CU23413B7 - Nuevos derivados de benzoimidazol útiles como agentes antiproliferativos - Google Patents
Nuevos derivados de benzoimidazol útiles como agentes antiproliferativosInfo
- Publication number
- CU23413B7 CU23413B7 CU20050031A CU20050031A CU23413B7 CU 23413 B7 CU23413 B7 CU 23413B7 CU 20050031 A CU20050031 A CU 20050031A CU 20050031 A CU20050031 A CU 20050031A CU 23413 B7 CU23413 B7 CU 23413B7
- Authority
- CU
- Cuba
- Prior art keywords
- formula
- new
- compounds
- derivatives useful
- antiproliferative agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La invención se refiere a compuestos de fórmula 1 ESPACIO PARA FÓRMULA y a sales, profármacos, y solvatos farmacéuticamente aceptables de los mismos, donde R1, R2, R3 y R4 son como se han definido anteriormente. La invención también se refiere a procedimientos para tratar el crecimiento celular anormal, tal como cáncer, en mamíferos administrando los compuestos de fórmula 1 y a composiciones farmacéuticas para tratar tales trastornos que contienen los compuestos de fórmula 1. La invención también se refiere a procedimientos para preparar los compuestos de fórmula 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40652402P | 2002-08-28 | 2002-08-28 | |
| US41704702P | 2002-10-08 | 2002-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23413B7 true CU23413B7 (es) | 2009-09-08 |
Family
ID=31981411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20050031A CU23413B7 (es) | 2002-08-28 | 2005-02-14 | Nuevos derivados de benzoimidazol útiles como agentes antiproliferativos |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US7071337B2 (es) |
| EP (1) | EP1594858B1 (es) |
| JP (1) | JP4551771B2 (es) |
| KR (2) | KR20070086768A (es) |
| CN (1) | CN1319966C (es) |
| AP (1) | AP2005003237A0 (es) |
| AR (1) | AR041055A1 (es) |
| AT (1) | ATE445610T1 (es) |
| AU (1) | AU2003250499B2 (es) |
| BR (1) | BRPI0313942C1 (es) |
| CA (1) | CA2495577C (es) |
| CR (1) | CR7698A (es) |
| CU (1) | CU23413B7 (es) |
| CY (1) | CY1110580T1 (es) |
| DE (1) | DE60329715D1 (es) |
| DK (1) | DK1594858T3 (es) |
| DO (1) | DOP2003000694A (es) |
| EA (1) | EA008448B1 (es) |
| EC (1) | ECSP055633A (es) |
| ES (1) | ES2333219T3 (es) |
| GE (1) | GEP20064005B (es) |
| HN (1) | HN2003000257A (es) |
| HR (1) | HRP20050191B1 (es) |
| IL (1) | IL166832A (es) |
| IS (1) | IS2738B (es) |
| MA (1) | MA27389A1 (es) |
| MX (1) | MXPA05001256A (es) |
| MY (1) | MY139357A (es) |
| NO (1) | NO20051303L (es) |
| NZ (1) | NZ538427A (es) |
| OA (1) | OA12916A (es) |
| PA (1) | PA8580301A1 (es) |
| PE (1) | PE20050131A1 (es) |
| PL (1) | PL377678A1 (es) |
| PT (1) | PT1594858E (es) |
| RS (1) | RS20050180A (es) |
| SI (1) | SI1594858T1 (es) |
| TW (1) | TW200407131A (es) |
| UY (1) | UY27952A1 (es) |
| WO (1) | WO2004020431A2 (es) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2315663T3 (es) * | 2003-06-24 | 2009-04-01 | Pfizer Products Incorporated | Procedimiento para la preparacion de derivados de 1-((benzoimidazol-1-il)quinolin-8-il)piperidin-4-ilamina. |
| JP2007530654A (ja) * | 2004-03-30 | 2007-11-01 | ファイザー・プロダクツ・インク | シグナル伝達阻害剤の組合せ |
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| MX2007004183A (es) * | 2004-10-07 | 2007-06-07 | Pfizer Prod Inc | Derivados de benzoimidazol utiles como agentes antiproliferacion. |
