CY1920A - (1H-azol-1-ylmethyl)substituted quinoline quinazoline or quinoxaline derivatives - Google Patents

(1H-azol-1-ylmethyl)substituted quinoline quinazoline or quinoxaline derivatives

Info

Publication number: CY1920A
Authority: CY; Cyprus
Prior art keywords: azol; ylmethyl; chem; compounds; quinoxaline derivatives
Prior art date: 1988-11-29

Application number

CY192097A

Other languages

English (en)

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-29

Filing date

1997-03-07

Publication date

1997-03-07

1988-11-29 Priority claimed from GB888827821A external-priority patent/GB8827821D0/en

1988-11-29 Priority claimed from GB888827820A external-priority patent/GB8827820D0/en

1988-11-29 Priority claimed from GB888827822A external-priority patent/GB8827822D0/en

1997-03-07 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-03-07 Publication of CY1920A publication Critical patent/CY1920A/xx

Links

-1 (1H-azol-1-ylmethyl)substituted quinoline quinazoline Chemical class 0.000 title abstract 2
125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
210000000981 epithelium Anatomy 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Luminescent Compositions (AREA)
Quinoline Compounds (AREA)
Developing Agents For Electrophotography (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

CY192097A 1988-11-29 1997-03-07 (1H-azol-1-ylmethyl)substituted quinoline quinazoline or quinoxaline derivatives CY1920A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888827821A GB8827821D0 (en)	1988-11-29	1988-11-29	(1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827820A GB8827820D0 (en)	1988-11-29	1988-11-29	(1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827822A GB8827822D0 (en)	1988-11-29	1988-11-29	(1h-azol-1-ylmethyl)substituted quinoline derivatives

Publications (1)

Publication Number	Publication Date
CY1920A true CY1920A (en)	1997-03-07

Family

ID=27264207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY192097A CY1920A (en)	1988-11-29	1997-03-07	(1H-azol-1-ylmethyl)substituted quinoline quinazoline or quinoxaline derivatives

Country Status (22)

Country	Link
EP (1)	EP0371564B1 (da)
JP (1)	JP2916181B2 (da)
CN (3)	CN1033752C (da)
AT (1)	ATE124941T1 (da)
AU (1)	AU620946B2 (da)
CA (1)	CA2002864C (da)
CY (1)	CY1920A (da)
DE (1)	DE68923430T2 (da)
DK (1)	DK172748B1 (da)
ES (1)	ES2088889T3 (da)
FI (1)	FI101964B (da)
GR (1)	GR3017351T3 (da)
HK (1)	HK118196A (da)
HU (2)	HU205106B (da)
IE (1)	IE67803B1 (da)
IL (1)	IL92486A (da)
MY (1)	MY105871A (da)
NO (1)	NO174509B (da)
NZ (1)	NZ231441A (da)
PT (1)	PT92448B (da)
RU (1)	RU1780536C (da)
ZW (1)	ZW15889A1 (da)

Families Citing this family (63)

