CZ334694A3 - 17-alkyl ketone steroids usable as inhibitors of 5-alpha-reductase - Google Patents

17-alkyl ketone steroids usable as inhibitors of 5-alpha-reductase Download PDF

Info

Publication number
CZ334694A3
CZ334694A3 CZ943346A CZ334694A CZ334694A3 CZ 334694 A3 CZ334694 A3 CZ 334694A3 CZ 943346 A CZ943346 A CZ 943346A CZ 334694 A CZ334694 A CZ 334694A CZ 334694 A3 CZ334694 A3 CZ 334694A3
Authority
CZ
Czechia
Prior art keywords
compound
formula
pharmaceutically acceptable
estra
carboxylic acid
Prior art date
Application number
CZ943346A
Other languages
Czech (cs)
English (en)
Inventor
Dennis Alan Holt
Mark Alan Levy
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CZ334694A3 publication Critical patent/CZ334694A3/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CZ943346A 1992-06-30 1993-06-30 17-alkyl ketone steroids usable as inhibitors of 5-alpha-reductase CZ334694A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds

Publications (1)

Publication Number Publication Date
CZ334694A3 true CZ334694A3 (en) 1995-10-18

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ943346A CZ334694A3 (en) 1992-06-30 1993-06-30 17-alkyl ketone steroids usable as inhibitors of 5-alpha-reductase

Country Status (23)

Country Link
EP (1) EP0651643A4 (fr)
JP (1) JPH08500821A (fr)
KR (1) KR950702118A (fr)
CN (1) CN1095382A (fr)
AP (1) AP412A (fr)
AU (1) AU4545993A (fr)
BG (1) BG99313A (fr)
BR (1) BR9306748A (fr)
CA (1) CA2138956A1 (fr)
CZ (1) CZ334694A3 (fr)
FI (1) FI946189A0 (fr)
GB (1) GB9213835D0 (fr)
HU (1) HUT69409A (fr)
IL (1) IL106158A0 (fr)
MA (1) MA22927A1 (fr)
MX (1) MX9303970A (fr)
NO (1) NO945074L (fr)
OA (1) OA10122A (fr)
RU (1) RU94046378A (fr)
SI (1) SI9300350A (fr)
SK (1) SK159994A3 (fr)
WO (1) WO1994000125A1 (fr)
ZA (1) ZA934645B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) * 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
AU676478B2 (en) * 1992-05-20 1997-03-13 Merck & Co., Inc. New delta-17 and delta-20 olefinic and saturated 17beta- substituted-4-aza-5alpha-androstan-3-ones as 5alpha- reductase inhibitors
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP2015129095A (ja) 2013-12-19 2015-07-16 ロレアル 組成物
CN114656514B (zh) * 2018-02-11 2024-05-14 江苏豪森药业集团有限公司 一种甾族类衍生物调节剂及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Also Published As

Publication number Publication date
FI946189A7 (fi) 1994-12-30
ZA934645B (en) 1994-01-25
SK159994A3 (en) 1996-01-10
KR950702118A (ko) 1995-06-19
EP0651643A1 (fr) 1995-05-10
EP0651643A4 (fr) 1995-10-04
CA2138956A1 (fr) 1994-01-06
WO1994000125A1 (fr) 1994-01-06
FI946189L (fi) 1994-12-30
RU94046378A (ru) 1996-10-10
IL106158A0 (en) 1993-10-20
OA10122A (en) 1996-12-18
AP412A (en) 1995-09-29
AP9300542A0 (en) 1993-07-31
FI946189A0 (fi) 1994-12-30
NO945074D0 (no) 1994-12-29
HUT69409A (en) 1995-09-28
NO945074L (no) 1995-02-16
CN1095382A (zh) 1994-11-23
BG99313A (en) 1995-09-29
MA22927A1 (fr) 1994-04-01
GB9213835D0 (en) 1992-08-12
MX9303970A (es) 1994-04-29
SI9300350A (sl) 1993-12-31
AU4545993A (en) 1994-01-24
BR9306748A (pt) 1998-12-08
JPH08500821A (ja) 1996-01-30

Similar Documents

Publication Publication Date Title
CA1319362C (fr) Derives androstenedione substitues en 4, et procede pour leur preparation
DK175522B1 (da) Steroid 5-alfa-reduktase inhibitorer
DK169787B1 (da) 3-trifluormethylsulfonatsteroidderivater
US5527806A (en) 17α and 17β substituted acyl 4 aza steroids
US5137882A (en) Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
CZ334694A3 (en) 17-alkyl ketone steroids usable as inhibitors of 5-alpha-reductase
SI9300601A (en) Pharmaceutical active 17-alpha and 17-beta substituted acyl-3-carboxy-3,5-diene steroidal compounds
EP0669931A1 (fr) Steroides 17-alpha-acyle inhibant 5-alpha-reductase
US5641877A (en) 17-α and 17-β substituted acyl-3-carboxy-3, 5-dienes and use in inhibiting 5-α-reductase
US5618806A (en) 17α and 17β-substituted estra-1,3,5(10)-triene-3-carbboxlic acid
JPH0586090A (ja) １７β−アシル−３−カルボキシ−アンドロスタ−３，５−ジエンの合成における新規な中間体
WO1995021185A1 (fr) STEROIDES A CYCLE A ACYLE 3-CARBOXY AROMATIQUE UTILISE COMME INHIBITEUR DE 5-α REDUCTASE
US5683995A (en) 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
WO1994000121A1 (fr) 17-acyl-4-aza-steroide-3-one a titre d'inhibiteurs de 5-alpha-reductase
JPH08503474A (ja) １７‐アルファおよび１７‐ベータ置換アシル−３−カルボキシ−３，５−ジエンおよび５−アルファ−リダクターゼの阻害における使用
WO1995028413A1 (fr) STEROIDES 3-CARBOXY A SUBSTITUTION 17β INHIBANT LA 5-α-REDUCTASE
CZ397291A3 (cs) Synthetické steroidní deriváty a farmaceutické prostředky sjejich obsahem