DE68912115D1 - Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien. - Google Patents

Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien.

Info

Publication number
DE68912115D1
DE68912115D1 DE90900532T DE68912115T DE68912115D1 DE 68912115 D1 DE68912115 D1 DE 68912115D1 DE 90900532 T DE90900532 T DE 90900532T DE 68912115 T DE68912115 T DE 68912115T DE 68912115 D1 DE68912115 D1 DE 68912115D1
Authority
DE
Germany
Prior art keywords
thromboplastin
thromboplastin reagents
extraction
sensitivity
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90900532T
Other languages
English (en)
Other versions
DE68912115T2 (de
Inventor
Pamela Hawkins
James Maynard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dade Behring Inc
Original Assignee
Baxter Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Diagnostics Inc filed Critical Baxter Diagnostics Inc
Application granted granted Critical
Publication of DE68912115D1 publication Critical patent/DE68912115D1/de
Publication of DE68912115T2 publication Critical patent/DE68912115T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
DE68912115T 1988-11-23 1989-11-03 Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien. Expired - Fee Related DE68912115T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27608388A 1988-11-23 1988-11-23
PCT/US1989/004867 WO1990005740A1 (en) 1988-11-23 1989-11-03 Improved extraction methods for preparing thromboplastin reagents

Publications (2)

Publication Number Publication Date
DE68912115D1 true DE68912115D1 (de) 1994-02-17
DE68912115T2 DE68912115T2 (de) 1994-08-11

Family

ID=23055093

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68912115T Expired - Fee Related DE68912115T2 (de) 1988-11-23 1989-11-03 Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien.

Country Status (9)

Country Link
US (1) US5426031A (de)
EP (1) EP0396733B1 (de)
JP (1) JP3348228B2 (de)
AT (1) ATE99697T1 (de)
CA (1) CA2002208C (de)
DE (1) DE68912115T2 (de)
DK (1) DK173090D0 (de)
NO (1) NO178578C (de)
WO (1) WO1990005740A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
US5358853A (en) * 1992-08-03 1994-10-25 Akzo Av Liquid thromboplastin reagent
DE4407386B4 (de) * 1994-03-05 2009-01-15 Dade Behring Marburg Gmbh Verfahren zur Reaktivierung von gereinigten Membranproteinen durch Einfrieren
JPH08512139A (ja) * 1994-04-28 1996-12-17 デイド、インターナショナル、インコーポレイテッド プロトロンビン時間（ｐｔ）アッセイ用のキャリブレーター
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
DE69832628T2 (de) * 1997-04-23 2006-09-07 Instrumentation Laboratory S.P.A. Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
JP2002526557A (ja) 1998-10-07 2002-08-20 シグマ−アルドリッチ・カンパニー トロンボプラスチン試薬ならびにそのような試薬の製造および使用方法
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
EP1869082B1 (de) * 2005-03-04 2011-04-13 The Board Of Trustees Of The University Of Illinois Modulator von coagulationskaskaden und fibrinolytischen kaskaden
WO2009046194A2 (en) * 2007-10-05 2009-04-09 The Board Of Trustees Of The University Of Illinois Fibrin sealant
US20100297257A1 (en) * 2007-11-09 2010-11-25 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) Anticoagulant antagonist and hemophillia procoagulant
CN112481355B (zh) * 2020-11-16 2023-05-30 武汉市长立生物技术有限责任公司 液体型凝血酶原时间测定试剂盒及其制备方法
CN115166268B (zh) * 2022-08-02 2025-07-04 南京颐兰贝生物科技有限责任公司 一种凝血酶原时间检测试剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522148A (en) * 1965-08-13 1970-07-28 Dade Reagents Inc Stabilized thromboplastin preparation
JPS6366556A (ja) * 1986-09-09 1988-03-25 Fujitsu Ltd フオトマスクの修正方法
US5017556A (en) * 1986-11-04 1991-05-21 Genentech, Inc. Treatment of bleeding disorders using lipid-free tissue factor protein

Also Published As

Publication number Publication date
DE68912115T2 (de) 1994-08-11
US5426031A (en) 1995-06-20
ATE99697T1 (de) 1994-01-15
NO903261L (no) 1990-07-20
EP0396733B1 (de) 1994-01-05
JPH03503534A (ja) 1991-08-08
NO178578B (no) 1996-01-15
EP0396733A1 (de) 1990-11-14
WO1990005740A1 (en) 1990-05-31
NO178578C (no) 1996-04-24
DK173090A (da) 1990-07-19
NO903261D0 (no) 1990-07-20
DK173090D0 (da) 1990-07-19
JP3348228B2 (ja) 2002-11-20
CA2002208C (en) 1998-02-24
CA2002208A1 (en) 1990-05-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DADE BEHRING, INC.(N.D.GES.DES STAATES DELAWARE),

8339 Ceased/non-payment of the annual fee