ATE191278T1 - Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen - Google Patents

Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen

Info

Publication number: ATE191278T1
Authority: AT; Austria
Prior art keywords: blood clotting; tetrahydroxyquinone; indicator; time test; partial thromboplastin
Prior art date: 1993-11-04

Application number

AT95901136T

Other languages

English (en)

Inventor

Ted C K Lee

Franz Hermann Pelzer

Leslie A Motley

Original Assignee

Dade Behring Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-04

Filing date

1994-11-04

Publication date

2000-04-15

1994-11-04 Application filed by Dade Behring Inc filed Critical Dade Behring Inc

2000-04-15 Application granted granted Critical

2000-04-15 Publication of ATE191278T1 publication Critical patent/ATE191278T1/de

Links

230000023555 blood coagulation Effects 0.000 title abstract 4
PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 2
102000002262 Thromboplastin Human genes 0.000 title abstract 2
108010000499 Thromboplastin Proteins 0.000 title abstract 2
239000012190 activator Substances 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
DGQOCLATAPFASR-UHFFFAOYSA-N tetrahydroxy-1,4-benzoquinone Chemical compound OC1=C(O)C(=O)C(O)=C(O)C1=O DGQOCLATAPFASR-UHFFFAOYSA-N 0.000 title 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT95901136T 1993-11-04 1994-11-04 Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen ATE191278T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14813993A	1993-11-04	1993-11-04
PCT/US1994/012693 WO1995012818A1 (en)	1993-11-04	1994-11-04	Tetrahydroxyquinone as an activator component for activated partial thromboplastine time test of blood coagulation and as a detector of blood coagulation disorders

Publications (1)

Publication Number	Publication Date
ATE191278T1 true ATE191278T1 (de)	2000-04-15

Family

ID=22524463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95901136T ATE191278T1 (de)	1993-11-04	1994-11-04	Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen

Country Status (8)

Country	Link
US (1)	US5550028A (de)
EP (1)	EP0677171B1 (de)
JP (1)	JPH08510057A (de)
AT (1)	ATE191278T1 (de)
AU (1)	AU674265B2 (de)
CA (1)	CA2152954A1 (de)
DE (1)	DE69423738T2 (de)
WO (1)	WO1995012818A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT405692B (de) *	1997-03-27	1999-10-25	Immuno Ag	Reagens zur bestimmung der aptt
ATE268477T1 (de)	1999-09-03	2004-06-15	Roche Diagnostics Corp	Verfahren, reagenz und messkartusche zur bestimmung der gerinnungszeit
US6448024B1 (en)	2000-10-03	2002-09-10	Roche Diagnostics Corporation	Method, reagent, cartridge, and device for determining fibrinogen
JP6577778B2 (ja) *	2015-07-30	2019-09-18	シスメックス株式会社	凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット
EP3859327A4 (de)	2018-09-25	2022-09-07	Sekisui Medical Co., Ltd.	Verfahren zur messung der blutgerinnungszeit

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3486981A (en) *	1965-03-15	1969-12-30	Roy E Speck	Substances relating to testing of blood-coagulation
BE722746A (de) *	1967-11-09	1969-04-01
US3839317A (en) *	1973-06-29	1974-10-01	Interx Research Corp	Digoxin complexes
US3880714A (en) *	1973-07-18	1975-04-29	Warner Lambert Co	Diagnostic reagent
JPS60174952A (ja) *	1984-02-21	1985-09-09	Sekisui Chem Co Ltd	血液凝固促進剤
DE3407280A1 (de) *	1984-02-28	1985-09-19	Gödecke AG, 1000 Berlin	Testsatz zur bestimmung der aktivierten partiellen thromboplastinzeit (ptt) mit erhoehter heparinempfindlichkeit
EP0241314B1 (de) *	1986-04-11	1994-08-10	Sekisui Kagaku Kogyo Kabushiki Kaisha	Beschleuniger der Aktivität von Hydrolase
US5126247A (en) *	1988-02-26	1992-06-30	Enzymatics, Inc.	Method, system and devices for the assay and detection of biochemical molecules
US5055412A (en) *	1989-03-21	1991-10-08	Proksch Gary J	Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
FI102273B (fi) *	1989-09-11	1998-11-13	Eisai Co Ltd	Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö
DE69120674T2 (de) *	1990-04-17	1996-11-07	Analytical Control Syst Inc	Koagulationsassays und reagenzien
US5302531A (en) *	1992-10-22	1994-04-12	Miles Inc.	Composition for the semiquantitative determination of specific gravity of a test sample

1994
- 1994-11-04 DE DE69423738T patent/DE69423738T2/de not_active Expired - Fee Related
- 1994-11-04 JP JP7513430A patent/JPH08510057A/ja active Pending
- 1994-11-04 AU AU10494/95A patent/AU674265B2/en not_active Ceased
- 1994-11-04 EP EP95901136A patent/EP0677171B1/de not_active Expired - Lifetime
- 1994-11-04 CA CA002152954A patent/CA2152954A1/en not_active Abandoned
- 1994-11-04 WO PCT/US1994/012693 patent/WO1995012818A1/en not_active Ceased
- 1994-11-04 AT AT95901136T patent/ATE191278T1/de not_active IP Right Cessation
1995
- 1995-06-07 US US08/484,373 patent/US5550028A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0677171A1 (de)	1995-10-18
US5550028A (en)	1996-08-27
AU1049495A (en)	1995-05-23
CA2152954A1 (en)	1995-05-11
WO1995012818A1 (en)	1995-05-11
DE69423738T2 (de)	2000-11-23
EP0677171B1 (de)	2000-03-29
JPH08510057A (ja)	1996-10-22
DE69423738D1 (de)	2000-05-04
AU674265B2 (en)	1996-12-12

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Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification
2002-02-15	REN	Ceased due to non-payment of the annual fee