CU23007A1 - Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos - Google Patents

Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos

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Publication number
CU23007A1
CU23007A1 CU2001008420010084A CU20010084A CU23007A1 CU 23007 A1 CU23007 A1 CU 23007A1 CU 2001008420010084 A CU2001008420010084 A CU 2001008420010084A CU 20010084 A CU20010084 A CU 20010084A CU 23007 A1 CU23007 A1 CU 23007A1
Authority
CU
Cuba
Prior art keywords
antibody
vaccines
gangliosides
present
tumors
Prior art date
Application number
CU2001008420010084A
Other languages
English (en)
Inventor
Requena Alejandro Lopez Requena Alejandro Lopez
De Acosta Del Rio Cristina Maria Mateo De Ac Mateo
Del Calvo Adriana Maria Rojas Del Calvo Adri Rojas
Navarro Lourdes Tatiana Roque Navarro Lourde Roque
Rodriguez Yildian Diaz Rodriguez Yildian Diaz
Valladares Josefa Lombardero Valladares Lombardero
Molina Luis Enrique Fernandez Molina Lui Fernandez
Gonzalez Alexis Perez Gonzalez Alexis Perez
Perez Adriana Carr Perez Adriana Carr
Lopez Ana Maria Vazquez Lopez Ana Maria Vazquez
Fernandez Angel Mauro Alfonso Fernandez An Alfonso
Rodriguez Rolando Perez Rodriguez Rolando Perez
Original Assignee
Ct De Inmunologia Molecular Ct De Inmunologia Mole
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Inmunologia Molecular Ct De Inmunologia Mole filed Critical Ct De Inmunologia Molecular Ct De Inmunologia Mole
Priority to CU2001008420010084A priority Critical patent/CU23007A1/es
Priority to UY27242A priority patent/UY27242A1/es
Priority to ARP020101263A priority patent/AR033122A1/es
Priority to MYPI20021228A priority patent/MY137078A/en
Priority to MYPI20021239A priority patent/MY157372A/en
Priority to ARP020101264A priority patent/AR033123A1/es
Priority to UY27243A priority patent/UY27243A1/es
Priority to MYPI20081190A priority patent/MY145703A/en
Priority to CNB028084330A priority patent/CN1319991C/zh
Priority to EA200301097A priority patent/EA006936B1/ru
Priority to HK05102752.9A priority patent/HK1070080B/xx
Priority to ES02759752T priority patent/ES2296986T3/es
Priority to ES02759751T priority patent/ES2312610T3/es
Priority to BRPI0208675-1A priority patent/BRPI0208675B1/pt
Priority to JP2002579482A priority patent/JP2004528033A/ja
Priority to NZ528599A priority patent/NZ528599A/en
Priority to HU0401695A priority patent/HU228105B1/hu
Priority to CA2441845A priority patent/CA2441845C/en
Priority to DE60223547T priority patent/DE60223547T2/de
Priority to AU2002308347A priority patent/AU2002308347B2/en
Priority to SG200506530-5A priority patent/SG161737A1/en
Priority to PCT/CU2002/000003 priority patent/WO2002081496A2/es
Priority to SK1226-2003A priority patent/SK287914B6/sk
Priority to KR1020037012969A priority patent/KR100946168B1/ko
Priority to SI200230660T priority patent/SI1411064T1/sl
Priority to CZ20032641A priority patent/CZ296276B6/cs
Priority to HU0401355A priority patent/HU228106B1/hu
Priority to AT02759752T priority patent/ATE378356T1/de
Priority to HK04109894.4A priority patent/HK1066818B/xx
Priority to JP2002580025A priority patent/JP4366080B2/ja
Priority to IL15824602A priority patent/IL158246A0/xx
Priority to PL371937A priority patent/PL208109B1/pl
Priority to HR20030806A priority patent/HRP20030806B1/xx
Priority to PT02759751T priority patent/PT1384726E/pt
Priority to EP02759752A priority patent/EP1411064B1/en
Priority to SK1216-2003A priority patent/SK287783B6/sk
Priority to NZ528598A priority patent/NZ528598A/en
Priority to PE2002000283A priority patent/PE20020972A1/es
Priority to DK02759751T priority patent/DK1384726T3/da
Priority to US10/473,978 priority patent/US20050069535A1/en
Priority to US10/473,977 priority patent/US20040253233A1/en
Priority to HR20030805A priority patent/HRP20030805B1/xx
Priority to CA2443372A priority patent/CA2443372C/en
Priority to AT06076643T priority patent/ATE477279T1/de
Priority to CZ2003-2668A priority patent/CZ304424B6/cs
Priority to PT02759752T priority patent/PT1411064E/pt
Priority to EP02759751A priority patent/EP1384726B1/en
Priority to AU2002308348A priority patent/AU2002308348B2/en
Priority to KR1020037012938A priority patent/KR100863509B1/ko
Priority to AT02759751T priority patent/ATE406386T1/de
Priority to BR0208675-1A priority patent/BR0208675A/pt
