ATE527269T1 - 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen - Google Patents

3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen

Info

Publication number: ATE527269T1
Authority: AT; Austria
Prior art keywords: promoting; reactions; substituted; glutamatergic synapse; benzotriazinone
Prior art date: 2007-01-03

Application number

AT07868093T

Other languages

English (en)

Inventor

Alexis Cordi

Gary Rogers

Rudolf Mueller

Original Assignee

Cortex Pharma Inc

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-03

Filing date

2007-12-28

Publication date

2011-10-15

2007-12-28 Application filed by Cortex Pharma Inc, Servier Lab filed Critical Cortex Pharma Inc

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE527269T1 publication Critical patent/ATE527269T1/de

Links

238000006243 chemical reaction Methods 0.000 title 1
ZGNITFSDLCMLGI-UHFFFAOYSA-N flubendiamide Chemical compound CC1=CC(C(F)(C(F)(F)F)C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)(=O)=O ZGNITFSDLCMLGI-UHFFFAOYSA-N 0.000 title 1
230000000848 glutamatergic effect Effects 0.000 title 1
230000001737 promoting effect Effects 0.000 title 1
210000000225 synapse Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT07868093T 2007-01-03 2007-12-28 3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen ATE527269T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US87850307P	2007-01-03	2007-01-03
US92143307P	2007-04-02	2007-04-02
PCT/US2007/026416 WO2008085506A1 (en)	2007-01-03	2007-12-28	3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses

Publications (1)

Publication Number	Publication Date
ATE527269T1 true ATE527269T1 (de)	2011-10-15

Family

ID=39608956

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07868093T ATE527269T1 (de)	2007-01-03	2007-12-28	3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen

Country Status (37)

Country	Link
US (1)	US8173644B2 (de)
EP (1)	EP2144506B1 (de)
JP (1)	JP5139446B2 (de)
CN (1)	CN101616592B (de)
AP (1)	AP2502A (de)
AR (1)	AR064740A1 (de)
AT (1)	ATE527269T1 (de)
AU (1)	AU2007342365B2 (de)
BR (1)	BRPI0720749A2 (de)
CA (1)	CA2674460C (de)
CR (1)	CR10906A (de)
CU (1)	CU23804B7 (de)
CY (1)	CY1112493T1 (de)
DK (1)	DK2144506T3 (de)
EA (1)	EA017437B1 (de)
EC (1)	ECSP099499A (de)
ES (1)	ES2374995T3 (de)
GE (1)	GEP20125438B (de)
GT (1)	GT200900189A (de)
HN (1)	HN2009001268A (de)
HR (1)	HRP20110970T1 (de)
IL (1)	IL199651A (de)
MA (1)	MA31160B1 (de)
ME (1)	ME00819B (de)
MX (1)	MX2009007242A (de)
MY (1)	MY154877A (de)
NI (1)	NI200900131A (de)
NZ (1)	NZ578293A (de)
PL (1)	PL2144506T3 (de)
PT (1)	PT2144506E (de)
RS (1)	RS52108B (de)
SG (1)	SG163545A1 (de)
SI (1)	SI2144506T1 (de)
SV (1)	SV2009003322A (de)
TN (1)	TN2009000277A1 (de)
WO (1)	WO2008085506A1 (de)
ZA (1)	ZA200904826B (de)

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BRPI0720323A2 (pt) *	2007-01-03	2016-08-09	Cortex Pharma Inc	composto, método de tratamento, composição farmacêutica e uso do composto
WO2008143963A1 (en)	2007-05-17	2008-11-27	Cortex Pharmaceuticals, Inc.	Di-substituted amides for enhancing glutamatergic synaptic responses
CA2695742C (en)	2007-08-10	2012-11-27	Rudolf Mueller	Bicyclic amides for enhancing glutamatergic synaptic responses
US8119632B2 (en)	2007-08-10	2012-02-21	Cortex Pharmaceuticals, Inc.	Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
US20110257186A1 (en) *	2010-04-15	2011-10-20	Staubli Ursula V	Compositions and methods for treating visual disorders
WO2013075624A1 (zh)	2011-11-22	2013-05-30	北京哈三联科技股份有限公司	甘氨酸重摄取抑制剂及其应用
FR3019464B1 (fr) *	2014-04-07	2016-05-06	Servier Lab	Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR3034019B1 (fr) *	2015-03-26	2017-03-17	Servier Lab	Nouvelle association entre le 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3h-[1,3]oxazino[6,5-g] [1,2,3]benzotriazine-4,9-dione et un antidepresseur et les compositions pharmaceutiques qui la contiennent
TN2017000508A1 (en) *	2015-06-26	2019-04-12	Takeda Pharmaceuticals Co	2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
EP3436021A4 (de)	2016-03-29	2019-11-06	RespireRx Pharmaceuticals Inc.	Zusammensetzungen und verfahren zur behandlung von aufmerksamkeitsdefizitstörungen
CN106226509B (zh) *	2016-08-12	2019-09-06	中国人民解放军第四军医大学	一种在小鼠前扣带回皮层诱发dse现象的方法

