DD296842A5 - Verfahren zur herstellung von gereinigten albuminloesungen - Google Patents
Verfahren zur herstellung von gereinigten albuminloesungen Download PDFInfo
- Publication number
- DD296842A5 DD296842A5 DD90341411A DD34141190A DD296842A5 DD 296842 A5 DD296842 A5 DD 296842A5 DD 90341411 A DD90341411 A DD 90341411A DD 34141190 A DD34141190 A DD 34141190A DD 296842 A5 DD296842 A5 DD 296842A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- albumin
- solution
- tween
- adjusted
- eluted
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title claims abstract description 61
- 108010088751 Albumins Proteins 0.000 title claims abstract description 61
- 238000000034 method Methods 0.000 title claims abstract description 38
- 230000015961 delipidation Effects 0.000 claims abstract description 10
- 239000003599 detergent Substances 0.000 claims abstract description 10
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 8
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000003456 ion exchange resin Substances 0.000 claims abstract description 6
- 229920003303 ion-exchange polymer Polymers 0.000 claims abstract description 6
- 238000000926 separation method Methods 0.000 claims abstract description 5
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 5
- 241001465754 Metazoa Species 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 53
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 11
- 229920000053 polysorbate 80 Polymers 0.000 claims description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007853 buffer solution Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 238000009928 pasteurization Methods 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 7
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- 229920002271 DEAE-Sepharose Polymers 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 238000013375 chromatographic separation Methods 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 239000012459 cleaning agent Substances 0.000 claims description 3
- 230000009849 deactivation Effects 0.000 claims description 3
- 238000010828 elution Methods 0.000 claims description 3
- 230000004962 physiological condition Effects 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017281 sodium acetate Nutrition 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 238000012606 in vitro cell culture Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 4
- 108010010234 HDL Lipoproteins Proteins 0.000 description 4
- 238000007796 conventional method Methods 0.000 description 4
- 238000000760 immunoelectrophoresis Methods 0.000 description 4
- 229960005480 sodium caprylate Drugs 0.000 description 4
- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 102000004895 Lipoproteins Human genes 0.000 description 3
- 108090001030 Lipoproteins Proteins 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000011210 chromatographic step Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012539 chromatography resin Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8907586A FR2648048B1 (fr) | 1989-06-08 | 1989-06-08 | Procede de preparation de solutions d'albumine purifiee |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD296842A5 true DD296842A5 (de) | 1991-12-19 |
Family
ID=9382510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD90341411A DD296842A5 (de) | 1989-06-08 | 1990-06-07 | Verfahren zur herstellung von gereinigten albuminloesungen |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6022954A (cs) |
| EP (1) | EP0402205B1 (cs) |
| JP (1) | JP2965623B2 (cs) |
| AT (1) | ATE131490T1 (cs) |
| AU (1) | AU633925B2 (cs) |
| CA (1) | CA2018511C (cs) |
| CS (1) | CS9002857A3 (cs) |
| DD (1) | DD296842A5 (cs) |
| DE (1) | DE69024105T2 (cs) |
| DK (1) | DK0402205T3 (cs) |
| ES (1) | ES2081952T3 (cs) |
| FI (1) | FI101228B (cs) |
| FR (1) | FR2648048B1 (cs) |
| GR (1) | GR3018983T3 (cs) |
| HR (1) | HRP920769B1 (cs) |
| HU (1) | HU204282B (cs) |
| NO (1) | NO300041B1 (cs) |
| PL (1) | PL165402B1 (cs) |
| YU (1) | YU48084B (cs) |
| ZA (1) | ZA904315B (cs) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3360315B2 (ja) * | 1992-07-31 | 2002-12-24 | 三菱ウェルファーマ株式会社 | ヒト血清アルブミンの高度精製方法 |
| US5728553A (en) * | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| AUPM388494A0 (en) * | 1994-02-16 | 1994-03-10 | Csl Limited | Process for removing endotoxins |
| AU673485B2 (en) * | 1994-02-16 | 1996-11-07 | Csl Limited | Process for removing endotoxins |
| AU4837996A (en) * | 1996-02-29 | 1997-09-16 | Delta Biotechnology Limited | High purity albumin production process |
| ATE215387T1 (de) | 1996-03-15 | 2002-04-15 | Aventis Pasteur | Verfahren zum entfernen von unkonventionellen krankheitserregern aus proteinlösungen |
| FR2746030B1 (fr) * | 1996-03-15 | 1998-04-17 | Procede pour eliminer les agents transmissibles non conventionnels (atnc) d'une solution d'albumine | |
