cortex Pharma Inc | mÉtodo de tratamento de depressço respiratària e uso de um composto na fabricaÇço de um medicamento para o tratamento de depressço respiratària |
| US20110257186A1 (en) * | 2010-04-15 | 2011-10-20 | Staubli Ursula V | Compositions and methods for treating visual disorders |
| US9242938B2 (en) | 2011-11-22 | 2016-01-26 | Beijing Medisan Technology Co., Ltd | Glycine reuptake inhibitor and use thereof |
| FR3019464B1 (fr) * | 2014-04-07 | 2016-05-06 | Servier Lab | Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent |
| FR3034019B1 (fr) | 2015-03-26 | 2017-03-17 | Servier Lab | Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un antidepresseur et les compositions pharmaceutiques qui la contiennent |
| KR20180019234A (ko) | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
| WO2018009256A1 (en) | 2016-03-29 | 2018-01-11 | Respirerx Pharmaceuticals, Inc. | Compositions and methods for treating attention deficit disorders |
| CN106226509B (zh) * | 2016-08-12 | 2019-09-06 | 中国人民解放军第四军医大学 | 一种在小鼠前扣带回皮层诱发dse现象的方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723436A (en) | 1971-02-25 | 1973-03-27 | Sun Oil Co | Process for aromatic lactams |
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| FR2597103B1 (fr) | 1986-04-15 | 1988-12-16 | Provesan Sa | Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde |
| ES2174851T3 (es) | 1992-07-24 | 2002-11-16 | Univ California | Farmacos que aumentan las respuestas sinapticas mediadas por receptores ampa. |
| US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
| EP0709384B1 (de) * | 1994-10-31 | 1998-12-23 | MERCK PATENT GmbH | Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren |
| US5650409A (en) | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| US6030968A (en) | 1996-09-17 | 2000-02-29 | The Regents Of The University Of California | Positive AMPA receptor modulation to enhance brain neurotrophic factor expression |
| US6110935A (en) | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| US5985871A (en) | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| HUP0101280A3 (en) | 1998-02-18 | 2003-02-28 | Neurosearch As | Positive ampa receptor modulator compounds and their use |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US6303542B1 (en) * | 2000-08-18 | 2001-10-16 | Rohm And Haas Company | Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones |
| CZ2004632A3 (cs) * | 2001-11-26 | 2004-08-18 | Cortexápharmaceuticalsźáinc | Karbonylbenzoxazinové sloučeniny pro zvýšení glutamátergních synaptických odpovědí |
| JP2003238555A (ja) * | 2002-02-20 | 2003-08-27 | Sumitomo Pharmaceut Co Ltd | 細胞死抑制剤 |
| AUPS255202A0 (en) * | 2002-05-27 | 2002-06-13 | Monash University | Agents and methods for the treatment of disorders associated with motor neuron degeneration |
| EA200501117A1 (ru) * | 2003-01-13 | 2006-02-24 | Кортекс Фармасеутикалс, Инк. | Способ лечения снижения когнитивной способности вследствие лишения сна и стресса |
| GB0317482D0 (en) | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| CN1897950A (zh) | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| NZ578290A (en) | 2007-01-03 | 2012-03-30 | Cortex Pharma Inc | 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses |
| WO2008143963A1 (en) | 2007-05-17 | 2008-11-27 | Cortex Pharmaceuticals, Inc. | Di-substituted amides for enhancing glutamatergic synaptic responses |
| BRPI0823262A2 (pt) | 2007-08-10 | 2013-09-24 | Cortex Pharma Inc | mÉtodo de tratamento de depressço respiratària e uso de um composto na fabricaÇço de um medicamento para o tratamento de depressço respiratària |
| KR20100063087A (ko) | 2007-09-20 | 2010-06-10 | 코텍스 파마슈티칼스, 인크. | 글루타메이트 시냅스 반응 향상을 위한 3-치환된 1,2,3-트리아진-4-온 및 3-치환된 1,3-피리미디논 |
-
2007
- 2007-12-28 WO PCT/US2007/026416 patent/WO2008085506A1/en not_active Ceased
- 2007-12-28 CN CN2007800508375A patent/CN101616592B/zh not_active Expired - Fee Related
- 2007-12-28 GE GEAP200711384A patent/GEP20125438B/en unknown
- 2007-12-28 CA CA2674460A patent/CA2674460C/en not_active Expired - Fee Related
- 2007-12-28 HR HR20110970T patent/HRP20110970T1/hr unknown
- 2007-12-28 MY MYPI20092796A patent/MY154877A/en unknown
- 2007-12-28 PL PL07868093T patent/PL2144506T3/pl unknown
- 2007-12-28 MX MX2009007242A patent/MX2009007242A/es active IP Right Grant
- 2007-12-28 AU AU2007342365A patent/AU2007342365B2/en not_active Ceased
- 2007-12-28 ZA ZA200904826A patent/ZA200904826B/xx unknown
- 2007-12-28 NZ NZ578293A patent/NZ578293A/en not_active IP Right Cessation
- 2007-12-28 US US12/448,784 patent/US8173644B2/en not_active Expired - Fee Related
- 2007-12-28 ES ES07868093T patent/ES2374995T3/es active Active
- 2007-12-28 AT AT07868093T patent/ATE527269T1/de active
- 2007-12-28 EA EA200900925A patent/EA017437B1/ru not_active IP Right Cessation
- 2007-12-28 EP EP07868093A patent/EP2144506B1/en active Active
- 2007-12-28 ME MEP-2009-238A patent/ME00819B/me unknown
- 2007-12-28 SI SI200730806T patent/SI2144506T1/sl unknown
- 2007-12-28 JP JP2009544857A patent/JP5139446B2/ja not_active Expired - Fee Related
- 2007-12-28 BR BRPI0720749-2A patent/BRPI0720749A2/pt not_active Application Discontinuation
- 2007-12-28 SG SG201004695-1A patent/SG163545A1/en unknown
- 2007-12-28 DK DK07868093.1T patent/DK2144506T3/da active
- 2007-12-28 PT PT07868093T patent/PT2144506E/pt unknown
- 2007-12-28 RS RS20110587A patent/RS52108B/sr unknown
- 2007-12-28 AP AP2009004931A patent/AP2502A/xx active
-
2008
- 2008-01-03 AR ARP080100022A patent/AR064740A1/es not_active Application Discontinuation
-
2009
- 2009-06-30 TN TNP2009000277A patent/TN2009000277A1/fr unknown
- 2009-07-01 NI NI200900131A patent/NI200900131A/es unknown
- 2009-07-02 CR CR10906A patent/CR10906A/es not_active Application Discontinuation
- 2009-07-02 SV SV2009003322A patent/SV2009003322A/es unknown
- 2009-07-02 GT GT200900189A patent/GT200900189A/es unknown
- 2009-07-02 IL IL199651A patent/IL199651A/en active IP Right Grant
- 2009-07-03 CU CU20090117A patent/CU23804B7/es active IP Right Grant
- 2009-07-03 HN HN2009001268A patent/HN2009001268A/es unknown
- 2009-07-07 EC EC2009009499A patent/ECSP099499A/es unknown
- 2009-07-31 MA MA32135A patent/MA31160B1/fr unknown
-
2011
- 2011-12-28 CY CY20111101287T patent/CY1112493T1/el unknown
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| Date | Code | Title | Description |
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| FG | Grant of patent |