DK0382637T3 - Pyrimidinyl-piperazinyl-alkyl-azolderivater med anxiolytisk og/eller beroligende aktivitet - Google Patents
Pyrimidinyl-piperazinyl-alkyl-azolderivater med anxiolytisk og/eller beroligende aktivitetInfo
- Publication number
- DK0382637T3 DK0382637T3 DK90400337.3T DK90400337T DK0382637T3 DK 0382637 T3 DK0382637 T3 DK 0382637T3 DK 90400337 T DK90400337 T DK 90400337T DK 0382637 T3 DK0382637 T3 DK 0382637T3
- Authority
- DK
- Denmark
- Prior art keywords
- radical
- alkyl
- represent
- general formula
- image
- Prior art date
Links
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 230000000949 anxiolytic effect Effects 0.000 title 1
- 230000001624 sedative effect Effects 0.000 title 1
- -1 alkyl radical Chemical class 0.000 abstract 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- NYOWYNSNCXRVNQ-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1h-indazole Chemical class C1=CCC2CNNC2=C1 NYOWYNSNCXRVNQ-UHFFFAOYSA-N 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical class [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- JEVCWSUVFOYBFI-UHFFFAOYSA-N cyanyl Chemical compound N#[C] JEVCWSUVFOYBFI-UHFFFAOYSA-N 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical compound O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-M oxidooxomethyl Chemical compound [O-][C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-M 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical compound C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8901700A FR2642759B1 (fr) | 1989-02-09 | 1989-02-09 | Derives de pyrimidyl-piperazinyl-alkyl azoles avec activite anxiolytique et/ou tranquillisante |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0382637T3 true DK0382637T3 (da) | 1993-09-20 |
Family
ID=9378642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90400337.3T DK0382637T3 (da) | 1989-02-09 | 1990-02-07 | Pyrimidinyl-piperazinyl-alkyl-azolderivater med anxiolytisk og/eller beroligende aktivitet |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5128343A (da) |
| EP (1) | EP0382637B1 (da) |
| JP (1) | JP2521170B2 (da) |
| KR (1) | KR950000779B1 (da) |
| AT (1) | ATE92059T1 (da) |
| AU (1) | AU623734B2 (da) |
| CA (1) | CA2009480A1 (da) |
| DD (1) | DD292000A5 (da) |
| DE (1) | DE69002341T2 (da) |
| DK (1) | DK0382637T3 (da) |
| ES (1) | ES2021941A6 (da) |
| FR (1) | FR2642759B1 (da) |
| HU (1) | HU204817B (da) |
| NO (1) | NO176880C (da) |
| PT (1) | PT93095B (da) |
| RU (1) | RU2071474C1 (da) |
| YU (1) | YU48071B (da) |
| ZA (1) | ZA90929B (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5219855A (en) * | 1988-01-29 | 1993-06-15 | Mitsubishi Kasei Corporation | Anxiolytic drug |
| FR2654621B1 (fr) * | 1989-11-22 | 1994-09-23 | Esteve Labor Dr | Inhibition du syndrome d'abstinence. |
| FR2672052B1 (fr) * | 1991-01-28 | 1995-05-24 | Esteve Labor Dr | Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments. |
| US5633377A (en) * | 1990-12-28 | 1997-05-27 | Neurogen Corporation | 4-piperidino- and piperazinomethyl-2-cyclohexyl imidazole derivatives; dopamine receptor subtype specific ligands |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| FR2671972B1 (fr) * | 1991-01-25 | 1995-03-03 | Esteve Labor Dr | Utilisation de derives 1-h-azole-(omega-(4-(2-pyrimidinyl)-1-piperazinyl)-alkyl) pour la preparation de medicaments destines au traitement des troubles des fonctions cognitives. |
| FR2673628B1 (fr) * | 1991-03-07 | 1993-07-09 | Esteve Labor Dr | Procede de preparation de derives d'aryl (ou heteroaryl)-piperazinyl-butyl-azoles. |
| FR2701260B1 (fr) * | 1993-02-05 | 1995-05-05 | Esteve Labor Dr | Dérivés de 2-[4-(4-azolylbutyl)-1-pipérazinyl]-5-hydroxypyrimidine, leur préparation et leur application en tant que médicaments. |
| FR2705098B1 (fr) * | 1993-05-10 | 1995-08-04 | Esteve Labor Dr | Procédé de préparation de 2-{4-[4-(chloro-1-pyrazolyl)butyl]1-pipérazinyl}pyrimidine (Lesopitron) . |
