ATE527269T1 - 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen - Google Patents

3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen

Info

Publication number: ATE527269T1
Authority: AT; Austria
Prior art keywords: promoting; reactions; substituted; glutamatergic synapse; benzotriazinone
Prior art date: 2007-01-03

Application number

AT07868093T

Other languages

English (en)

Inventor

Alexis Cordi

Gary Rogers

Rudolf Mueller

Original Assignee

Cortex Pharma Inc

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-03

Filing date

2007-12-28

Publication date

2011-10-15

2007-12-28 Application filed by Cortex Pharma Inc, Servier Lab filed Critical Cortex Pharma Inc

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE527269T1 publication Critical patent/ATE527269T1/de

Links

238000006243 chemical reaction Methods 0.000 title 1
ZGNITFSDLCMLGI-UHFFFAOYSA-N flubendiamide Chemical compound CC1=CC(C(F)(C(F)(F)F)C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)(=O)=O ZGNITFSDLCMLGI-UHFFFAOYSA-N 0.000 title 1
230000000848 glutamatergic effect Effects 0.000 title 1
230000001737 promoting effect Effects 0.000 title 1
210000000225 synapse Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT07868093T 2007-01-03 2007-12-28 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen ATE527269T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US87850307P	2007-01-03	2007-01-03
US92143307P	2007-04-02	2007-04-02
PCT/US2007/026416 WO2008085506A1 (en)	2007-01-03	2007-12-28	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number	Publication Date
ATE527269T1 true ATE527269T1 (de)	2011-10-15

Family

ID=39608956

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07868093T ATE527269T1 (de)	2007-01-03	2007-12-28	3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen

Country Status (37)

