CY1812A - Pyrrolidine derivatives - Google Patents

Pyrrolidine derivatives

Info

Publication number: CY1812A
Authority: CY; Cyprus
Prior art keywords: chem; formula; pyrrolidine derivatives; pyrrolidine; ch2s
Prior art date: 1989-03-17

Application number

CY181295A

Other languages

English (en)

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-17

Filing date

1995-10-20

Publication date

1995-10-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10653525&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1812(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-10-20 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

1995-10-20 Publication of CY1812A publication Critical patent/CY1812A/xx

Links

150000003235 pyrrolidines Chemical class 0.000 title 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
125000003373 pyrazinyl group Chemical group 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

CY181295A 1989-03-17 1995-10-20 Pyrrolidine derivatives CY1812A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898906166A GB8906166D0 (en)	1989-03-17	1989-03-17	Therapeutic agents

Publications (1)

Publication Number	Publication Date
CY1812A true CY1812A (en)	1995-10-20

Family

ID=10653525

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CY181295A CY1812A (en)	1989-03-17	1995-10-20	Pyrrolidine derivatives
CY2005005C CY2005005I1 (el)	1989-03-17	2005-04-04	Pyrrolidine derivatives

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CY2005005C CY2005005I1 (el)	1989-03-17	2005-04-04	Pyrrolidine derivatives

Country Status (37)

Country	Link
US (1)	US5096890B1 (fr)
EP (1)	EP0388054B1 (fr)
JP (2)	JPH0764809B2 (fr)
KR (2)	KR920008166B1 (fr)
CN (1)	CN1023007C (fr)
AT (1)	ATE96783T1 (fr)
AU (1)	AU614224B2 (fr)
BA (1)	BA98300A (fr)
CA (1)	CA2012295C (fr)
CL (1)	CL2003002756A1 (fr)
CY (2)	CY1812A (fr)
CZ (1)	CZ280053B6 (fr)
DD (1)	DD292911A5 (fr)
DE (2)	DE122005000022I2 (fr)
DK (1)	DK0388054T3 (fr)
EG (1)	EG18951A (fr)
ES (1)	ES2060020T3 (fr)
FI (1)	FI95573C (fr)
GB (1)	GB8906166D0 (fr)
HK (1)	HK130294A (fr)
HU (2)	HU217433B (fr)
IE (1)	IE62515B1 (fr)
IL (1)	IL93694A (fr)
LU (1)	LU91161I2 (fr)
MX (1)	MX9319890A (fr)
MY (1)	MY105527A (fr)
NL (1)	NL300191I2 (fr)
NO (2)	NO176316C (fr)
NZ (1)	NZ232958A (fr)
PL (1)	PL164136B1 (fr)
PT (1)	PT93443B (fr)
RU (2)	RU1833374C (fr)
SG (1)	SG143394G (fr)
SK (1)	SK129590A3 (fr)
UA (1)	UA18263A (fr)
YU (1)	YU47587B (fr)
ZA (1)	ZA901982B (fr)

Families Citing this family (68)

