CU24476B1 - Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih - Google Patents

Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih

Info

Publication number
CU24476B1
CU24476B1 CU2017000102A CU20170102A CU24476B1 CU 24476 B1 CU24476 B1 CU 24476B1 CU 2017000102 A CU2017000102 A CU 2017000102A CU 20170102 A CU20170102 A CU 20170102A CU 24476 B1 CU24476 B1 CU 24476B1
Authority
CU
Cuba
Prior art keywords
triterpenone
new
amide derivatives
hiv inhibitors
inverse amide
Prior art date
Application number
CU2017000102A
Other languages
English (en)
Other versions
CU20170102A7 (es
Inventor
Reddy Kasireddy Bhaskar
Krupadanam Gazula Levi David
Reddy Adulla Panduranga
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Subrahmanyam Lanka Vl
Original Assignee
Dfh Therapeutics Inc
Hetero Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57153504&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24476(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dfh Therapeutics Inc, Hetero Labs Ltd filed Critical Dfh Therapeutics Inc
Publication of CU20170102A7 publication Critical patent/CU20170102A7/es
Publication of CU24476B1 publication Critical patent/CU24476B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

<p>La invención se refiere a una nueva triterpenona C-3 con derivados amida inversa C-17 y compuestos relacionados útiles para el tratamiento terapéutico de enfermedades virales y particularmente enfermedades mediadas por VIH. </p>
CU2017000102A 2015-02-09 2016-02-09 Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih CU24476B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN623CH2015 2015-02-09
PCT/IB2016/000811 WO2016178092A2 (en) 2015-02-09 2016-02-09 C-3 novel triterpenone with c-28 reverse amide derivatives as hiv inhibitors

Publications (2)

Publication Number Publication Date
CU20170102A7 CU20170102A7 (es) 2018-01-10
CU24476B1 true CU24476B1 (es) 2020-03-04

Family

ID=57153504

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2017000102A CU24476B1 (es) 2015-02-09 2016-02-09 Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih

Country Status (22)

Country Link
US (3) US10533035B2 (es)
EP (1) EP3256483B1 (es)
JP (1) JP2018505216A (es)
KR (1) KR20170110143A (es)
CN (1) CN107428797A (es)
AU (1) AU2016258274B2 (es)
BR (1) BR112017017109A2 (es)
CA (1) CA2975359A1 (es)
CL (1) CL2017002034A1 (es)
CO (1) CO2017008765A2 (es)
CU (1) CU24476B1 (es)
DK (1) DK3256483T3 (es)
EA (1) EA033264B1 (es)
ES (1) ES2780649T3 (es)
IL (1) IL253844A0 (es)
MA (1) MA40886B1 (es)
MX (1) MX2017010297A (es)
PE (1) PE20171433A1 (es)
PH (1) PH12017550077A1 (es)
SG (1) SG11201706189PA (es)
WO (1) WO2016178092A2 (es)
ZA (1) ZA201705253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
WO2018029604A1 (en) * 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2019150300A1 (en) 2018-02-02 2019-08-08 Glaxosmithkline Intellectual Property (No.2) Limited Crystalline forms of 4-(((3ar,5ar,5br,7ar,9s,11ar,11br,13as)-3a-((r)-2-((4-chlorobenzyl)(2-(dimethylamino)ethyl)amino)-1-hydroxyethyl)-1-isopropyl-5a,5b,8,8,11a-pentamethyl-2-oxo-3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a-octadecahydro-2h-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4-oxobutanoic acid
SG11202101827RA (en) 2018-09-21 2021-04-29 Pfizer N-substituted-dioxocyclobutenylamino-3-hydroxy-picolinamides useful as ccr6 inhibitors
CN109705189B (zh) * 2018-12-29 2020-06-05 中国医学科学院药用植物研究所 具有式i所示结构的三萜衍生物及其制备方法和应用
EP3924362A4 (en) * 2019-02-11 2022-10-26 Hetero Labs Limited NEW TRITERPENONE DERIVATIVES AS HIV Inhibitors

