CY2012A - Medicaments for treating gastrointestinal disorders - Google Patents

Medicaments for treating gastrointestinal disorders Download PDF

Info

Publication number: CY2012A
Authority: CY; Cyprus
Prior art keywords: metronidazole; tetracyclin; gastrointestinal disorders; bismuth citrate; treating
Prior art date: 1991-09-20

Application number

CY201298A

Other languages

English (en)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-20

Filing date

1998-02-20

Publication date

1998-02-20

1998-02-20 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1998-02-20 Publication of CY2012A publication Critical patent/CY2012A/en

Links

208000018522 Gastrointestinal disease Diseases 0.000 title claims abstract description 16
239000003814 drug Substances 0.000 title claims description 5
XAUTYMZTJWXZHZ-IGUOPLJTSA-K bismuth;(e)-1-n'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-n-methyl-2-nitroethene-1,1-diamine;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Bi+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 XAUTYMZTJWXZHZ-IGUOPLJTSA-K 0.000 claims abstract description 43
229960004696 ranitidine bismuth citrate Drugs 0.000 claims abstract description 43
239000003242 anti bacterial agent Substances 0.000 claims abstract description 28
229940088710 antibiotic agent Drugs 0.000 claims abstract description 28
230000002401 inhibitory effect Effects 0.000 claims abstract description 11
238000000034 method Methods 0.000 claims abstract description 9
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
238000002360 preparation method Methods 0.000 claims abstract description 7
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 22
229960000282 metronidazole Drugs 0.000 claims description 21
239000000203 mixture Substances 0.000 claims description 16
229930101283 tetracycline Natural products 0.000 claims description 16
229960003022 amoxicillin Drugs 0.000 claims description 12
LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 12
150000001875 compounds Chemical class 0.000 claims description 12
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 12
241000589989 Helicobacter Species 0.000 claims description 8
229960002626 clarithromycin Drugs 0.000 claims description 7
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims description 7
239000000546 pharmaceutical excipient Substances 0.000 claims description 6
229960001668 cefuroxime Drugs 0.000 claims description 5
JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 claims description 5
KEJCWVGMRLCZQQ-YJBYXUATSA-N Cefuroxime axetil Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(=O)OC(C)OC(C)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 KEJCWVGMRLCZQQ-YJBYXUATSA-N 0.000 claims description 4
229960002620 cefuroxime axetil Drugs 0.000 claims description 4
241001465754 Metazoa Species 0.000 claims description 2
229940087281 cefuroxime and metronidazole Drugs 0.000 claims description 2
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OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 claims 6
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NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 10
239000003795 chemical substances by application Substances 0.000 description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
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VMXUWOKSQNHOCA-UKTHLTGXSA-N ranitidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-UKTHLTGXSA-N 0.000 description 4
241000590006 Helicobacter mustelae Species 0.000 description 3
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239000004480 active ingredient Substances 0.000 description 3
229910052797 bismuth Inorganic materials 0.000 description 3
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KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000011260 co-administration Methods 0.000 description 3
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
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MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
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JFUIHGAGFMFNRD-UHFFFAOYSA-N fica Chemical group FC1=CC=C2NC(C(=O)NCCS)=CC2=C1 JFUIHGAGFMFNRD-UHFFFAOYSA-N 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 1
WKJGTOYAEQDNIA-IOOZKYRYSA-N (6r,7r)-7-[[(2r)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate Chemical compound O.C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 WKJGTOYAEQDNIA-IOOZKYRYSA-N 0.000 description 1
KKMOSYLWYLMHAL-UHFFFAOYSA-N 2-bromo-6-nitroaniline Chemical compound NC1=C(Br)C=CC=C1[N+]([O-])=O KKMOSYLWYLMHAL-UHFFFAOYSA-N 0.000 description 1
YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 1
HETSDWRDICBRSQ-UHFFFAOYSA-N 3h-quinolin-4-one Chemical class C1=CC=C2C(=O)CC=NC2=C1 HETSDWRDICBRSQ-UHFFFAOYSA-N 0.000 description 1
GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 description 1
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229930189077 Rifamycin Natural products 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
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229920002472 Starch Polymers 0.000 description 1
208000007107 Stomach Ulcer Diseases 0.000 description 1
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WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
HJLSLZFTEKNLFI-UHFFFAOYSA-N Tinidazole Chemical compound CCS(=O)(=O)CCN1C(C)=NC=C1[N+]([O-])=O HJLSLZFTEKNLFI-UHFFFAOYSA-N 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
229940032147 starch Drugs 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
230000001629 suppression Effects 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
229960005053 tinidazole Drugs 0.000 description 1
230000036269 ulceration Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CY201298A 1991-09-20 1998-02-20 Medicaments for treating gastrointestinal disorders CY2012A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919120131A GB9120131D0 (en)	1991-09-20	1991-09-20	Medicaments