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EP0651746B1 (de)	1992-07-24	2002-03-27	The Regents of the University of California	Arzneimittel, die den durch ampa rezeptoren vermittelten synaptischen respons erhöhen
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ATE174915T1 (de) *	1994-10-31	1999-01-15	Merck Patent Gmbh	Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
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US6030968A (en)	1996-09-17	2000-02-29	The Regents Of The University Of California	Positive AMPA receptor modulation to enhance brain neurotrophic factor expression
US6110935A (en)	1997-02-13	2000-08-29	The Regents Of The University Of California	Benzofurazan compounds for enhancing glutamatergic synaptic responses
US5985871A (en) *	1997-12-24	1999-11-16	Cortex Pharmaceuticals, Inc.	Benzoxazine compounds for enhancing synaptic response
IL137720A0 (en)	1998-02-18	2001-10-31	Neurosearch As	Compounds and their use as positive ampa receptor modulators
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BRPI0720323A2 (pt)	2007-01-03	2016-08-09	Cortex Pharma Inc	composto, método de tratamento, composição farmacêutica e uso do composto
WO2008143963A1 (en)	2007-05-17	2008-11-27	Cortex Pharmaceuticals, Inc.	Di-substituted amides for enhancing glutamatergic synaptic responses
CA2695742C (en)	2007-08-10	2012-11-27	Rudolf Mueller	Bicyclic amides for enhancing glutamatergic synaptic responses
KR20100063087A (ko)	2007-09-20	2010-06-10	코텍스 파마슈티칼스, 인크.	글루타메이트 시냅스 반응 향상을 위한 3-치환된 1,2,3-트리아진-4-온 및 3-치환된 1,3-피리미디논

2007
- 2007-12-28 GE GEAP200711384A patent/GEP20125438B/en unknown
- 2007-12-28 BR BRPI0720749-2A patent/BRPI0720749A2/pt not_active Application Discontinuation
- 2007-12-28 SG SG201004695-1A patent/SG163545A1/en unknown
- 2007-12-28 RS RS20110587A patent/RS52108B/sr unknown
- 2007-12-28 WO PCT/US2007/026416 patent/WO2008085506A1/en not_active Ceased
- 2007-12-28 MX MX2009007242A patent/MX2009007242A/es active IP Right Grant
- 2007-12-28 ES ES07868093T patent/ES2374995T3/es active Active
- 2007-12-28 AT AT07868093T patent/ATE527269T1/de active
- 2007-12-28 US US12/448,784 patent/US8173644B2/en not_active Expired - Fee Related
- 2007-12-28 EA EA200900925A patent/EA017437B1/ru not_active IP Right Cessation
- 2007-12-28 EP EP07868093A patent/EP2144506B1/de active Active
- 2007-12-28 NZ NZ578293A patent/NZ578293A/en not_active IP Right Cessation
- 2007-12-28 DK DK07868093.1T patent/DK2144506T3/da active
- 2007-12-28 PT PT07868093T patent/PT2144506E/pt unknown
- 2007-12-28 PL PL07868093T patent/PL2144506T3/pl unknown
- 2007-12-28 ME MEP-2009-238A patent/ME00819B/me unknown
- 2007-12-28 ZA ZA200904826A patent/ZA200904826B/xx unknown
- 2007-12-28 SI SI200730806T patent/SI2144506T1/sl unknown
- 2007-12-28 AP AP2009004931A patent/AP2502A/xx active
- 2007-12-28 CA CA2674460A patent/CA2674460C/en not_active Expired - Fee Related
- 2007-12-28 AU AU2007342365A patent/AU2007342365B2/en not_active Ceased
- 2007-12-28 MY MYPI20092796A patent/MY154877A/en unknown
- 2007-12-28 CN CN2007800508375A patent/CN101616592B/zh not_active Expired - Fee Related
- 2007-12-28 HR HR20110970T patent/HRP20110970T1/hr unknown
- 2007-12-28 JP JP2009544857A patent/JP5139446B2/ja not_active Expired - Fee Related
2008
- 2008-01-03 AR ARP080100022A patent/AR064740A1/es not_active Application Discontinuation
2009
- 2009-06-30 TN TNP2009000277A patent/TN2009000277A1/fr unknown
- 2009-07-01 NI NI200900131A patent/NI200900131A/es unknown
- 2009-07-02 SV SV2009003322A patent/SV2009003322A/es unknown
- 2009-07-02 GT GT200900189A patent/GT200900189A/es unknown
- 2009-07-02 CR CR10906A patent/CR10906A/es not_active Application Discontinuation
- 2009-07-02 IL IL199651A patent/IL199651A/en active IP Right Grant
- 2009-07-03 HN HN2009001268A patent/HN2009001268A/es unknown
- 2009-07-03 CU CU20090117A patent/CU23804B7/es active IP Right Grant
- 2009-07-07 EC EC2009009499A patent/ECSP099499A/es unknown
- 2009-07-31 MA MA32135A patent/MA31160B1/fr unknown
2011
- 2011-12-28 CY CY20111101287T patent/CY1112493T1/el unknown

