DD297165A5 - Neue sulfatierte polysaccharide, physiologisch vertraegliche salze davon und verfahren zu ihrer herstellung - Google Patents

Neue sulfatierte polysaccharide, physiologisch vertraegliche salze davon und verfahren zu ihrer herstellung Download PDF

Info

Publication number: DD297165A5
Authority: DD; German Democratic Republic
Prior art keywords: reaction; fgag; sulfated polysaccharides; physiologically acceptable; sodium
Prior art date: 1989-02-06

Application number

DD90343252A

Other languages

German (de)

English (en)

Inventor

Hui-Zeng Fan

Song Yu

Etsuji Yamanaka

Kazuhiro Numata

Toshinori Oka

Norihiko Suzuki

Yoshiyuki Muranaka

Original Assignee

��@��@��Kk��Kk��

��@��@�K�Kk��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-06

Filing date

1990-08-06

Publication date

1992-01-02

1990-08-06 Application filed by ��@��@��Kk��Kk��, ��@��@�K�Kk�� filed Critical ��@��@��Kk��Kk��

1990-08-06 Priority to DD90343252A priority Critical patent/DD297165A5/de

1992-01-02 Publication of DD297165A5 publication Critical patent/DD297165A5/de

Links

150000004676 glycans Chemical class 0.000 title claims abstract description 34
229920001282 polysaccharide Polymers 0.000 title claims abstract description 26
239000005017 polysaccharide Substances 0.000 title claims abstract description 26
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238000004519 manufacturing process Methods 0.000 title description 5
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 67
150000003839 salts Chemical class 0.000 claims abstract description 42
238000006243 chemical reaction Methods 0.000 claims abstract description 32
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 30
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
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SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims abstract description 15
SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims abstract description 15
229940079593 drug Drugs 0.000 claims abstract description 15
208000007536 Thrombosis Diseases 0.000 claims abstract description 13
MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 claims abstract description 10
PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims abstract description 8
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FNEHAOQZWPHONV-UHFFFAOYSA-N 9h-carbazole;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC=C2C3=CC=CC=C3NC2=C1 FNEHAOQZWPHONV-UHFFFAOYSA-N 0.000 claims description 3
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241000251512 Leptosynapta inhaerens Species 0.000 description 1
241001674233 Molpadia musculus Species 0.000 description 1
241000251508 Paracaudina chilensis Species 0.000 description 1
241001295374 Parastichopus nigripunctatus Species 0.000 description 1
241000915706 Pentacta Species 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
108010094028 Prothrombin Proteins 0.000 description 1
102100027378 Prothrombin Human genes 0.000 description 1
244000184734 Pyrus japonica Species 0.000 description 1
229920001800 Shellac Polymers 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
241000258161 Stichopus Species 0.000 description 1
241000887536 Stichopus horrens Species 0.000 description 1
241000980131 Synapta maculata Species 0.000 description 1
241000941622 Thelenota Species 0.000 description 1
244000299461 Theobroma cacao Species 0.000 description 1
235000009470 Theobroma cacao Nutrition 0.000 description 1
239000007983 Tris buffer Substances 0.000 description 1
238000000862 absorption spectrum Methods 0.000 description 1
230000001133 acceleration Effects 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
235000019257 ammonium acetate Nutrition 0.000 description 1
229940043376 ammonium acetate Drugs 0.000 description 1
239000003708 ampul Substances 0.000 description 1
230000002785 anti-thrombosis Effects 0.000 description 1
229960005348 antithrombin iii Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
ITHZDDVSAWDQPZ-UHFFFAOYSA-L barium acetate Chemical compound [Ba+2].CC([O-])=O.CC([O-])=O ITHZDDVSAWDQPZ-UHFFFAOYSA-L 0.000 description 1
229940112016 barium acetate Drugs 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
239000001639 calcium acetate Substances 0.000 description 1
235000011092 calcium acetate Nutrition 0.000 description 1
229960005147 calcium acetate Drugs 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
229940023913 cation exchange resins Drugs 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical class CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 description 1
239000000701 coagulant Substances 0.000 description 1
230000001112 coagulating effect Effects 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
229940099112 cornstarch Drugs 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000000440 effect on coagulation Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
239000003205 fragrance Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000011521 glass Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical class CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
CUILPNURFADTPE-UHFFFAOYSA-N hypobromous acid Chemical compound BrO CUILPNURFADTPE-UHFFFAOYSA-N 0.000 description 1
QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
239000012535 impurity Substances 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
239000002674 ointment Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
210000004623 platelet-rich plasma Anatomy 0.000 description 1
239000002574 poison Substances 0.000 description 1
231100000614 poison Toxicity 0.000 description 1
229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920001289 polyvinyl ether Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
230000009024 positive feedback mechanism Effects 0.000 description 1
229960004109 potassium acetate Drugs 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003222 pyridines Chemical class 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000008279 sol Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000758 substrate Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000002834 transmittance Methods 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Birds (AREA)
Oil, Petroleum & Natural Gas (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DD90343252A 1989-02-06 1990-08-06 Neue sulfatierte polysaccharide, physiologisch vertraegliche salze davon und verfahren zu ihrer herstellung DD297165A5 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DD90343252A DD297165A5 (de)	1989-02-06	1990-08-06	Neue sulfatierte polysaccharide, physiologisch vertraegliche salze davon und verfahren zu ihrer herstellung

