CU24123B1 - Procedimiento para la preparación de 4-{ 4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenixi}-n-metilpiridina-2-carboxamida y su monohidrato - Google Patents

Procedimiento para la preparación de 4-{ 4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenixi}-n-metilpiridina-2-carboxamida y su monohidrato

Info

Publication number
CU24123B1
CU24123B1 CU20120147A CU20120147A CU24123B1 CU 24123 B1 CU24123 B1 CU 24123B1 CU 20120147 A CU20120147 A CU 20120147A CU 20120147 A CU20120147 A CU 20120147A CU 24123 B1 CU24123 B1 CU 24123B1
Authority
CU
Cuba
Prior art keywords
amino
fluorofenixi
monohidrate
trifluorometil
carbonil
Prior art date
Application number
CU20120147A
Other languages
English (en)
Other versions
CU20120147A7 (es
Inventor
Juergen Stiehl
Werner Heilmann
Michael Lögers
Joachim Rehse
Michael Gottfried
Saskia Wichmann
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44070712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24123(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of CU20120147A7 publication Critical patent/CU20120147A7/es
Publication of CU24123B1 publication Critical patent/CU24123B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CU20120147A 2010-04-15 2011-04-08 Procedimiento para la preparación de 4-{ 4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenixi}-n-metilpiridina-2-carboxamida y su monohidrato CU24123B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10004022 2010-04-15
PCT/EP2011/055508 WO2011128261A1 (en) 2010-04-15 2011-04-08 Process for the preparation of 4- {4-[({[4 -chloro-3 -(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-n-methylpyridine-2-carboxamide, its salts and monohydrate

Publications (2)

Publication Number Publication Date
CU20120147A7 CU20120147A7 (es) 2013-01-30
CU24123B1 true CU24123B1 (es) 2015-08-27

Family

ID=44070712

Family Applications (2)

Application Number Title Priority Date Filing Date
CU20120147A CU24123B1 (es) 2010-04-15 2011-04-08 Procedimiento para la preparación de 4-{ 4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenixi}-n-metilpiridina-2-carboxamida y su monohidrato
CU2014000060A CU20140060A7 (es) 2010-04-15 2014-05-26 4-{4-[({[ 4- cloro-3-( trifluorometil) fenil] amino} carbonil) amino]-3- fluorofenoxi}-n-metilpiridina-2- carboxamida y su monohidrato

Family Applications After (1)

Application Number Title Priority Date Filing Date
CU2014000060A CU20140060A7 (es) 2010-04-15 2014-05-26 4-{4-[({[ 4- cloro-3-( trifluorometil) fenil] amino} carbonil) amino]-3- fluorofenoxi}-n-metilpiridina-2- carboxamida y su monohidrato

Country Status (40)

Country Link
US (5) US8748622B2 (es)
EP (1) EP2558448B1 (es)
JP (1) JP5934182B2 (es)
KR (2) KR101800041B1 (es)
CN (2) CN103980191A (es)
AR (2) AR081060A1 (es)
AU (1) AU2011240113B2 (es)
BR (1) BR112012026117B1 (es)
CA (1) CA2796238C (es)
CL (1) CL2012002840A1 (es)
CO (1) CO6630136A2 (es)
CR (1) CR20120526A (es)
CU (2) CU24123B1 (es)
DK (1) DK2558448T3 (es)
DO (2) DOP2012000268A (es)
EC (1) ECSP12012234A (es)
ES (1) ES2542610T3 (es)
GT (1) GT201200280A (es)
HK (1) HK1200831A1 (es)
HR (1) HRP20150885T1 (es)
HU (1) HUE026821T2 (es)
IL (2) IL222348B (es)
JO (1) JO3158B1 (es)
MA (1) MA34156B1 (es)
MX (1) MX2012011734A (es)
MY (2) MY177066A (es)
NZ (1) NZ602997A (es)
PE (2) PE20160838A1 (es)
PH (1) PH12012502060A1 (es)
PL (1) PL2558448T3 (es)
PT (1) PT2558448E (es)
RS (1) RS54219B1 (es)
RU (1) RU2581585C2 (es)
SG (2) SG10201501221UA (es)
SI (1) SI2558448T1 (es)
TN (1) TN2012000492A1 (es)
TW (2) TWI539951B (es)
UA (1) UA110613C2 (es)
UY (2) UY33290A (es)
WO (1) WO2011128261A1 (es)