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HU221425B (en) *	1990-11-06	2002-10-28	Yamanouchi Pharma Co Ltd	Condensed pyrazine derivatives, process for their production and pharmaceutical preparations containing these compounds
DE4107038A1 (de) *	1991-03-01	1992-09-03	Schering Ag	Triheteroarylmethane, verfahren zu deren herstellung, pharmazeutische praeparate die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
WO1994010164A1 (en) *	1992-10-27	1994-05-11	Janssen Pharmaceutica N.V.	4-quinolinyl derivatives with anti-helicobacter activity
NO940245D0 (no) *	1993-01-28	1994-01-24	Takeda Chemical Industries Ltd	Quinolin eller quinazolinderivater, deres fremstilling og anvendelse
WO1995000524A1 (fr) *	1993-06-17	1995-01-05	Otsuka Pharmaceutical Factory, Inc.	Derive de diester phosphonique
TW316902B (da) *	1994-12-28	1997-10-01	Janssen Pharmaceutica Nv
US6110911A (en) *	1995-06-07	2000-08-29	Warner-Lambert Company	Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
MY132385A (en) *	1995-08-31	2007-10-31	Novartis Ag	2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives
TW349948B (en) *	1995-10-31	1999-01-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 2-quinolone derivatives
SK283335B6 (sk) *	1995-12-08	2003-06-03	Janssen Pharmaceutica N. V.	(Imidazol-5-yl)metyl-2-chinolinónové deriváty, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické kompozície na ich báze
US5739338A (en) *	1996-11-05	1998-04-14	Allergan	N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
TW591030B (en)	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
RU2205831C2 (ru)	1997-04-25	2003-06-10	Янссен Фармацевтика Н.В.	Хиназолиноны, ингибирующие фарнезилтрансферазу
TW403740B (en)	1997-06-10	2000-09-01	Novartis Ag	Novel crystal modifications of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
DK1037880T3 (da)	1997-12-11	2004-11-15	Janssen Pharmaceutica Nv	Anilider som retinsyremimetika
ES2237125T3 (es) *	1998-08-27	2005-07-16	Pfizer Products Inc.	Derivados de quinolin-2-ona utiles como agentes anticancerigenos.
ID29241A (id) *	1998-12-23	2001-08-16	Janssen Pharmaceutica Nv	Turunan-turunan kinolin teranelasi-1,2
AU2001267852B2 (en) *	2000-06-30	2006-01-19	Msd K.K.	Novel pyrazinone derivatives
US7067531B2 (en)	2000-09-25	2006-06-27	Angibaud Patrick Rene	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
WO2002024682A1 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
US7173040B2 (en)	2000-09-25	2007-02-06	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
WO2002024686A2 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
JP4348080B2 (ja) *	2000-11-21	2009-10-21	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体
ES2260316T3 (es)	2000-12-27	2006-11-01	Janssen Pharmaceutica N.V.	Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
KR100417705B1 (ko) *	2001-07-24	2004-02-11	한국화학연구원	4-아졸일-2-퀴놀리논 유도체 및 이를 포함하는 살균제조성물
ATE336496T1 (de)	2002-04-15	2006-09-15	Janssen Pharmaceutica Nv	Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
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JP4864718B2 (ja) *	2003-11-20	2012-02-01	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤としての６−アルケニルおよび６−フェニルアルキル置換２−キノリノンおよび２−キノキサリノン
CA2546002C (en) *	2003-11-20	2012-09-18	Janssen Pharmaceutica N.V.	7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
