CZ291075B6 - 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinová sloučenina, způsob její přípravy a farmaceutický prostředek obsahující tuto sloučeninu - Google Patents

4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinová sloučenina, způsob její přípravy a farmaceutický prostředek obsahující tuto sloučeninu Download PDF

Info

Publication number: CZ291075B6
Authority: CZ; Czechia
Prior art keywords: formula; compound; tetrahydropyridine; carbon atoms; group
Prior art date: 1995-06-28

Application number

CZ19974222A

Other languages

Czech (cs)

English (en)

Other versions

CZ422297A3 (cs

Inventor

Domenico Badone

Marco Baroni

Rosanna Cardamone

Jacqueline Fournier

Umberto Guzzi

Alessandra Ielmini

Original Assignee

Sanofi-Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-28

Filing date

1996-06-26

Publication date

2002-12-11

1996-06-26 Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo

1998-04-15 Publication of CZ422297A3 publication Critical patent/CZ422297A3/cs

2001-06-08 Priority to CZ20012051A priority Critical patent/CZ291185B6/cs

2002-12-11 Publication of CZ291075B6 publication Critical patent/CZ291075B6/cs

Links

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150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 14
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239000002253 acid Substances 0.000 claims description 24
239000004480 active ingredient Substances 0.000 claims description 17
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125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
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CNEWKIDCGDXBDE-UHFFFAOYSA-N 1-[2-(4-phenylphenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridine Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=CC(=CC=3)C=3C=CC=CC=3)CC=2)=C1 CNEWKIDCGDXBDE-UHFFFAOYSA-N 0.000 claims description 4
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)

CZ19974222A 1995-06-28 1996-06-26 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinová sloučenina, způsob její přípravy a farmaceutický prostředek obsahující tuto sloučeninu CZ291075B6 (cs)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CZ20012051A CZ291185B6 (cs)	1995-06-28	2001-06-08	Způsob přípravy bifenylových derivátů vhodných pro přípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinů

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9507760A FR2736053B1 (fr)	1995-06-28	1995-06-28	Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines

Publications (2)

Publication Number	Publication Date
CZ422297A3 CZ422297A3 (cs)	1998-04-15
CZ291075B6 true CZ291075B6 (cs)	2002-12-11

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ID=9480466

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CZ19974222A CZ291075B6 (cs)	1995-06-28	1996-06-26	4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinová sloučenina, způsob její přípravy a farmaceutický prostředek obsahující tuto sloučeninu

Country Status (29)

Country	Link
US (1)	US5981754A (da)
EP (2)	EP1216996A3 (da)
JP (2)	JP3147906B2 (da)
KR (1)	KR100460581B1 (da)
CN (1)	CN1153765C (da)
AT (1)	ATE223897T1 (da)
AU (1)	AU715090B2 (da)
BR (1)	BR9608662A (da)
CA (1)	CA2225746C (da)
CY (1)	CY2312B1 (da)
CZ (1)	CZ291075B6 (da)
DE (1)	DE69623631T2 (da)
DK (1)	DK0837848T3 (da)
EE (1)	EE03870B1 (da)
ES (1)	ES2183965T3 (da)
FR (1)	FR2736053B1 (da)
HU (1)	HUP9900055A3 (da)
IL (1)	IL122159A (da)
IS (1)	IS1999B (da)
NO (1)	NO310144B1 (da)
NZ (1)	NZ312723A (da)
PL (2)	PL192353B1 (da)
PT (1)	PT837848E (da)
RU (1)	RU2163237C2 (da)
SK (2)	SK283707B6 (da)
TR (1)	TR199701710T1 (da)
UA (1)	UA62914C2 (da)
WO (1)	WO1997001536A1 (da)
ZA (1)	ZA965527B (da)