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58152815A (ja) 1982-03-05 1983-09-10 Tamio Nishimura 医療用抗ウイルス剤
CA2165188A1 (en) 1993-07-09 1995-01-19 Neal A. Deluca Selection and use of antiviral peptides
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
WO1998046238A1 (en) 1997-04-15 1998-10-22 Medichem Research, Inc. Biflavinoids and derivatives thereof as antiviral agents, alone or in combination with at least one known antiviral agent
HUP9701080A3 (en) 1997-06-23 1999-05-28 Gene Res Lab Inc New York N Pharmaceutical composition containing a compound of antiviral activity and a hydroximic acid ester derivative
US6670345B1 (en) 1997-09-30 2003-12-30 Dabur Research Foundation Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid
US6427248B1 (en) 1997-10-09 2002-08-06 David M. Albert Grip-enhancing glove
WO2000046235A1 (en) 1998-11-18 2000-08-10 Dabur Research Foundation Novel betulinic acid derivatives, processes for preparing such derivatives and its use as cancer growth inhibitors
AU7268000A (en) 1999-07-21 2001-02-13 Martin Heinkelein Method for quantization of the antiviral effect of antiviral active principles
ATE267837T1 (de) 1999-09-09 2004-06-15 Dabur Res Foundation Betulinsäure-derivate mit antiangiogener wirkung, verfahren zur herstellung solcher derivate und deren verwendung für die behandlung tumorassoziierter angiogenese
EP2567625A1 (en) 2001-05-11 2013-03-13 University Of Ottawa Preparation containing betulinic acid, obtained from a plant of the family Marcgraviaceae
WO2003037908A1 (en) 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
CN100432094C (zh) 2003-02-11 2008-11-12 诺瓦利克斯制药公司 抑制肿瘤生长的药物
US7026305B2 (en) 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
BRPI0508854A (pt) 2004-03-17 2007-08-28 Panacos Pharmaceuticals Inc sais farmacêuticos de ácido-3-o-(3',3'-dimetilsuccinil) betulìnico
TW200619191A (en) 2004-10-27 2006-06-16 Sankyo Co Phenyl compounds with more than 2 substitutes
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
EP1869063A2 (en) 2005-03-29 2007-12-26 Regents Of The University Of Minnesota Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
JP2008543945A (ja) 2005-06-22 2008-12-04 ミリアド ジェネティクス， インコーポレイテッド 抗ウイルス化合物
CN101287744A (zh) 2005-06-22 2008-10-15 美瑞德生物工程公司 抗病毒化合物
CN100475835C (zh) 2006-05-12 2009-04-08 中国药科大学 23-羟基白桦酸类衍生物、其制备方法、制剂及用途
FI121468B (fi) 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
FI20065389A7 (fi) 2006-06-07 2007-12-31 Valtion Teknillinen Tutkimuskeskus Betuliiniperäiset yhdisteet kasvien tuholaisten syönnin estäjinä
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
WO2008115281A2 (en) 2006-10-16 2008-09-25 Myriad Genetics, Inc. Compounds for treating viral infections
CA2668452A1 (en) * 2006-11-03 2008-05-15 Panacos Pharmaceuticals, Inc. Extended triterpene derivatives
US20110152229A1 (en) 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
WO2008091532A1 (en) 2007-01-19 2008-07-31 Panacos Pharmaceuticals, Inc. Salts of 3-o-(3',3'-dimethylsuccinyl)betulinic acid and solid state forms thereof
US8269026B2 (en) 2008-01-03 2012-09-18 Vertex Pharmaceuticals Incorporated Lupane derivatives useful for treating HIV
CA2711424A1 (en) * 2008-01-03 2009-07-09 Virochem Pharma Inc. Novel lupane derivatives
EP2240504A1 (en) 2008-01-03 2010-10-20 Virochem Pharma Inc. Novel c-21-keto lupane derivatives preparation and use thereof
CA2714049A1 (en) 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17.beta. lupane derivatives
US20120101098A1 (en) 2009-05-15 2012-04-26 Kuo-Hsiung Lee 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
WO2011100308A1 (en) 2010-02-11 2011-08-18 Glaxosmithkline Llc Derivatives of betulin
US8754068B2 (en) 2010-06-04 2014-06-17 Bristol-Myers Squibb Company Modified C-3 betulinic acid derivatives as HIV maturation inhibitors
RS54239B1 (sr) 2010-06-04 2015-12-31 Bristol-Myers Squibb Company C-28 amidi modifikovanih derivata c-3 betulinske kiseline kao inhibitori sazrevanja hiv-a
US20140221328A1 (en) 2011-01-10 2014-08-07 Bandi Parthasaradhi Reddy Pharmaceutically acceptable salts of novel betulinic acid derivatives
EP2727047A4 (en) 2011-06-30 2015-04-22 Nokia Corp METHOD AND DEVICE FOR FACE TRACKING WITH INTEGRATED GRADIENT PROJECTIONS
WO2013020245A1 (en) 2011-08-08 2013-02-14 Glaxosmithkline Llc Carbonyl derivatives of betulin
BR112014014046A2 (pt) 2011-12-14 2017-06-13 Glaxosmithkline Llc composto, composição, e, método para tratar hiv
WO2013091144A1 (en) 2011-12-21 2013-06-27 Glaxosmithkline Llc Propenoate derivatives of betulin
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
CN103242413B (zh) 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane三萜系衍生物及其药学用途
WO2013160810A2 (en) 2012-04-24 2013-10-31 Hetero Research Foundation Novel betulinic acid derivatives as hiv inhibitors
SG10201704467SA (en) 2012-12-14 2017-06-29 Glaxosmithkline Llc Pharmaceutical compositions
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017017630A1 (en) 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017021922A1 (en) 2015-08-05 2017-02-09 Hetero Research Foundation Novel substituted amides of triterpene derivatives as hiv inhibitors
WO2017064628A1 (en) 2015-10-13 2017-04-20 Hetero Research Foundation C-3 novel triterpenone with c-28 urea derivatives as hiv inhibitors
WO2017115329A1 (en) 2015-12-30 2017-07-06 Hetero Research Foundation C-3 novel triterpenone derivatives as hiv inhibitors
WO2017149518A1 (en) 2016-03-04 2017-09-08 Hetero Labs Limited C-3 novel triterpene with c-17 amine derivatives as hiv inhibitors
WO2018025247A1 (en) 2016-08-05 2018-02-08 Hetero Labs Limited C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors
WO2018029602A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-28 heterocycle derivatives as hiv inhibitors
WO2018029604A1 (en) 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018029610A1 (en) 2016-08-09 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors
US20180097839A1 (en) 2016-10-01 2018-04-05 Neeraj S. Upasani Systems, apparatuses, and methods for platform security
WO2018069857A1 (en) 2016-10-12 2018-04-19 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors

Also Published As

Publication number Publication date
AU2016258274A1 (en) 2017-09-07
CO2017008765A2 (es) 2017-11-10
BR112017017109A2 (pt) 2018-04-03
EA201791807A1 (ru) 2018-01-31
EP3256483B1 (en) 2019-12-11
CL2017002034A1 (es) 2018-04-27
EP3256483A2 (en) 2017-12-20
KR20170110143A (ko) 2017-10-10
WO2016178092A8 (en) 2017-09-21
US20170008921A1 (en) 2017-01-12
US11034718B2 (en) 2021-06-15
US10533035B2 (en) 2020-01-14
JP2018505216A (ja) 2018-02-22
DK3256483T3 (da) 2020-03-23
PH12017550077A1 (en) 2018-02-12
CU20170102A7 (es) 2018-01-10
WO2016178092A2 (en) 2016-11-10
EA033264B1 (ru) 2019-09-30
CN107428797A (zh) 2017-12-01
ES2780649T3 (es) 2020-08-26
MA40886B1 (fr) 2020-03-31
ZA201705253B (en) 2020-01-29
US20200087342A1 (en) 2020-03-19
SG11201706189PA (en) 2017-08-30
MX2017010297A (es) 2018-11-12
US20180215780A1 (en) 2018-08-02
IL253844A0 (en) 2017-09-28
AU2016258274B2 (en) 2019-12-05
WO2016178092A3 (en) 2017-01-05
CA2975359A1 (en) 2016-11-10
PE20171433A1 (es) 2017-09-26

Similar Documents

Publication Publication Date Title
CU24476B1 (es) Nueva triterpenona c-3 con derivados de amida inversa c-17 como inhibidores de vih
CL2018000684A1 (es) Moduladores de la proteína de núcleo de la hepatitis b.
CL2015002445A1 (es) Compuestos amida para el tratamiento del vih
CL2016000698A1 (es) Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del vih
JOP20190194A1 (ar) مركبات نيوكليوتيدات ثنائية حلقية لعلاج السرطان
CU24397B1 (es) Derivados de piperidinil-indol como inhibidores del factor de complemento b
CO2017003279A2 (es) Compuestos y composiciones farmacéuticamente aceptables de los mismos, eficaces como inhibidores de mk2
UY33886A (es) Triterpenoides c-17 y c-3 modificados con actividad inhibidora de la maduracion del vih
CL2016000424A1 (es) Métodos y composiciones para el arn-guiado tratamiento de la infección por vih
CL2016001973A1 (es) Derivados de nucleosido sustituidos con 4&#39; -difluorometilo como inhibidores de la replicación de arn de la influenza.
CL2016003277A1 (es) Métodos para preparar análogos de nucleótido sustituidos
CR20170005A (es) Derivados de insoindolina
EP3206706A4 (en) Stable injectable composition of pharmaceutically active agents and process for its preparation
CL2018000688A1 (es) Compuestos heterociclicos que contienen bencilamina y composiciones útiles contra infección por micobacterias
MX376122B (es) Composiciones de plinabulina.
CL2017000152A1 (es) Derivados de isoindolinona
UY36708A (es) MODULADORES DE ROR GAMMA (RORy)
IL253619A0 (en) Encapsulation of high potency active agents
MX2017001352A (es) Derivados de pirrolidinona como inhibidores de metionina aminopeptidasa 2 (metap-2).
UY36263A (es) Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso
MX2017011655A (es) Compuestos de aza-piridona y usos de estos.
DOP2016000170A (es) Compuestos derivados de hidroxiformamida y usos del mismo
EP3355890A4 (en) HUMAN PLASMA CALLICINE REMEDY
CL2016000597A1 (es) Derivados de desoxino jirimicina y sus métodos de uso.
HUE054337T2 (hu) C-3 és C-17 módosított triterpenoidok HIV-1 inhibitorokként