Country	Link
US (1)	US8173644B2 (de)
EP (1)	EP2144506B1 (de)
JP (1)	JP5139446B2 (de)
CN (1)	CN101616592B (de)
AP (1)	AP2502A (de)
AR (1)	AR064740A1 (de)
AT (1)	ATE527269T1 (de)
AU (1)	AU2007342365B2 (de)
BR (1)	BRPI0720749A2 (de)
CA (1)	CA2674460C (de)
CR (1)	CR10906A (de)
CU (1)	CU23804B7 (de)
CY (1)	CY1112493T1 (de)
DK (1)	DK2144506T3 (de)
EA (1)	EA017437B1 (de)
EC (1)	ECSP099499A (de)
ES (1)	ES2374995T3 (de)
GE (1)	GEP20125438B (de)
GT (1)	GT200900189A (de)
HN (1)	HN2009001268A (de)
HR (1)	HRP20110970T1 (de)
IL (1)	IL199651A (de)
MA (1)	MA31160B1 (de)
ME (1)	ME00819B (de)
MX (1)	MX2009007242A (de)
MY (1)	MY154877A (de)
NI (1)	NI200900131A (de)
NZ (1)	NZ578293A (de)
PL (1)	PL2144506T3 (de)
PT (1)	PT2144506E (de)
RS (1)	RS52108B (de)
SG (1)	SG163545A1 (de)
SI (1)	SI2144506T1 (de)
SV (1)	SV2009003322A (de)
TN (1)	TN2009000277A1 (de)
WO (1)	WO2008085506A1 (de)
ZA (1)	ZA200904826B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2007342364A1 (en) *	2007-01-03	2008-07-17	Cortex Pharmaceuticals, Inc.	3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
EA200901546A1 (ru)	2007-05-17	2010-04-30	Кортекс Фармасеутикалс, Инк.	Дизамещенные амиды для усиления глутаматергических синаптических ответов
US8119632B2 (en)	2007-08-10	2012-02-21	Cortex Pharmaceuticals, Inc.	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
BRPI0814149A2 (pt)	2007-08-10	2011-09-13	Cortex Pharma Inc	composto, composição farmacêutica, métodos de tratamento e uso do composto
US20110257186A1 (en) *	2010-04-15	2011-10-20	Staubli Ursula V	Compositions and methods for treating visual disorders
WO2013075624A1 (zh)	2011-11-22	2013-05-30	北京哈三联科技股份有限公司	甘氨酸重摄取抑制剂及其应用
FR3019464B1 (fr)	2014-04-07	2016-05-06	Servier Lab	Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR3034019B1 (fr)	2015-03-26	2017-03-17	Servier Lab	Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un antidepresseur et les compositions pharmaceutiques qui la contiennent
KR20180019234A (ko)	2015-06-26	2018-02-23	다케다 야쿠힌 고교 가부시키가이샤	콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체
US20190112300A1 (en)	2016-03-29	2019-04-18	Arnold Stan Lippa	Compositions And Methods For Treating Attention Deficit Disorders
CN106226509B (zh) *	2016-08-12	2019-09-06	中国人民解放军第四军医大学	一种在小鼠前扣带回皮层诱发dse现象的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3723436A (en) *	1971-02-25	1973-03-27	Sun Oil Co	Process for aromatic lactams
DK623586A (da) *	1985-12-27	1987-06-28	Eisai Co Ltd	Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
FR2597103B1 (fr) *	1986-04-15	1988-12-16	Provesan Sa	Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde
EP1156043B1 (de)	1992-07-24	2003-11-12	The Regents Of The University Of California	Arzneimittel die den durch AMPA Rezeptoren vermittelten synaptischen Response erhöhen
US5962477A (en) *	1994-04-12	1999-10-05	Adolor Corporation	Screening methods for cytokine inhibitors
DE59504622D1 (de) *	1994-10-31	1999-02-04	Merck Patent Gmbh	Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
US5650409A (en) *	1995-06-02	1997-07-22	Cortex Pharmaceuticals, Inc.	Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) *	1996-04-03	1998-04-07	The Regents Of The University Of California	Benzoxazines for enhancing synaptic response
AU4416197A (en) *	1996-09-17	1998-04-14	Regents Of The University Of California, The	Positive ampa receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en) *	1997-02-13	2000-08-29	The Regents Of The University Of California	Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en)	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response
CA2320354A1 (en)	1998-02-18	1999-08-26	Neurosearch A/S	Novel compounds and their use as positive ampa receptor modulators
US6713474B2 (en) *	1998-09-18	2004-03-30	Abbott Gmbh & Co. Kg	Pyrrolopyrimidines as therapeutic agents
US6303542B1 (en) *	2000-08-18	2001-10-16	Rohm And Haas Company	Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones
PL371722A1 (en) *	2001-11-26	2005-06-27	Cortex Pharmaceuticals, Inc.	Carbonylbenzoxazine compounds for enhancing glutamatergic synaptic responses
JP2003238555A (ja) *	2002-02-20	2003-08-27	Sumitomo Pharmaceut Co Ltd	細胞死抑制剤
AUPS255202A0 (en) *	2002-05-27	2002-06-13	Monash University	Agents and methods for the treatment of disorders associated with motor neuron degeneration
WO2004062616A2 (en) *	2003-01-13	2004-07-29	Cortex Pharmaceuticals, Inc.	Method of treating cognitive decline due to sleep deprivation and stress
GB0317482D0 (en) *	2003-07-25	2003-08-27	Pfizer Ltd	Nicotinamide derivatives useful as pde4 inhibitors
CN1897950A (zh) *	2003-10-14	2007-01-17	惠氏公司	稠合芳基和杂芳基衍生物及其使用方法
AU2007342364A1 (en)	2007-01-03	2008-07-17	Cortex Pharmaceuticals, Inc.	3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
EA200901546A1 (ru)	2007-05-17	2010-04-30	Кортекс Фармасеутикалс, Инк.	Дизамещенные амиды для усиления глутаматергических синаптических ответов
BRPI0814149A2 (pt)	2007-08-10	2011-09-13	Cortex Pharma Inc	composto, composição farmacêutica, métodos de tratamento e uso do composto
CN101801939A (zh)	2007-09-20	2010-08-11	科泰克斯药品公司	用于增强谷氨酸能突触反应的3-取代1,2,3-三嗪-4-酮类和3-取代1,3-嘧啶酮类