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JP4864342B2 (ja) *	2005-04-27	2012-02-01	北興化学工業株式会社	ビアリール化合物の製造方法
CA2621255A1 (en) *	2005-09-21	2007-04-05	Incyte Corporation	Amido compounds and their use as pharmaceuticals
CA2630492C (en) *	2005-12-05	2015-04-14	Incyte Corporation	Spiro-lactam compounds
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1995
- 1995-06-28 FR FR9507760A patent/FR2736053B1/fr not_active Expired - Fee Related
1996
- 1996-06-26 BR BR9608662A patent/BR9608662A/pt not_active IP Right Cessation
- 1996-06-26 US US08/973,712 patent/US5981754A/en not_active Expired - Fee Related
- 1996-06-26 CZ CZ19974222A patent/CZ291075B6/cs not_active IP Right Cessation
- 1996-06-26 JP JP50420697A patent/JP3147906B2/ja not_active Expired - Fee Related
- 1996-06-26 DK DK96924023T patent/DK0837848T3/da active
- 1996-06-26 EP EP02006482A patent/EP1216996A3/fr not_active Withdrawn
- 1996-06-26 CN CNB961950900A patent/CN1153765C/zh not_active Expired - Fee Related
- 1996-06-26 PT PT96924023T patent/PT837848E/pt unknown
- 1996-06-26 DE DE69623631T patent/DE69623631T2/de not_active Expired - Fee Related
- 1996-06-26 EP EP96924023A patent/EP0837848B1/fr not_active Expired - Lifetime
- 1996-06-26 WO PCT/FR1996/000995 patent/WO1997001536A1/fr not_active Ceased
- 1996-06-26 SK SK1781-97A patent/SK283707B6/sk unknown
- 1996-06-26 IL IL12215996A patent/IL122159A/en not_active IP Right Cessation
- 1996-06-26 EE EE9700348A patent/EE03870B1/xx not_active IP Right Cessation
- 1996-06-26 UA UA97126360A patent/UA62914C2/uk unknown
- 1996-06-26 TR TR97/01710T patent/TR199701710T1/xx unknown
- 1996-06-26 HU HU9900055A patent/HUP9900055A3/hu unknown
- 1996-06-26 PL PL357052A patent/PL192353B1/pl not_active IP Right Cessation
- 1996-06-26 RU RU98101492/04A patent/RU2163237C2/ru not_active IP Right Cessation
- 1996-06-26 ES ES96924023T patent/ES2183965T3/es not_active Expired - Lifetime
- 1996-06-26 KR KR1019970709747A patent/KR100460581B1/ko not_active Expired - Fee Related
- 1996-06-26 AU AU64619/96A patent/AU715090B2/en not_active Ceased
- 1996-06-26 AT AT96924023T patent/ATE223897T1/de not_active IP Right Cessation
- 1996-06-26 SK SK593-2003A patent/SK285433B6/sk unknown
- 1996-06-26 CA CA002225746A patent/CA2225746C/en not_active Expired - Fee Related
- 1996-06-26 NZ NZ312723A patent/NZ312723A/en unknown
- 1996-06-26 PL PL96324216A patent/PL187087B1/pl not_active IP Right Cessation
- 1996-06-28 ZA ZA965527A patent/ZA965527B/xx unknown
1997
- 1997-12-23 IS IS4641A patent/IS1999B/is unknown
- 1997-12-23 NO NO19976079A patent/NO310144B1/no unknown
2000
- 2000-07-31 JP JP2000231069A patent/JP3302351B2/ja not_active Expired - Fee Related
2003
- 2003-01-15 CY CY0300004A patent/CY2312B1/xx unknown

