DD283329A5 - Verfahren zur herstellung von heteroanellierten phenylglycin-beta-lactam-antibiotika - Google Patents

Verfahren zur herstellung von heteroanellierten phenylglycin-beta-lactam-antibiotika Download PDF

Info

Publication number
DD283329A5
DD283329A5 DD89325418A DD32541889A DD283329A5 DD 283329 A5 DD283329 A5 DD 283329A5 DD 89325418 A DD89325418 A DD 89325418A DD 32541889 A DD32541889 A DD 32541889A DD 283329 A5 DD283329 A5 DD 283329A5
Authority
DD
German Democratic Republic
Prior art keywords
carbon atoms
optionally substituted
hydrogen
stand
represent
Prior art date
Application number
DD89325418A
Other languages
German (de)
English (en)
Inventor
Gunter Schmidt
Wolfgang Hartwig
Wilfried Schroeck
Rainer Endermann
Karl G Metzger
Ingo Haller
Hans-Joachim Zeiler
Original Assignee
�����@������������������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �����@������������������k�� filed Critical �����@������������������k��
Publication of DD283329A5 publication Critical patent/DD283329A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DD89325418A 1988-02-03 1989-02-01 Verfahren zur herstellung von heteroanellierten phenylglycin-beta-lactam-antibiotika DD283329A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3803169A DE3803169A1 (de) 1988-02-03 1988-02-03 Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln

Publications (1)

Publication Number Publication Date
DD283329A5 true DD283329A5 (de) 1990-10-10

Family

ID=6346529

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89325418A DD283329A5 (de) 1988-02-03 1989-02-01 Verfahren zur herstellung von heteroanellierten phenylglycin-beta-lactam-antibiotika

Country Status (17)

Country Link
US (1) US4980348A (da)
EP (1) EP0326887B1 (da)
JP (1) JPH021488A (da)
KR (1) KR890013055A (da)
CN (1) CN1035511A (da)
AT (1) ATE80629T1 (da)
AU (1) AU616453B2 (da)
CA (1) CA1329198C (da)
DD (1) DD283329A5 (da)
DE (2) DE3803169A1 (da)
DK (1) DK48489A (da)
FI (1) FI890482A7 (da)
HU (1) HU204825B (da)
IL (1) IL89126A0 (da)
NO (1) NO890287L (da)
PT (1) PT89582B (da)
ZA (1) ZA89811B (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099015A (en) * 1991-01-10 1992-03-24 Eli Lilly And Company Trifluoromethyl 1-carba(1-dethia)cephems
JP3238209B2 (ja) * 1992-09-30 2001-12-10 塩野義製薬株式会社 チオメチルチオカルバセファロスポリン誘導体
CN103965214B (zh) * 2014-05-28 2016-04-13 东南大学 一种β-内酰胺类化合物及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1174335A (en) 1967-03-07 1969-12-17 Lilly Co Eli 7-Alpha-Amino-3-Methyl Cephalosporin Analogues, Pharmaceutical Compositions comprising the same and processes for preparing the same
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
YU36970B (en) 1973-02-23 1984-08-31 Lilly Co Eli Process for obtaining 7-(amino)-acylamido-3-halocephalosporins
IL52144A (en) 1976-07-01 1979-10-31 Lilly Co Eli De-esterification process for -lactam antibiotic esters
NO155548C (no) 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
NO155547C (no) 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge og salter derav samt fremgangsmaate for deres fremstilling.
US4255424A (en) * 1979-04-27 1981-03-10 Merck & Co., Inc. 7-N-Heterocyclyl 1-oxa, 1-aza, and 1-carbadethiacephalosporins
EP0025602B1 (en) 1979-09-13 1984-12-19 Kyowa Hakko Kogyo Co., Ltd Acylated cephalosporin analogs, process for their preparation and pharmaceutical compositions comprising them
NO802714L (no) 1979-10-25 1981-04-27 Kyowa Hakko Kogyo Kk Optisk aktive cefalosporin-analoge karbacefemforbindelser og salter derav, samt fremgangsmaate til fremstilling derav
JPS5849382A (ja) 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS5874680A (ja) * 1981-10-01 1983-05-06 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
ZA832226B (en) * 1982-03-31 1984-02-29 Beecham Group Plc Penicillins,a process for the preparation and compositions containing them
JPS60174787A (ja) 1984-02-21 1985-09-09 Kyowa Hakko Kogyo Co Ltd 3位置換カルバセフエム化合物
GB8409986D0 (en) * 1984-04-17 1984-05-31 Beecham Group Plc Beta-lactam antibacterial agents
PH22107A (en) * 1984-06-07 1988-06-01 Takeda Chemical Industries Ltd 3-pyrazolo(1,5-a)pyrdinium cephem compounds
JPH0653739B2 (ja) * 1984-11-15 1994-07-20 協和醗酵工業株式会社 3位置換カルバセフエム化合物
DE3508258A1 (de) * 1985-03-08 1986-09-18 Bayer Ag, 5090 Leverkusen Ss-lactamantibiotika, verfahren zur herstellung und ihre verwendung als und in arzneimitteln
DE3509618A1 (de) 1985-03-16 1986-09-18 Bayer Ag, 5090 Leverkusen Ss-lactam-antibiotika, verfahren zur herstellung und ihre verwendung als arzneimittel
ATE103923T1 (de) * 1985-12-13 1994-04-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.

