CU23632A1 - Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. - Google Patents
Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales.Info
- Publication number
- CU23632A1 CU23632A1 CU20060091A CU20060091A CU23632A1 CU 23632 A1 CU23632 A1 CU 23632A1 CU 20060091 A CU20060091 A CU 20060091A CU 20060091 A CU20060091 A CU 20060091A CU 23632 A1 CU23632 A1 CU 23632A1
- Authority
- CU
- Cuba
- Prior art keywords
- identification
- flavivirus
- methods
- therapeutic candidates
- diseases caused
- Prior art date
Links
- 229940124598 therapeutic candidate Drugs 0.000 title abstract 2
- 241000710831 Flavivirus Species 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 3
- 108010078791 Carrier Proteins Proteins 0.000 abstract 3
- 102100021923 Prolow-density lipoprotein receptor-related protein 1 Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 206010054261 Flavivirus infection Diseases 0.000 abstract 1
- 101000799972 Homo sapiens Alpha-2-macroglobulin Proteins 0.000 abstract 1
- 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 abstract 1
- 108010001831 LDL receptors Proteins 0.000 abstract 1
- 102000000853 LDL receptors Human genes 0.000 abstract 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 102000049437 human A2M Human genes 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 101150084157 lrp-1 gene Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con un método para la identificación de candidatos terapéuticos contra la infección por flavivirus que comprenda la interferencia en la interacción de la proteína de la envoltura del virus con un receptor celular directamente o através de una proteína portadora y los usos relacionados, siendo el receptor celular el receptor de la alfa2-macroglobulina también conocido como proteína relacionada al receptor de lipoproteínas de baja densidad o CD91 y siendo la proteína portadora la alfa2-macroglobulina humana.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060091A CU23632A1 (es) | 2006-04-28 | 2006-04-28 | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
| CA2650591A CA2650591C (en) | 2006-04-28 | 2007-04-26 | Methods for the treatment of flavivirus infection, molecules and uses thereof |
| RU2008146997/13A RU2008146997A (ru) | 2006-04-28 | 2007-04-26 | Способ блокирования заражения флавивирусами молекулы и применения |
| EP07721810.5A EP2022506B1 (en) | 2006-04-28 | 2007-04-26 | Method for the treatment of flavivirus infection, molecules and uses thereof |
| MYPI20084354 MY150685A (en) | 2006-04-28 | 2007-04-26 | Molecules for blocking the infections by flaviviruses |
| PCT/CU2007/000014 WO2007124698A2 (es) | 2006-04-28 | 2007-04-26 | Métodos para tratar la infección por flavivirus, moléculas y usos |
| AU2007246076A AU2007246076B2 (en) | 2006-04-28 | 2007-04-26 | Methods for the treatment of flavivirus infection, molecules and uses thereof |
| CN2007800224852A CN101472606B (zh) | 2006-04-28 | 2007-04-26 | 用于治疗黄病毒感染的方法、分子及用途 |
| US12/298,808 US8420311B2 (en) | 2006-04-28 | 2007-04-26 | Method to block the infection by flaviviruses, molecules and uses |
| ES07721810.5T ES2645679T3 (es) | 2006-04-28 | 2007-04-26 | Método para el tratamiento de infección por flavivirus, moléculas y sus usos |
| ARP070101838A AR060827A1 (es) | 2006-04-28 | 2007-04-27 | Metodo para bloquear la infeccion por flavivirus, moleculas y usos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060091A CU23632A1 (es) | 2006-04-28 | 2006-04-28 | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU23632A1 true CU23632A1 (es) | 2011-02-24 |
Family
ID=38476089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20060091A CU23632A1 (es) | 2006-04-28 | 2006-04-28 | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8420311B2 (es) |
| EP (1) | EP2022506B1 (es) |
| CN (1) | CN101472606B (es) |
| AR (1) | AR060827A1 (es) |
| AU (1) | AU2007246076B2 (es) |
| CA (1) | CA2650591C (es) |
| CU (1) | CU23632A1 (es) |
| ES (1) | ES2645679T3 (es) |
| MY (1) | MY150685A (es) |
| RU (1) | RU2008146997A (es) |
| WO (1) | WO2007124698A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU23245A1 (es) | 2001-07-16 | 2007-10-17 | Inst De Medicina Tropical Pedr | CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS |
