DK0889885T3 - Fremgangsmåde til selektiv beskyttelse af baccatinderivater og anvendelse deraf ved syntese af taxaner - Google Patents

Fremgangsmåde til selektiv beskyttelse af baccatinderivater og anvendelse deraf ved syntese af taxaner

Info

Publication number: DK0889885T3
Authority: DK; Denmark
Prior art keywords: taxanes; synthesis; selective protection; baccatin derivatives; derivatives
Prior art date: 1995-12-27

Application number

DK96944097T

Other languages

Danish (da)

English (en)

Inventor

Luc Chanteloup

Bruno Chauveau

Christine Corbin

Robert Dhal

Guen Sonia Le

Arnaud Lamy

Antoine Leze

Jean-Pierre Robin

Original Assignee

Seripharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-27

Publication date

2002-09-16

1996-12-27 Application filed by Seripharm filed Critical Seripharm

2002-09-16 Application granted granted Critical

2002-09-16 Publication of DK0889885T3 publication Critical patent/DK0889885T3/da

Links

238000000034 method Methods 0.000 title abstract 3
229930190007 Baccatin Natural products 0.000 title 1
229940123237 Taxane Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000000543 intermediate Substances 0.000 abstract 2
-1 2,2,2-trichloroethoxycarbonyl Chemical group 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
238000007068 beta-elimination reaction Methods 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK96944097T 1995-12-27 1996-12-27 Fremgangsmåde til selektiv beskyttelse af baccatinderivater og anvendelse deraf ved syntese af taxaner DK0889885T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9515557A FR2743074B1 (fr)	1995-12-27	1995-12-27	Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes
PCT/FR1996/002097 WO1997024345A1 (fr)	1995-12-27	1996-12-27	Procede de protection selective des derives de la baccatine et son utilisation dans la synthese des taxanes

Publications (1)

Publication Number	Publication Date
DK0889885T3 true DK0889885T3 (da)	2002-09-16

Family

ID=9486008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96944097T DK0889885T3 (da)	1995-12-27	1996-12-27	Fremgangsmåde til selektiv beskyttelse af baccatinderivater og anvendelse deraf ved syntese af taxaner

Country Status (25)

Country	Link
US (1)	US6180802B1 (cs)
EP (1)	EP0889885B1 (cs)
JP (1)	JP4068663B2 (cs)
KR (1)	KR100510017B1 (cs)
CN (3)	CN1243745C (cs)
AT (1)	ATE218133T1 (cs)
AU (1)	AU716876B2 (cs)
BR (1)	BR9612242A (cs)
CA (1)	CA2238889C (cs)
CZ (1)	CZ20191998A3 (cs)
DE (1)	DE69621463T2 (cs)
DK (1)	DK0889885T3 (cs)
ES (1)	ES2177825T3 (cs)
FR (1)	FR2743074B1 (cs)
HK (2)	HK1044765B (cs)
HU (1)	HUP0000508A3 (cs)
IL (2)	IL125049A (cs)
NO (1)	NO982719L (cs)
NZ (1)	NZ325323A (cs)
PL (1)	PL327581A1 (cs)
PT (1)	PT889885E (cs)
RU (1)	RU2162844C2 (cs)
SK (1)	SK88498A3 (cs)
TR (1)	TR199801232T2 (cs)
WO (1)	WO1997024345A1 (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0875508T3 (da) *	1997-05-02	2004-01-26	Pharmachemie Bv	Fremgangsmåde til fremstilling af baccatin lll og derivater ud fra 10-deacetylbaccatin lll
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
RU2437875C2 (ru) *	2006-03-21	2011-12-27	Др. Редди'С Лабораторис Лтд.	Полиморфы доцетаксела и способы их получения
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
CN101835769A (zh) *	2007-08-22	2010-09-15	6570763加拿大有限公司	将9-二氢-13-乙酰基浆果赤霉素ⅲ转化为多烯紫杉醇或太平洋紫杉醇的方法
PL388144A1 (pl)	2009-05-29	2010-12-06	Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością	Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN115260130A (zh) *	2022-07-07	2022-11-01	上海卓鼎生物技术有限公司	一种10-脱乙酰基紫杉醇的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr)	1986-07-17	1988-09-23	Rhone Poulenc Sante	Procede de preparation du taxol et du desacetyl-10 taxol
RU2017724C1 (ru) *	1990-07-12	1994-08-15	Дзе Юниверсити оф Канзас	Способ получения производных таксола
IL127598A (en) *	1994-01-28	2003-04-10	Upjohn Co	Process for preparing isotaxol analogs

