CZ20191998A3 - Způsob selektivní ochrany derivátů baccatinu a jeho použití při syntéze taxanů - Google Patents

Způsob selektivní ochrany derivátů baccatinu a jeho použití při syntéze taxanů

Info

Publication number: CZ20191998A3
Authority: CZ; Czechia
Prior art keywords: taxan; synthesis; application; selective protection; baccatin derivatives
Prior art date: 1995-12-27

Application number

CZ982019A

Other languages

English (en)

Inventor

Luc Chanteloup

Bruno Chauveau

Christine Corbin

Robert Dhal

Guen Sonia Le

Arnaud Lamy

Antoine Leze

Jean-Pierre Robin

Original Assignee

Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-27

Publication date

1998-09-16

1996-12-27 Application filed by Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm filed Critical Societe D'etude Et De Recherche En Ingenierie Pharmaceutique Seripharm

1998-09-16 Publication of CZ20191998A3 publication Critical patent/CZ20191998A3/cs

Links

238000000034 method Methods 0.000 title abstract 3
229930190007 Baccatin Natural products 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2
-1 2,2,2-trichloroethoxycarbonyl Chemical group 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
238000007068 beta-elimination reaction Methods 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

CZ982019A 1995-12-27 1996-12-27 Způsob selektivní ochrany derivátů baccatinu a jeho použití při syntéze taxanů CZ20191998A3 (cs)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9515557A FR2743074B1 (fr)	1995-12-27	1995-12-27	Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes

Publications (1)

Publication Number	Publication Date
CZ20191998A3 true CZ20191998A3 (cs)	1998-09-16

Family

ID=9486008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ982019A CZ20191998A3 (cs)	1995-12-27	1996-12-27	Způsob selektivní ochrany derivátů baccatinu a jeho použití při syntéze taxanů

Country Status (25)

Country	Link
US (1)	US6180802B1 (cs)
EP (1)	EP0889885B1 (cs)
JP (1)	JP4068663B2 (cs)
KR (1)	KR100510017B1 (cs)
CN (3)	CN1243745C (cs)
AT (1)	ATE218133T1 (cs)
AU (1)	AU716876B2 (cs)
BR (1)	BR9612242A (cs)
CA (1)	CA2238889C (cs)
CZ (1)	CZ20191998A3 (cs)
DE (1)	DE69621463T2 (cs)
DK (1)	DK0889885T3 (cs)
ES (1)	ES2177825T3 (cs)
FR (1)	FR2743074B1 (cs)
HK (2)	HK1044765B (cs)
HU (1)	HUP0000508A3 (cs)
IL (2)	IL125049A (cs)
NO (1)	NO982719L (cs)
NZ (1)	NZ325323A (cs)
PL (1)	PL327581A1 (cs)
PT (1)	PT889885E (cs)
RU (1)	RU2162844C2 (cs)
SK (1)	SK88498A3 (cs)
TR (1)	TR199801232T2 (cs)
WO (1)	WO1997024345A1 (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0875508T3 (da) *	1997-05-02	2004-01-26	Pharmachemie Bv	Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
RU2437875C2 (ru) *	2006-03-21	2011-12-27	Др. Редди'С Лабораторис Лтд.	Полиморфы доцетаксела и способы их получения
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
CN101835769A (zh) *	2007-08-22	2010-09-15	6570763加拿大有限公司	将9-二氢-13-乙酰基浆果赤霉素ⅲ转化为多烯紫杉醇或太平洋紫杉醇的方法
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN115260130A (zh) *	2022-07-07	2022-11-01	上海卓鼎生物技术有限公司	一种10-脱乙酰基紫杉醇的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr)	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
RU2017724C1 (ru) *	1990-07-12	1994-08-15	Дзе Юниверсити оф Канзас	Способ получения производных таксола
IL127598A (en) *	1994-01-28	2003-04-10	Upjohn Co	Process for preparing isotaxol analogs