2007
- 2007-12-28 MY MYPI20092796A patent/MY154877A/en unknown
- 2007-12-28 EA EA200900925A patent/EA017437B1/ru not_active IP Right Cessation
- 2007-12-28 US US12/448,784 patent/US8173644B2/en not_active Expired - Fee Related
- 2007-12-28 EP EP07868093A patent/EP2144506B1/de active Active
- 2007-12-28 SG SG201004695-1A patent/SG163545A1/en unknown
- 2007-12-28 AU AU2007342365A patent/AU2007342365B2/en not_active Ceased
- 2007-12-28 AT AT07868093T patent/ATE527269T1/de active
- 2007-12-28 ZA ZA200904826A patent/ZA200904826B/xx unknown
- 2007-12-28 JP JP2009544857A patent/JP5139446B2/ja not_active Expired - Fee Related
- 2007-12-28 HR HR20110970T patent/HRP20110970T1/hr unknown
- 2007-12-28 CN CN2007800508375A patent/CN101616592B/zh not_active Expired - Fee Related
- 2007-12-28 ME MEP-2009-238A patent/ME00819B/me unknown
- 2007-12-28 PT PT07868093T patent/PT2144506E/pt unknown
- 2007-12-28 CA CA2674460A patent/CA2674460C/en not_active Expired - Fee Related
- 2007-12-28 SI SI200730806T patent/SI2144506T1/sl unknown
- 2007-12-28 AP AP2009004931A patent/AP2502A/xx active
- 2007-12-28 ES ES07868093T patent/ES2374995T3/es active Active
- 2007-12-28 GE GEAP200711384A patent/GEP20125438B/en unknown
- 2007-12-28 MX MX2009007242A patent/MX2009007242A/es active IP Right Grant
- 2007-12-28 WO PCT/US2007/026416 patent/WO2008085506A1/en not_active Ceased
- 2007-12-28 NZ NZ578293A patent/NZ578293A/en not_active IP Right Cessation
- 2007-12-28 BR BRPI0720749-2A patent/BRPI0720749A2/pt not_active Application Discontinuation
- 2007-12-28 RS RS20110587A patent/RS52108B/sr unknown
- 2007-12-28 DK DK07868093.1T patent/DK2144506T3/da active
- 2007-12-28 PL PL07868093T patent/PL2144506T3/pl unknown
2008
- 2008-01-03 AR ARP080100022A patent/AR064740A1/es not_active Application Discontinuation
2009
- 2009-06-30 TN TNP2009000277A patent/TN2009000277A1/fr unknown
- 2009-07-01 NI NI200900131A patent/NI200900131A/es unknown
- 2009-07-02 GT GT200900189A patent/GT200900189A/es unknown
- 2009-07-02 SV SV2009003322A patent/SV2009003322A/es unknown
- 2009-07-02 CR CR10906A patent/CR10906A/es not_active Application Discontinuation
- 2009-07-02 IL IL199651A patent/IL199651A/en active IP Right Grant
- 2009-07-03 CU CU20090117A patent/CU23804B7/es active IP Right Grant
- 2009-07-03 HN HN2009001268A patent/HN2009001268A/es unknown
- 2009-07-07 EC EC2009009499A patent/ECSP099499A/es unknown
- 2009-07-31 MA MA32135A patent/MA31160B1/fr unknown
2011
- 2011-12-28 CY CY20111101287T patent/CY1112493T1/el unknown