Publications (1)

Publication Number	Publication Date
CY2012A true CY2012A (en)	1998-02-20

Family

ID=10701750

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY201298A CY2012A (en)	1991-09-20	1998-02-20	Medicaments for treating gastrointestinal disorders

Country Status (26)

Country	Link
US (3)	US5674858A (fr)
EP (1)	EP0533281B1 (fr)
JP (1)	JPH0692850A (fr)
KR (1)	KR100257367B1 (fr)
AT (2)	ATE228835T1 (fr)
BE (1)	BE1005808A5 (fr)
CA (1)	CA2078579A1 (fr)
CH (1)	CH685372A5 (fr)
CY (1)	CY2012A (fr)
CZ (1)	CZ282840B6 (fr)
DE (1)	DE69232864T2 (fr)
ES (1)	ES2188582T3 (fr)
FR (1)	FR2682040B1 (fr)
GB (2)	GB9120131D0 (fr)
HK (1)	HK78197A (fr)
HU (1)	HU211170A9 (fr)
IE (1)	IE922673A1 (fr)
IL (1)	IL103213A (fr)
IT (1)	IT1262993B (fr)
MX (1)	MX9205313A (fr)
NO (1)	NO301456B1 (fr)
NZ (1)	NZ244390A (fr)
PT (1)	PT533281E (fr)
RU (1)	RU2116071C1 (fr)
SK (1)	SK280283B6 (fr)
ZA (1)	ZA927157B (fr)

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WO1990005315A1 (fr) *	1988-10-31	1990-05-17	Sumitomo Cement Co., Ltd.	Articles antireflet, procede de production et preparation servant de revetement
WO1994028898A1 (fr) *	1993-06-15	1994-12-22	Pfizer Inc.	Antagonistes d'h2 utilises comme stimulants immunitaires pour traiter des infections bacteriennes chez le betail ou les cochons
EP0995447A1 (fr) *	1993-09-09	2000-04-26	Takeda Chemical Industries, Ltd.	Formulation comprenant un agent antibactérien et un agent antiulcère
TW420610B (en) *	1994-04-07	2001-02-01	Pfizer	A pharmaceutical composition for treating a H. pylori infection or gastric or duodenal ulcers
CA2189001A1 (fr) *	1994-04-26	1995-11-02	Nobuhiro Narita	Composition medicinale servant de medicament contre le cancer bronchopulmonaire "non a petites cellules"
GB9501560D0 (en) *	1995-01-26	1995-03-15	Nycomed Imaging As	Contrast agents
JPH10512877A (ja) *	1995-01-26	1998-12-08	ニコムドイメージングエイ／エス	ビスマス化合物
US5981522A (en) *	1995-09-01	1999-11-09	Kaneka Corporation	Treatment of disease caused by infection of Helicobacter
KR970032861A (ko) *	1995-12-29	1997-07-22	김준웅	헬리코박터 피로리 제거용 약제 투여방법
US5900410A (en) *	1996-08-27	1999-05-04	Hartmann; John F.	Monotherapy of peptic ulcers and gastritis
DE19709897A1 (de) *	1997-03-11	1998-09-17	Hoechst Ag	Wismutsalze von Antibiotika der Moenomycin-Gruppe, Verfahren zu ihrer Herstellung, ihre Verwendung und solche Salze enthaltende Arzneimittel
US6017950A (en)	1997-08-05	2000-01-25	Millennium Pharmaceuticals, Inc.	Methods for controlling gram negative bacteria in mammals
IT1296980B1 (it) *	1997-12-17	1999-08-03	Istituto Pirri S R L	Capsula doppia come forma farmaceutica per la somministrazione di principi attivi in terapie multiple
WO2000066174A2 (fr) *	1999-04-29	2000-11-09	Russinsky Limited	Composes
WO2001064224A1 (fr) *	2000-02-29	2001-09-07	Teva Pharmaceutical Industries Ltd.	Procedes de preparation de la clarithromycine et d'un intermediaire de la clarithromycine, notamment la clarithromycine exempte d'oxime, et composition pharmaceutique correspondante
RU2207115C1 (ru) *	2001-12-27	2003-06-27	Закрытое акционерное общество "Брынцалов-А"	Противомикробное средство тариферид
US7670612B2 (en)	2002-04-10	2010-03-02	Innercap Technologies, Inc.	Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
BRPI0408442A (pt)	2003-03-17	2006-04-04	Japan Tobacco Inc	método para aumento da biodisponibilidade oral de s-[2-([[1-(2-etilbutil)ciclohexil]carbonil]amino)fenil]2- metilpropanotioato
US20060194748A1 (en) *	2005-02-28	2006-08-31	National University Corporation Nagoya University	Methods for treating disorders induced by H. pylori infections and pharmaceutical compositions for the same
CA2886042C (fr)	2012-09-28	2015-11-24	Santen Pharmaceutical Co., Ltd.	Agent therapeutique ou preventif pour le dysfonctionnement de la glande de meibomius ou le blocage de la glande de meibomius
US10201518B2 (en)	2016-09-28	2019-02-12	The University Of Hong Kong	Bismuth(III) compounds and methods thereof
US11890295B2 (en)	2018-08-31	2024-02-06	Korea Institute Of Geoscience And Mineral Resources	Helicobacter pylori eradication method including step for orally administering composition including complex of non-absorbable antibiotic and clay mineral to subject