Priority to MXPA03008739A priority patent/MXPA03008739A/es
Priority to EA200301098A priority patent/EA006310B1/ru
Priority to DK02759752T priority patent/DK1411064T3/da
Priority to CNB028086309A priority patent/CN100349920C/zh
Priority to DE60228561T priority patent/DE60228561D1/de
Priority to SI200230766T priority patent/SI1384726T1/sl
Priority to CN2007101021039A priority patent/CN101054417B/zh
Priority to PL02371770A priority patent/PL371770A1/xx
Priority to PCT/CU2002/000002 priority patent/WO2002081661A2/es
Priority to EP06076643A priority patent/EP1798243B1/en
Priority to BRPI0208676-0A priority patent/BR0208676B1/pt
Priority to MXPA03008738A priority patent/MXPA03008738A/es
Priority to UA2003108988A priority patent/UA76745C2/uk
Priority to UA2003108989A priority patent/UA75393C2/uk
Priority to IS6964A priority patent/IS2701B/is
Priority to IS6965A priority patent/IS6965A/is
Priority to ZA200307585A priority patent/ZA200307585B/en
Priority to EC2003004787A priority patent/ECSP034787A/es
Priority to EC2003004788A priority patent/ECSP034788A/es
Priority to ZA2003/07679A priority patent/ZA200307679B/en
Priority to IL158246A priority patent/IL158246A/en
Priority to BG108228A priority patent/BG66304B1/bg
Priority to NO20034436A priority patent/NO331533B1/no
Priority to BG108227A priority patent/BG66293B1/en
Priority to NO20034437A priority patent/NO20034437L/no
Publication of CU23007A1 publication Critical patent/CU23007A1/es
Priority to UAA200512270A priority patent/UA86768C2/ru
Priority to AU2007231687A priority patent/AU2007231687B2/en
Priority to HK07114311.6A priority patent/HK1109160B/xx
Priority to KR1020087019420A priority patent/KR100919617B1/ko
Priority to US12/407,046 priority patent/US8758753B2/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se relaciona con el campo deLa presente invención se relaciona con el campo de la inmunología y más específicamente con la inmun la inmunología y más específicamente con la inmunoterapia del cáncer, particularmente con combinacioterapia del cáncer, particularmente con combinaciones inmunoterapéuticas y métodos de tratamiento pones inmunoterapéuticas y métodos de tratamiento para impedir el crecimiento de células tumorales y/ara impedir el crecimiento de células tumorales y/o eliminar dichas células. Los métodos descritos eo eliminar dichas células. Los métodos descritos en la presente invención se basan en el efecto teran la presente invención se basan en el efecto terapéutico obtenido por la combinación de vacunas idipéutico obtenido por la combinación de vacunas idiotípicas cuyo principio activo es un anticuerpo anotípicas cuyo principio activo es un anticuerpo antigangliósido (Ab1) o versiones recombinantes de dtigangliósido (Ab1) o versiones recombinantes de dicho anticuerpo, con vacunas idiotípicas cuyo prinicho anticuerpo, con vacunas idiotípicas cuyo principio activo es un anticuerpo antidiotipo obtenidocipio activo es un anticuerpo antidiotipo obtenido contra un anticuerpo antigangliósido (Ab2) o vers contra un anticuerpo antigangliósido (Ab2) o versiones recombinantes del mismo, o con vacunas cuyo iones recombinantes del mismo, o con vacunas cuyo principio activo es uno o más gangliósidos. Se desprincipio activo es uno o más gangliósidos. Se describen combinaciones de estas vacunas que provocancriben combinaciones de estas vacunas que provocan un sinergismo del efecto anti-tumoral que induce un sinergismo del efecto anti-tumoral que induce cada una de las vacunas por separado, y los procedcada una de las vacunas por separado, y los procedimientos referidos pueden ser aplicados a pacienteimientos referidos pueden ser aplicados a pacientes en diferentes estadíos clínicos de tumores que ss en diferentes estadíos clínicos de tumores que sobre-expresan gangliósidos. La presente invención obre-expresan gangliósidos. La presente invención también se relaciona con la obtención de los antictambién se relaciona con la obtención de los anticuerpos recombinantes (químericos y humanizados) a uerpos recombinantes (químericos y humanizados) a partir del anticuerpo murino antigangliósido, P3 (partir del anticuerpo murino antigangliósido, P3 (Ab1) y de su anticuerpo anti-idiotipo 1E10 (Ab2). Ab1) y de su anticuerpo anti-idiotipo 1E10 (Ab2).