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US5932594A (en) *	1988-11-01	1999-08-03	Pfizer, Inc.	Muscarinic receptor antagonists
GB8825505D0 (en) *	1988-11-01	1988-12-07	Pfizer Ltd	Therapeutic agents
GB8928042D0 (en) *	1989-12-12	1990-02-14	Pfizer Ltd	Muscarinic receptor antagonists
US5607950A (en) *	1990-01-06	1997-03-04	Pfizer Inc.	Muscarinic receptor antagonists
US5486527A (en) *	1990-01-06	1996-01-23	Pfizer Inc.	Anticholinergic agents
DE69330272T2 (de) *	1992-04-23	2001-10-25	Merrell Pharmaceuticals Inc., Bridgewater	4-imidomethyl-1-[2'-phenyl-2-oxoethyl]-piperidine als serotonin-5ht2-antagonisten, ihre herstellung und therapeutische anwendung
GB9400600D0 (en) *	1994-01-14	1994-03-09	Pfizer Ltd	Treatment of motion seckness
US6017931A (en) *	1994-03-01	2000-01-25	Fmc Corporation	Insecticidal compositions containing n-(substituted phenylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
US5639763A (en) *	1994-03-01	1997-06-17	Fmc Corporation	Insecticidal N-(substituted arylmethyl)-4-[bis(substituted phenyl)methyl]piperidines
ATE385496T1 (de) *	1994-07-27	2008-02-15	Univ Vanderbilt	Dihydrobenzofurane und verwandte verbindungen als entzündungshemmende mittel
US5674891A (en) *	1994-07-27	1997-10-07	The Procter & Gamble Company	Dihydrobenzothiophene compounds useful as anti-inflammatory agents
GB9518953D0 (en) *	1995-09-15	1995-11-15	Pfizer Ltd	Pharmaceutical formulations
US5684031A (en) *	1996-02-01	1997-11-04	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) *	1996-02-01	1997-09-30	The Procter & Gamble Company	Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
AU733209B2 (en) *	1996-12-02	2001-05-10	Kyorin Pharmaceutical Co. Ltd.	Novel n-substituted pyrrolidine derivatives and process for preparing the same
US6131129A (en) *	1997-07-30	2000-10-10	Sony Corporation Of Japan	Computer system within an AV/C based media changer subunit providing a standarized command set
US6693202B1 (en)	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
IL141235A (en) *	2000-02-09	2012-04-30	Novartis Int Pharm Ltd	Combined use of an alpha-adrenoceptor antagonist and a muscarinic antagonist in the preparation of a drug for the treatment of non-malignant prostatic hyperplasia
US6653339B2 (en)	2001-08-15	2003-11-25	Pfizer Inc.	Method of treating irritable bowel syndrome
MY130316A (en) *	2001-10-26	2007-06-29	Pharmacia & Upjohn Co Llc	Quaternary ammonium compounds
SE0103668D0 (sv) *	2001-11-02	2001-11-02	Astrazeneca Ab	Method for the treatment of overactive blader
BR0206300A (pt) *	2001-11-05	2008-04-08	Upjohn Co	composição farmacêutica para tratar distúrbio urinário em um mamìfero e uso
GB0129962D0 (en) *	2001-12-14	2002-02-06	Pfizer Ltd	Method of treatment
GB0207104D0 (en)	2002-03-26	2002-05-08	Pfizer Ltd	Stable hydrate of a muscarinic receptor antagonist
AU2002345266B2 (en)	2002-07-08	2009-07-02	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
US7265147B2 (en)	2002-07-31	2007-09-04	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
US7410993B2 (en)	2002-08-09	2008-08-12	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists
CN1688544A (zh)	2002-08-23	2005-10-26	兰贝克赛实验室有限公司	作为蕈毒碱受体拮抗剂的含氟代和磺酰氨基的3,6－二取代的氮杂双环(3.1.0)己烷衍生物
TW200412945A (en) *	2002-10-25	2004-08-01	Upjohn Co	Quaternary ammonium compounds
TWI295669B (en)	2002-10-30	2008-04-11	Theravance Inc	Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
DE60227576D1 (de)	2002-12-10	2008-08-21	Ranbaxy Lab Ltd	3,6-DISUBSTITUIERTE AZABICYCLO i3.1.0 -HEXANDERIVATIVE ALS ANTAGONISTEN DES MUSCARINREZEPTORS
WO2004056767A1 (fr) *	2002-12-23	2004-07-08	Ranbaxy Laboratories Limited	Derives de 1-substitues-3-pyrrolidines comme antagonistes de recepteurs muscariniques
US7501443B2 (en)	2002-12-23	2009-03-10	Ranbaxy Laboratories Limited	Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en)	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1615881A2 (fr)	2003-04-01	2006-01-18	Theravance, Inc.	Diarylmethyle et composes apparentes ayant les activites agoniste du recepteur beta2 adrenergique et antagoniste de recepteur de muscarinic