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GB772567A (en) *	1954-05-06	1957-04-17	Siegfried Fischl	Preparation of stable, injectable bismuth-containing pharmaceutical compositions and the compositions formed thereby
WO1986005981A1 (fr) *	1985-04-18	1986-10-23	Borody Thomas J	Traitement de la dyspepsie non ulcereuse avec des sels de bismuth
US5256684A (en) *	1985-06-13	1993-10-26	The Procter & Gamble Company	Methods and compositions for the treatment of gastrointestinal disorders
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IL85472A (en) *	1987-03-09	1991-06-30	Procter & Gamble	Pharmaceutical compositions for treating gastrointestinal disorders
JP2733849B2 (ja) *	1987-10-12	1998-03-30	ボロディー，ソーマス・ユリウス	胃腸障害治療のための改良された方法
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FI910088A7 (fi) *	1990-01-09	1991-07-10	Brocades Pharma Bv	Oraalinen farmaseuttinen koostumus
YU45590A (sh) *	1990-03-07	1992-07-20	PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o.	Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
GB9019875D0 (en) *	1990-09-11	1990-10-24	Glaxo Group Ltd	Pharmaceutical compositions
WO1992010302A1 (fr) *	1990-12-04	1992-06-25	Mueller Werner	Systeme d'irrigation pour sols de maneges d'equitation, serres chaudes ou analogue
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1991
- 1991-09-20 GB GB919120131A patent/GB9120131D0/en active Pending
1992
- 1992-09-16 PT PT92202832T patent/PT533281E/pt unknown
- 1992-09-16 AT AT92202832T patent/ATE228835T1/de not_active IP Right Cessation
- 1992-09-16 ES ES92202832T patent/ES2188582T3/es not_active Expired - Lifetime
- 1992-09-16 DE DE69232864T patent/DE69232864T2/de not_active Expired - Fee Related
- 1992-09-16 EP EP92202832A patent/EP0533281B1/fr not_active Expired - Lifetime
- 1992-09-18 IT ITRM920681A patent/IT1262993B/it active IP Right Grant
- 1992-09-18 CA CA002078579A patent/CA2078579A1/fr not_active Abandoned
- 1992-09-18 CZ CS922878A patent/CZ282840B6/cs not_active IP Right Cessation
- 1992-09-18 NZ NZ244390A patent/NZ244390A/en unknown
- 1992-09-18 KR KR1019920017020A patent/KR100257367B1/ko not_active Expired - Fee Related
- 1992-09-18 JP JP4275092A patent/JPH0692850A/ja active Pending
- 1992-09-18 NO NO923643A patent/NO301456B1/no not_active IP Right Cessation
- 1992-09-18 GB GB9219749A patent/GB2259647B/en not_active Expired - Fee Related
- 1992-09-18 IE IE267392A patent/IE922673A1/en unknown
- 1992-09-18 AT AT0186692A patent/AT403656B/de not_active IP Right Cessation
- 1992-09-18 SK SK2878-92A patent/SK280283B6/sk not_active IP Right Cessation
- 1992-09-18 CH CH2942/92A patent/CH685372A5/fr not_active IP Right Cessation
- 1992-09-18 RU SU5052864A patent/RU2116071C1/ru active
- 1992-09-18 FR FR9211167A patent/FR2682040B1/fr not_active Expired - Fee Related
- 1992-09-18 ZA ZA927157A patent/ZA927157B/xx unknown
- 1992-09-18 MX MX9205313A patent/MX9205313A/es active IP Right Grant
- 1992-09-18 IL IL10321392A patent/IL103213A/xx not_active IP Right Cessation
- 1992-09-18 BE BE9200815A patent/BE1005808A5/fr not_active IP Right Cessation
1995
- 1995-06-02 HU HU95P/P00153P patent/HU211170A9/hu unknown
- 1995-06-05 US US08/462,586 patent/US5674858A/en not_active Expired - Fee Related
- 1995-06-05 US US08/462,583 patent/US5668130A/en not_active Expired - Lifetime
- 1995-06-05 US US08/462,584 patent/US5629297A/en not_active Expired - Lifetime
1997
- 1997-06-12 HK HK78197A patent/HK78197A/xx not_active IP Right Cessation
1998
- 1998-02-20 CY CY201298A patent/CY2012A/en unknown