CU2001008420010084A 2001-04-06 2001-04-06 Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos CU23007A1 (es)

Priority Applications (81)

Application Number Priority Date Filing Date Title
CU2001008420010084A CU23007A1 (es) 2001-04-06 2001-04-06 Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos
UY27242A UY27242A1 (es) 2001-04-06 2002-04-05 Anticuerpos recombinantes asociados a gangliosidos. su uso en el diasnostico y tratamiento de tumores
ARP020101263A AR033122A1 (es) 2001-04-06 2002-04-05 Combinaciones inmunoterapeuticas para el tratamiento de tumores que sobre-expresan gangliosidos
MYPI20021228A MY137078A (en) 2001-04-06 2002-04-05 Recombinant antibodies associated to gangliosides. their use indiagnosis and treatment of tumors.
MYPI20021239A MY157372A (en) 2001-04-06 2002-04-05 Immunotherapeutic combinations for the treatment of tumors that over-express gangliosides
ARP020101264A AR033123A1 (es) 2001-04-06 2002-04-05 Anticuerpos recombinantes asociados a gangliosidos. su uso en el diagnostico y tratamiento de tumores
UY27243A UY27243A1 (es) 2001-04-06 2002-04-05 Combinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos
MYPI20081190A MY145703A (en) 2001-04-06 2002-04-05 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors
CNB028084330A CN1319991C (zh) 2001-04-06 2002-04-08 用于治疗过度表达神经节苷脂的肿瘤的免疫治疗组合物
EA200301097A EA006936B1 (ru) 2001-04-06 2002-04-08 Иммунотерапевтические комбинации для лечения опухолей, которые сверхэкспрессируют ганглиозиды
HK05102752.9A HK1070080B (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the preparation of medicament for the diagnosis and treatment of tumors
ES02759752T ES2296986T3 (es) 2001-04-06 2002-04-08 Anticuerpos recombinantes asociados a gancliosidos y el uso de los mismos en la diagnosis y el tratamiento de tumores.
ES02759751T ES2312610T3 (es) 2001-04-06 2002-04-08 Combinaciones inmunoterapeuticas para el tratamiento de tumores que sobreexpresan gangliosidos.
