DK173090A - Forbedrede ekstraktionsmetoder til fremstilling af thromboplastinreagenser - Google Patents

Forbedrede ekstraktionsmetoder til fremstilling af thromboplastinreagenser Download PDF

Info

Publication number: DK173090A
Authority: DK; Denmark
Prior art keywords: reagents; thromboplastic; preparing; thromboplastin; extraction methods
Prior art date: 1988-11-23

Application number

DK173090A

Other languages

English (en)

Other versions

DK173090D0 (da

Inventor

Pamela L H Hawkins

James R Maynard

Original Assignee

Baxter Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-23

Filing date

1990-07-19

Publication date

1990-07-19

1990-07-19 Application filed by Baxter Int filed Critical Baxter Int

1990-07-19 Publication of DK173090D0 publication Critical patent/DK173090D0/da

1990-07-19 Publication of DK173090A publication Critical patent/DK173090A/da

Links

239000003153 chemical reaction reagent Substances 0.000 title abstract 3
238000000605 extraction Methods 0.000 title abstract 3
238000000034 method Methods 0.000 title 1
230000001026 thromboplastic effect Effects 0.000 title 1
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 abstract 3
108010000499 Thromboplastin Proteins 0.000 abstract 3
102000002262 Thromboplastin Human genes 0.000 abstract 3
108010094028 Prothrombin Proteins 0.000 abstract 2
102100027378 Prothrombin Human genes 0.000 abstract 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
229940039716 prothrombin Drugs 0.000 abstract 2
230000035945 sensitivity Effects 0.000 abstract 2
239000003146 anticoagulant agent Substances 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000003196 chaotropic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
208000014763 coagulation protein disease Diseases 0.000 abstract 1
229940072645 coumadin Drugs 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
230000006624 extrinsic pathway Effects 0.000 abstract 1
238000012544 monitoring process Methods 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Ultra Sonic Daignosis Equipment (AREA)

DK173090A 1988-11-23 1990-07-19 Forbedrede ekstraktionsmetoder til fremstilling af thromboplastinreagenser DK173090A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27608388A	1988-11-23	1988-11-23
PCT/US1989/004867 WO1990005740A1 (en)	1988-11-23	1989-11-03	Improved extraction methods for preparing thromboplastin reagents

Publications (2)

Publication Number	Publication Date
DK173090D0 DK173090D0 (da)	1990-07-19
DK173090A true DK173090A (da)	1990-07-19

Family

ID=23055093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK173090A DK173090A (da)	1988-11-23	1990-07-19	Forbedrede ekstraktionsmetoder til fremstilling af thromboplastinreagenser

Country Status (9)

Country	Link
US (1)	US5426031A (da)
EP (1)	EP0396733B1 (da)
JP (1)	JP3348228B2 (da)
AT (1)	ATE99697T1 (da)
CA (1)	CA2002208C (da)
DE (1)	DE68912115T2 (da)
DK (1)	DK173090A (da)
NO (1)	NO178578C (da)
WO (1)	WO1990005740A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5281528A (en) *	1989-12-18	1994-01-25	Warner-Lambert Company	Process for purified thromboplastin for ultra-pure thrombin preparation
US5254350A (en) *	1991-07-22	1993-10-19	Helena Laboratories Corporation	Method of preparing a thromboplastin extract
US5358853A (en) *	1992-08-03	1994-10-25	Akzo Av	Liquid thromboplastin reagent
DE4407386B4 (de) *	1994-03-05	2009-01-15	Dade Behring Marburg Gmbh	Verfahren zur Reaktivierung von gereinigten Membranproteinen durch Einfrieren
CA2165412A1 (en) *	1994-04-28	1995-10-29	Barry John Woodhams	Calibrator for prothrombin time (pt) assays
US6379975B1 (en)	1996-11-27	2002-04-30	T.A.C. Thrombosis And Coagulation Aktiebolag	Methods and reagents for determining protein S
EP1015890B1 (en) *	1997-04-23	2005-11-30	INSTRUMENTATION LABORATORY S.p.A.	Recombinant rabbit tissue factor based prothrombin time reagent
ATE313068T1 (de)	1998-10-07	2005-12-15	Trinity Biotech Mfg Ltd	Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben
US6855509B2 (en)	2000-12-19	2005-02-15	Instrumentation Laboratory Company	Protein S functional assay and kit therefor
US7148067B2 (en) *	2004-08-31	2006-12-12	The Board Of Trustees Of The University Of Illinois	Thromboplastin reagents
US20080260858A1 (en) *	2005-02-16	2008-10-23	The Board Of Trustees Of The University Of Illnois	Universal Procoagulant
JP2008531692A (ja) *	2005-03-04	2008-08-14	ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ	凝固及び線維素溶解カスケードのモジュレーター
WO2009046194A2 (en) *	2007-10-05	2009-04-09	The Board Of Trustees Of The University Of Illinois	Fibrin sealant
WO2009061697A1 (en)	2007-11-09	2009-05-14	The Board Of Trustees Of The University Of Illinois	Anticoagulant antagonist and hemophilia procoagulant
CN112481355B (zh) *	2020-11-16	2023-05-30	武汉市长立生物技术有限责任公司	液体型凝血酶原时间测定试剂盒及其制备方法
CN115166268B (zh) *	2022-08-02	2025-07-04	南京颐兰贝生物科技有限责任公司	一种凝血酶原时间检测试剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3522148A (en) *	1965-08-13	1970-07-28	Dade Reagents Inc	Stabilized thromboplastin preparation
JPS6366556A (ja) *	1986-09-09	1988-03-25	Fujitsu Ltd	フオトマスクの修正方法
US5017556A (en) *	1986-11-04	1991-05-21	Genentech, Inc.	Treatment of bleeding disorders using lipid-free tissue factor protein

