CY1404A - 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same - Google Patents

6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same

Info

Publication number
CY1404A
CY1404A CY140481A CY140481A CY1404A CY 1404 A CY1404 A CY 1404A CY 140481 A CY140481 A CY 140481A CY 140481 A CY140481 A CY 140481A CY 1404 A CY1404 A CY 1404A
Authority
CY
Cyprus
Prior art keywords
hydroxy
methyl
lower alkyl
same
hydroxy acid
Prior art date
Application number
CY140481A
Other languages
English (en)
Inventor
Alvin K Willard
Robert L Smith
William F Hoffman
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27494171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1404(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/175,232 external-priority patent/US4293496A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CY1404A publication Critical patent/CY1404A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
CY140481A 1980-02-04 1981-02-02 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same CY1404A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11805180A 1980-02-04 1980-02-04
US11804980A 1980-02-04 1980-02-04
US17546080A 1980-08-05 1980-08-05
US06/175,232 US4293496A (en) 1980-02-04 1980-08-05 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

Publications (1)

Publication Number Publication Date
CY1404A true CY1404A (en) 1988-04-22

Family

ID=27494171

Family Applications (1)

Application Number Title Priority Date Filing Date
CY140481A CY1404A (en) 1980-02-04 1981-02-02 6(r)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same

Country Status (22)

Country Link
EP (1) EP0033538B1 (fr)
AU (1) AU548996B2 (fr)
CA (1) CA1199322A (fr)
CY (1) CY1404A (fr)
DD (1) DD155989A5 (fr)
DE (1) DE3173042D1 (fr)
DK (1) DK157292C (fr)
ES (1) ES499079A0 (fr)
FI (1) FI78082C (fr)
GR (1) GR74798B (fr)
HK (1) HK16488A (fr)
IE (1) IE51478B1 (fr)
IL (1) IL62044A (fr)
MA (1) MA19054A1 (fr)
MY (1) MY8700745A (fr)
NL (1) NL930009I2 (fr)
NO (2) NO154229C (fr)
NZ (1) NZ196172A (fr)
PT (1) PT72441B (fr)
RO (1) RO82367B (fr)
SG (1) SG61087G (fr)
YU (1) YU28181A (fr)

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EP2327682A1 (fr) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Utilisation de composés amphiphiles pour la crystallisation controlée de statines et d'intermediaires de statines.
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WO2011002424A2 (fr) 2009-07-02 2011-01-06 Bilgic Mahmut Préparation pharmaceutique améliorant la solubilité et la stabilité
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Also Published As

Publication number Publication date
AU548996B2 (en) 1986-01-09
NO154229B (no) 1986-05-05
DE3173042D1 (en) 1986-01-09
NO810358L (no) 1981-08-05
ES8609296A1 (es) 1985-10-16
CA1199322A (fr) 1986-01-14
AU6657381A (en) 1981-08-13
RO82367A (fr) 1984-02-21
IL62044A0 (en) 1981-03-31
NO154229C (no) 1986-08-13
DD155989A5 (de) 1982-07-21
IE810204L (en) 1981-08-04
ES499079A0 (es) 1985-10-16
PT72441B (pt) 1984-08-01
IL62044A (en) 1987-03-31
FI78082C (fi) 1989-06-12
NL930009I1 (nl) 1993-04-01
NO1994001I1 (no) 1994-07-01
FI810287L (fi) 1981-08-05
PT72441A (pt) 1981-03-01
HK16488A (en) 1988-03-11
SG61087G (en) 1987-10-23
RO82367B (ro) 1984-02-28
NZ196172A (en) 1985-01-31
EP0033538A2 (fr) 1981-08-12
DK157292C (da) 1990-05-07
IE51478B1 (en) 1987-01-07
EP0033538A3 (en) 1982-02-24
DK46181A (da) 1981-08-05
DK157292B (da) 1989-12-04
FI78082B (fi) 1989-02-28
YU28181A (en) 1983-10-31
NL930009I2 (nl) 1993-09-16
GR74798B (fr) 1984-07-12
MA19054A1 (fr) 1981-10-01
EP0033538B1 (fr) 1985-11-27
MY8700745A (en) 1987-12-31

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