BRPI0208675-1A BRPI0208675B1 (pt) 2001-04-06 2002-04-08 Combinação imunoterapêutica para a imunoterapia de tumores que superexpressam gangliosídeos, uso da mesma, e, uso de um método para controlar o crescimento e/ou a proliferação de tumores que superexpressam gangliosídeos
JP2002579482A JP2004528033A (ja) 2001-04-06 2002-04-08 ガングリオシド関連組換え抗体及び腫瘍の診断及び治療への使用
NZ528599A NZ528599A (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors
HU0401695A HU228105B1 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
CA2441845A CA2441845C (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
DE60223547T DE60223547T2 (de) 2001-04-06 2002-04-08 Gangliosid-assoziierte rekombinante antikörper und deren verwendung bei der diagnose und behandlung von tumoren
AU2002308347A AU2002308347B2 (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
SG200506530-5A SG161737A1 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors
PCT/CU2002/000003 WO2002081496A2 (es) 2001-04-06 2002-04-08 Anticuerpos recombinantes asociados a gangliósidos. su uso en el diagnóstico y tratamiento de tumores
SK1226-2003A SK287914B6 (sk) 2001-04-06 2002-04-08 Chimeric monoclonal antibody and its use in the preparation of medicament for the treatment of malignant tumors, cell line and pharmaceutical composition
KR1020037012969A KR100946168B1 (ko) 2001-04-06 2002-04-08 강글리오사이드-관련 재조합 항체 및 종양의 진단 및치료에 있어서 이의 용도
SI200230660T SI1411064T1 (sl) 2001-04-06 2002-04-08 Rekombinantna protitelesa v povezavi z gangliozidi in njihova uporaba pri diagnozi in zdravljenju tumorjev
CZ20032641A CZ296276B6 (cs) 2001-04-06 2002-04-08 Imunoterapeutické kombinace pro lécbu nádoru, nadmerne exprimujících gangliosidy
HU0401355A HU228106B1 (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
AT02759752T ATE378356T1 (de) 2001-04-06 2002-04-08 Gangliosid-assoziierte rekombinante antikörper und deren verwendung bei der diagnose und behandlung von tumoren
HK04109894.4A HK1066818B (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
JP2002580025A JP4366080B2 (ja) 2001-04-06 2002-04-08 ガングリオシドを過剰発現する腫瘍を治療するための免疫併用療法
IL15824602A IL158246A0 (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
PL371937A PL208109B1 (pl) 2001-04-06 2002-04-08 Kombinacja immunoterapeutyczna do immunoterapii nowotworów, które nadwyrażają gangliozydy i jej zastosowanie
HR20030806A HRP20030806B1 (hr) 2001-04-06 2002-04-08 Imunoterapijske kombinacije za liječenje tumora koji pretjerano izražavaju gangliozide
PT02759751T PT1384726E (pt) 2001-04-06 2002-04-08 Combinações imunoterapêuticas para o tratamento de tumores que sobreexpressam gangliosidos
EP02759752A EP1411064B1 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
SK1216-2003A SK287783B6 (sk) 2001-04-06 2002-04-08 Imunoterapeutická kombinácia na imunoterapiu nádorov, ktoré nadmerne exprimujú gangliozidy, a jej použitie
NZ528598A NZ528598A (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
PE2002000283A PE20020972A1 (es) 2001-04-06 2002-04-08 Anticuerpos recombinantes asociados a gangliosidos
DK02759751T DK1384726T3 (da) 2001-04-06 2002-04-08 Immunoterapeutiske kombinationer til behandling af tumorer, der overudtrykker gangliosider
US10/473,978 US20050069535A1 (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
US10/473,977 US20040253233A1 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors
HR20030805A HRP20030805B1 (hr) 2001-04-06 2002-04-08 Rekombinantna protutijela povezana s gangliozidima i njihova upotreba u dijagnostici i liječenju tumora
CA2443372A CA2443372C (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumors that over-express gangliosides
AT06076643T ATE477279T1 (de) 2001-04-06 2002-04-08 Ganglioside-assozierte rekombinante antikörper und deren gebrauch fuer diagnose und therapien von tumoren
CZ2003-2668A CZ304424B6 (cs) 2001-04-06 2002-04-08 Rekombinantní protilátky související s gangliosidy a jejich použití při diagnóze a léčbě nádorů
PT02759752T PT1411064E (pt) 2001-04-06 2002-04-08 ''anticorpos recombinantes associados a gangliósidos e sua utilização no diagnóstico e tratamento de tumores''
EP02759751A EP1384726B1 (en) 2001-04-06 2002-04-08 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
AU2002308348A AU2002308348B2 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
KR1020037012938A KR100863509B1 (ko) 2001-04-06 2002-04-08 강글리오사이드를 과발현하는 종양의 치료용 면역치료 조합
AT02759751T ATE406386T1 (de) 2001-04-06 2002-04-08 Immunotherapeutische kombinationen zur behandlung von tumoren, die ganglioside überexprimieren
BR0208675-1A BR0208675A (pt) 2001-04-06 2002-04-08 Combinação imunoterapêutica para a imunoterapaia de tumores que superexpressam gangliosìdeos, uso da mesma e método para controlar o crescimento e/ou a proliferação de células tumorais que superexpressam gangliosìdeos
MXPA03008739A MXPA03008739A (es) 2001-04-06 2002-04-08 Anticuerpos recombinantes asociados a gangliosidos. su uso en el diagnostico y tratamiento de tumores.