| CU23578A1 (es) | 2005-09-16 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal |
| CU23630A1 (es) * | 2006-10-30 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Moléculas peptídicas quiméricas con propiedades antivirales contra los virus de la familia flaviviridae |
| CU20080028A6 (es) * | 2008-02-29 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Compuestos químicos obtenidos in silico para la preparación de composiciones farmacéuticas para atenuar o inhibir la infección por virus dengue y otros flavivirus |
| US10265388B2 (en) | 2012-02-21 | 2019-04-23 | Cytonics Corporation | Systems, compositions, and methods for transplantation |
| MX366886B (es) | 2012-08-07 | 2019-07-30 | Massachusetts Inst Technology | Anticuerpos anti-virus del dengue y usos de los mismos. |
| WO2014160088A2 (en) * | 2013-03-14 | 2014-10-02 | Rhode Island Hospital, A Lifespan-Partner | Treating hepatitis b virus infections |
| CN106211773B (zh) | 2014-02-11 | 2021-09-03 | 威特拉公司 | 用于登革病毒的抗体分子及其应用 |
| KR20160119806A (ko) | 2014-02-11 | 2016-10-14 | 메사추세츠 인스티튜트 오브 테크놀로지 | 신규한 온전한 범위의 항-뎅기 항체 |
| CU20140026A7 (es) * | 2014-03-03 | 2015-11-27 | Ct De Ingeniería Genética Y Biotecnología Biocubafarma | Péptidos horquilla beta con propiedades antivirales contra el virus dengue |
| WO2017165736A1 (en) | 2016-03-25 | 2017-09-28 | Visterra, Inc. | Formulation of antibody molecules to dengue virus |
| JP2019523633A (ja) * | 2016-04-29 | 2019-08-29 | アライム ファーマシューティカルズ,インコーポレーテッド | 組織の損傷に関連した疾患及び障害を予防及び治療する組織保護ペプチド |
| CN111537316A (zh) * | 2020-06-17 | 2020-08-14 | 陕西健吉跃生物科技有限公司 | 一种检测蛋白含量的氨基黑染色液、试剂盒及方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494671A (en) * | 1990-08-27 | 1996-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | C-terminally truncated dengue and Japanese encephalitis virus envelope proteins |
| US6403092B1 (en) | 1998-04-01 | 2002-06-11 | Duke University | Immune response modulator alpha-2 macroglobulin complex |
| AU2003263853A1 (en) * | 2002-08-16 | 2004-03-03 | Board Of Regents The University Of Texas System | Compositions and methods related to flavivirus envelope protein domain iii antigens |
| US7449321B2 (en) * | 2003-01-22 | 2008-11-11 | National University Of Singapore | Molecules, compositions, methods and kits for applications associated with flaviviruses |
| CA2548808C (en) * | 2003-12-08 | 2015-07-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind or neutralize dengue virus |
| US20090130123A1 (en) * | 2004-06-15 | 2009-05-21 | Erol Fikrig | Antibodies to west nile virus polypeptides |
| DE102006014892B4 (de) | 2005-03-31 | 2020-09-24 | Ngk Spark Plug Co., Ltd. | Gassensorelement, Verfahren zu seiner Herstellung, und Gassensor |
-
2006
- 2006-04-28 CU CU20060091A patent/CU23632A1/es unknown
-
2007
- 2007-04-26 CA CA2650591A patent/CA2650591C/en active Active
- 2007-04-26 ES ES07721810.5T patent/ES2645679T3/es active Active
- 2007-04-26 AU AU2007246076A patent/AU2007246076B2/en not_active Ceased
- 2007-04-26 CN CN2007800224852A patent/CN101472606B/zh not_active Expired - Fee Related
- 2007-04-26 WO PCT/CU2007/000014 patent/WO2007124698A2/es not_active Ceased
- 2007-04-26 US US12/298,808 patent/US8420311B2/en active Active
- 2007-04-26 EP EP07721810.5A patent/EP2022506B1/en active Active
- 2007-04-26 MY MYPI20084354 patent/MY150685A/en unknown
- 2007-04-26 RU RU2008146997/13A patent/RU2008146997A/ru not_active Application Discontinuation
- 2007-04-27 AR ARP070101838A patent/AR060827A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MY150685A (en) | 2014-02-28 |
| CN101472606A (zh) | 2009-07-01 |
| EP2022506B1 (en) | 2017-10-11 |
| AU2007246076A1 (en) | 2007-11-08 |
| EP2022506A2 (en) | 2009-02-11 |
| CN101472606B (zh) | 2012-09-19 |
| US8420311B2 (en) | 2013-04-16 |
| AU2007246076B2 (en) | 2011-06-23 |
| AR060827A1 (es) | 2008-07-16 |
| WO2007124698A2 (es) | 2007-11-08 |
| RU2008146997A (ru) | 2010-06-10 |
| CA2650591C (en) | 2014-10-07 |
| ES2645679T3 (es) | 2017-12-07 |
| WO2007124698A3 (es) | 2007-12-27 |
| US20110212105A1 (en) | 2011-09-01 |
| CA2650591A1 (en) | 2007-11-08 |
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