DE60222000D1 - Sprühgetrocknete zubereitungen und verfahren für deren herstellung - Google Patents

Sprühgetrocknete zubereitungen und verfahren für deren herstellung

Info

Publication number
DE60222000D1
DE60222000D1 DE60222000T DE60222000T DE60222000D1 DE 60222000 D1 DE60222000 D1 DE 60222000D1 DE 60222000 T DE60222000 T DE 60222000T DE 60222000 T DE60222000 T DE 60222000T DE 60222000 D1 DE60222000 D1 DE 60222000D1
Authority
DE
Germany
Prior art keywords
composition
production
dried
spray
spray dried
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60222000T
Other languages
English (en)
Other versions
DE60222000T2 (de
Inventor
Anandaraman Subramaniam
Robert Clark Mciver
Florin Joseph Vlad
Daniel Benczedi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich SA
Original Assignee
Firmenich SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich SA filed Critical Firmenich SA
Application granted granted Critical
Publication of DE60222000D1 publication Critical patent/DE60222000D1/de
Publication of DE60222000T2 publication Critical patent/DE60222000T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/221—Mono, di- or trisaccharides or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/90—Preservation of foods or foodstuffs, in general by drying or kilning; Subsequent reconstitution
    • A23B2/93—Spray drying
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D11/00—Special methods for preparing compositions containing mixtures of detergents
    • C11D11/02—Preparation in the form of powder by spray drying
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/50—Perfumes
    • C11D3/502—Protected perfumes
    • C11D3/505—Protected perfumes encapsulated or adsorbed on a carrier, e.g. zeolite or clay
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Seasonings (AREA)
  • Fats And Perfumes (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
DE60222000T 2001-10-18 2002-10-15 Sprühgetrocknete zubereitungen und verfahren für deren herstellung Expired - Lifetime DE60222000T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US982648 2001-10-18
US09/982,648 US6723359B2 (en) 2001-10-18 2001-10-18 Spray-dried compositions and method for their preparation
PCT/IB2002/004312 WO2003032749A1 (en) 2001-10-18 2002-10-15 Spray-dried compositions and method for their preparation

Publications (2)

Publication Number Publication Date
DE60222000D1 true DE60222000D1 (de) 2007-10-04
DE60222000T2 DE60222000T2 (de) 2008-05-15

Family

ID=25529380

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60222000T Expired - Lifetime DE60222000T2 (de) 2001-10-18 2002-10-15 Sprühgetrocknete zubereitungen und verfahren für deren herstellung

Country Status (10)