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2829989		1989-02-06
DD90343252A DD297165A5 (de)	1989-02-06	1990-08-06	Neue sulfatierte polysaccharide, physiologisch vertraegliche salze davon und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
DD297165A5 true DD297165A5 (de)	1992-01-02

Family

ID=12244736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD90343252A DD297165A5 (de)	1989-02-06	1990-08-06	Neue sulfatierte polysaccharide, physiologisch vertraegliche salze davon und verfahren zu ihrer herstellung

Country Status (12)

Country	Link
EP (1)	EP0408770B1 (fr)
JP (1)	JP2714718B2 (fr)
KR (1)	KR970000528B1 (fr)
AT (1)	ATE138938T1 (fr)
AU (1)	AU634521B2 (fr)
CA (1)	CA2026992C (fr)
DD (1)	DD297165A5 (fr)
DE (1)	DE69027256T2 (fr)
DK (1)	DK0408770T3 (fr)
ES (1)	ES2087907T3 (fr)
HU (1)	HU211988A9 (fr)
WO (1)	WO1990008784A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0491027A (ja) *	1990-08-02	1992-03-24	Taiho Yakuhin Kogyo Kk	抗ヒト免疫不全症ウィルス剤
AU644464B2 (en) *	1990-08-02	1993-12-09	Taiho Pharmaceutical Co., Ltd.	Anti-human immunodeficiency virus agent
US6255296B1 (en) *	1994-01-11	2001-07-03	Endomatrix, Inc.	Composition and method for treating a patient susceptible to or suffering from a cardiovascular disorder or disease
KR100240544B1 (ko) *	1995-12-20	2000-01-15	고바야시 유끼오	혈관 내막 비후 억제제
US5876762A (en) *	1996-08-05	1999-03-02	Coastside Bio Resources	Process for obtaining medically active fractions from sea cucumbers
US6399105B1 (en)	1999-01-20	2002-06-04	Peter Donald Collin	Sea cucumber carotenoid lipid fraction products and methods of use
FR2797768B1 (fr)	1999-09-01	2003-06-13	Ifremer	Utilisation d'un polysaccharide sulfate de bas poids moleculaire pour l'obtention d'un medicament actif contre la thrombose vasculaire
EP2980103B1 (fr)	2013-03-26	2020-11-04	Jiuzhitang Co., Ltd.	Dérivé de glycosaminoglycane de faible poids moléculaire, composition pharmaceutique de celui-ci, procédé de préparation de celui-ci et utilisation de celui-ci
CN103788222B (zh)	2014-01-08	2016-08-31	中国科学院昆明植物研究所	Fuc3S4S取代的低聚糖胺聚糖及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3118588C2 (de) *	1981-05-11	1983-07-07	Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München	Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung
JPS63128001A (ja) *	1986-11-19	1988-05-31	Taiho Yakuhin Kogyo Kk	Ｆｇａｇ及びその塩、その製造方法並びにそれを含有する播種性血管内凝固症候群治療剤
JP2785611B2 (ja) *	1992-10-13	1998-08-13	宇部興産株式会社	被処理鋼板材コイルの先端口出し装置

1990
- 1990-02-06 DE DE69027256T patent/DE69027256T2/de not_active Expired - Fee Related
- 1990-02-06 DK DK90902694.0T patent/DK0408770T3/da active
- 1990-02-06 JP JP2502725A patent/JP2714718B2/ja not_active Expired - Fee Related
- 1990-02-06 CA CA002026992A patent/CA2026992C/fr not_active Expired - Fee Related
- 1990-02-06 WO PCT/JP1990/000141 patent/WO1990008784A1/fr not_active Ceased
- 1990-02-06 AU AU50325/90A patent/AU634521B2/en not_active Ceased
- 1990-02-06 AT AT90902694T patent/ATE138938T1/de not_active IP Right Cessation
- 1990-02-06 EP EP90902694A patent/EP0408770B1/fr not_active Expired - Lifetime
- 1990-02-06 ES ES90902694T patent/ES2087907T3/es not_active Expired - Lifetime
- 1990-08-06 DD DD90343252A patent/DD297165A5/de unknown
- 1990-10-06 KR KR1019900702212A patent/KR970000528B1/ko not_active Expired - Fee Related
1995
- 1995-06-30 HU HU95P/P00729P patent/HU211988A9/hu unknown

