ZW15889A1 - (1h-azol-1-ylmethyl)substituted quinoline,quinazoline or quinoxaline derivatives - Google Patents

(1h-azol-1-ylmethyl)substituted quinoline,quinazoline or quinoxaline derivatives

Info

Publication number: ZW15889A1
Authority: ZW; Zimbabwe
Prior art keywords: azol; quinazoline; ylmethyl; chem; compounds
Prior art date: 1988-11-29

Application number

ZW158/89A

Other languages

English (en)

Inventor

Jean Edgard Freyne Eddy

Herman Margaretha Raeym Alfons

Gaston Venet Marc

Charles Sanz Gerard

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-29

Filing date

1989-11-28

Publication date

1991-07-17

1988-11-29 Priority claimed from GB888827821A external-priority patent/GB8827821D0/en

1988-11-29 Priority claimed from GB888827822A external-priority patent/GB8827822D0/en

1988-11-29 Priority claimed from GB888827820A external-priority patent/GB8827820D0/en

1989-11-28 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1991-07-17 Publication of ZW15889A1 publication Critical patent/ZW15889A1/xx

Links

-1 1h-azol-1-ylmethyl Chemical group 0.000 title abstract 2
JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title abstract 2
SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
150000003248 quinolines Chemical class 0.000 title 1
150000003252 quinoxalines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
210000000981 epithelium Anatomy 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Luminescent Compositions (AREA)
Quinoline Compounds (AREA)
Developing Agents For Electrophotography (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

ZW158/89A 1988-11-29 1989-11-28 (1h-azol-1-ylmethyl)substituted quinoline,quinazoline or quinoxaline derivatives ZW15889A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB888827821A GB8827821D0 (en)	1988-11-29	1988-11-29	(1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827822A GB8827822D0 (en)	1988-11-29	1988-11-29	(1h-azol-1-ylmethyl)substituted quinoline derivatives
GB888827820A GB8827820D0 (en)	1988-11-29	1988-11-29	(1h-azol-1-ylmethyl)substituted quinoline derivatives

Publications (1)

Publication Number	Publication Date
ZW15889A1 true ZW15889A1 (en)	1991-07-17

Family

ID=27264207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZW158/89A ZW15889A1 (en)	1988-11-29	1989-11-28	(1h-azol-1-ylmethyl)substituted quinoline,quinazoline or quinoxaline derivatives

Country Status (22)

Country	Link
EP (1)	EP0371564B1 (da)
JP (1)	JP2916181B2 (da)
CN (3)	CN1033752C (da)
AT (1)	ATE124941T1 (da)
AU (1)	AU620946B2 (da)
CA (1)	CA2002864C (da)
CY (1)	CY1920A (da)
DE (1)	DE68923430T2 (da)
DK (1)	DK172748B1 (da)
ES (1)	ES2088889T3 (da)
FI (1)	FI101964B (da)
GR (1)	GR3017351T3 (da)
HK (1)	HK118196A (da)
HU (2)	HU205106B (da)
IE (1)	IE67803B1 (da)
IL (1)	IL92486A (da)
MY (1)	MY105871A (da)
NO (1)	NO174509B (da)
NZ (1)	NZ231441A (da)
PT (1)	PT92448B (da)
RU (1)	RU1780536C (da)
ZW (1)	ZW15889A1 (da)