BRPI0416206A (pt)	2003-11-20	2006-12-26	Janssen Pharmaceutica Nv	2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose)
SG151249A1 (en)	2003-12-05	2009-04-30	Janssen Pharmaceutica Nv	6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
US7652014B2 (en) *	2003-12-10	2010-01-26	Janssen Pharmaceutica	Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
EA011552B1 (ru)	2004-06-30	2009-04-28	Янссен Фармацевтика Н.В.	Производные хиназолиндиона в качестве ингибиторов parp
SG154433A1 (en)	2004-06-30	2009-08-28	Janssen Pharmaceutica Nv	Phthalazine derivatives as parp inhibitors
ATE540936T1 (de)	2004-06-30	2012-01-15	Janssen Pharmaceutica Nv	Substituierte 2-alkyl-chinazolinonderivate als parp-hemmer
US8426429B2 (en)	2004-08-06	2013-04-23	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en)	2004-08-06	2013-05-07	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en)	2004-08-06	2013-02-26	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
JP4643948B2 (ja) *	2004-08-23	2011-03-02	大日本住友製薬株式会社	キナゾリノン化合物の安定化方法
US7932261B2 (en)	2006-02-06	2011-04-26	Janssen Pharmaceutica Nv	Macrocycle derivatives useful as inhibitors of β-secretase (BACE)
US7868022B2 (en)	2006-02-06	2011-01-11	Janssen Pharmaceutica Nv	2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
KR101307497B1 (ko) *	2006-04-19	2013-09-11	주식회사 동진쎄미켐	디이미다졸계 화합물 및 이를 이용한 유기발광소자
US7429589B2 (en) *	2006-04-27	2008-09-30	Hoffmann-La Roche Inc.	Mono-nitration of aromatic compounds via nitrate salts
WO2008024963A1 (en) *	2006-08-24	2008-02-28	Serenex, Inc.	Benzene, pyridine, and pyridazine derivatives
US8299256B2 (en)	2007-03-08	2012-10-30	Janssen Pharmaceutica Nv	Quinolinone derivatives as PARP and TANK inhibitors
US8404713B2 (en)	2007-10-26	2013-03-26	Janssen Pharmaceutica Nv	Quinolinone derivatives as PARP inhibitors
WO2009097278A1 (en)	2008-01-28	2009-08-06	Janssen Pharmaceutica N.V.	6-SUBSTITUTED-THIO-2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)
CN101981013B (zh)	2008-03-27	2013-05-29	詹森药业有限公司	作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
ES2367760T3 (es)	2008-03-27	2011-11-08	Janssen Pharmaceutica, N.V.	Derivados de quinazolinona como inhibidores de la polimerización de la tubulina.
GB0914767D0 (en) *	2009-08-24	2009-09-30	Sterix Ltd	Compound
US9394290B2 (en) *	2010-10-21	2016-07-19	Universitaet Des Saarlandes Campus Saarbruecken	Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
WO2013049565A1 (en) *	2011-09-30	2013-04-04	Endo Pharmaceuticals Inc.	Imidazole derivatives as cyp17 inhibitors for the treatment of cancer
US9199975B2 (en)	2011-09-30	2015-12-01	Asana Biosciences, Llc	Biaryl imidazole derivatives for regulating CYP17
CN105073729A (zh)	2012-10-16	2015-11-18	詹森药业有限公司	RORγt的苯基连接的喹啉基调节剂
CN104884448A (zh)	2012-10-16	2015-09-02	詹森药业有限公司	Rorγt的杂芳基连接的喹啉基调节剂
US9290476B2 (en)	2012-10-16	2016-03-22	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
BR112016008215A2 (pt)	2013-10-15	2017-09-26	Janssen Pharmaceutica Nv	moduladores de quinolinila ligados por alquila de roryt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
BR112016008258A2 (pt)	2013-10-15	2017-10-10	Janssen Pharmaceutica Nv	moduladores de ror?t de quinolinila
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt

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GB2101115A (en) *	1980-10-23	1983-01-12	Pfizer Ltd	Thromboxane synthetase inhibitors
US4792561A (en) *	1986-05-29	1988-12-20	Syntex (U.S.A.) Inc.	Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
NZ221729A (en) *	1986-09-15	1989-07-27	Janssen Pharmaceutica Nv	Imidazolyl methyl-substituted benzimidazole derivatives and pharmaceutical compositions
FR2629456B1 (fr) *	1988-03-31	1991-07-05	Esteve Labor Dr	Derives des acides 7-(1-imidazolyl),1,4-dihydro-4-oxo-6,8-difluoro-1-cyclopropyl-3-quinoleincarboxylique, leur preparation et leur application en tant que medicaments

1989
- 1989-11-14 CA CA002002864A patent/CA2002864C/en not_active Expired - Fee Related
- 1989-11-17 NZ NZ231441A patent/NZ231441A/en unknown
- 1989-11-25 MY MYPI89001638A patent/MY105871A/en unknown
- 1989-11-28 RU SU894742543A patent/RU1780536C/ru active
- 1989-11-28 FI FI895687A patent/FI101964B/fi not_active IP Right Cessation
- 1989-11-28 IL IL92486A patent/IL92486A/xx not_active IP Right Cessation
- 1989-11-28 NO NO894734A patent/NO174509B/no unknown
- 1989-11-28 EP EP89203014A patent/EP0371564B1/en not_active Expired - Lifetime
- 1989-11-28 AU AU45646/89A patent/AU620946B2/en not_active Ceased
- 1989-11-28 DK DK198905994A patent/DK172748B1/da not_active IP Right Cessation
- 1989-11-28 DE DE68923430T patent/DE68923430T2/de not_active Expired - Fee Related
- 1989-11-28 ZW ZW158/89A patent/ZW15889A1/xx unknown
- 1989-11-28 HU HU896220A patent/HU205106B/hu not_active IP Right Cessation
- 1989-11-28 ES ES89203014T patent/ES2088889T3/es not_active Expired - Lifetime
- 1989-11-28 IE IE378289A patent/IE67803B1/en not_active IP Right Cessation
- 1989-11-28 AT AT89203014T patent/ATE124941T1/de not_active IP Right Cessation
- 1989-11-29 JP JP1307793A patent/JP2916181B2/ja not_active Expired - Fee Related
- 1989-11-29 CN CN89108925A patent/CN1033752C/zh not_active Expired - Fee Related
- 1989-11-29 PT PT92448A patent/PT92448B/pt not_active IP Right Cessation
1994
- 1994-11-02 CN CN94117801A patent/CN1036002C/zh not_active Expired - Fee Related
- 1994-11-02 CN CN94117802A patent/CN1036003C/zh not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00329P patent/HU211686A9/hu unknown
- 1995-09-13 GR GR950402466T patent/GR3017351T3/el unknown
1996
- 1996-07-04 HK HK118196A patent/HK118196A/en not_active IP Right Cessation
1997
- 1997-03-07 CY CY192097A patent/CY1920A/xx unknown

Also Published As

Publication number	Publication date
CN1042912A (zh)	1990-06-13
IL92486A (en)	1993-07-08
DK172748B1 (da)	1999-06-28
DK599489A (da)	1990-05-30
HU211686A9 (en)	1995-12-28
NO174509C (da)	1994-05-18
HUT52498A (en)	1990-07-28
AU4564689A (en)	1990-06-07
CN1036003C (zh)	1997-10-01
JP2916181B2 (ja)	1999-07-05
AU620946B2 (en)	1992-02-27
EP0371564A2 (en)	1990-06-06
FI895687A0 (fi)	1989-11-28
MY105871A (en)	1995-02-28
HK118196A (en)	1996-07-12
PT92448B (pt)	1995-07-18
CA2002864A1 (en)	1990-05-29
ATE124941T1 (de)	1995-07-15
PT92448A (pt)	1990-05-31
FI101964B1 (fi)	1998-09-30
FI101964B (fi)	1998-09-30
EP0371564A3 (en)	1991-05-29
CN1036002C (zh)	1997-10-01
HU205106B (en)	1992-03-30
IE893782L (en)	1990-05-29
NO894734D0 (no)	1989-11-28
CA2002864C (en)	1999-11-16
CN1033752C (zh)	1997-01-08
DE68923430T2 (de)	1996-02-15
JPH02223579A (ja)	1990-09-05
EP0371564B1 (en)	1995-07-12
ES2088889T3 (es)	1996-10-01
HU896220D0 (en)	1990-02-28
CN1106004A (zh)	1995-08-02
IL92486A0 (en)	1990-08-31
IE67803B1 (en)	1996-05-01
RU1780536C (ru)	1992-12-07
DE68923430D1 (de)	1995-08-17
DK599489D0 (da)	1989-11-28
NO174509B (no)	1994-02-07
GR3017351T3 (en)	1995-12-31
ZW15889A1 (en)	1991-07-17
CN1106005A (zh)	1995-08-02
NZ231441A (en)	1991-05-28
NO894734L (no)	1990-05-30

Publication	Publication Date	Title
AU620946B2 (en)	1992-02-27	(1-h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
AU616838B2 (en)	1991-11-07	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro- 2h-benzopyran or dihydrobenzodioxin)carboxamide derivatives
AU617918B2 (en)	1991-12-05	2-aminopyrimidinone derivatives
GR3004114T3 (da)	1993-03-31
AU6599186A (en)	1987-06-02	N-(6-(4-0-hydrxyphenyl-1,3-dioxan-cis-5-yl)hexenoyl) suphonamide derivatives
HUT51622A (en)	1990-05-28	Process for producing 3-piperidinole-indazole derivatives and pharmaceutical preparations having effect against high blood pressure containing these compounds as active substance