1995
- 1995-12-27 FR FR9515557A patent/FR2743074B1/fr not_active Expired - Fee Related
1996
- 1996-12-27 EP EP96944097A patent/EP0889885B1/fr not_active Expired - Lifetime
- 1996-12-27 ES ES96944097T patent/ES2177825T3/es not_active Expired - Lifetime
- 1996-12-27 WO PCT/FR1996/002097 patent/WO1997024345A1/fr not_active Ceased
- 1996-12-27 AT AT96944097T patent/ATE218133T1/de not_active IP Right Cessation
- 1996-12-27 KR KR10-1998-0704853A patent/KR100510017B1/ko not_active Expired - Fee Related
- 1996-12-27 DK DK96944097T patent/DK0889885T3/da active
- 1996-12-27 CN CNB011409983A patent/CN1243745C/zh not_active Expired - Fee Related
- 1996-12-27 IL IL12504996A patent/IL125049A/xx not_active IP Right Cessation
- 1996-12-27 CZ CZ982019A patent/CZ20191998A3/cs unknown
- 1996-12-27 TR TR1998/01232T patent/TR199801232T2/xx unknown
- 1996-12-27 AU AU13815/97A patent/AU716876B2/en not_active Ceased
- 1996-12-27 SK SK884-98A patent/SK88498A3/sk unknown
- 1996-12-27 RU RU98113957/04A patent/RU2162844C2/ru not_active IP Right Cessation
- 1996-12-27 HU HU0000508A patent/HUP0000508A3/hu not_active Application Discontinuation
- 1996-12-27 CA CA002238889A patent/CA2238889C/fr not_active Expired - Fee Related
- 1996-12-27 CN CNB011409991A patent/CN1244567C/zh not_active Expired - Fee Related
- 1996-12-27 PT PT96944097T patent/PT889885E/pt unknown
- 1996-12-27 NZ NZ325323A patent/NZ325323A/xx unknown
- 1996-12-27 US US09/077,099 patent/US6180802B1/en not_active Expired - Fee Related
- 1996-12-27 CN CN96199356A patent/CN1090625C/zh not_active Expired - Fee Related
- 1996-12-27 BR BR9612242A patent/BR9612242A/pt not_active Application Discontinuation
- 1996-12-27 DE DE69621463T patent/DE69621463T2/de not_active Expired - Lifetime
- 1996-12-27 JP JP52408197A patent/JP4068663B2/ja not_active Expired - Fee Related
- 1996-12-27 PL PL96327581A patent/PL327581A1/xx unknown
1998
- 1998-06-12 NO NO982719A patent/NO982719L/no unknown
2000
- 2000-09-28 IL IL138769A patent/IL138769A/en not_active IP Right Cessation
2002
- 2002-08-20 HK HK02106058.4A patent/HK1044765B/zh not_active IP Right Cessation
- 2002-11-29 HK HK02108638.9A patent/HK1047099B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL138769A (en)	2006-04-10
HUP0000508A3 (en)	2001-05-28
RU2162844C2 (ru)	2001-02-10
US6180802B1 (en)	2001-01-30
HK1047099A1 (en)	2003-02-07
AU716876B2 (en)	2000-03-09
NZ325323A (en)	1999-11-29
SK88498A3 (en)	1998-11-04
AU1381597A (en)	1997-07-28
DE69621463D1 (de)	2002-07-04
NO982719D0 (no)	1998-06-12
IL125049A (en)	2003-10-31
JP4068663B2 (ja)	2008-03-26
FR2743074B1 (fr)	1998-03-27
CN1244567C (zh)	2006-03-08
HK1047099B (zh)	2006-09-29
CN1356326A (zh)	2002-07-03
KR19990076733A (ko)	1999-10-15
CN1206412A (zh)	1999-01-27
ES2177825T3 (es)	2002-12-16
PL327581A1 (en)	1998-12-21
ATE218133T1 (de)	2002-06-15
FR2743074A1 (fr)	1997-07-04
DK0889885T3 (da)	2002-09-16
KR100510017B1 (ko)	2005-12-16
DE69621463T2 (de)	2002-11-28
HK1044765B (zh)	2006-09-29
TR199801232T2 (xx)	1998-09-21
CN1356325A (zh)	2002-07-03
CA2238889C (fr)	2008-06-10
CN1090625C (zh)	2002-09-11
HK1044765A1 (en)	2002-11-01
HUP0000508A2 (en)	2000-07-28
BR9612242A (pt)	1999-07-13
CN1243745C (zh)	2006-03-01
NO982719L (no)	1998-06-12
IL125049A0 (en)	1999-01-26
CA2238889A1 (fr)	1997-07-10
WO1997024345A1 (fr)	1997-07-10
EP0889885A1 (fr)	1999-01-13
JP2000502696A (ja)	2000-03-07
PT889885E (pt)	2002-10-31
EP0889885B1 (fr)	2002-05-29

Publication	Publication Date	Title
AU591310B2 (en)	1989-11-30	Process for the preparation of taxol and 10-deacetyltaxol
DK0863887T3 (da)	2002-04-22	Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstilling
FR2703049B1 (fr)	1995-04-21	Procédé de purification des taxoïdes.
MX9707706A (es)	1997-12-31	Compuestos intermediarios novedosos y proceso para la manufactura de derivados de la camptotecina (cpt-11) y compuestos relacionados.
HU9601857D0 (en)	1996-08-28	New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
CA2279960A1 (en)	1998-08-06	Synthesis of terfenadine and derivatives
BR0007643A (pt)	2001-10-16	Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina
IL125049A (en)	2003-10-31	Method for selective protection of baccatin derivatives and its application to taxane synthesis
MX9604466A (es)	1997-07-31	Proceso de preparacion de 7-trialquilsilil-baccatina iii.
ATE266015T1 (de)	2004-05-15	Verfahren zur herstellung eines c-4- methylcarbonat-analogons von paclitaxel
NO20002600D0 (no)	2000-05-19	Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
NO974155L (no)	1997-11-07	Ny fremgangsmåte for fremstilling av 2,3-dihydrobenzofuranolderivater
IL145869A0 (en)	2002-07-25	A process for the production of paclitaxel and novel paclitaxel derivatives
BG104073A (en)	2001-05-31	Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds
WO2000003681A3 (en)	2000-04-20	Process for the synthesis of benzopyran derivatives
DK0842924T3 (da)	2003-12-08	Pyridine intermediates, useful in the synthesis ofbeta-adrenergic receptor agonists
DE69629112D1 (de)	2003-08-21	Verfahren zur synthese von phosphororganischen verbindungen
NZ332245A (en)	2000-03-27	Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
YU71400A (sh)	2003-04-30	Poboljšani postupak za pripremanje farmaceutski dragocenih derivata norbenzomorfana
KR0150337B1 (en)	1998-10-15	A method for isolating taxol from taxus genus plant by chromatography
TW350842B (en)	1999-01-21	Novel process for the preparation of form I ranitidine hydrochloride
TW200420553A (en)	2004-10-16	Process for the synthesis of 3, 3a, 6, 6a-tetrahydro-2H-cyclopentan[b]furan-2-one