Also Published As

Publication number	Publication date
FR2736053A1 (fr)	1997-01-03
JP3302351B2 (ja)	2002-07-15
BR9608662A (pt)	1999-05-04
ES2183965T3 (es)	2003-04-01
DK0837848T3 (da)	2003-01-06
JP2001114763A (ja)	2001-04-24
EE03870B1 (et)	2002-10-15
KR19990028431A (ko)	1999-04-15
DE69623631T2 (de)	2003-08-07
ATE223897T1 (de)	2002-09-15
SK283707B6 (sk)	2003-12-02
SK285433B6 (sk)	2007-01-04
CA2225746A1 (en)	1997-01-16
KR100460581B1 (ko)	2005-04-14
WO1997001536A1 (fr)	1997-01-16
EP1216996A2 (fr)	2002-06-26
HUP9900055A2 (hu)	1999-04-28
JPH11506118A (ja)	1999-06-02
SK178197A3 (en)	1998-07-08
IL122159A0 (en)	1998-04-05
PL187087B1 (pl)	2004-05-31
DE69623631D1 (en)	2002-10-17
FR2736053B1 (fr)	1997-09-19
JP3147906B2 (ja)	2001-03-19
RU2163237C2 (ru)	2001-02-20
PT837848E (pt)	2002-12-31
CN1153765C (zh)	2004-06-16
NO976079D0 (no)	1997-12-23
US5981754A (en)	1999-11-09
IL122159A (en)	2001-06-14
EP0837848A1 (fr)	1998-04-29
IS4641A (is)	1997-12-23
EE9700348A (et)	1998-06-15
TR199701710T1 (xx)	1998-05-21
CZ422297A3 (cs)	1998-04-15
HK1014952A1 (en)	1999-10-08
HUP9900055A3 (en)	1999-11-29
EP0837848B1 (fr)	2002-09-11
UA62914C2 (en)	2004-01-15
MX9710472A (es)	1998-03-31
EP1216996A3 (fr)	2003-10-15
CA2225746C (en)	2004-05-18
PL324216A1 (en)	1998-05-11
PL192353B1 (pl)	2006-10-31
CY2312B1 (en)	2003-11-14
NO976079L (no)	1997-12-23
ZA965527B (en)	1997-01-24
IS1999B (is)	2005-04-15
NZ312723A (en)	1999-10-28
CN1189154A (zh)	1998-07-29
AU6461996A (en)	1997-01-30
AU715090B2 (en)	2000-01-13
NO310144B1 (no)	2001-05-28

Legal Events

Date	Code	Title	Description
2000-06-30	PD00	Pending as of 2000-06-30 in czech republic
2009-01-28	MM4A	Patent lapsed due to non-payment of fee	Effective date: 20080626

Publication	Publication Date	Title
CZ291075B6 (cs)	2002-12-11	4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinová sloučenina, způsob její přípravy a farmaceutický prostředek obsahující tuto sloučeninu
EP0742207B1 (en)	2001-08-29	2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation
EP0374801A2 (en)	1990-06-27	Novel N-sustituted azaheterocyclic carboxylic acids
CZ217495A3 (en)	1996-03-13	2,3-cyclically condensed 1,4-dihydropyridines, process of their preparation, medicaments in which said substances are comprised and their use
EP0215250B1 (en)	1992-12-30	2-substituted-1,4-dihydropyridines, method for their preparation and pharmaceutical compositions containing them
HU228591B1 (hu)	2013-04-29	Etánszulfonil-piperidin-származékok, eljárás elõállításukra és a vegyületeket tartalmazó gyógyászati készítmények
EP0106276B1 (en)	1988-10-26	1,4-dihydropyridine derivatives
KR20000069422A (ko)	2000-11-25	알츠하이머 질환 치료용 1-페닐알킬-1,2,3,6-테트라히드로피리딘
US4405631A (en)	1983-09-20	Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'pyrrolidine] compounds and their use as antihypertensive agents
IE49998B1 (en)	1986-01-22	4-(naphthalenyloxy)piperidine derivatives
PL192926B1 (pl)	2006-12-29	Dwufenyloalkilo-czterohydropirydyny, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające
US4579950A (en)	1986-04-01	Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine] compounds
CA2420620A1 (en)	1997-01-16	4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity
MXPA97010472A (en)	1998-10-15	4-aril-phenylalkil-1,2,3,6-tetrahydropiridines that have a neuroprophic activity and neuroprotect
NO325140B1 (no)	2008-02-11	Nye benzoylalkyl-1,2,3,6-tetrahydropyridiner, fremgangsmate for fremstilling derav, farmasoytisk preaparat inneholdende disse, og anvendelse av forbindelsene for fremstilling av farmasoytiske preparater
US4569998A (en)	1986-02-11	Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds
US4472580A (en)	1984-09-18	Spiro (2H-1,4-benzodioxepin-3 (5H)4-piperidine and -3-pyrrolidine) compounds and their use as anti-hypertensive agents
US4668791A (en)	1987-05-26	Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'piperidine and -3'-pyrrolidine] compounds
CZ291185B6 (cs)	2003-01-15	Způsob přípravy bifenylových derivátů vhodných pro přípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridinů
HU193784B (en)	1987-11-30	Process for producing dihydro-pyridine derivatives
EP0295769A2 (en)	1988-12-21	1,4 Dihydropyridine derivatives, process for their preparation and their uses in pharmaceutical compositions
NO174419B (no)	1994-01-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske forbindelser