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ATE194985T1 (de) *	1990-11-06	2000-08-15	Yamanouchi Pharma Co Ltd	Kondensiertes pyrazinderivat
DE4107038A1 (de) *	1991-03-01	1992-09-03	Schering Ag	Triheteroarylmethane, verfahren zu deren herstellung, pharmazeutische praeparate die diese enthalten sowie ihre verwendung zur herstellung von arzneimitteln
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NO306992B1 (no) *	1993-01-28	2000-01-24	Takeda Chemical Industries Ltd	Quinolinderivater, farmasoeytiske preparater inneholdende forbindelsene og anvendelsen av forbindelsene
US5624918A (en) *	1993-06-17	1997-04-29	Otsuka Pharmaceutical Factory, Inc.	Phosphonic diester derivatives
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US6110911A (en) *	1995-06-07	2000-08-29	Warner-Lambert Company	Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
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EE03484B1 (et)	1995-12-08	2001-08-15	Janssen Pharmaceutica N.V.	Farnesüülproteiintransferaasi inhibeerivad (5-imidasolüül)metüül-2-kinolinooni derivaadid ja nende kasutamine
US5739338A (en) *	1996-11-05	1998-04-14	Allergan	N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
TW591030B (en)	1997-03-10	2004-06-11	Janssen Pharmaceutica Nv	Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
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TW526195B (en)	1997-06-10	2003-04-01	Novartis Ag	Crystal modifications of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide and their use
TR200001645T2 (tr)	1997-12-11	2000-12-21	Janssen Pharmaceutica N.V.	Retinoyik asit taklidi anilürler.
ATE289602T1 (de) *	1998-08-27	2005-03-15	Pfizer Prod Inc	Quinolin-2-on-derivate verwendbar als antikrebsmittel
BR9916827A (pt)	1998-12-23	2001-10-16	Janssen Pharmaceutica Nv	Derivados de quinolina 1,2-anelados
CA2413002A1 (en)	2000-06-30	2002-12-19	Banyu Pharmaceutical Co., Ltd.	Novel pyrazinone derivatives
US7173040B2 (en)	2000-09-25	2007-02-06	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives
WO2002024686A2 (en)	2000-09-25	2002-03-28	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
JP4974439B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−ヘテロシクリルメチルキノリノン誘導体
ATE321038T1 (de)	2000-09-25	2006-04-15	Janssen Pharmaceutica Nv	Chinolin- und chinazolinderivate und deren verwendung als farnesyl transferase inhibitoren
DE60139080D1 (de) *	2000-11-21	2009-08-06	Janssen Pharmaceutica Nv	Farnesyltransferase hemmende benzoheterocyclische derivate
WO2002051835A1 (en)	2000-12-27	2002-07-04	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives
KR100417705B1 (ko) *	2001-07-24	2004-02-11	한국화학연구원	4-아졸일-2-퀴놀리논 유도체 및 이를 포함하는 살균제조성물
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EA011211B1 (ru) *	2003-11-20	2009-02-27	Янссен Фармацевтика Н. В.	7-фенилалкилзамещённые 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза)полимеразы
AU2004295058B9 (en)	2003-11-20	2011-06-30	Janssen Pharmaceutica N.V.	6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
EP1709012B1 (en) *	2003-12-05	2015-07-29	Janssen Pharmaceutica NV	6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose)polymerase inhibitors
WO2005058843A1 (en) *	2003-12-10	2005-06-30	Janssen Pharmaceutica N.V.	Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
WO2006003150A1 (en)	2004-06-30	2006-01-12	Janssen Pharmaceutica N.V.	Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
SG154432A1 (en)	2004-06-30	2009-08-28	Janssen Pharmaceutica Nv	Quinazolinedione derivatives as parp inhibitors
JP4852540B2 (ja)	2004-06-30	2012-01-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｐａｒｐ阻害剤としてのフタラジン誘導体
US8426429B2 (en)	2004-08-06	2013-04-23	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8436006B2 (en)	2004-08-06	2013-05-07	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
US8383637B2 (en)	2004-08-06	2013-02-26	Jansssen Pharmaceutica N.V.	2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