Country Link
US (1) US6723359B2 (de)
EP (1) EP1435797B1 (de)
JP (1) JP2005523346A (de)
AT (1) ATE370666T1 (de)
BR (1) BRPI0212783B1 (de)
CA (1) CA2459593A1 (de)
DE (1) DE60222000T2 (de)
ES (1) ES2290334T3 (de)
MX (1) MXPA04003485A (de)
WO (1) WO2003032749A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060148672A1 (en) † 2003-05-28 2006-07-06 Kao Corporation Process for releasing fragrance
US7579495B2 (en) 2003-12-19 2009-08-25 Momentive Performance Materials Inc. Active-releasing cyclic siloxanes
US7576170B2 (en) 2003-12-19 2009-08-18 Momentive Performance Materials Cyclic siloxane compositions for the release of active ingredients
EP1722643B1 (de) * 2004-01-23 2007-11-14 Firmenich SA Grosse glasartige perlen
JP2006238783A (ja) * 2005-03-03 2006-09-14 National Food Research Institute 機能性米菓
CN101272848B (zh) * 2005-07-28 2013-03-13 Isp投资有限公司 改进喷雾干燥的粉末和颗粒材料性质的方法，以及由此生产的产品
US20070078071A1 (en) * 2005-09-30 2007-04-05 Kaiping Lee Spray dry capsule products and methods for preparing and using same
JP4823675B2 (ja) * 2005-12-16 2011-11-24 花王株式会社 ハイドロゲル粒子の製造方法、並びに、それによって製造されるハイドロゲル粒子及びそれを用いた分散体
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
US20080152717A1 (en) * 2006-12-14 2008-06-26 Isp Investments, Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
US20080181961A1 (en) * 2007-01-26 2008-07-31 Isp Investments, Inc. Amorphous oxcarbazepine and the production thereof
US10189957B2 (en) * 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
KR101593285B1 (ko) 2008-10-29 2016-02-11 아블린쓰 엔.브이. 단일 도메인 항원 결합 분자의 제형
US11458105B2 (en) * 2008-12-04 2022-10-04 International Flavors & Fragrances Inc. Hybrid fragrance encapsulate formulation and method for using the same
US10099194B2 (en) 2011-03-18 2018-10-16 International Flavors & Fragrances Inc. Microcapsules produced from blended sol-gel precursors and method for producing the same
US9763861B2 (en) 2008-12-04 2017-09-19 International Flavors & Fragrances Inc. Stable, flowable silica capsule formulation
US20140287008A1 (en) * 2008-12-04 2014-09-25 International Flavors & Fragrances Inc. Hybrid polyurea fragrance encapsulate formulation and method for using the same
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
DE102012223423A1 (de) * 2012-12-17 2014-06-18 Henkel Ag & Co. Kgaa Wasch-, Reinigungs- oder Pflegemittel enthaltend Duftpartikel
CN104968213A (zh) 2013-02-04 2015-10-07 弗门尼舍有限公司 贮藏稳定的喷雾干燥的颗粒
NL1040254C2 (en) 2013-05-17 2014-11-24 Ablynx Nv Stable formulations of immunoglobulin single variable domains and uses thereof.
EP3419663A1 (de) 2016-02-24 2019-01-02 Visterra, Inc. Formulierungen von antikörpermolekülen gegen influenzavirus
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
AU2018312095B2 (en) 2017-08-04 2021-10-28 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
WO2019169167A1 (en) * 2018-03-01 2019-09-06 463Ip Partners, Llc Microencapsulated products, clear solutions thereof, and methods of making
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
ES2945216T3 (es) * 2018-11-26 2023-06-29 Purac Biochem Bv Composición de conservante alimentario particulada
MY189497A (en) * 2019-01-23 2022-02-16 Mizkan Holdings Co Ltd Dried powder of edible plant, food and beverage, and production method therefor
RU2726637C1 (ru) * 2019-07-26 2020-07-15 Общество с ограниченной ответственностью "Научно-внедренческий центр Агроветзащита" (ООО "НВЦ Агроветзащита") Фармацевтическая композиция и способ ее получения
WO2021104619A1 (de) * 2019-11-27 2021-06-03 Symrise Ag Partikuläre erzeugnisse und verfahren zu deren herstellung
WO2022106976A1 (en) 2020-11-18 2022-05-27 Pfizer Inc. Stable pharmaceutical formulations of soluble fgfr3 decoys