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CN104592105B (zh) * 2015-02-10 2017-01-18 杭州朱养心药业有限公司 瑞戈非尼及其制法
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CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
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CN109438336B (zh) * 2018-11-27 2019-11-22 广东安诺药业股份有限公司 一种瑞戈非尼水合物的制备方法
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Also Published As

Publication number Publication date
RU2581585C2 (ru) 2016-04-20
IL222348A0 (en) 2012-12-31
CO6630136A2 (es) 2013-03-01
CU20140060A7 (es) 2014-10-02
KR20130061670A (ko) 2013-06-11
TW201204356A (en) 2012-02-01
KR101800041B1 (ko) 2017-11-21
IL222348B (en) 2018-08-30
EP2558448B1 (en) 2015-05-20
AU2011240113B2 (en) 2014-12-18
EP2558448A1 (en) 2013-02-20
CA2796238A1 (en) 2011-10-20
UY39590A (es) 2022-01-31
PL2558448T3 (pl) 2015-10-30
CN102947271B (zh) 2016-11-09
TN2012000492A1 (en) 2014-04-01
US9458107B2 (en) 2016-10-04
US8748622B2 (en) 2014-06-10
JP5934182B2 (ja) 2016-06-15
RS54219B1 (sr) 2015-12-31
HK1200831A1 (en) 2015-08-14
SI2558448T1 (sl) 2015-11-30
CL2012002840A1 (es) 2013-01-18
PT2558448E (pt) 2015-09-01
JO3158B1 (ar) 2017-09-20
PE20160838A1 (es) 2016-09-24
ES2542610T3 (es) 2015-08-07
TWI475992B (zh) 2015-03-11
MY177066A (en) 2020-09-03
HUE026821T2 (en) 2016-07-28
IL253119A0 (en) 2017-08-31
BR112012026117B1 (pt) 2022-08-30
US10822305B2 (en) 2020-11-03
HRP20150885T1 (hr) 2015-10-09
TW201509415A (zh) 2015-03-16
MX2012011734A (es) 2012-12-17
UY33290A (es) 2011-12-01
SG10201501221UA (en) 2015-04-29
AR116395A2 (es) 2021-05-05
MY162359A (en) 2017-06-15
DOP2016000285A (es) 2016-11-30
BR112012026117A2 (pt) 2015-09-08
US20170334857A1 (en) 2017-11-23
WO2011128261A1 (en) 2011-10-20
US20130116442A1 (en) 2013-05-09
KR20170129276A (ko) 2017-11-24
CA2796238C (en) 2019-12-31
US20170057918A1 (en) 2017-03-02
DK2558448T3 (en) 2015-08-24
CN103980191A (zh) 2014-08-13
GT201200280A (es) 2014-07-23
SG184172A1 (en) 2012-11-29
BR112012026117A8 (pt) 2017-12-19
NZ602997A (en) 2014-10-31
US20140221661A1 (en) 2014-08-07
TWI539951B (zh) 2016-07-01
ECSP12012234A (es) 2012-11-30
MA34156B1 (fr) 2013-04-03
PH12012502060A1 (en) 2013-02-04
AU2011240113A1 (en) 2012-10-11
CU20120147A7 (es) 2013-01-30
JP2013523851A (ja) 2013-06-17
CN102947271A (zh) 2013-02-27
RU2012148386A (ru) 2014-05-20
CR20120526A (es) 2013-03-11
IL253119B (en) 2018-03-29
US20190144391A1 (en) 2019-05-16
PE20130181A1 (es) 2013-02-23
AR081060A1 (es) 2012-06-06
DOP2012000268A (es) 2012-12-15
UA110613C2 (uk) 2016-01-25

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