1989
- 1989-11-03 WO PCT/US1989/004867 patent/WO1990005740A1/en not_active Ceased
- 1989-11-03 EP EP90900532A patent/EP0396733B1/en not_active Expired - Lifetime
- 1989-11-03 DE DE68912115T patent/DE68912115T2/de not_active Expired - Fee Related
- 1989-11-03 CA CA002002208A patent/CA2002208C/en not_active Expired - Lifetime
- 1989-11-03 JP JP50074490A patent/JP3348228B2/ja not_active Expired - Fee Related
- 1989-11-03 AT AT90900532T patent/ATE99697T1/de not_active IP Right Cessation
1990
- 1990-07-19 DK DK173090A patent/DK173090A/da not_active IP Right Cessation
- 1990-07-20 NO NO903261A patent/NO178578C/no not_active IP Right Cessation
1993
- 1993-05-25 US US08/070,875 patent/US5426031A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE68912115T2 (de)	1994-08-11
DK173090D0 (da)	1990-07-19
NO903261L (no)	1990-07-20
EP0396733B1 (en)	1994-01-05
CA2002208A1 (en)	1990-05-23
WO1990005740A1 (en)	1990-05-31
EP0396733A1 (en)	1990-11-14
CA2002208C (en)	1998-02-24
JP3348228B2 (ja)	2002-11-20
NO178578C (no)	1996-04-24
DE68912115D1 (de)	1994-02-17
ATE99697T1 (de)	1994-01-15
US5426031A (en)	1995-06-20
NO178578B (no)	1996-01-15
NO903261D0 (no)	1990-07-20
JPH03503534A (ja)	1991-08-08

Legal Events

Date	Code	Title
2000-01-10	B1	Patent granted (law 1993)
2001-07-09	AHB	Application shelved due to non-payment
2002-07-01	PBP	Patent lapsed

Publication	Publication Date	Title
DK173090A (da)	1990-07-19	Forbedrede ekstraktionsmetoder til fremstilling af thromboplastinreagenser
DE69801210D1 (de)	2001-08-30	Verbesserte in vitro Verfahren, Testkits und Reagenzien zum Screening von Blutgerinnungsfehlern
ATE78098T1 (de)	1992-07-15	Testverfahren mit oberflaechengebundenem fibrinogen und loesliches markiertes fibrinogen.
ES2059394T3 (es)	1994-11-16	Metodo y dispositivo inmunocromatograficos cualitativos.
TWI256975B (en)	2006-06-21	Compositions containing a urea derivative dye for detecting an analyte and methods for using the same
ES2072243T3 (es)	2000-03-16	Prueba de coagulacion cuantitativa para medir la concentracion de factor vii activo.
FI915150A7 (fi)	1991-10-31	Menetelmät, reagenssit ja testikäyttöpakkaukset biologisten yksiköiden alapopulaatioiden määrittämiseksi
ATE376187T1 (de)	2007-11-15	Nachweis von erkrankungen der nieren und behandlung
ATE71459T1 (de)	1992-01-15	Verfahren zur ueberwachung der blutgerinnung.
DK0434377T3 (da)	1995-09-25	Metode til bestemmelse af ekstrinsiske og intrinsiske størkningsfaktorer og protein C
DE3587724D1 (de)	1994-02-24	Antikörper verwendende diagnostische Methoden.
DK118187A (da)	1987-09-08	Fremgangsmaade til fotometrisk bestemmelse af protein c- og/eller protein s-aktivitet
ATE51029T1 (de)	1990-03-15	Siebtest fuer reverse-transcriptase enthaltenden virus.
ES2056154T3 (es)	1994-10-01	Procedimiento para la determinacion de una sustancia capaz de fijarse especificamente.
DK0690991T4 (da)	2004-02-16	Ny antikoagulant-cofaktor-aktivitet
WO1998032389A1 (en)	1998-07-30	Method and apparatus for the measurement of blood coagulation properties with absorbent materials
Kirchhof et al.	1979	Control of anticoagulant therapy with a chromogenic substrate
ES2090106T3 (es)	1996-10-16	Metodo de asociacion quimica directa de dimero d procedente de una muestra biologica y que permite el diagnostico y el seguimiento de estados de trombolisis y de hipercoagulabilidad.
ATE191278T1 (de)	2000-04-15	Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen
Hawkins et al.	1996	Extraction methods for preparing thromboplastin reagents
ATE200710T1 (de)	2001-05-15	Verfahren zur diagnose von blutgerinnungsstörungen
Dejanov et al.	1990	A method of heparin therapy control with Vipera venom and diluted tissue thromboplastin preparations
Dati et al.	1987	RESULTS OF THE MULTICENTRIC EVALUATION OF A NEW SYSTEM FOR PHOTOMETRIC DETERMINATION OF COAGULATION PARAMETERS
JPS6450960A (en)	1989-02-27	Quantitative measuring method of active type protein s
HUT53229A (en)	1990-09-28	Process for radioimmunological determination of 3'-azido-3'-deoxythymidine content of biological samples