1995
- 1995-12-27 FR FR9515557A patent/FR2743074B1/fr not_active Expired - Fee Related
1996
- 1996-12-27 EP EP96944097A patent/EP0889885B1/fr not_active Expired - Lifetime
- 1996-12-27 ES ES96944097T patent/ES2177825T3/es not_active Expired - Lifetime
- 1996-12-27 WO PCT/FR1996/002097 patent/WO1997024345A1/fr not_active Ceased
- 1996-12-27 AT AT96944097T patent/ATE218133T1/de not_active IP Right Cessation
- 1996-12-27 KR KR10-1998-0704853A patent/KR100510017B1/ko not_active Expired - Fee Related
- 1996-12-27 DK DK96944097T patent/DK0889885T3/da active
- 1996-12-27 CN CNB011409983A patent/CN1243745C/zh not_active Expired - Fee Related
- 1996-12-27 IL IL12504996A patent/IL125049A/xx not_active IP Right Cessation
- 1996-12-27 CZ CZ982019A patent/CZ20191998A3/cs unknown
- 1996-12-27 TR TR1998/01232T patent/TR199801232T2/xx unknown
- 1996-12-27 AU AU13815/97A patent/AU716876B2/en not_active Ceased
- 1996-12-27 SK SK884-98A patent/SK88498A3/sk unknown
- 1996-12-27 RU RU98113957/04A patent/RU2162844C2/ru not_active IP Right Cessation
- 1996-12-27 HU HU0000508A patent/HUP0000508A3/hu not_active Application Discontinuation
- 1996-12-27 CA CA002238889A patent/CA2238889C/fr not_active Expired - Fee Related
- 1996-12-27 CN CNB011409991A patent/CN1244567C/zh not_active Expired - Fee Related
- 1996-12-27 PT PT96944097T patent/PT889885E/pt unknown
- 1996-12-27 NZ NZ325323A patent/NZ325323A/xx unknown
- 1996-12-27 US US09/077,099 patent/US6180802B1/en not_active Expired - Fee Related
- 1996-12-27 CN CN96199356A patent/CN1090625C/zh not_active Expired - Fee Related
- 1996-12-27 BR BR9612242A patent/BR9612242A/pt not_active Application Discontinuation
- 1996-12-27 DE DE69621463T patent/DE69621463T2/de not_active Expired - Lifetime
- 1996-12-27 JP JP52408197A patent/JP4068663B2/ja not_active Expired - Fee Related
- 1996-12-27 PL PL96327581A patent/PL327581A1/xx unknown
1998
- 1998-06-12 NO NO982719A patent/NO982719L/no unknown
2000
- 2000-09-28 IL IL138769A patent/IL138769A/en not_active IP Right Cessation
2002
- 2002-08-20 HK HK02106058.4A patent/HK1044765B/zh not_active IP Right Cessation
- 2002-11-29 HK HK02108638.9A patent/HK1047099B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL138769A (en)	2006-04-10
HUP0000508A3 (en)	2001-05-28
RU2162844C2 (ru)	2001-02-10
US6180802B1 (en)	2001-01-30
HK1047099A1 (en)	2003-02-07
AU716876B2 (en)	2000-03-09
NZ325323A (en)	1999-11-29
SK88498A3 (en)	1998-11-04
AU1381597A (en)	1997-07-28
DE69621463D1 (de)	2002-07-04
NO982719D0 (no)	1998-06-12
IL125049A (en)	2003-10-31
JP4068663B2 (ja)	2008-03-26
FR2743074B1 (fr)	1998-03-27
CN1244567C (zh)	2006-03-08
HK1047099B (zh)	2006-09-29
CN1356326A (zh)	2002-07-03
KR19990076733A (ko)	1999-10-15
CN1206412A (zh)	1999-01-27
CZ20191998A3 (cs)	1998-09-16
ES2177825T3 (es)	2002-12-16
PL327581A1 (en)	1998-12-21
ATE218133T1 (de)	2002-06-15
FR2743074A1 (fr)	1997-07-04
KR100510017B1 (ko)	2005-12-16
DE69621463T2 (de)	2002-11-28
HK1044765B (zh)	2006-09-29
TR199801232T2 (xx)	1998-09-21
CN1356325A (zh)	2002-07-03
CA2238889C (fr)	2008-06-10
CN1090625C (zh)	2002-09-11
HK1044765A1 (en)	2002-11-01
HUP0000508A2 (en)	2000-07-28
BR9612242A (pt)	1999-07-13
CN1243745C (zh)	2006-03-01
NO982719L (no)	1998-06-12
IL125049A0 (en)	1999-01-26
CA2238889A1 (fr)	1997-07-10
WO1997024345A1 (fr)	1997-07-10
EP0889885A1 (fr)	1999-01-13
JP2000502696A (ja)	2000-03-07
PT889885E (pt)	2002-10-31
EP0889885B1 (fr)	2002-05-29