GB202018435D0 (en) * 2020-11-24 2021-01-06 Givaudan Sa Improvements in or relating to organic compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1249219B (de) 1958-12-22 1967-09-07 The National Cash Register Company, Dayton, Ohio (V. St. A.) Herstellen von Mikrokapseln, die eine Emulsion aus Öl in hydrophiler Flüssigkeit enthalten
GB911483A (en) 1958-12-22 1962-11-28 Upjohn Co Encapsulated emulsions and processes for their preparation
NL127470C (de) 1960-03-09
JPS61282374A (ja) * 1985-06-07 1986-12-12 San Ei Chem Ind Ltd Ｌ−アスコルビン酸の保存法
JPS63238015A (ja) * 1987-03-24 1988-10-04 Morishita Jintan Kk 徐放性カプセル製剤
US5367643A (en) * 1991-02-06 1994-11-22 International Business Machines Corporation Generic high bandwidth adapter having data packet memory configured in three level hierarchy for temporary storage of variable length data packets
US5124162A (en) 1991-11-26 1992-06-23 Kraft General Foods, Inc. Spray-dried fixed flavorants in a carbohydrate substrate and process
FI944518A0 (fi) * 1992-03-30 1994-09-29 Tastemaker Lämmönkestäviä ja rikottavissa olevia suihkukuivattuja, vapaasti virtaavia aromiöljykapseleita ja menetelmä niiden valmistamiseksi ja käyttämiseksi elintarvikkeissa
JPH06254382A (ja) * 1993-03-05 1994-09-13 Riken Vitamin Co Ltd マイクロカプセルの製造法およびその製造装置
WO1994023593A1 (en) * 1993-04-16 1994-10-27 Mccormick & Company, Inc. Encapsulation compositions
US5709895A (en) 1994-05-31 1998-01-20 Takasago International Corporation Usa Process for producing flavor-containing capsule
WO1998033394A1 (en) 1997-01-31 1998-08-06 Fmc Corporation Texture and stabilizer composition
JPH11196779A (ja) * 1998-01-07 1999-07-27 Nonogawa Shoji Kk 食品用顆粒組成物
DE19813010A1 (de) * 1998-03-25 1999-10-14 Aventis Res & Tech Gmbh & Co Mikrokapseln mit verzögertem Release
US6343351B1 (en) * 1998-09-03 2002-01-29 International Business Machines Corporation Method and system for the dynamic scheduling of requests to access a storage system
EP1124443B1 (de) 1998-11-04 2005-02-09 Firmenich Sa Festes zuführsystem für aromazutaten
US6205494B1 (en) * 1998-12-18 2001-03-20 Western Digital Corporation Controller with automatic generation of linked list of data transfer descriptors for sequential commands, with linked list being used for execution of sequential data transfers
US6438629B1 (en) * 1999-02-02 2002-08-20 Maxtor Corporation Storage device buffer access control in accordance with a monitored latency parameter
ES2213948T3 (es) * 1999-07-02 2004-09-01 Cognis Iberia, S.L. Microcapsulas ii.
US6500463B1 (en) * 1999-10-01 2002-12-31 General Mills, Inc. Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles
AU782212B2 (en) * 1999-11-18 2005-07-14 Quest International B.V. Stable, spray-dried composition in a carbohydrate substrate and process for obtaining said composition
EP1106081A1 (de) 1999-11-18 2001-06-13 Quest International B.V. Stabile, durch Sprühtrocknung in einen Kohlehydratsubstrat hergestellte Zubereitung und Verfahren zu deren Herstellung
KR100351603B1 (ko) * 2000-02-29 2002-09-05 주식회사 봉림 감식초 분말 및 그의 제조방법
JP2001271089A (ja) * 2000-03-24 2001-10-02 Snow Brand Milk Prod Co Ltd アミノ酸配合香料
EP1208754A1 (de) 2000-11-21 2002-05-29 Givaudan SA Teilchenförmiges Material
JP4105457B2 (ja) * 2002-03-20 2008-06-25 アサマ化成株式会社 安定化された香料組成物および香料の安定化方法

Also Published As

Publication number Publication date
EP1435797A1 (de) 2004-07-14
US20030082276A1 (en) 2003-05-01
HK1067015A1 (en) 2005-04-01
ES2290334T3 (es) 2008-02-16
BR0212783A (pt) 2004-10-13
ATE370666T1 (de) 2007-09-15
BRPI0212783B1 (pt) 2015-10-06
DE60222000T2 (de) 2008-05-15
US6723359B2 (en) 2004-04-20
WO2003032749A1 (en) 2003-04-24
JP2005523346A (ja) 2005-08-04
MXPA04003485A (es) 2004-07-30
EP1435797B1 (de) 2007-08-22
CA2459593A1 (en) 2003-04-24

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