CY1230A - N-cyano-n'-alkynyl-n''-(2-mercaptoethyl)-guanidines - Google Patents

N-cyano-n'-alkynyl-n''-(2-mercaptoethyl)-guanidines Download PDF

Info

Publication number
CY1230A
CY1230A CY1230A CY123078A CY1230A CY 1230 A CY1230 A CY 1230A CY 1230 A CY1230 A CY 1230A CY 123078 A CY123078 A CY 123078A CY 1230 A CY1230 A CY 1230A
Authority
CY
Cyprus
Prior art keywords
cyano
compound
mercaptoethyl
butyn
formula
Prior art date
Application number
CY1230A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,959 external-priority patent/US4112234A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CY1230A publication Critical patent/CY1230A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CY1230A 1977-06-03 1978-05-26 N-cyano-n'-alkynyl-n''-(2-mercaptoethyl)-guanidines CY1230A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03
US82679677A 1977-08-22 1977-08-22
US05/848,959 US4112234A (en) 1977-08-22 1977-11-07 Imidazolylmethylthioethyl alkynyl guanidines

Publications (1)

Publication Number Publication Date
CY1230A true CY1230A (en) 1984-06-29

Family

ID=27419995

Family Applications (3)

Application Number Title Priority Date Filing Date
CY1230A CY1230A (en) 1977-06-03 1978-05-26 N-cyano-n'-alkynyl-n''-(2-mercaptoethyl)-guanidines
CY1229A CY1229A (en) 1977-06-03 1978-05-26 Guanidine derivatives
CY1231A CY1231A (en) 1977-06-03 1978-05-26 N-cyano-n'-alkynyl-s-substituted isothioureas

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY1229A CY1229A (en) 1977-06-03 1978-05-26 Guanidine derivatives
CY1231A CY1231A (en) 1977-06-03 1978-05-26 N-cyano-n'-alkynyl-s-substituted isothioureas

Country Status (26)

Country Link
JP (1) JPS543067A (de)
AR (2) AR222797A1 (de)
CA (1) CA1110251A (de)
CH (2) CH641167A5 (de)
CY (3) CY1230A (de)
DD (1) DD140038A5 (de)
DE (1) DE2824066A1 (de)
DK (1) DK243178A (de)
ES (3) ES470474A1 (de)
FI (1) FI69069C (de)
FR (2) FR2401143A1 (de)
GB (3) GB1598628A (de)
GR (1) GR73860B (de)
HK (3) HK38284A (de)
HU (1) HU186766B (de)
IE (1) IE47543B1 (de)
IL (1) IL54819A (de)
KE (1) KE3373A (de)
LU (1) LU79725A1 (de)
MY (3) MY8500453A (de)
NL (1) NL7805935A (de)
NO (3) NO152214C (de)
NZ (1) NZ187376A (de)
SE (3) SE443784B (de)
SG (1) SG8584G (de)
YU (4) YU129778A (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4339439A (en) * 1981-01-19 1982-07-13 Bristol-Myers Company Pharmaceutical methods and compositions
JPS6018010U (ja) * 1983-07-18 1985-02-07 日産自動車株式会社 車両用空気調和装置の温度調整機構
JPS60113211U (ja) * 1984-01-06 1985-07-31 松下電器産業株式会社 自動車用空気調和装置
ES2007948A6 (es) * 1988-07-06 1989-07-01 Vinas Lab Procedimiento para la obtencion de derivados propargilguanidicos.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