Also Published As

Publication number	Publication date
AP2502A (en)	2012-10-23
SI2144506T1 (sl)	2012-01-31
AU2007342365A1 (en)	2008-07-17
HK1140105A1 (en)	2010-10-08
TN2009000277A1 (en)	2010-10-18
IL199651A0 (en)	2010-04-15
EA200900925A1 (ru)	2009-12-30
EP2144506B1 (de)	2011-10-05
WO2008085506A1 (en)	2008-07-17
ECSP099499A (es)	2009-10-30
AU2007342365B2 (en)	2012-11-15
GEP20125438B (en)	2012-03-26
AR064740A1 (es)	2009-04-22
BRPI0720749A2 (pt)	2014-01-14
CA2674460C (en)	2014-07-15
HN2009001268A (es)	2011-12-27
EP2144506A4 (de)	2010-05-05
SG163545A1 (en)	2010-08-30
PL2144506T3 (pl)	2012-04-30
AP2009004931A0 (en)	2009-08-31
MX2009007242A (es)	2009-09-02
ME00819B (me)	2012-03-20
DK2144506T3 (da)	2012-03-05
CU23804B7 (es)	2012-03-15
JP5139446B2 (ja)	2013-02-06
ES2374995T3 (es)	2012-02-23
GT200900189A (es)	2011-08-02
US20100137295A1 (en)	2010-06-03
CA2674460A1 (en)	2008-07-17
NZ578293A (en)	2012-01-12
EP2144506A1 (de)	2010-01-20
RS52108B (sr)	2012-08-31
CR10906A (es)	2009-10-23
PT2144506E (pt)	2011-12-21
CN101616592A (zh)	2009-12-30
SV2009003322A (es)	2010-02-05
CU20090117A7 (es)	2011-10-05
ZA200904826B (en)	2010-09-29
MA31160B1 (fr)	2010-02-01
NI200900131A (es)	2010-03-11
JP2010514838A (ja)	2010-05-06
US8173644B2 (en)	2012-05-08
EA017437B1 (ru)	2012-12-28
HRP20110970T1 (hr)	2012-01-31
CY1112493T1 (el)	2015-12-09
CN101616592B (zh)	2013-06-05
MY154877A (en)	2015-08-14
IL199651A (en)	2015-08-31

Publication	Publication Date	Title
BRPI0811718A2 (pt)	2014-11-18	Derivados de 3,3-espiroindolinona
BRPI0815717A2 (pt)	2015-02-10	Compostos de imidazopirazina.
BRPI0923786A2 (pt)	2016-07-26	compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos
DK2035396T3 (da)	2014-06-02	Triazolforbindelser der modulerer hsp90-aktivitet
BRPI0816970A2 (pt)	2015-03-24	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
DK2035398T3 (da)	2013-07-08	Immobiliseret 1,2-benzisothioazolin-3-on
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
EP2129224A4 (de)	2011-01-05	5,6-dihydro-1h-pyridin-2-on-verbindungen
CL2008000325S1 (es)	2008-09-05	Automovil.
CL2008000782S1 (es)	2008-09-26	Automovil.
DE502007005406D1 (de)	2010-12-02	Flurförderzeug für den Mitfahrbetrieb
DK2144506T3 (da)	2012-03-05	3-substitueret [1,2,3]-benzotriazinonforbindelse til at fremme glutamaterge synaptiske responser
FI20090127L (fi)	2010-10-01	Polymeerikoostumus, joka soveltuu pastöroitavien säilytysastioiden valmistamiseen
CL2008000916S1 (es)	2008-09-05	Automovil.
BRPI0916395A2 (pt)	2016-02-16	compostos de 1,6-di-hidro-2h-3-oxa-6-aza-as-indaceno
BRPI0812460A2 (pt)	2014-12-02	" compostos orgânicos ".
BRPI0819653A2 (pt)	2014-11-04	Método para a produção de um composto de tetrapirrol, e, composto de tetrapirrol.
BRPI0907749A2 (pt)	2015-07-21	Derivados de 3,8-diaminotetrahidroquinolina
FR2922934B1 (fr)	2012-08-24	Verrou pour battant.
BRPI0818848A2 (pt)	2015-04-14	Compostos de 2,3-di-idro-benzofurano
ES1059248Y (es)	2006-01-01	Deposito de cadaveres para granjas
ES1060653Y (es)	2006-06-01	Estructura de cerramiento para la construccion.
FI20075785L (fi)	2009-05-06	Antimikrobiologinen pinnoite, pinnoiteliuos ja menetelmä pinnoitteen valmistamiseksi ja uudistamiseksi
EP1975147A4 (de)	2010-05-19	Tetrafluortoluolverbindung, herstellungsverfahren dafür und verwendung davon
ITRM20050333A1 (it)	2006-12-28	Apparato per la produzione energetica.