EA200301098A EA006310B1 (ru) 2001-04-06 2002-04-08 Ассоциированные с ганглиозидами рекомбинантные антитела и их применение в диагностике и лечении опухолей
DK02759752T DK1411064T3 (da) 2001-04-06 2002-04-08 Gangliosid-associerede rekombinante antistoffer og anvendelsen deraf i diagnosen og behandlingen af tumorer
CNB028086309A CN100349920C (zh) 2001-04-06 2002-04-08 神经节苷脂相关的重组抗体及其在制备肿瘤的诊断和治疗的药物中的应用
DE60228561T DE60228561D1 (de) 2001-04-06 2002-04-08 Immunotherapeutische kombinationen zur behandlung von tumoren, die ganglioside überexprimieren
SI200230766T SI1384726T1 (sl) 2001-04-06 2002-04-08 Imunoterapevtske kombinacije za zdravljenje tumorjev, ki ÄŤezmerno izraĹľajo gangliozide
CN2007101021039A CN101054417B (zh) 2001-04-06 2002-04-08 神经节苷脂相关的重组抗体及其在肿瘤的诊断和治疗中的应用
PL02371770A PL371770A1 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
PCT/CU2002/000002 WO2002081661A2 (es) 2001-04-06 2002-04-08 Combinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos
EP06076643A EP1798243B1 (en) 2001-04-06 2002-04-08 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors
BRPI0208676-0A BR0208676B1 (pt) 2001-04-06 2002-04-08 Chemical monoclonal antibody, pharmaceutical composition, and, use of a monoclonal antibody
MXPA03008738A MXPA03008738A (es) 2001-04-06 2002-04-08 Combinaciones inmunoterapeuticas para el tratamiento de tumores que sobre-expresan glangliosidos.
UA2003108988A UA76745C2 (uk) 2001-04-06 2002-08-04 Імунотерапевтичні комбінації для лікування пухлин, які надекспресують гангліозиди
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ZA200307585A ZA200307585B (en) 2001-04-06 2003-09-29 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours.
EC2003004787A ECSP034787A (es) 2001-04-06 2003-09-30 Combinaciones inmunoterapeuticas para el tratamiento de tumores que sobre expresan gangliosidos
EC2003004788A ECSP034788A (es) 2001-04-06 2003-09-30 Anticuerpos recombinantes asociados a gangliosidos su uso en el diagnostico y tratamiento de tumores
ZA2003/07679A ZA200307679B (en) 2001-04-06 2003-10-01 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
IL158246A IL158246A (en) 2001-04-06 2003-10-02 Pharmaceutical compositions for the treatment of tumours that overexpress gangliosides and uses thereof
BG108228A BG66304B1 (bg) 2001-04-06 2003-10-03 Рекомбинантни антитела, свързващи ганглиозид и тяхното използване при диагностициране и лечение на тумори
NO20034436A NO331533B1 (no) 2001-04-06 2003-10-03 Immunoterapeutiske kombinasjoner for behandling av tumorer som overuttrykker gangliosider
BG108227A BG66293B1 (en) 2001-04-06 2003-10-03 Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides
NO20034437A NO20034437L (no) 2001-04-06 2003-10-03 Gangliosid-assosierte rekombinante antistoffer og anvendelse derav ved diagnostikk og behandling av tumorer
UAA200512270A UA86768C2 (ru) 2001-04-06 2005-12-20 ХИМЕРНОЕ МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, ПОЛУЧЕННОЕ ИЗ МЫШИНОГО АНТИИДИОТИПИЧНОГО МОНОКЛОНАЛЬНОГО АНТИТЕЛА 1Е10, КОТОРОЕ РАСПОЗНАЕТ МЫШИНОЕ MAbР3
AU2007231687A AU2007231687B2 (en) 2001-04-06 2007-10-26 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumors
HK07114311.6A HK1109160B (en) 2001-04-06 2007-12-31 Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours
KR1020087019420A KR100919617B1 (ko) 2001-04-06 2008-08-07 강글리오사이드-관련 재조합 항체 및 종양의 진단 및치료에 있어서 이의 용도
US12/407,046 US8758753B2 (en) 2001-04-06 2009-03-19 Ganglioside associated recombinant antibodies and the use thereof in the treatment of tumors

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