Also Published As

Publication number	Publication date
JP2714718B2 (ja)	1998-02-16
KR970000528B1 (ko)	1997-01-13
EP0408770A1 (fr)	1991-01-23
WO1990008784A1 (fr)	1990-08-09
ATE138938T1 (de)	1996-06-15
KR910700269A (ko)	1991-03-14
DE69027256T2 (de)	1996-12-19
DE69027256D1 (de)	1996-07-11
EP0408770A4 (en)	1992-03-18
CA2026992C (fr)	1998-11-10
CA2026992A1 (fr)	1990-08-07
AU634521B2 (en)	1993-02-25
AU5032590A (en)	1990-08-24
EP0408770B1 (fr)	1996-06-05
HU211988A9 (en)	1996-01-29
DK0408770T3 (da)	1996-10-07
ES2087907T3 (es)	1996-08-01

Legal Events

Date	Code	Title	Description
1994-03-17	RPI	Change in the person, name or address of the patentee (searches according to art. 11 and 12 extension act)
1994-05-05	RPV	Change in the person, the name or the address of the representative (searches according to art. 11 and 12 extension act)
1996-03-14	RPI	Change in the person, name or address of the patentee (searches according to art. 11 and 12 extension act)
1996-03-14	RPV	Change in the person, the name or the address of the representative (searches according to art. 11 and 12 extension act)
2004-04-28	ASS	Change of applicant or owner	Owner name: KOTAI KASEI CO., LTD., OAZA MOTOHARA, SAITAMA Effective date: 19960116 Owner name: TAIHO PHARMACEUTICAL CO., LTD., TOKYO Effective date: 19960116
2004-04-28	IF04	In force in the year 2004	Expiry date: 20100807

Publication	Publication Date	Title
DE3102621C2 (fr)	1992-08-06
DE69023957T2 (de)	1996-07-04	Sulfatierte Polysaccharide, Antikoagulierungs- und Antikomplementärmittel, hergestellt aus Fukanen aus braunen Algen, und Verfahren zu deren Herstellung.
DE68917040T2 (de)	1995-01-12	Heparinderivate und Verfahren zu deren Herstellung.
DE3851973T2 (de)	1995-06-08	Heparine mit niedrigem Molekulargewicht und regelmässiger Struktur, ihre Herstellung und biologische Verwendungen.
DE69012154T2 (de)	1995-02-23	Heparinderivate und Verfahren zu ihrer Herstellung.
AT398976B (de)	1995-02-27	Gemische von polysacchariden mit niedrigem molekulargewicht, deren herstellungsverfahren und verwendung
DE2833898C2 (fr)	1988-06-23
DE69228362T2 (de)	1999-09-09	Hochmolekulare, N,O-sulfatierte Heparosane; Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE68921633T2 (de)	1995-10-19	Oligosaccharide mit antiatherosclerotischer wirkung.
DE69016383T2 (de)	1995-07-13	Supersulfatierte Heparine.
DD251355A5 (de)	1987-11-11	Verfahren zur herstellung von oligosacchariden
JPS59133202A (ja)	1984-07-31	解重合及び超硫酸化ヘパリン、その製造方法並びに製薬組成物
DE69722434T2 (de)	2004-04-08	Buttersäure-ester mit antiproliferativer wirkung und diese enthaltende pharmazeutische zusammensetzungen
DE69708862T2 (de)	2002-08-14	Derivate von k5 polysaccharid mit hoher, blutgerinnungshemmender wirkung
DE3689493T2 (de)	1994-04-28	Verfahren zur Herstellung von reinem natürlichen Heparansulfat und Dermatansulfat und ihre pharmazeutische Verwendung.
EP0504645B1 (fr)	1995-10-18	Utilisation d'oligosaccharides sulphatés pour le traitement des maladies artériosclérotiques et pour la prévention de la resténose
US5519010A (en)	1996-05-21	Sulfated polysaccharide, pharmaceutically acceptable salt thereof, process for preparing same and medicament containing same as effective component
DE69806468T2 (de)	2003-02-27	Glykosaminoglykane mit hoher antithrombotischer wirkung
DE68916878T2 (de)	1995-03-16	Selektiv O-acylierte Glycosaminoglykane.
DE69814140T2 (de)	2004-04-08	Kohlenhydrat-derivate
DE2751570A1 (de)	1978-05-24	Carboxymethylierte beta-1,3-glucane, verfahren zu deren herstellung und antitumormittel
DE68904264T2 (de)	1993-05-27	Fragmente und fraktionen von heparin mit wirkung gegen hiv.
DE69223153T2 (de)	1998-03-05	Dermatansulfat mit trombolytischer wirkung und arzneiformen welche dieses enthalten
DE60208528T2 (de)	2006-08-17	Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung
DE3787996T2 (de)	1994-03-03	Heparine, frei von E.D.T.A., Fraktionen und Fragmente von Heparin, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, welche diese enthalten.