| ES2099031B1 (es) * | 1995-05-31 | 1997-12-01 | Esteve Labor Dr | Nuevos polimorfos de diclorhidrato de lesopitron y sus formas hidratadas, procedimientos de preparacion y composiciones que los contienen. |
| FR2763950B1 (fr) * | 1997-06-02 | 2002-09-20 | Esteve Labor Dr | 2- {4- [4-(4,5-dichloro-2-methylimidazol-1-yl)butyl] -1- piperazinyl }-5-fluoropyrimidine, sa preparation et son utilisation therapeutique |
| ES2125206B1 (es) * | 1997-07-21 | 1999-11-16 | Esteve Labor Dr | Derivados de acil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
| US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
| US7589202B2 (en) | 2000-08-14 | 2009-09-15 | Ortho Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
| EP1309593B1 (en) | 2000-08-14 | 2006-03-15 | Ortho-McNeil Pharmaceutical, Inc. | Substituted pyrazoles |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| HK1052705B (en) | 2000-08-14 | 2006-09-29 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted pyrazole |
| CN1642973A (zh) | 2000-09-06 | 2005-07-20 | 奥索-麦克尼尔药品公司 | 治疗变态反应的方法 |
| ES2167276B1 (es) * | 2000-10-20 | 2003-04-01 | Esteve Labor Dr | Nuevos derivados de cianoaril (o cianoheteroaril)-carbonil-piperazinil-pirimidinas, su preparacion y su aplicacion como medicamentos. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4487773A (en) * | 1981-03-16 | 1984-12-11 | Mead Johnson & Company | 1,2,4-Triazol-3-one antidepressants |
| US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
| DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4547499A (en) * | 1984-05-10 | 1985-10-15 | The Upjohn Company | 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use |
| US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
-
1989
- 1989-02-09 FR FR8901700A patent/FR2642759B1/fr not_active Expired - Lifetime
-
1990
- 1990-01-29 NO NO900411A patent/NO176880C/no not_active IP Right Cessation
- 1990-02-07 DE DE90400337T patent/DE69002341T2/de not_active Expired - Fee Related
- 1990-02-07 US US07/476,815 patent/US5128343A/en not_active Expired - Fee Related
- 1990-02-07 AU AU49192/90A patent/AU623734B2/en not_active Ceased
- 1990-02-07 EP EP90400337A patent/EP0382637B1/en not_active Expired - Lifetime
- 1990-02-07 AT AT90400337T patent/ATE92059T1/de not_active IP Right Cessation
- 1990-02-07 CA CA002009480A patent/CA2009480A1/fr not_active Abandoned
- 1990-02-07 DK DK90400337.3T patent/DK0382637T3/da active
- 1990-02-08 ZA ZA90929A patent/ZA90929B/xx unknown
- 1990-02-08 DD DD90337677A patent/DD292000A5/de unknown
- 1990-02-08 ES ES9000369A patent/ES2021941A6/es not_active Expired - Lifetime
- 1990-02-08 HU HU90716A patent/HU204817B/hu not_active IP Right Cessation
- 1990-02-08 JP JP2031353A patent/JP2521170B2/ja not_active Expired - Lifetime
- 1990-02-08 KR KR1019900001536A patent/KR950000779B1/ko not_active Expired - Fee Related
- 1990-02-08 PT PT93095A patent/PT93095B/pt not_active IP Right Cessation
- 1990-02-09 YU YU25790A patent/YU48071B/sh unknown
-
1991
- 1991-09-18 RU SU915001503A patent/RU2071474C1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| HUT53100A (en) | 1990-09-28 |
| PT93095A (pt) | 1990-08-31 |
| DE69002341D1 (de) | 1993-09-02 |
| ATE92059T1 (de) | 1993-08-15 |
| NO176880C (no) | 1995-06-14 |
| RU2071474C1 (ru) | 1997-01-10 |
| HU900716D0 (en) | 1990-04-28 |
| KR950000779B1 (ko) | 1995-02-02 |
| NO176880B (no) | 1995-03-06 |
| DE69002341T2 (de) | 1993-12-02 |
| NO900411L (no) | 1990-08-10 |
| YU48071B (sh) | 1997-01-08 |
| DD292000A5 (de) | 1991-07-18 |
| JPH032179A (ja) | 1991-01-08 |
| KR900012929A (ko) | 1990-09-03 |
| FR2642759A1 (fr) | 1990-08-10 |
| PT93095B (pt) | 1995-12-29 |
| EP0382637A1 (fr) | 1990-08-16 |
| FR2642759B1 (fr) | 1991-05-17 |
| YU25790A (en) | 1991-08-31 |
| EP0382637B1 (en) | 1993-07-28 |
| NO900411D0 (no) | 1990-01-29 |
| ES2021941A6 (es) | 1991-11-16 |
| AU623734B2 (en) | 1992-05-21 |
| US5128343A (en) | 1992-07-07 |
| AU4919290A (en) | 1990-08-16 |
| CA2009480A1 (fr) | 1990-08-09 |
| ZA90929B (en) | 1990-11-28 |
| HU204817B (en) | 1992-02-28 |
| JP2521170B2 (ja) | 1996-07-31 |
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