Publication	Publication Date	Title
AU591310B2 (en)	1989-11-30	Process for the preparation of taxol and 10-deacetyltaxol
DK0863887T3 (da)	2002-04-22	Mellemprodukter til hemisyntese af taxaner og fremgangsmåder til deres fremstilling
FR2703049B1 (fr)	1995-04-21	Procédé de purification des taxoïdes.
FR2696463B1 (fr)	1994-11-25	Procédé d'obtention de la désacétyl-10 baccatine III.
BR0007643A (pt)	2001-10-16	Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina
NO995531L (no)	1999-12-13	Nye mellomprodukter og fremgangsmåte for fremstilling derav
NO982719D0 (no)	1998-06-12	FremgangsmÕte for selektiv beskyttelse av baccatinderivater og dens anvendelse ved syntese av taksaner
MX9604466A (es)	1997-07-31	Proceso de preparacion de 7-trialquilsilil-baccatina iii.
DK1049686T3 (da)	2006-01-16	Nyttige mellemprodukter og fremgangsmåder ved semisyntese af paclitaxel og analoger deraf
DK0805806T3 (da)	2000-05-01	Fremgangsmåde til fremstilling af 4,10-diacetoxy-2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxotax-11-en-13alpha-
DK1206461T3 (da)	2004-08-16	Fremgangsmåde til fremstilling af en paclitaxel C-4-methylcarbonatanalog
NO20001167L (no)	2000-03-07	Fremgangsmõte for fremstilling av dihydroksydifenylkopolykarbonater ved smelteomforestring
DK0912504T3 (da)	2003-01-20	Fremgangsmåde til fremstilling af taxol
BR9916805A (pt)	2001-10-23	Processo para o isolamento de 10-desacetil bacatina iii da parte recuperável de uma planta da espécie taxus
DK0703907T3 (da)	1998-03-23	Fremgangsmåde til fremstilling af terapeutisk aktive taxoider
ES2195378T3 (es)	2003-12-01	Procedimiento para la sintesis de taxanos.
DE602006003204D1 (de)	2008-11-27	Reinigungsverfahren von Moxonidine
DE69724000D1 (de)	2003-09-11	Indan- oder dihydroindol-derivate
CY1110375T1 (el)	2015-04-29	Μεθοδος παρασκευης του 4,10 βητα-διακετοξυ-2-αλφα-βενζοϋλοξυ-5 βητα 20-εποξυ-1,13 αλφα-διυδροξυ-9-οξο-19-νορκυκλοπροπα[g]ταξ-11-ενιου