DD207376A5 - Verfahren zur herstellung von thiazolderivaten - Google Patents

Verfahren zur herstellung von thiazolderivaten Download PDF

Info

Publication number
DD207376A5
DD207376A5 DD83248911A DD24891183A DD207376A5 DD 207376 A5 DD207376 A5 DD 207376A5 DD 83248911 A DD83248911 A DD 83248911A DD 24891183 A DD24891183 A DD 24891183A DD 207376 A5 DD207376 A5 DD 207376A5
Authority
DD
German Democratic Republic
Prior art keywords
formula
ethyl
alkyl
thiazolylmethylthio
singlet
Prior art date
Application number
DD83248911A
Other languages
German (de)
English (en)
Inventor
Richard P Pioch
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD207376A5 publication Critical patent/DD207376A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Earth Drilling (AREA)
  • Inert Electrodes (AREA)
  • Treating Waste Gases (AREA)
  • Fats And Perfumes (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
DD83248911A 1982-03-19 1983-03-17 Verfahren zur herstellung von thiazolderivaten DD207376A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/360,034 US4474794A (en) 1982-03-19 1982-03-19 N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds

Publications (1)

Publication Number Publication Date
DD207376A5 true DD207376A5 (de) 1984-02-29

Family

ID=23416322

Family Applications (1)

Application Number Title Priority Date Filing Date
DD83248911A DD207376A5 (de) 1982-03-19 1983-03-17 Verfahren zur herstellung von thiazolderivaten

Country Status (22)

Country Link
US (1) US4474794A (el)
EP (1) EP0091220B1 (el)
JP (1) JPS58170773A (el)
KR (1) KR840004091A (el)
AT (1) ATE27156T1 (el)
AU (1) AU1254583A (el)
CA (1) CA1190547A (el)
CS (1) CS236788B2 (el)
DD (1) DD207376A5 (el)
DE (1) DE3371514D1 (el)
DK (1) DK91083A (el)
ES (1) ES520791A0 (el)
FI (1) FI830879A7 (el)
GB (1) GB2116973B (el)
GR (1) GR77882B (el)
IL (1) IL68152A0 (el)
NZ (1) NZ203605A (el)
PH (1) PH18504A (el)
PL (1) PL241066A1 (el)
PT (1) PT76397B (el)
RO (1) RO85385B (el)
ZA (1) ZA831882B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL80961A0 (en) * 1985-12-18 1987-03-31 Lilly Co Eli Synthesis of nizatidine
EP0285681B1 (de) * 1987-04-06 1993-03-10 HEUMANN PHARMA GMBH & CO Verfahren zur Herstellung von Nitroethenderivaten
NL9000132A (nl) * 1990-01-19 1991-08-16 Cedona Pharm Bv Nieuwe thiazoolderivaten.
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200578A (en) * 1978-12-18 1980-04-29 Bristol-Myers Company Thiazole derivatives
US4375547A (en) * 1980-10-02 1983-03-01 Eli Lilly And Company N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine

Also Published As

Publication number Publication date
US4474794A (en) 1984-10-02
PT76397A (en) 1983-04-01
EP0091220A3 (en) 1984-05-23
FI830879A0 (fi) 1983-03-16
RO85385B (ro) 1984-11-30
PL241066A1 (en) 1985-01-02
FI830879L (fi) 1983-09-20
NZ203605A (en) 1985-10-11
FI830879A7 (fi) 1983-09-20
RO85385A (ro) 1984-11-25
EP0091220B1 (en) 1987-05-13
DK91083A (da) 1983-09-20
PH18504A (en) 1985-08-02
JPS58170773A (ja) 1983-10-07
EP0091220A2 (en) 1983-10-12
IL68152A0 (en) 1983-06-15
AU1254583A (en) 1983-09-22
ZA831882B (en) 1984-11-28
GB8307201D0 (en) 1983-04-20
CS236788B2 (en) 1985-05-15
KR840004091A (ko) 1984-10-06
ES8405386A1 (es) 1984-06-01
GR77882B (el) 1984-09-25
GB2116973B (en) 1985-08-29
CA1190547A (en) 1985-07-16
DK91083D0 (da) 1983-02-25
DE3371514D1 (en) 1987-06-19
PT76397B (en) 1986-02-04
GB2116973A (en) 1983-10-05
ATE27156T1 (de) 1987-05-15
ES520791A0 (es) 1984-06-01

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