| KR100990027B1 (ko) | 2005-04-26 | 2010-10-26 | 화이자 인코포레이티드 | Ｐ-카드헤린 항체 |
| EP2960253B1 (en) | 2005-09-07 | 2018-06-06 | Amgen Fremont Inc. | Human monoclonal antibodies to activin receptor-like kinase-1 |
| UA91129C2 (ru) | 2006-05-09 | 2010-06-25 | Пфайзер Продактс Инк. | Производные циклоалкиламинокислот и фармацевтическая композиция, которая их содержит |
| US8138181B2 (en) | 2007-04-03 | 2012-03-20 | Array Biopharma Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
| DK2300455T3 (en) * | 2008-05-21 | 2017-10-30 | Incyte Holdings Corp | SALTS OF 2-FLUORO-N-METHYL-4- [7- (QUINOLIN-6-YL-METHYL) - IMIDAZO [1,2-B] [1,2,4] TRIAZIN-2-YL] BENZAMIDE AND PROCEDURES WITH THE PREPARATION THEREOF |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| EP2611808B1 (en) | 2010-09-02 | 2014-11-12 | Merck Patent GmbH | Pyrazolopyridinone derivatives as lpa receptor antagonists |
| GB201103578D0 (en) | 2011-03-02 | 2011-04-13 | Sabrepharm Ltd | Dipyridinium derivatives |
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| JP6042157B2 (ja) | 2012-09-26 | 2016-12-14 | アログ・ファーマシューティカルズ・リミテッド・ライアビリティ・カンパニーＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，ＬＬＣ | 変異型ｃ−ｋｉｔの阻害方法 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| BR112015016282A2 (en) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals, Inc. | crenolanib for treatment of mutated flt3 proliferative disorders |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| SI3212629T1 (sl) * | 2014-10-31 | 2019-02-28 | Genoscience Pharma Sas | Substituiran 2,4 diamino-kinolon kot nova sredstva proti raku |
| GB2543550A (en) | 2015-10-21 | 2017-04-26 | Hox Therapeutics Ltd | Peptides |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| JP6969800B2 (ja) * | 2016-05-04 | 2021-11-24 | ジェノシアンス ファルマ | 増殖性疾患の治療に使用される置換２，４−ジアミノ−キノリン誘導体 |
| CA3024012A1 (en) | 2016-11-02 | 2018-05-11 | Arog Pharmaceuticals, Inc. | Crenolanib for treating flt3 mutated proliferative disorders associated mutations |
| US12534764B2 (en) | 2016-11-02 | 2026-01-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN114702428B (zh) * | 2019-12-09 | 2023-11-28 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| CN118767143A (zh) | 2019-12-12 | 2024-10-15 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2022019998A1 (en) * | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| EP4181923A4 (en) * | 2020-07-20 | 2024-08-07 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| IL300205A (en) * | 2020-08-05 | 2023-03-01 | Massachusetts Gen Hospital | Salt-inducible kinase inhibitors |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| WO2022090547A1 (en) | 2020-10-30 | 2022-05-05 | Dsm Ip Assets B.V. | Production of carotenoids by fermentation |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
| KR20240115979A (ko) | 2021-11-08 | 2024-07-26 | 프로젠토스 테라퓨틱스, 인크. | 혈소판-유래 성장 인자 수용체(pdgfr) 알파 억제제 및 이의 용도 |
| CN114409632B (zh) * | 2022-02-22 | 2024-04-30 | 北京鲲达宇科技有限公司 | 2-取代氨基-3-苯并咪唑取代的喹啉衍生物及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607683D0 (en) | 1986-03-27 | 1986-04-30 | Ici Plc | Anti-tumor agents |
