MA34156B1 - Procédédepréparationde 4-{4-[({[4-chloro-3-(trifluorométhyl)-phényl]amino}carbonyl)amino]-3-fluorophénoxy}-n-éthylpyridine - Google Patents

Procédédepréparationde 4-{4-[({[4-chloro-3-(trifluorométhyl)-phényl]amino}carbonyl)amino]-3-fluorophénoxy}-n-éthylpyridine

Info

Publication number
MA34156B1
MA34156B1 MA35304A MA35304A MA34156B1 MA 34156 B1 MA34156 B1 MA 34156B1 MA 35304 A MA35304 A MA 35304A MA 35304 A MA35304 A MA 35304A MA 34156 B1 MA34156 B1 MA 34156B1
Authority
MA
Morocco
Prior art keywords
amino
trifluoromethyl
carbonyl
chloro
phenyl
Prior art date
Application number
MA35304A
Other languages
English (en)
Inventor
Juergen Stiehl
Werner Heilmann
Michael Loegers
Joachim Rehse
Michael Gottfried
Saskia Wichmann
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44070712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34156(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA34156B1 publication Critical patent/MA34156B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne un procédé de préparation de 4-{4-[({[4-chloro-3-(trifluorométhyl)-phényl]amino}carbonyl)amino]
MA35304A 2010-04-15 2011-04-08 Procédédepréparationde 4-{4-[({[4-chloro-3-(trifluorométhyl)-phényl]amino}carbonyl)amino]-3-fluorophénoxy}-n-éthylpyridine MA34156B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10004022 2010-04-15
PCT/EP2011/055508 WO2011128261A1 (fr) 2010-04-15 2011-04-08 Procédé de préparation de 4-{4-[({[4-chloro-3-(trifluorométhyl)-phényl]amino}carbonyl)amino]-3-fluorophénoxy}-n-méthylpyridine-2-carboxamide, ses sels et son monohydrate

Publications (1)

Publication Number Publication Date
MA34156B1 true MA34156B1 (fr) 2013-04-03

Family

ID=44070712

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35304A MA34156B1 (fr) 2010-04-15 2011-04-08 Procédédepréparationde 4-{4-[({[4-chloro-3-(trifluorométhyl)-phényl]amino}carbonyl)amino]-3-fluorophénoxy}-n-éthylpyridine

Country Status (40)

Country Link
US (5) US8748622B2 (fr)
EP (1) EP2558448B1 (fr)
JP (1) JP5934182B2 (fr)
KR (2) KR101800041B1 (fr)
CN (2) CN103980191A (fr)
AR (2) AR081060A1 (fr)
AU (1) AU2011240113B2 (fr)
BR (1) BR112012026117B1 (fr)
CA (1) CA2796238C (fr)
CL (1) CL2012002840A1 (fr)
CO (1) CO6630136A2 (fr)
CR (1) CR20120526A (fr)
CU (2) CU24123B1 (fr)
DK (1) DK2558448T3 (fr)
DO (2) DOP2012000268A (fr)
EC (1) ECSP12012234A (fr)
ES (1) ES2542610T3 (fr)
GT (1) GT201200280A (fr)
HK (1) HK1200831A1 (fr)
HR (1) HRP20150885T1 (fr)
HU (1) HUE026821T2 (fr)
IL (2) IL222348B (fr)
JO (1) JO3158B1 (fr)
MA (1) MA34156B1 (fr)
MX (1) MX2012011734A (fr)
MY (2) MY177066A (fr)
NZ (1) NZ602997A (fr)
PE (2) PE20160838A1 (fr)
PH (1) PH12012502060A1 (fr)
PL (1) PL2558448T3 (fr)
PT (1) PT2558448E (fr)
RS (1) RS54219B1 (fr)
RU (1) RU2581585C2 (fr)
SG (2) SG10201501221UA (fr)
SI (1) SI2558448T1 (fr)
TN (1) TN2012000492A1 (fr)
TW (2) TWI539951B (fr)
UA (1) UA110613C2 (fr)
UY (2) UY33290A (fr)
WO (1) WO2011128261A1 (fr)