Also Published As

Publication number	Publication date
ZA200904826B (en)	2010-09-29
TN2009000277A1 (en)	2010-10-18
AU2007342365A1 (en)	2008-07-17
GEP20125438B (en)	2012-03-26
EP2144506A4 (de)	2010-05-05
MY154877A (en)	2015-08-14
JP5139446B2 (ja)	2013-02-06
EP2144506B1 (de)	2011-10-05
CN101616592A (zh)	2009-12-30
EA017437B1 (ru)	2012-12-28
AP2009004931A0 (en)	2009-08-31
AR064740A1 (es)	2009-04-22
NI200900131A (es)	2010-03-11
GT200900189A (es)	2011-08-02
EA200900925A1 (ru)	2009-12-30
SI2144506T1 (sl)	2012-01-31
CU23804B7 (es)	2012-03-15
AU2007342365B2 (en)	2012-11-15
PT2144506E (pt)	2011-12-21
IL199651A0 (en)	2010-04-15
US8173644B2 (en)	2012-05-08
ES2374995T3 (es)	2012-02-23
ME00819B (me)	2012-03-20
CN101616592B (zh)	2013-06-05
DK2144506T3 (da)	2012-03-05
CY1112493T1 (el)	2015-12-09
HN2009001268A (es)	2011-12-27
RS52108B (sr)	2012-08-31
JP2010514838A (ja)	2010-05-06
MA31160B1 (fr)	2010-02-01
ECSP099499A (es)	2009-10-30
SG163545A1 (en)	2010-08-30
MX2009007242A (es)	2009-09-02
WO2008085506A1 (en)	2008-07-17
CA2674460C (en)	2014-07-15
PL2144506T3 (pl)	2012-04-30
CA2674460A1 (en)	2008-07-17
AP2502A (en)	2012-10-23
IL199651A (en)	2015-08-31
CU20090117A7 (es)	2011-10-05
NZ578293A (en)	2012-01-12
US20100137295A1 (en)	2010-06-03
CR10906A (es)	2009-10-23
EP2144506A1 (de)	2010-01-20
BRPI0720749A2 (pt)	2014-01-14
SV2009003322A (es)	2010-02-05
HK1140105A1 (en)	2010-10-08
HRP20110970T1 (hr)	2012-01-31

Publication	Publication Date	Title
ATE527269T1 (de)	2011-10-15	3-substituierte ä1,2,3ü-benzotriazinonverbindung zur förderung der glutamatergen synapsenreaktionen
BRPI0811718A2 (pt)	2014-11-18	Derivados de 3,3-espiroindolinona
BRPI0923786A2 (pt)	2016-07-26	compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos
BRPI0816970A2 (pt)	2015-03-24	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
DK2035398T3 (da)	2013-07-08	Immobiliseret 1,2-benzisothioazolin-3-on
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
EP2129224A4 (de)	2011-01-05	5,6-dihydro-1h-pyridin-2-on-verbindungen
CL2008000325S1 (es)	2008-09-05	Automovil.
CL2008000782S1 (es)	2008-09-26	Automovil.
DE502007005406D1 (de)	2010-12-02	Flurförderzeug für den Mitfahrbetrieb
FI20090127L (fi)	2010-10-01	Polymeerikoostumus, joka soveltuu pastöroitavien säilytysastioiden valmistamiseen
CL2008000916S1 (es)	2008-09-05	Automovil.
BRPI0916395A2 (pt)	2016-02-16	compostos de 1,6-di-hidro-2h-3-oxa-6-aza-as-indaceno
BRPI0812460A2 (pt)	2014-12-02	" compostos orgânicos ".
BRPI0819653A2 (pt)	2014-11-04	Método para a produção de um composto de tetrapirrol, e, composto de tetrapirrol.
BRPI0907749A2 (pt)	2015-07-21	Derivados de 3,8-diaminotetrahidroquinolina
BRPI0810655A2 (pt)	2014-11-04	Derivados de di-hidro-benzo[b][1,4] diazepin-2-ona sulfonamida
BRPI0818848A2 (pt)	2015-04-14	Compostos de 2,3-di-idro-benzofurano
ES1059248Y (es)	2006-01-01	Deposito de cadaveres para granjas
ES1060653Y (es)	2006-06-01	Estructura de cerramiento para la construccion.
FI20075785L (fi)	2009-05-06	Antimikrobiologinen pinnoite, pinnoiteliuos ja menetelmä pinnoitteen valmistamiseksi ja uudistamiseksi
ITRM20050333A1 (it)	2006-12-28	Apparato per la produzione energetica.
ES1061821Y (es)	2006-07-16	Burlete para cerramientos.
ES1059896Y (es)	2005-10-01	Dispositivo para la produccion de escarcha.
ES1061830Y (es)	2006-07-16	Contenedor para pintura.