Also Published As

Publication number	Publication date
HU211170A9 (en)	1995-11-28
FR2682040B1 (fr)	1994-10-28
IT1262993B (it)	1996-07-23
FR2682040A1 (fr)	1993-04-09
GB2259647A (en)	1993-03-24
EP0533281A1 (fr)	1993-03-24
NO301456B1 (no)	1997-11-03
ITRM920681A1 (it)	1994-03-18
EP0533281B1 (fr)	2002-12-04
ITRM920681A0 (it)	1992-09-18
GB9219749D0 (en)	1992-10-28
IL103213A0 (en)	1993-02-21
PT533281E (pt)	2003-04-30
KR100257367B1 (ko)	2000-05-15
US5674858A (en)	1997-10-07
ES2188582T3 (es)	2003-07-01
HK78197A (en)	1997-06-20
DE69232864T2 (de)	2003-11-20
US5668130A (en)	1997-09-16
ZA927157B (en)	1993-06-15
GB2259647B (en)	1995-11-29
US5629297A (en)	1997-05-13
IL103213A (en)	2000-02-29
ATE228835T1 (de)	2002-12-15
CZ287892A3 (en)	1993-12-15
AU663520B2 (en)	1995-10-12
AU2458492A (en)	1993-03-25
CZ282840B6 (cs)	1997-10-15
ATA186692A (de)	1997-09-15
MX9205313A (es)	1993-04-01
CA2078579A1 (fr)	1993-03-21
DE69232864D1 (de)	2003-01-16
AT403656B (de)	1998-04-27
KR930005619A (ko)	1993-04-20
BE1005808A5 (fr)	1994-02-01
NO923643L (no)	1993-03-22
NO923643D0 (no)	1992-09-18
RU2116071C1 (ru)	1998-07-27
GB9120131D0 (en)	1991-11-06
SK280283B6 (sk)	1999-11-08
NZ244390A (en)	1997-06-24
SK287892A3 (en)	1995-06-07
JPH0692850A (ja)	1994-04-05
CH685372A5 (fr)	1995-06-30
IE922673A1 (en)	1993-03-24

Publication	Publication Date	Title
US5629297A (en)	1997-05-13	Medicament for treating gastrointestinal disorders
US5883074A (en)	1999-03-16	Potentiators of antibacterial agents
US20120283175A1 (en)	2012-11-08	Antibacterial compositions
EP0550083B1 (fr)	1999-03-24	Médicaments pour le traitement de conditions inflammatoires ou pour l'analgésie contenants un NSAID et du citrate de bismuth-ranitidine
US5843987A (en)	1998-12-01	Method of stimulating gastrointestinal motility with ellagic acid
EP0282131A2 (fr)	1988-09-14	Composés et procédés de traitement d'affections gastro-intestinales
EP0680322B1 (fr)	2000-07-05	Utilisation de clavulanate et un antibiotique pour le traitement d'infections
CN103826639A (zh)	2014-05-28	包含头孢菌素和β-内酰胺酶抑制剂的组合的抗生素
KR20260022303A (ko)	2026-02-19	항박테리아제들을 포함하는 약학적 조합 및 이의 조성물
JPH08512321A (ja)	1996-12-24	Ｈ▲下２▼拮抗剤−アルギネート−制酸剤の組合せ物
EP2916653A1 (fr)	2015-09-16	Méthodes antibiotiques et compositions d'antibiotique pour des infections bactériennes
US20030109503A1 (en)	2003-06-12	Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
KR20010024050A (ko)	2001-03-26	항균제
US20060235076A1 (en)	2006-10-19	Medicinal composition for treating infection with drug-resistant staphylococcus aureus
GB1577545A (en)	1980-10-22	Treatment of swine dysenter
EP0384410B1 (fr)	1995-05-17	Composition anti-microbienne
JP2002029966A (ja)	2002-01-29	抗ヘリコバクター・ピロリ剤
JPWO1999052530A1 (ja)	2001-05-15	抗菌剤