WO2004089898A1 (fr)	2003-04-09	2004-10-21	Ranbaxy Laboratories Limited	Derives d'azabicyclo hexane substitues en tant qu'antagonistes de recepteurs muscariniques
EP1615634B1 (fr)	2003-04-10	2007-05-16	Ranbaxy Laboratories, Ltd.	Derives d'azabicyclo hexane en tant qu'antagonistes des recepteurs muscariniques
AU2003223010A1 (en)	2003-04-10	2004-11-01	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CN100436414C (zh)	2003-04-11	2008-11-26	兰贝克赛实验室有限公司	作为毒蕈碱受体拮抗剂的氮杂双环衍生物
MXPA05011059A (es) *	2003-04-15	2005-12-12	Pharmacia & Upjohn Co Llc	Compuestos de amonio cuaternario y su uso como agentes antimuscarinicos.
WO2004091597A2 (fr) *	2003-04-15	2004-10-28	Pharmacia & Upjohn Company Llc	Procede pour traiter le syndrome du colon irritable
EP1620083A2 (fr) *	2003-04-18	2006-02-01	Pharmacia & Upjohn Company LLC	Polytherapies
TW200510298A (en)	2003-06-13	2005-03-16	Theravance Inc	Substituted pyrrolidine and related compounds
WO2005007645A1 (fr)	2003-07-11	2005-01-27	Theravance, Inc.	Composes de 4-amino-1-benzylpiperidine substitues
EP1725525A1 (fr) *	2004-03-11	2006-11-29	Theravance, Inc.	Composes biphenyle convenant en tant qu'antagonistes du recepteur muscarinique
JP2007528418A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
WO2005092341A1 (fr) *	2004-03-22	2005-10-06	Ranbaxy Laboratories Limited	Therapie combinee destinee a reduire les symptomes des voies urinaires
US20090221664A1 (en)	2005-10-19	2009-09-03	Abhijit Ray	Pharmaceutical compositions of muscarinic receptor antagonists
WO2007076159A2 (fr) *	2005-12-27	2007-07-05	Teva Pharmaceutical Industries Ltd.	Bromhydrate de darifenacine pur sensiblement exempt de darifenacine oxydee, sels de celui-ci, et procedes de preparation de ceux-ci
AR062676A1 (es)	2006-09-07	2008-11-26	Medichem Sa	Procedimiento mejorado para preparar compuestos de pirrolidina 1,3-disustituidas
US20100112061A1 (en) *	2006-12-13	2010-05-06	William Baker	Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
WO2008100651A2 (fr) *	2007-01-05	2008-08-21	Dr. Reddy's Laboratories Ltd.	Préparation de darifénacine et ses sels
KR101495708B1 (ko) *	2007-02-23	2015-02-25	세라밴스 바이오파마 알앤디 아이피, 엘엘씨	무스카린 수용체 안타고니스트로 유용한 4차 암모늄 디페닐메틸 화합물
WO2008126106A2 (fr) *	2007-04-16	2008-10-23	Manne Satyanarayana Reddy	Procédés nouveaux et perfectionnés pour la préparation d'intermédiaires de darifénacine, de la darifénacine et de ses sels pharmaceutiquement acceptables
US20100204296A1 (en) *	2007-06-08	2010-08-12	Actavis Group Ptc Ehf	Novel Polymorphs of Darifenacin Free Base and its Hydrobromide Salt
EP2160372A1 (fr) *	2007-06-15	2010-03-10	Medichem, S.A.	Procédé de détermination de la pureté énantiomérique de la darifénacine et de ses intermédiaires
WO2009006413A1 (fr) *	2007-06-30	2009-01-08	Auspex Pharmaceuticals, Inc.	Pyrrolidines substituées
AR068322A1 (es) *	2007-07-13	2009-11-11	Medichem Sa	Forma amorfa de hidrobromuro de darifenacina y procedimientos para su preparacion
CZ200845A3 (cs) *	2008-01-28	2009-09-02	Zentiva, A. S.	Zpusob prípravy Darifenacinu
WO2009125430A2 (fr) *	2008-03-17	2009-10-15	Matrix Laboratoires Limited	Procédé perfectionné pour la fabrication de darifénacine
CN101983187A (zh) *	2008-04-02	2011-03-02	株式会社钟化	(s)-3-(1-氰基-1，1-二苯基甲基)吡咯烷的制备方法
US20110144354A1 (en) *	2008-09-22	2011-06-16	Watson Pharma Private Limited	Process for Preparation of Darifenacin and Intermediates Used in the Process
EP2236509A1 (fr)	2009-04-01	2010-10-06	Ragactives, S.L.	Méthode de préparation de dérivés de la pyrrolidine 1,3 substituée
NZ610978A (en)	2009-05-15	2014-11-28	Redx Pharma Ltd	Redox drug derivatives
WO2011070419A1 (fr)	2009-12-10	2011-06-16	Aurobindo Pharma Limited	Procédé perfectionné pour la préparation de bromhydrate de darifénacine
US8748433B2 (en)	2010-04-30	2014-06-10	Merck Sharp & Dohme Corp.	β3 adrenergic receptor agonists
CN101857581A (zh) *	2010-06-22	2010-10-13	浙江美诺华药物化学有限公司	一种制备达非那新中间体5-(2-溴乙基)-2,3-二氢-1-苯并呋喃的方法
WO2011161504A1 (fr)	2010-06-23	2011-12-29	Micro Labs Limited	Formulations à libération prolongée contenant de la darifénacine ou des sels pharmaceutiquement acceptables de celle-ci