JP4643948B2 (ja) *	2004-08-23	2011-03-02	大日本住友製薬株式会社	キナゾリノン化合物の安定化方法
US7868022B2 (en)	2006-02-06	2011-01-11	Janssen Pharmaceutica Nv	2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
WO2007092839A2 (en)	2006-02-06	2007-08-16	Janssen Pharmaceutica N.V.	Macrocycle derivatives useful as inhibitors of beta-secretase (bace)
KR101307497B1 (ko) *	2006-04-19	2013-09-11	주식회사 동진쎄미켐	디이미다졸계 화합물 및 이를 이용한 유기발광소자
US7429589B2 (en) *	2006-04-27	2008-09-30	Hoffmann-La Roche Inc.	Mono-nitration of aromatic compounds via nitrate salts
US20080076800A1 (en) *	2006-08-24	2008-03-27	Huang Kenneth H	Benzene, Pyridine, and Pyridazine Derivatives
HRP20120346T1 (hr)	2007-03-08	2012-05-31	Janssen Pharmaceutica N.V.	Derivati kinolinona kao parp i tank inhibitori
PL2215075T3 (pl)	2007-10-26	2014-04-30	Janssen Pharmaceutica Nv	Pochodne chinolinonu jako inhibitory PARP
NZ586831A (en)	2008-01-28	2012-02-24	Janssen Pharmaceutica Nv	6-substituted-thio-2-amino-quinoline derivatives useful as inhibitors of beta-secretase (bace)
AU2009228945B2 (en)	2008-03-27	2013-05-02	Janssen Pharmaceutica Nv	Quinazolinone derivatives as tubulin polymerization inhibitors
JP5492183B2 (ja)	2008-03-27	2014-05-14	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｐａｒｐおよびチューブリン重合阻害剤としてのテトラヒドロフェナントリジノンおよびテトラヒドロシクロペンタキノリノン
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US9394290B2 (en) *	2010-10-21	2016-07-19	Universitaet Des Saarlandes Campus Saarbruecken	Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
US9199975B2 (en)	2011-09-30	2015-12-01	Asana Biosciences, Llc	Biaryl imidazole derivatives for regulating CYP17
EP2760854B1 (en) *	2011-09-30	2017-08-30	Asana BioSciences, LLC	Imidazole derivatives as cyp17 inhibitors for the treatment of cancer
JP6466335B2 (ja)	2012-10-16	2019-02-06	ヤンセンファーマシューティカエヌ．ベー．	ＲＯＲ−γ−Ｔのメチレン連結キノリニルモジュレーター
CN104884448A (zh)	2012-10-16	2015-09-02	詹森药业有限公司	Rorγt的杂芳基连接的喹啉基调节剂
US9309222B2 (en)	2012-10-16	2016-04-12	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
KR20160068956A (ko)	2013-10-15	2016-06-15	얀센 파마슈티카 엔.브이.	RORyT의 퀴놀리닐 조절제
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
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1989
- 1989-11-14 CA CA002002864A patent/CA2002864C/en not_active Expired - Fee Related
- 1989-11-17 NZ NZ231441A patent/NZ231441A/en unknown
- 1989-11-25 MY MYPI89001638A patent/MY105871A/en unknown
- 1989-11-28 IL IL92486A patent/IL92486A/xx not_active IP Right Cessation
- 1989-11-28 NO NO894734A patent/NO174509B/no unknown
- 1989-11-28 DK DK198905994A patent/DK172748B1/da not_active IP Right Cessation
- 1989-11-28 ES ES89203014T patent/ES2088889T3/es not_active Expired - Lifetime
- 1989-11-28 AT AT89203014T patent/ATE124941T1/de not_active IP Right Cessation
- 1989-11-28 EP EP89203014A patent/EP0371564B1/en not_active Expired - Lifetime
- 1989-11-28 HU HU896220A patent/HU205106B/hu not_active IP Right Cessation
- 1989-11-28 FI FI895687A patent/FI101964B/fi not_active IP Right Cessation
- 1989-11-28 AU AU45646/89A patent/AU620946B2/en not_active Ceased
- 1989-11-28 DE DE68923430T patent/DE68923430T2/de not_active Expired - Fee Related
- 1989-11-28 RU SU894742543A patent/RU1780536C/ru active
- 1989-11-28 IE IE378289A patent/IE67803B1/en not_active IP Right Cessation
- 1989-11-28 ZW ZW158/89A patent/ZW15889A1/xx unknown
- 1989-11-29 PT PT92448A patent/PT92448B/pt not_active IP Right Cessation
- 1989-11-29 CN CN89108925A patent/CN1033752C/zh not_active Expired - Fee Related
- 1989-11-29 JP JP1307793A patent/JP2916181B2/ja not_active Expired - Fee Related
1994
- 1994-11-02 CN CN94117801A patent/CN1036002C/zh not_active Expired - Fee Related
- 1994-11-02 CN CN94117802A patent/CN1036003C/zh not_active Expired - Fee Related
1995
- 1995-06-22 HU HU95P/P00329P patent/HU211686A9/hu unknown
- 1995-09-13 GR GR950402466T patent/GR3017351T3/el unknown
1996
- 1996-07-04 HK HK118196A patent/HK118196A/en not_active IP Right Cessation
1997
- 1997-03-07 CY CY192097A patent/CY1920A/xx unknown