Also Published As

Publication number Publication date
FR2401143B1 (de) 1981-12-11
IE781112L (en) 1978-12-03
HK38284A (en) 1984-05-11
LU79725A1 (fr) 1979-02-02
JPS543067A (en) 1979-01-11
KE3373A (en) 1984-03-23
JPS5639313B2 (de) 1981-09-11
FI781737A7 (fi) 1978-12-04
NO151824B (no) 1985-03-04
GR73860B (de) 1984-05-08
GB1598628A (en) 1981-09-23
NO152214C (no) 1985-08-28
HK38084A (en) 1984-05-11
ES470474A1 (es) 1979-09-01
AR222797A1 (es) 1981-06-30
YU40625B (en) 1986-02-28
GB1598629A (en) 1981-09-23
CY1231A (en) 1984-06-29
NO791637L (no) 1978-12-05
FR2401143A1 (fr) 1979-03-23
NO152214B (no) 1985-05-13
SE8401492L (sv) 1984-03-16
IL54819A (en) 1983-03-31
MY8500451A (en) 1985-12-31
GB1598630A (en) 1981-09-23
SE8401491D0 (sv) 1984-03-16
YU215582A (en) 1983-02-28
AR222503A1 (es) 1981-05-29
SE8401492D0 (sv) 1984-03-16
YU129778A (en) 1983-02-28
NO833255L (no) 1978-12-05
NO151824C (no) 1985-06-12
NZ187376A (en) 1981-05-29
ES478203A1 (es) 1979-06-01
FR2436138A1 (fr) 1980-04-11
FI69069B (fi) 1985-08-30
CH641167A5 (en) 1984-02-15
IL54819A0 (en) 1978-07-31
IE47543B1 (en) 1984-04-18
HU186766B (en) 1985-09-30
CH644591A5 (en) 1984-08-15
CY1229A (en) 1984-06-29
SE7806525L (sv) 1978-12-04
FI69069C (fi) 1985-12-10
YU41620B (en) 1987-12-31
YU53079A (en) 1983-09-30
SG8584G (en) 1985-02-08
YU40624B (en) 1986-02-28
SE443784B (sv) 1986-03-10
ES478202A1 (es) 1979-06-01
DD140038A5 (de) 1980-02-06
CA1110251A (en) 1981-10-06
NL7805935A (nl) 1978-12-05
NO781928L (no) 1978-12-05
MY8500453A (en) 1985-12-31
DE2824066A1 (de) 1978-12-14
MY8500452A (en) 1985-12-31
HK38184A (en) 1984-05-11
DK243178A (da) 1978-12-04
FR2436138B1 (de) 1982-12-03
YU215482A (en) 1983-02-28
SE8401491L (sv) 1984-03-16

Similar Documents

Publication Publication Date Title
ZA941119B (en) Substituted benzoylguanidines process for their preparation their use as a pharmaceutical as inhibitors of the cellular N+/H+ exchange or as a diagnostic and pharmaceutical containing them
SU1538893A3 (ru) Способ получени гидрохлорида N-деформил-N [N,N -бис(2-хлорэтил)]дистамицина А
ES8203076A1 (es) Procedimiento para preparar derivados de guanidina.
KR880701231A (ko) N-(2-치환된 알킬)-n'-((이미다졸-4-일)알킬) 구 아니딘
GB1598630A (en) N-cyano-n'-alkynyl-n''-(2-mercaptoethyl)-guanidines
SU508182A3 (ru) Способ получени замещенного фенил-ацетилгуанидина
CA1118445A (en) N,n'-[bis(n-cyanoguanyl)] crystamine derivatives
DK1213279T3 (da) Fremgangsmåde til fremstilling af venlafaxin
ES2167869T3 (es) Procedimiento para preparar acidos nicotinicos.
KR830007510A (ko) 심장질환 치료제의 제조방법
KR900016119A (ko) 치환 에텐류의 제조 방법
IE47545B1 (en) N-cyano-n'-alkynyl-n"-(2-mercaptoethyl)-guanidines
Howell et al. Toxic Fluorine Compounds. VII. 1 ι-Fluoroalkyl Thiocyanates and ι-Fluoroalkyl Mercaptans
JPS63243070A (ja) チオプロピオネートの改良されたエステル化法
GB2102791A (en) Alkynylamino ethylenes
ES425830A1 (es) Procedimiento para la obtencion de derivados aromaticos de la guanidina.
US3917679A (en) Quaternary ammonium salts of N-dialkylaminoalkyl-N-(2-indanyl)anilines
KR890014566A (ko) 알콕시- 및 알킬아미노-카보닐알킬포스포리피드, 이의 제조방법 및 약제로서의 이의 용도
RU2042671C1 (ru) Производное дикетен-имина в качестве промежуточного продукта для синтеза ранитидина и способ его получения
NZ200923A (en) Cystine derivatives and pharmaceutical compositions containing such
RU2015963C1 (ru) Способ получения производных фенилгуанидина и производные сульфокислоты в качестве промежуточных продуктов в синтезе производных фенилгуанидина
KR930007909A (ko) N-메톡시페닐에틸-n'-이미다졸릴페닐아미딘 유도체 및 그의 제조방법
AP371A (en) Amine salts of leukotrine antagonist and its use for crystallizing selectively optical isomers thereof.
ES554243A0 (es) Procedimiento para la sintesis del trifluor-2,2,2 etanol
EP0375279A3 (de) Verfahren zur Herstellung von Alkylenaminen