Family Cites Families (7)

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GB1057145A (en) *	1963-08-16	1967-02-01	Bellon Labor Sa Roger	Phenylcyclohexylacetonitrile derivatives
US4002766A (en) *	1974-12-26	1977-01-11	A. H. Robins Company, Incorporated	Antiarrhythmia methods
US4242261A (en) *	1979-07-19	1980-12-30	A. H. Robins Company, Inc.	Production of methylene-cycloamines
US4594343A (en) *	1984-10-19	1986-06-10	Shanklin Jr James R	1-[(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl]-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
IL76583A (en) *	1984-10-19	1988-08-31	Robins Co Inc A H	1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
EP0235463A3 (fr) *	1985-12-20	1990-01-17	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Arylalkyl et arylalkylène piperidines substitués sur l'azote utilisés comme agents antihistaminiques cardiovasculaires et antisécrétion
IN163948B (fr) *	1986-01-17	1988-12-10	Robins Co Inc A H

1989
- 1989-03-17 GB GB898906166A patent/GB8906166D0/en active Pending
1990
- 1990-03-02 DE DE200512000022 patent/DE122005000022I2/de active Active
- 1990-03-02 AT AT90302269T patent/ATE96783T1/de active
- 1990-03-02 DE DE90302269T patent/DE69004302T2/de not_active Expired - Lifetime
- 1990-03-02 ES ES90302269T patent/ES2060020T3/es not_active Expired - Lifetime
- 1990-03-02 DK DK90302269.7T patent/DK0388054T3/da active
- 1990-03-02 EP EP90302269A patent/EP0388054B1/fr not_active Expired - Lifetime
- 1990-03-09 IL IL9369490A patent/IL93694A/en not_active IP Right Cessation
- 1990-03-13 US US07493068 patent/US5096890B1/en not_active Expired - Lifetime
- 1990-03-14 HU HU580/90A patent/HU217433B/hu unknown
- 1990-03-14 MX MX1989090A patent/MX9319890A/es unknown
- 1990-03-15 EG EG17090A patent/EG18951A/xx active
- 1990-03-15 KR KR1019900003453A patent/KR920008166B1/ko not_active Expired
- 1990-03-15 ZA ZA901982A patent/ZA901982B/xx unknown
- 1990-03-15 JP JP2065521A patent/JPH0764809B2/ja not_active Expired - Lifetime
- 1990-03-15 CA CA002012295A patent/CA2012295C/fr not_active Expired - Lifetime
- 1990-03-15 PT PT93443A patent/PT93443B/pt not_active IP Right Cessation
- 1990-03-16 CZ CS901295A patent/CZ280053B6/cs not_active IP Right Cessation
- 1990-03-16 DD DD90338829A patent/DD292911A5/de not_active IP Right Cessation
- 1990-03-16 YU YU52790A patent/YU47587B/sh unknown
- 1990-03-16 FI FI901333A patent/FI95573C/fi active Protection Beyond IP Right Term
- 1990-03-16 MY MYPI90000416A patent/MY105527A/en unknown
- 1990-03-16 SK SK1295-90A patent/SK129590A3/sk not_active IP Right Cessation
- 1990-03-16 RU SU904743599A patent/RU1833374C/ru active
- 1990-03-16 NZ NZ232958A patent/NZ232958A/en unknown
- 1990-03-16 PL PL90284342A patent/PL164136B1/pl unknown
- 1990-03-16 UA UA4743599A patent/UA18263A/uk unknown
- 1990-03-16 IE IE95590A patent/IE62515B1/en not_active IP Right Cessation
- 1990-03-16 NO NO901241A patent/NO176316C/no not_active IP Right Cessation
- 1990-03-16 AU AU51402/90A patent/AU614224B2/en not_active Expired
- 1990-03-17 CN CN90101543A patent/CN1023007C/zh not_active Expired - Lifetime
1991
- 1991-03-13 RU SU914894696A patent/RU2015965C1/ru active
1992
- 1992-08-12 KR KR1019920014485A patent/KR960015142B1/ko not_active Expired - Lifetime
1994
- 1994-09-26 JP JP6229807A patent/JPH07149640A/ja active Pending
- 1994-10-03 SG SG143394A patent/SG143394G/en unknown
- 1994-11-24 HK HK130294A patent/HK130294A/en not_active IP Right Cessation
1995
- 1995-06-28 HU HU95P/P00505P patent/HU211640A9/hu active Protection Beyond IP Right Term
- 1995-10-20 CY CY181295A patent/CY1812A/xx unknown
1998
- 1998-03-30 BA BA980300A patent/BA98300A/bs unknown
2003
- 2003-12-26 CL CL200302756A patent/CL2003002756A1/es unknown
2005
- 2005-04-01 NO NO2005008C patent/NO2005008I2/no unknown
- 2005-04-04 CY CY2005005C patent/CY2005005I1/el unknown
- 2005-04-08 NL NL300191C patent/NL300191I2/nl unknown
- 2005-04-11 LU LU91161C patent/LU91161I2/fr unknown