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JO3479B1 (ar) 2012-09-06 2020-07-05 Bayer Healthcare Llc تركيبة دوائية مغلفة تحتوي على ريجورافنيب
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CN104250227A (zh) * 2013-06-29 2014-12-31 广东东阳光药业有限公司 瑞戈非尼新晶型及其制备方法
WO2015049698A2 (fr) * 2013-10-04 2015-04-09 Hetero Research Foundation Procédé pour le régorafénib
CN105218439B (zh) * 2014-06-06 2018-11-20 连云港润众制药有限公司 一种瑞格非尼的晶体及其制备方法
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CN104557689B (zh) * 2015-01-26 2016-06-29 重庆两江药物研发中心有限公司 制备4-[4-({[4-氯-3-(三氟甲基)苯基]氨基甲酰}氨基)-3-氟苯氧基]-n-甲基吡啶-2-甲酰胺及其一水合物的方法
CN104592105B (zh) * 2015-02-10 2017-01-18 杭州朱养心药业有限公司 瑞戈非尼及其制法
CN105330600B (zh) * 2015-11-30 2018-05-22 山东罗欣药业集团股份有限公司 一种瑞戈菲尼的制备方法
SG11201806116SA (en) * 2016-01-18 2018-08-30 Natco Pharma Ltd An improved process for the preparation of regorafenib
CN107118153A (zh) * 2016-02-25 2017-09-01 石药集团中奇制药技术（石家庄）有限公司 一种瑞戈非尼一水合物晶型及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
PT3630112T (pt) 2017-06-02 2024-04-23 Bayer Healthcare Llc Combinação de regorafenib e nivolumab para tratamento de cancro
CN109438337B (zh) * 2018-11-27 2019-08-09 广东安诺药业股份有限公司 一种瑞戈非尼中间体的制备工艺
CN109438336B (zh) * 2018-11-27 2019-11-22 广东安诺药业股份有限公司 一种瑞戈非尼水合物的制备方法
EP3861989A1 (fr) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Composition pharmaceutique contenant du régorafénib et un agent de stabilisation
WO2021160708A1 (fr) 2020-02-14 2021-08-19 Bayer Aktiengesellschaft Combinaison de régorafenib et de msln-ttc pour traiter le cancer
CN114315710B (zh) * 2022-01-07 2024-04-26 江苏豪森药业集团有限公司 一种制备或纯化瑞戈非尼的方法

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Also Published As

Publication number Publication date
RU2581585C2 (ru) 2016-04-20
IL222348A0 (en) 2012-12-31
CO6630136A2 (es) 2013-03-01
CU20140060A7 (es) 2014-10-02
KR20130061670A (ko) 2013-06-11
TW201204356A (en) 2012-02-01
KR101800041B1 (ko) 2017-11-21
IL222348B (en) 2018-08-30
EP2558448B1 (fr) 2015-05-20
AU2011240113B2 (en) 2014-12-18
EP2558448A1 (fr) 2013-02-20
CA2796238A1 (fr) 2011-10-20
UY39590A (es) 2022-01-31
PL2558448T3 (pl) 2015-10-30
CN102947271B (zh) 2016-11-09
TN2012000492A1 (en) 2014-04-01
US9458107B2 (en) 2016-10-04
US8748622B2 (en) 2014-06-10
JP5934182B2 (ja) 2016-06-15
RS54219B1 (sr) 2015-12-31
HK1200831A1 (en) 2015-08-14
SI2558448T1 (sl) 2015-11-30
CL2012002840A1 (es) 2013-01-18
PT2558448E (pt) 2015-09-01
JO3158B1 (ar) 2017-09-20
PE20160838A1 (es) 2016-09-24
ES2542610T3 (es) 2015-08-07
TWI475992B (zh) 2015-03-11
MY177066A (en) 2020-09-03
HUE026821T2 (en) 2016-07-28
IL253119A0 (en) 2017-08-31
BR112012026117B1 (pt) 2022-08-30
US10822305B2 (en) 2020-11-03
HRP20150885T1 (hr) 2015-10-09
TW201509415A (zh) 2015-03-16
CU24123B1 (es) 2015-08-27
MX2012011734A (es) 2012-12-17
UY33290A (es) 2011-12-01
SG10201501221UA (en) 2015-04-29
AR116395A2 (es) 2021-05-05
MY162359A (en) 2017-06-15
DOP2016000285A (es) 2016-11-30
BR112012026117A2 (pt) 2015-09-08
US20170334857A1 (en) 2017-11-23
WO2011128261A1 (fr) 2011-10-20
US20130116442A1 (en) 2013-05-09
KR20170129276A (ko) 2017-11-24
CA2796238C (fr) 2019-12-31
US20170057918A1 (en) 2017-03-02
DK2558448T3 (en) 2015-08-24
CN103980191A (zh) 2014-08-13
GT201200280A (es) 2014-07-23
SG184172A1 (en) 2012-11-29
BR112012026117A8 (pt) 2017-12-19
NZ602997A (en) 2014-10-31
US20140221661A1 (en) 2014-08-07
TWI539951B (zh) 2016-07-01
ECSP12012234A (es) 2012-11-30
PH12012502060A1 (en) 2013-02-04
AU2011240113A1 (en) 2012-10-11
CU20120147A7 (es) 2013-01-30
JP2013523851A (ja) 2013-06-17
CN102947271A (zh) 2013-02-27
RU2012148386A (ru) 2014-05-20
CR20120526A (es) 2013-03-11
IL253119B (en) 2018-03-29
US20190144391A1 (en) 2019-05-16
PE20130181A1 (es) 2013-02-23
AR081060A1 (es) 2012-06-06
DOP2012000268A (es) 2012-12-15
UA110613C2 (uk) 2016-01-25

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