CL2010001407A1 - Compuestos derivados de purina y pirimidina sustituidos; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades virales tales como hepatitis c, dengue, fiebre amarilla, polio, hepatitis a, entre otras. - Google Patents

Compuestos derivados de purina y pirimidina sustituidos; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades virales tales como hepatitis c, dengue, fiebre amarilla, polio, hepatitis a, entre otras.

Info

Publication number
CL2010001407A1
CL2010001407A1 CL2010001407A CL2010001407A CL2010001407A1 CL 2010001407 A1 CL2010001407 A1 CL 2010001407A1 CL 2010001407 A CL2010001407 A CL 2010001407A CL 2010001407 A CL2010001407 A CL 2010001407A CL 2010001407 A1 CL2010001407 A1 CL 2010001407A1
Authority
CL
Chile
Prior art keywords
hepatitis
polio
dengue
pyrimidine
pharmaceutical composition
Prior art date
Application number
CL2010001407A
Other languages
English (en)
Inventor
Jinfa Du
Dhanapalan Nagarathnam
Michael Joseph Sofia
Ganapati Reddy Pamulapati
Bruce S Ross
Original Assignee
Gilead Pharmasset Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Pharmasset Llc filed Critical Gilead Pharmasset Llc
Publication of CL2010001407A1 publication Critical patent/CL2010001407A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Compuestos derivados de purina y pirimidina; procedimiento de preparación de los compuestos; composición farmacéutica que comprende a dichos compuestos; y su uso para tratar enfermedades virales tales como hepatitis C, dengue, fiebre amarilla, polio, hepatitis A, entre otras.
CL2010001407A 2008-06-11 2010-12-10 Compuestos derivados de purina y pirimidina sustituidos; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades virales tales como hepatitis c, dengue, fiebre amarilla, polio, hepatitis a, entre otras. CL2010001407A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6068308P 2008-06-11 2008-06-11
US14036908P 2008-12-23 2008-12-23
US12/479,075 US8173621B2 (en) 2008-06-11 2009-06-05 Nucleoside cyclicphosphates

Publications (1)

Publication Number Publication Date
CL2010001407A1 true CL2010001407A1 (es) 2011-05-06

Family

ID=40974681

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010001407A CL2010001407A1 (es) 2008-06-11 2010-12-10 Compuestos derivados de purina y pirimidina sustituidos; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar enfermedades virales tales como hepatitis c, dengue, fiebre amarilla, polio, hepatitis a, entre otras.

Country Status (19)

Country Link
US (2) US8173621B2 (es)
EP (1) EP2313422B1 (es)
JP (2) JP5749160B2 (es)
KR (2) KR101682494B1 (es)
CN (1) CN102119167A (es)
AR (1) AR072104A1 (es)
AU (1) AU2009257647C1 (es)
BR (1) BRPI0915484A2 (es)
CA (1) CA2727495C (es)
CL (1) CL2010001407A1 (es)
CO (1) CO6321272A2 (es)
ES (1) ES2536727T3 (es)
IL (1) IL209916A (es)
MX (1) MX2010013768A (es)
PT (1) PT2313422E (es)
TW (1) TW201002733A (es)
UY (1) UY31892A (es)
WO (1) WO2009152095A2 (es)
ZA (1) ZA201008829B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11485753B2 (en) 2012-12-21 2022-11-01 Janssen Pharmaceutica Nv Substituted nucleosides, nucleotides and analogs thereof

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WO2009152095A3 (en) 2010-11-04
US8173621B2 (en) 2012-05-08
WO2009152095A2 (en) 2009-12-17
ES2536727T3 (es) 2015-05-28
IL209916A0 (en) 2011-02-28
PT2313422E (pt) 2015-06-05
CA2727495A1 (en) 2009-12-17
AR072104A1 (es) 2010-08-04
AU2009257647A1 (en) 2009-12-17
JP5749160B2 (ja) 2015-07-15
ZA201008829B (en) 2011-09-28
EP2313422B1 (en) 2015-03-04
US20100081628A1 (en) 2010-04-01
JP2015180655A (ja) 2015-10-15
AU2009257647C1 (en) 2014-10-23
TW201002733A (en) 2010-01-16
CA2727495C (en) 2017-08-29
BRPI0915484A2 (pt) 2019-09-17
KR20110016501A (ko) 2011-02-17
AU2009257647B2 (en) 2014-04-10
IL209916A (en) 2014-04-30
UY31892A (es) 2010-01-05
CN102119167A (zh) 2011-07-06
CO6321272A2 (es) 2011-09-20
US20120258928A1 (en) 2012-10-11
KR20160139060A (ko) 2016-12-06
JP2011524356A (ja) 2011-09-01
EP2313422A2 (en) 2011-04-27
KR101682494B1 (ko) 2016-12-05

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