Also Published As

Publication number	Publication date
HUT58313A (en)	1992-02-28
PL164136B1 (pl)	1994-06-30
SK278434B6 (en)	1997-05-07
HK130294A (en)	1994-12-02
PT93443B (pt)	1996-02-29
JPH07149640A (ja)	1995-06-13
NL300191I2 (nl)	2005-08-01
NL300191I1 (nl)	2005-07-01
US5096890A (en)	1992-03-17
GB8906166D0 (en)	1989-05-04
MY105527A (en)	1994-10-31
FI95573B (fi)	1995-11-15
CY2005005I2 (el)	2010-07-28
CZ280053B6 (cs)	1995-10-18
SG143394G (en)	1995-01-13
DE69004302D1 (de)	1993-12-09
ZA901982B (en)	1991-10-30
IE900955L (en)	1990-09-17
UA18263A (uk)	1997-12-25
JPH0764809B2 (ja)	1995-07-12
YU52790A (sh)	1992-07-20
US5096890B1 (en)	1995-03-28
DE122005000022I2 (de)	2006-02-02
FI95573C (fi)	1996-02-26
NO901241L (no)	1990-09-18
HU901580D0 (en)	1990-06-28
CN1045580A (zh)	1990-09-26
CZ129590A3 (en)	1995-05-17
CA2012295A1 (fr)	1990-09-17
NO901241D0 (no)	1990-03-16
NO2005008I2 (no)	2006-11-27
DE69004302T2 (de)	1994-02-24
KR900014367A (ko)	1990-10-23
IL93694A (en)	1994-08-26
RU1833374C (ru)	1993-08-07
PT93443A (pt)	1990-11-07
CY2005005I1 (el)	2010-07-28
EP0388054A1 (fr)	1990-09-19
NO2005008I1 (en)	2005-04-11
ES2060020T3 (es)	1994-11-16
NO176316C (no)	1995-03-15
DD292911A5 (de)	1991-08-14
MX9319890A (es)	1993-08-01
JPH02282360A (ja)	1990-11-19
NZ232958A (en)	1992-05-26
IL93694A0 (en)	1990-12-23
EG18951A (en)	1994-03-30
EP0388054B1 (fr)	1993-11-03
AU614224B2 (en)	1991-08-22
FI901333A0 (fi)	1990-03-16
CN1023007C (zh)	1993-12-08
KR960015142B1 (ko)	1996-11-01
KR920008166B1 (ko)	1992-09-24
DK0388054T3 (da)	1993-12-06
LU91161I2 (fr)	2005-06-13
NO176316B (no)	1994-12-05
SK129590A3 (en)	1997-05-07
ATE96783T1 (de)	1993-11-15
CA2012295C (fr)	1996-11-12
RU2015965C1 (ru)	1994-07-15
AU5140290A (en)	1990-09-20
DE122005000022I1 (de)	2005-08-04
CL2003002756A1 (es)	2005-02-11
IE62515B1 (en)	1995-02-08
HU211640A9 (en)	1995-12-28
HU217433B (hu)	2000-01-28
YU47587B (sh)	1995-10-24
BA98300A (bs)	2001-09-14

Publication	Publication Date	Title
US5096890B1 (en)	1995-03-28	Pyrrolidine derivatives
CA2067817A1 (fr)	1991-07-07	Antagonistes des recepteurs muscariniques
FI922343A0 (fi)	1992-05-22	Menetelmä terapeuttisesti käyttökelpoisten piperidiini- ja pyrrolidiinijohdannaisten valmistamiseksi
FI97468B (fi)	1996-09-13	Menetelmä terapeuttisesti aktiivisten piperidiinijohdannaisten valmistamiseksi
CA2072575A1 (fr)	1991-07-07	Agents anticholinergiques
DE69006745D1 (de)	1994-03-24	Muscarin-rezeptor-antagonisten.