| US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| JP2001518470A (ja) | 1997-09-26 | 2001-10-16 | メルク エンド カムパニー インコーポレーテッド | 新規な血管形成阻害剤 |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| CA2393026A1 (en) * | 1999-11-30 | 2001-06-07 | Paul A. Wender | Bryostatin analogues, synthetic methods and uses |
| JP2008002005A (ja) * | 2006-06-21 | 2008-01-10 | Shimada Shoji Kk | 衣服用パッド |
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2003
- 2003-08-12 PA PA8580301A patent/PA8580301A1/es unknown
- 2003-08-14 KR KR1020077014809A patent/KR20070086768A/ko not_active Ceased
- 2003-08-14 DK DK03791110T patent/DK1594858T3/da active
- 2003-08-14 BR BRPI0313942A patent/BRPI0313942C1/pt not_active IP Right Cessation
- 2003-08-14 CA CA 2495577 patent/CA2495577C/en not_active Expired - Lifetime
- 2003-08-14 ES ES03791110T patent/ES2333219T3/es not_active Expired - Lifetime
- 2003-08-14 PT PT03791110T patent/PT1594858E/pt unknown
- 2003-08-14 JP JP2004569727A patent/JP4551771B2/ja not_active Expired - Lifetime
- 2003-08-14 EP EP20030791110 patent/EP1594858B1/en not_active Expired - Lifetime
- 2003-08-14 CN CNB038206218A patent/CN1319966C/zh not_active Expired - Lifetime
- 2003-08-14 SI SI200331687T patent/SI1594858T1/sl unknown
- 2003-08-14 NZ NZ538427A patent/NZ538427A/en not_active IP Right Cessation
- 2003-08-14 DE DE60329715T patent/DE60329715D1/de not_active Expired - Lifetime
- 2003-08-14 AU AU2003250499A patent/AU2003250499B2/en not_active Ceased
- 2003-08-14 GE GEAU2003008665 patent/GEP20064005B/en unknown
- 2003-08-14 KR KR20057003493A patent/KR100816166B1/ko not_active Expired - Fee Related
- 2003-08-14 PL PL37767803A patent/PL377678A1/pl not_active Application Discontinuation
- 2003-08-14 MX MXPA05001256A patent/MXPA05001256A/es active IP Right Grant
- 2003-08-14 HR HRP20050191AA patent/HRP20050191B1/hr not_active IP Right Cessation
- 2003-08-14 EA EA200500174A patent/EA008448B1/ru not_active IP Right Cessation
- 2003-08-14 WO PCT/IB2003/003634 patent/WO2004020431A2/en not_active Ceased
- 2003-08-14 AT AT03791110T patent/ATE445610T1/de active
- 2003-08-14 OA OA1200500059A patent/OA12916A/en unknown
- 2003-08-14 AP AP2005003237A patent/AP2005003237A0/xx unknown
- 2003-08-19 DO DO2003000694A patent/DOP2003000694A/es unknown
- 2003-08-25 HN HN2003000257A patent/HN2003000257A/es unknown
- 2003-08-25 PE PE2003000864A patent/PE20050131A1/es active IP Right Grant
- 2003-08-26 US US10/648,151 patent/US7071337B2/en not_active Expired - Lifetime
- 2003-08-26 UY UY27952A patent/UY27952A1/es not_active Application Discontinuation
- 2003-08-26 MY MYPI20033225 patent/MY139357A/en unknown
- 2003-08-26 AR ARP030103073 patent/AR041055A1/es unknown
- 2003-08-27 TW TW92123585A patent/TW200407131A/zh unknown
-
2005
- 2005-01-20 IS IS7660A patent/IS2738B/is unknown
- 2005-02-10 IL IL166832A patent/IL166832A/en active IP Right Grant
- 2005-02-14 CU CU20050031A patent/CU23413B7/es not_active IP Right Cessation
- 2005-02-22 CR CR7698A patent/CR7698A/es unknown
- 2005-02-28 MA MA28124A patent/MA27389A1/fr unknown
- 2005-02-28 EC ECSP055633 patent/ECSP055633A/es unknown
- 2005-03-14 NO NO20051303A patent/NO20051303L/no not_active Application Discontinuation
- 2005-08-14 RS YUP-2005/0180A patent/RS20050180A/sr unknown
-
2009
- 2009-11-30 CY CY20091101249T patent/CY1110580T1/el unknown
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