Also Published As

Publication number Publication date
JPH021488A (ja) 1990-01-05
DK48489D0 (da) 1989-02-02
NO890287D0 (no) 1989-01-23
PT89582B (pt) 1994-01-31
HUT49886A (en) 1989-11-28
US4980348A (en) 1990-12-25
FI890482A0 (fi) 1989-02-01
AU2776389A (en) 1989-08-03
HU204825B (en) 1992-05-28
ATE80629T1 (de) 1992-10-15
EP0326887A1 (de) 1989-08-09
ZA89811B (en) 1989-10-25
AU616453B2 (en) 1991-10-31
DE58902264D1 (de) 1992-10-22
CA1329198C (en) 1994-05-03
IL89126A0 (en) 1989-08-15
DE3803169A1 (de) 1989-08-17
FI890482L (fi) 1989-08-04
NO890287L (no) 1989-08-04
EP0326887B1 (de) 1992-09-16
PT89582A (pt) 1989-10-04
KR890013055A (ko) 1989-09-21
FI890482A7 (fi) 1989-08-04
CN1035511A (zh) 1989-09-13
DK48489A (da) 1989-08-04

Similar Documents

Publication Publication Date Title
AU658667B2 (en) Quinoline derivative and its salts derivatives
EP0195947B1 (de) Beta-Lactamantibiotika, Verfahren zur Herstellung und ihre Verwendung als und in Arzneimitteln
DE2819479C2 (da)
EP0247431B1 (de) Substituierte 6-Hydroxymethylcarbapenem-Antibiotika, Verfahren zu ihrer Herstellung und ihre Verwendung
NO802686L (no) Fremgangsmaate for fremstilling av en ester av et klavulansyreamin
EP0197294B1 (de) Beta-Lactam-Antibiotika, Verfahren zur Herstellung und ihre Verwendung als Arzneimittel
EP0292808B1 (de) Substituierte Vinylcephalosporine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5171854A (en) Substituted vinylcephalosporins
EP0292806B1 (de) Substituierte Vinylcephalosporine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DD283329A5 (de) Verfahren zur herstellung von heteroanellierten phenylglycin-beta-lactam-antibiotika
EP0162394A2 (de) Neue Cephalosporine und Verfahren zu ihrer Herstellung
EP0405217A1 (de) 2-Isocepheme und 2-Oxa-isocepheme, Verfahren zu ihrer Herstellung und ihre Verwendung als und in Arzneimitteln
EP0000526B1 (de) Pharmazeutische Präparate die Penicilline oder Cephalosporine und Clavulansäure enthalten, Verfahren zu deren Herstellung
EP0223184A2 (de) Neue Cephalosporine, Verfahren zu deren Herstellung sowie ihre Verwendung als Arzneimittel
EP0268963A1 (de) Benzazolylthio-carbapenem-Antibiotika
DE3711343A1 (de) Cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3733626A1 (de) Heteroanellierte phenylglycin-(beta)-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DD281601A5 (de) Verfahren zur herstellung von beta-lactam-verbindungen
DD274422A5 (de) Verfahren zur herstellung von beta-lactam-verbindungen
EP0000891A1 (de) Synergistische Kombinationen von Penicillinen und sie enthaltende antibiotische Mittel

Legal Events

Date Code Title Description
ENJ Ceased due to non-payment of renewal fee