| DE19831061A1 (de) * | 1998-07-10 | 2000-01-13 | Rotkreuzstiftung Zentrallab | Herstellung von Proteinpräparationen mit verringertem Aggregatgehalt |
| DE19830914C1 (de) * | 1998-07-10 | 1999-06-24 | Centeon Pharma Gmbh | Verfahren zur Herstellung einer Proteinlösung |
| DE19858188A1 (de) | 1998-12-17 | 2000-07-06 | Centeon Pharma Gmbh | Verfahren zum Auflösen von Albuminflocken in einer Flüssigkeit sowie Einrichtung zur Durchführung des Verfahrens |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| ES2221817B1 (es) * | 2004-07-26 | 2005-10-01 | Probitas Pharma, S.A. | "soluciones de albumina humana terapeutica con baja actividad del activador de precalicreina (pka) y procedimiento de obtencion de las mismas". |
| CA3058234A1 (en) | 2017-03-16 | 2018-09-20 | Therapure Biopharma Inc. | Method for purification of albumin |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| CN116744984A (zh) | 2020-12-28 | 2023-09-12 | 达沃有限公司 | 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2190437B1 (cs) * | 1972-07-05 | 1975-08-08 | Merieux Inst | |
| FR2322871A1 (fr) * | 1975-09-08 | 1977-04-01 | New Zealand Inventions Dev | Procede d'isolement d'albumine |
| SE405549B (sv) * | 1975-10-09 | 1978-12-18 | Pharmacia Fine Chemicals Ab | Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering |
| US4228154A (en) * | 1979-02-26 | 1980-10-14 | Armour Pharmaceutical Company | Purification of plasma albumin by ion exchange chromatography |
| US4315919A (en) * | 1980-10-06 | 1982-02-16 | Edward Shanbrom | Depyrogenation process |
| DE3173208D1 (en) * | 1980-10-06 | 1986-01-23 | Edward Shanbrom | Method of reducing undesirable activities of biological and pharmaceutical products |
| JPS5795997A (en) * | 1980-12-08 | 1982-06-15 | Nippon Sekijiyuujishiya | Removal of admixed protein from albumin-containing solution in presence of water-soluble high polymer |
| FR2543448A1 (fr) * | 1983-04-01 | 1984-10-05 | Rhone Poulenc Spec Chim | Procede de fractionnement du plasma |
-
1989
- 1989-06-08 FR FR8907586A patent/FR2648048B1/fr not_active Expired - Fee Related
-
1990
- 1990-05-31 DK DK90401459.4T patent/DK0402205T3/da active
- 1990-05-31 DE DE69024105T patent/DE69024105T2/de not_active Expired - Fee Related
- 1990-05-31 ES ES90401459T patent/ES2081952T3/es not_active Expired - Lifetime
- 1990-05-31 EP EP90401459A patent/EP0402205B1/fr not_active Expired - Lifetime
- 1990-05-31 AT AT90401459T patent/ATE131490T1/de not_active IP Right Cessation
- 1990-06-05 ZA ZA904315A patent/ZA904315B/xx unknown
- 1990-06-05 AU AU56812/90A patent/AU633925B2/en not_active Ceased
- 1990-06-06 PL PL90285505A patent/PL165402B1/pl not_active IP Right Cessation
- 1990-06-06 NO NO902499A patent/NO300041B1/no not_active IP Right Cessation
- 1990-06-07 FI FI902843A patent/FI101228B/fi active IP Right Grant
- 1990-06-07 CA CA002018511A patent/CA2018511C/en not_active Expired - Lifetime
- 1990-06-07 DD DD90341411A patent/DD296842A5/de unknown
- 1990-06-07 HU HU903524A patent/HU204282B/hu not_active IP Right Cessation
- 1990-06-08 CS CS902857A patent/CS9002857A3/cs not_active IP Right Cessation
- 1990-06-08 YU YU112490A patent/YU48084B/sh unknown
- 1990-06-08 JP JP2148824A patent/JP2965623B2/ja not_active Expired - Fee Related
-
1991
- 1991-10-11 US US07/774,745 patent/US6022954A/en not_active Expired - Fee Related
-
1992
- 1992-10-01 HR HRP-1124/90A patent/HRP920769B1/xx not_active IP Right Cessation
-
1996
- 1996-02-14 GR GR960400384T patent/GR3018983T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA904315B (en) | 1991-03-27 |
| NO902499L (no) | 1990-12-10 |
| NO300041B1 (no) | 1997-03-24 |
| EP0402205B1 (fr) | 1995-12-13 |
| HRP920769B1 (en) | 1998-12-31 |
| DK0402205T3 (da) | 1996-04-22 |
| FR2648048B1 (fr) | 1994-06-03 |
| EP0402205A1 (fr) | 1990-12-12 |
| NO902499D0 (no) | 1990-06-06 |
| PL165402B1 (pl) | 1994-12-30 |
| HRP920769A2 (hr) | 1994-04-30 |
| CA2018511C (en) | 2001-07-31 |
| CS275600B2 (en) | 1992-02-19 |
| DE69024105T2 (de) | 1996-07-25 |
| ES2081952T3 (es) | 1996-03-16 |
| US6022954A (en) | 2000-02-08 |
| HU204282B (en) | 1991-12-30 |
| FR2648048A1 (fr) | 1990-12-14 |
| YU48084B (sh) | 1997-01-08 |
| JPH0381290A (ja) | 1991-04-05 |
| FI101228B1 (fi) | 1998-05-15 |
| AU5681290A (en) | 1990-12-13 |
| GR3018983T3 (en) | 1996-05-31 |
| AU633925B2 (en) | 1993-02-11 |
| HUT54382A (en) | 1991-02-28 |
| ATE131490T1 (de) | 1995-12-15 |
| HU903524D0 (en) | 1990-10-28 |
| CA2018511A1 (en) | 1990-12-08 |
| JP2965623B2 (ja) | 1999-10-18 |
| CS9002857A3 (en) | 1992-02-19 |
| FI902843A0 (fi) | 1990-06-07 |
| FI101228B (fi) | 1998-05-15 |
| DE69024105D1 (de) | 1996-01-25 |
| PL285505A1 (en) | 1991-01-28 |
| YU112490A (en) | 1991-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF04 | In force in the year 2004 |
Expiry date: 20100608 |