Also Published As

Publication number	Publication date
IE893782L (en)	1990-05-29
AU4564689A (en)	1990-06-07
ATE124941T1 (de)	1995-07-15
NZ231441A (en)	1991-05-28
IL92486A (en)	1993-07-08
PT92448B (pt)	1995-07-18
DK599489D0 (da)	1989-11-28
HU896220D0 (en)	1990-02-28
CN1036003C (zh)	1997-10-01
DE68923430T2 (de)	1996-02-15
NO894734D0 (no)	1989-11-28
EP0371564A3 (en)	1991-05-29
AU620946B2 (en)	1992-02-27
NO894734L (no)	1990-05-30
HK118196A (en)	1996-07-12
EP0371564B1 (en)	1995-07-12
CN1042912A (zh)	1990-06-13
RU1780536C (ru)	1992-12-07
CN1106004A (zh)	1995-08-02
NO174509B (no)	1994-02-07
DK172748B1 (da)	1999-06-28
DK599489A (da)	1990-05-30
JP2916181B2 (ja)	1999-07-05
MY105871A (en)	1995-02-28
CN1036002C (zh)	1997-10-01
ES2088889T3 (es)	1996-10-01
FI101964B1 (fi)	1998-09-30
NO174509C (da)	1994-05-18
GR3017351T3 (en)	1995-12-31
CY1920A (en)	1997-03-07
HU205106B (en)	1992-03-30
IE67803B1 (en)	1996-05-01
EP0371564A2 (en)	1990-06-06
JPH02223579A (ja)	1990-09-05
CN1106005A (zh)	1995-08-02
CA2002864C (en)	1999-11-16
PT92448A (pt)	1990-05-31
IL92486A0 (en)	1990-08-31
CN1033752C (zh)	1997-01-08
HU211686A9 (en)	1995-12-28
FI895687A0 (fi)	1989-11-28
DE68923430D1 (de)	1995-08-17
HUT52498A (en)	1990-07-28
CA2002864A1 (en)	1990-05-29
FI101964B (fi)	1998-09-30

Publication	Publication Date	Title
AU620946B2 (en)	1992-02-27	(1-h-azol-1-ylmethyl) substituted quinoline, quinazoline or quinoxaline derivatives
AU616838B2 (en)	1991-11-07	N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro- 2h-benzopyran or dihydrobenzodioxin)carboxamide derivatives
AU617918B2 (en)	1991-12-05	2-aminopyrimidinone derivatives
GR3004114T3 (da)	1993-03-31
IE892535L (en)	1990-02-05	Antipsychotic 3-piperazinylbenzazole derivatives
AU6599186A (en)	1987-06-02	N-(6-(4-0-hydrxyphenyl-1,3-dioxan-cis-5-yl)hexenoyl) suphonamide derivatives
HUT51622A (en)	1990-05-28	Process for producing 3-piperidinole-indazole derivatives and pharmaceutical preparations having effect against high blood pressure containing these compounds as active substance